| Adenosine A1 receptor |
IC50 |
= |
1660.0 |
nM |
Concentration required for 50% inhibition of [3H]-CHA binding on rat brain adenosine A1 receptor |
CHEMBL1125861 |
| Adenosine A2 receptor |
IC50 |
= |
78.0 |
nM |
Concentration required for 50% inhibition of [3H]NECA binding on rat brain adenosine A2 receptor |
CHEMBL1125861 |
| Rattus norvegicus |
ED25 |
= |
0.006999999999999999 |
mg kg-1 |
25% reduction in blood pressure in the rat. |
CHEMBL1125861 |
| Rattus norvegicus |
Delta HR |
= |
13.0 |
% |
Change in heart rate was expressed in percent at at a dose 0.07 mg/kg iv in anesthetized rat |
CHEMBL1125861 |
| Rattus norvegicus |
Mean arterial blood pressure |
= |
177.0 |
mmHg |
Mean arterial pressure were recorded as baseline prior to the drug administration in hypertensive rats at 10.0 mg/kg dose |
CHEMBL1125861 |
| Rattus norvegicus |
Mean arterial blood pressure |
= |
-43.0 |
mmHg |
Mean arterial pressure were recorded as change after 6 hr of following oral dosing hypertensive rats at 10.0 mg/kg dose |
CHEMBL1125861 |
| Rattus norvegicus |
Mean arterial blood pressure |
= |
342.0 |
mmHg |
Heart rate was recorded as baseline prior to the drug administration in hypertensive rats at 10.0 mg/kg dose |
CHEMBL1125861 |
| Rattus norvegicus |
Mean arterial blood pressure |
= |
123.0 |
mmHg |
Heart rate was recorded as change after 6 hr of following oral dosing hypertensive rats at 10.0 mg/kg dose |
CHEMBL1125861 |
| Adenosine receptors; A1 & A2 |
Ratio |
= |
21.0 |
|
Ratio of IC50 values for A1 receptor binding to that of A2 receptor |
CHEMBL1125861 |
| Rattus norvegicus |
dose BP/BP |
|
|
|
Effect on blood pressure measured on anaesthetized rats; 0.007/1-25/1-25 |
CHEMBL1125861 |
