Showing 1 to 50 of 156627 entries Per page:
Compound ID Target/Cell Structure Activity Assay Description Source
NAs.000000 2 ribose-match Adenosine A1 receptor NAs.000000 Ki = 120.0 nM Inhibition of binding of [3H]N6-cyclohexyladenosine to adenosine A1 receptor of rat whole brain membranes. CHEMBL1124694
NAs.000000 2 ribose-match J82 NAs.000000 Other None None None Cytotoxicity against human J82 cells at 10 uM after 72 hrs by MTT assay CHEMBL1287719
NAs.000000 2 ribose-match K562 NAs.000000 GI50 = 2920.0 nM Growth inhibition of 1 uM 1,4-dihydro-2-methyl-6-phenyl-4-(phenylethyl)-3,5-pyridine-dicarboxylic acid 3-ethyl-5-[(3-nitrophenyl) methyl] ester pretreated human K562 cells after 72 hrs by MTS assay CHEMBL1155110
NAs.000000 2 ribose-match K562 NAs.000000 GI50 = 2920.0 nM Growth inhibition of 0.1 uM 1,4-dihydro-2-methyl-6-phenyl-4-(phenylethyl)-3,5-pyridine-dicarboxylic acid 3-ethyl-5-[(3-nitrophenyl) methyl] ester pretreated human K562 cells after 72 hrs by MTS assay CHEMBL1155110
NAs.000000 2 ribose-match K562 NAs.000000 GI50 = 4170.0 nM Growth inhibition of 1 uM 1,4-dihydro-2-methyl-6-phenyl-4-(phenylethyl)-3,5-pyridine-dicarboxylic acid 3-ethyl-5-[(3-nitrophenyl) methyl] ester pretreated human K562 cells after 48 hrs by MTS assay CHEMBL1155110
NAs.000000 2 ribose-match K562 NAs.000000 GI50 = 3910.0 nM Growth inhibition of 0.1 uM 1,4-dihydro-2-methyl-6-phenyl-4-(phenylethyl)-3,5-pyridine-dicarboxylic acid 3-ethyl-5-[(3-nitrophenyl) methyl] ester pretreated human K562 cells after 48 hrs by MTS assay CHEMBL1155110
NAs.000000 2 ribose-match Adenosine A3 receptor NAs.000000 Ki = 41.3 nM Inhibition of human adenosine A3 receptor CHEMBL1155110
NAs.000000 2 ribose-match MCF7 NAs.000000 GI50 = 61000.0 nM Antitumor activity against human MCF7 cells after 48 hrs by MTS assay CHEMBL1155110
NAs.000000 2 ribose-match HT-29 NAs.000000 GI50 = 22300.0 nM Antitumor activity against human HT29 cells after 48 hrs by MTS assay CHEMBL1155110
NAs.000000 2 ribose-match Caco-2 NAs.000000 GI50 = 7400.0 nM Antitumor activity against human CaCo2 cells after 48 hrs by MTS assay CHEMBL1155110
NAs.000000 2 ribose-match K562 NAs.000000 GI50 = 4600.0 nM Antitumor activity against human K562 cells after 48 hrs by MTS assay CHEMBL1155110
NAs.000000 2 ribose-match Adenosine A2b receptor NAs.000000 Other = -1.491 None Agonist activity human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase relative to NECA CHEMBL1145544
NAs.000000 2 ribose-match Adenosine A2b receptor NAs.000000 Other = -4.799 None Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase CHEMBL1145544
NAs.000000 2 ribose-match Equilibrative nucleoside transporter 1 NAs.000000 IC50 = 10715.19 nM Binding affinity to ENT1 transporter CHEMBL1145549
NAs.000000 2 ribose-match NON-PROTEIN TARGET NAs.000000 IC50 = 5400.0 nM Antitumor activity against human MCF cells after 72 hrs by Calcein AM assay CHEMBL1143049
NAs.000000 2 ribose-match ADMET NAs.000000 IC50 = 39000.0 nM Cytotoxicity against mouse NIH 3T3 cells after 72 hrs by Calcein AM assay CHEMBL1143049
NAs.000000 2 ribose-match B16 NAs.000000 IC50 > 166700.0 nM Antitumor activity against mouse B16 cells after 72 hrs by Calcein AM assay CHEMBL1143049
NAs.000000 2 ribose-match G-361 NAs.000000 IC50 > 166700.0 nM Antitumor activity against human G361 cells after 72 hrs by Calcein AM assay CHEMBL1143049
NAs.000000 2 ribose-match HL-60 NAs.000000 IC50 = 940.0 nM Antitumor activity against human HL60 cells after 72 hrs by Calcein AM assay CHEMBL1143049
NAs.000000 2 ribose-match CCRF-CEM NAs.000000 IC50 = 1400.0 nM Antitumor activity against human CEM cells after 72 hrs by Calcein AM assay CHEMBL1143049
NAs.000000 2 ribose-match K562 NAs.000000 IC50 = 5500.0 nM Antitumor activity against human K562 cells after 72 hrs by Calcein AM assay CHEMBL1143049
NAs.000000 2 ribose-match HOS NAs.000000 IC50 > 166700.0 nM Antitumor activity against human HOS cells after 72 hrs by Calcein AM assay CHEMBL1143049
NAs.000000 2 ribose-match Caco-2 NAs.000000 Other None None None Cytotoxicity against human Caco-2 cells at 10 uM after 72 hrs by MTT assay CHEMBL1287719
NAs.000000 2 ribose-match MDA-MB-231 NAs.000000 Other None None None Cytotoxicity against human MDA-MB-231 cells at 10 uM after 72 hrs by MTT assay CHEMBL1287719
NAs.000000 2 ribose-match T-24 NAs.000000 Other None None None Cytotoxicity against human T24 cells assessed as inhibition of clones formation at 10 uM after 1 week by clonogenic assay CHEMBL1287719
NAs.000000 2 ribose-match T-24 NAs.000000 Other None None None Growth inhibition of human T24 cells assessed as reduction of cell count after trypsinization at 10 uM after 72 hrs by MTT assay CHEMBL1287719
NAs.000000 2 ribose-match Stimulator of interferon genes protein NAs.000000 Other None None None Activation of human STING expressed in monocytes co-expressing IFN assessed as alkaline phosphatase secretion by SEAP reporter gene assay CHEMBL4602626
NAs.000000 2 ribose-match Unchecked NAs.000000 CC50 > 50000.0 nM Cytotoxicity against PEK cells after 7 days CHEMBL3994636
NAs.000000 2 ribose-match Unchecked NAs.000000 CC50 > 50000.0 nM Cytotoxicity against PEK cells after 24 hrs CHEMBL3994636
NAs.000000 2 ribose-match Tick-borne encephalitis virus NAs.000000 EC50 > 50000.0 nM Antiviral activity against TEBV Absettarov infected in PEK cells assessed as inhibition of viral reproduction preincubated with virus for 1 hr followed by addition to PEK cells measured after 1 hr by gentian violet staining based plaque reduction assay CHEMBL3994636
NAs.000000 2 ribose-match Tick-borne encephalitis virus NAs.000000 Other None None % Antiviral activity against TEBV Absettarov infected in PEK cells assessed as inhibition of viral reproduction at 50 uM preincubated with virus for 1 hr followed by addition to PEK cells measured after 1 hr by gentian violet staining based plaque reduction assay relative to control CHEMBL3994636
NAs.000000 2 ribose-match Unchecked NAs.000000 Ratio CC50/EC50 = 14.0 None Selectivity index, ratio of CC50 for human RD cells to EC50 for Enterovirus 71 CHEMBL3792372
NAs.000000 2 ribose-match RD NAs.000000 CC50 = 4000.0 nM Cytotoxicity against human RD cells CHEMBL3792372
NAs.000000 2 ribose-match Human enterovirus 71 NAs.000000 EC50 = 280.0 nM Antiviral activity against Enterovirus 71 infected in human RD cells assessed as cell viability after 3 days by MTS assay CHEMBL3792372
NAs.000000 2 ribose-match Platelet NAs.000000 IC50 = 37120.0 nM Inhibition of collagen-induced human platelet aggregation after 3 mins by light transmission aggregometry CHEMBL3351821
NAs.000000 2 ribose-match Unchecked NAs.000000 Other None 28183.8 nM PubChem BioAssay. qHTS for Inhibitors of binding or entry into cells for Marburg Virus. (Class of assay: confirmatory) CHEMBL1201862
NAs.000000 2 ribose-match Histidine kinase NAs.000000 Other = 0.35 % Activation of Arabidopsis thaliana CRE1/AHK4 cytokinin receptor relative to trans-zeatin CHEMBL1143049
NAs.000000 2 ribose-match Unchecked NAs.000000 Other None 11220.2 nM PubChem BioAssay. qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) CHEMBL1201862
NAs.000000 2 ribose-match Tyrosyl-DNA phosphodiesterase 1 NAs.000000 Other None 1883.7 nM PubChem BioAssay. qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT. (Class of assay: confirmatory) CHEMBL1201862
NAs.000000 2 ribose-match Adenosine kinase NAs.000000 IC50 = 794328.23 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.000000 2 ribose-match 78 kDa glucose-regulated protein NAs.000000 Other None 19952.6 nM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) CHEMBL1201862
NAs.000000 2 ribose-match DNA dC->dU-editing enzyme APOBEC-3G NAs.000000 Other None 23715.0 nM PUBCHEM_BIOASSAY: qHTS for inhibitors of Vif-A3G interactions: Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588444] CHEMBL1201862
NAs.000000 2 ribose-match Cellular tumor antigen p53 NAs.000000 Other = 6309.6 nM PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] CHEMBL1201862
NAs.000000 2 ribose-match Cellular tumor antigen p53 NAs.000000 Other = 10000.0 nM PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) CHEMBL1201862
NAs.000000 2 ribose-match Tyrosyl-DNA phosphodiesterase 1 NAs.000000 Other = 1000.0 nM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) CHEMBL1201862
NAs.000000 2 ribose-match T-24 NAs.000000 Other None None None Inhibition of human T24 cell migration by wound healing assay CHEMBL1287719
NAs.000000 2 ribose-match Matrix metalloproteinase 9 NAs.000000 Other None None None Induction of MMP9 activity in human T24 cells after 1 hr by zymography CHEMBL1287719
NAs.000000 2 ribose-match T-24 NAs.000000 Other None None % Inhibition of human T24 cells invasion on Matrigel after 24 hrs CHEMBL1287719
NAs.000000 2 ribose-match Tyrosyl-DNA phosphodiesterase 1 NAs.000000 Other None 2660.9 nM PubChem BioAssay. qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT. (Class of assay: confirmatory) CHEMBL1201862
NAs.000000 2 ribose-match Histidine kinase NAs.000000 Other = 2.53 % Activation of Arabidopsis thaliana AHK3 cytokinin receptor relative to trans-zeatin CHEMBL1143049