| Cyclin-dependent kinase 1 |
IC50 |
= |
650.0 |
nM |
In vitro inhibitory activity against cyclin-dependent kinase 1-cyclin B (Cyclin-Dependent Kinase) harvested from starfish oocytes. |
CHEMBL1132322 |
| HCT-116 |
GI50 |
= |
7943.28 |
nM |
The logarithmic molar concentration inhibiting 50% net cell growth was measured on HCT116 (M)colon cancer cell lines (in experiment 1) |
CHEMBL1132322 |
| HCT-116 |
GI50 |
= |
7943.28 |
nM |
The logarithmic molar concentration inhibiting 50% net cell growth was measured on HCT116 (M)colon cancer cell lines (in experiment 2) |
CHEMBL1132322 |
| Tumor Cell lines |
GI50 |
= |
15848.93 |
nM |
Antitumor activity for each out of 60 human tumor cell lines. |
CHEMBL1132322 |
| Tumor Cell lines |
GI50 |
= |
19952.62 |
nM |
Antitumor activity for each out of 60 human tumor cell lines. |
CHEMBL1132322 |
| Cyclin-dependent kinase 1 |
IC50 |
= |
650.0 |
nM |
Inhibitory activity against purified cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis. |
CHEMBL1130316 |
| Cyclin-dependent kinase 1 |
IC50 |
= |
650.0 |
nM |
Inhibition of Cyclin-dependent kinase 1 (CDK1) |
CHEMBL1133090 |
| Cyclin-dependent kinase 5 |
IC50 |
= |
160.0 |
nM |
Inhibitory activity against Cyclin-dependent kinase 5 |
CHEMBL1133090 |
| MDA-N |
GI50 |
|
30269.13 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NCI-H23 |
GI50 |
|
13614.45 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SN12C |
GI50 |
|
32734.07 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| ACHN |
GI50 |
|
18836.49 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| UO-31 |
GI50 |
|
12445.15 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| HL-60 |
GI50 |
|
17458.22 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| HOP-92 |
GI50 |
|
17179.08 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| DU-145 |
GI50 |
|
35809.64 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SF-539 |
GI50 |
|
12560.3 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Malme-3M |
GI50 |
|
25703.96 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SK-MEL-5 |
GI50 |
|
15848.93 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| K562 |
GI50 |
|
46558.61 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| OVCAR-3 |
GI50 |
|
9225.71 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the OVCAR-3 Ovarian cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| A498 |
GI50 |
|
23933.16 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| HOP-62 |
GI50 |
|
11885.02 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| MOLT-4 |
GI50 |
|
28510.18 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MOLT-4 Leukemia cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NCI/ADR-RES |
GI50 |
|
15381.55 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI/ADR-RES Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| U-251 |
GI50 |
|
27925.44 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the U251 Central Nervous System cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| OVCAR-8 |
GI50 |
|
16710.91 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the OVCAR-8 Ovarian cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| OVCAR-5 |
GI50 |
|
20749.14 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the OVCAR-5 Ovarian cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SNB-19 |
GI50 |
|
34914.03 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SNB-19 Central Nervous System cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SR |
GI50 |
|
7095.78 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SR Leukemia cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| MDA-MB-231 |
GI50 |
|
25763.21 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-231/ATCC Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| TK-10 |
GI50 |
|
24378.11 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the TK-10 Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SW-620 |
GI50 |
|
25234.81 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SW-620 Colon cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NCI-H522 |
GI50 |
|
16481.62 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H522 Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| KM12 |
GI50 |
|
12735.03 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the KM12 Colon cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| M14 |
GI50 |
|
16788.04 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the M14 Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NCI-H322M |
GI50 |
|
29040.23 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H322M Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| OVCAR-4 |
GI50 |
|
20230.19 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the OVCAR-4 Ovarian cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| RPMI-8226 |
GI50 |
|
22594.36 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the RPMI-8226 Leukemia cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Serine/threonine-protein kinase MST2 |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: STK3 |
CHEMBL1201862 |
| Dual specificity protein kinase CLK2 |
Ki |
= |
501.19 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CLK2 |
CHEMBL1201862 |
| Serine/threonine-protein kinase MRCK-A |
Ki |
< |
10000.0 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDC42BPA |
CHEMBL1201862 |
| Serine/threonine-protein kinase PLK3 |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PLK3 |
CHEMBL1201862 |
| Casein kinase I gamma 2 |
Ki |
= |
2511.89 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CSNK1G2 |
CHEMBL1201862 |
| Inhibitor of nuclear factor kappa B kinase beta subunit |
Ki |
< |
3162.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: IKBKB |
CHEMBL1201862 |
| BT-549 |
GI50 |
|
18535.32 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| CaM kinase II gamma |
Ki |
< |
6309.57 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CAMK2G |
CHEMBL1201862 |
| Tyrosine-protein kinase receptor UFO |
Ki |
< |
1995.26 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: AXL |
CHEMBL1201862 |
| Serine/threonine-protein kinase AKT3 |
Ki |
< |
10000.0 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: AKT3 |
CHEMBL1201862 |
| Serine/threonine-protein kinase PLK4 |
Ki |
< |
3981.07 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PLK4 |
CHEMBL1201862 |
| Serine/threonine-protein kinase EEF2K |
Ki |
< |
3981.07 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: EEF2K |
CHEMBL1201862 |
| Macrophage colony stimulating factor receptor |
Ki |
< |
2511.89 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CSF1R |
CHEMBL1201862 |
| Tyrosine-protein kinase CTK |
Ki |
< |
1995.26 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MATK |
CHEMBL1201862 |
| BR serine/threonine-protein kinase 1 |
Ki |
< |
10000.0 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: KIAA1811 |
CHEMBL1201862 |
| Casein kinase I isoform gamma-3 |
Ki |
< |
6309.57 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CSNK1G3 |
CHEMBL1201862 |
| Protein kinase C zeta |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKCZ |
CHEMBL1201862 |
| AMP-activated protein kinase, alpha-1 subunit |
Ki |
< |
6309.57 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKAA1 |
CHEMBL1201862 |
| Serine/threonine-protein kinase D2 |
Ki |
< |
10000.0 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKD2 |
CHEMBL1201862 |
| Tyrosine-protein kinase FRK |
Ki |
< |
2511.89 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: FRK |
CHEMBL1201862 |
| Ribosomal protein S6 kinase alpha 3 |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: RPS6KA3 |
CHEMBL1201862 |
| Mitogen-activated protein kinase kinase kinase kinase 4 |
Ki |
< |
10000.0 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAP4K4 |
CHEMBL1201862 |
| Phosphorylase kinase gamma subunit 2 |
Ki |
< |
5011.87 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PHKG2 |
CHEMBL1201862 |
| Ribosomal protein S6 kinase 1 |
Ki |
< |
6309.57 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: RPS6KB1 |
CHEMBL1201862 |
| LOX IMVI |
GI50 |
|
16519.62 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the LOX IMVI Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Dual-specificity tyrosine-phosphorylation regulated kinase 1A |
Ki |
= |
1584.89 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: DYRK1A |
CHEMBL1201862 |
| Protein kinase C delta |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKCD |
CHEMBL1201862 |
| MAP kinase p38 delta |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAPK13 |
CHEMBL1201862 |
| Rho-associated protein kinase 2 |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ROCK2 |
CHEMBL1201862 |
| Serine/threonine-protein kinase PIM1 |
Ki |
< |
10000.0 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PIM1 |
CHEMBL1201862 |
| Casein kinase I gamma 1 |
Ki |
= |
3981.07 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CSNK1G1 |
CHEMBL1201862 |
| Tyrosine-protein kinase SRC |
Ki |
< |
3981.07 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: SRC |
CHEMBL1201862 |
| Hepatocyte growth factor receptor |
Ki |
< |
3162.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MET |
CHEMBL1201862 |
| Serine/threonine-protein kinase Aurora-B |
Ki |
< |
6309.57 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: STK12 |
CHEMBL1201862 |
| Serine/threonine-protein kinase 17A |
Ki |
< |
3981.07 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: STK17A |
CHEMBL1201862 |
| Ribosomal protein S6 kinase alpha 5 |
Ki |
< |
1995.26 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: RPS6KA5 |
CHEMBL1201862 |
| LIM domain kinase 1 |
Ki |
< |
10000.0 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: LIMK1 |
CHEMBL1201862 |
| Inhibitor of nuclear factor kappa B kinase alpha subunit |
Ki |
< |
3981.07 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CHUK |
CHEMBL1201862 |
| Serine/threonine-protein kinase Chk1 |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CHEK1 |
CHEMBL1201862 |
| Serine/threonine-protein kinase Sgk2 |
Ki |
< |
10000.0 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: SGK |
CHEMBL1201862 |
| Serine/threonine-protein kinase AKT2 |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: AKT2 |
CHEMBL1201862 |
| Serine/threonine-protein kinase c-TAK1 |
Ki |
< |
6309.57 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MARK3 |
CHEMBL1201862 |
| Mixed lineage kinase 7 |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ZAK |
CHEMBL1201862 |
| Vascular endothelial growth factor receptor 2 |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: KDR |
CHEMBL1201862 |
| Serine/threonine-protein kinase Aurora-A |
Ki |
< |
3981.07 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: STK6 |
CHEMBL1201862 |
| Tyrosine-protein kinase LCK |
Ki |
< |
2511.89 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: LCK |
CHEMBL1201862 |
| Cyclin-dependent kinase 2 |
Ki |
= |
199.53 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK2 |
CHEMBL1201862 |
| Serine/threonine-protein kinase TAO1 |
Ki |
< |
10000.0 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: TAO1 |
CHEMBL1201862 |
| Serine/threonine-protein kinase PIM3 |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PIM3 |
CHEMBL1201862 |
| Casein kinase I delta |
Ki |
= |
1258.93 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CSNK1D |
CHEMBL1201862 |
| MAP kinase ERK2 |
Ki |
< |
6309.57 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAPK1 |
CHEMBL1201862 |
| Casein kinase II alpha |
Ki |
< |
6309.57 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CSNK2A1 |
CHEMBL1201862 |
| Nerve growth factor receptor Trk-A |
Ki |
< |
2511.89 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: NTRK1 |
CHEMBL1201862 |
| Fibroblast growth factor receptor 1 |
Ki |
< |
5011.87 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: FGFR1 |
CHEMBL1201862 |
| Proto-oncogene tyrosine-protein kinase ROS |
Ki |
< |
1995.26 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ROS1 |
CHEMBL1201862 |
| Glycogen synthase kinase-3 alpha |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: GSK3A |
CHEMBL1201862 |
| Serine/threonine-protein kinase SRPK1 |
Ki |
= |
2511.89 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: SRPK1 |
CHEMBL1201862 |
| Tyrosine-protein kinase TYK2 |
Ki |
< |
1995.26 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: TYK2 |
CHEMBL1201862 |
| Misshapen-like kinase 1 |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MINK |
CHEMBL1201862 |
| Tyrosine-protein kinase receptor TYRO3 |
Ki |
< |
1995.26 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: TYRO3 |
CHEMBL1201862 |
| c-Jun N-terminal kinase 2 |
Ki |
< |
3981.07 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAPK9 |
CHEMBL1201862 |
| Tyrosine-protein kinase receptor FLT3 |
Ki |
< |
2511.89 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: FLT3 |
CHEMBL1201862 |
| Cyclin-dependent kinase 5 |
Ki |
= |
199.53 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK5 |
CHEMBL1201862 |
| Interleukin-1 receptor-associated kinase 1 |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: IRAK1 |
CHEMBL1201862 |
| MAP kinase-activated protein kinase 2 |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAPKAPK2 |
CHEMBL1201862 |
| Serine/threonine-protein kinase PAK 4 |
Ki |
< |
5011.87 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PAK4 |
CHEMBL1201862 |
| Mitogen-activated protein kinase kinase kinase kinase 2 |
Ki |
< |
6309.57 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAP4K2 |
CHEMBL1201862 |
| Serine/threonine-protein kinase Nek4 |
Ki |
< |
6309.57 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: NEK4 |
CHEMBL1201862 |
| c-Jun N-terminal kinase 1 |
Ki |
< |
3162.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAPK8 |
CHEMBL1201862 |
| Casein kinase I alpha |
Ki |
< |
6309.57 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CSNK1A1 |
CHEMBL1201862 |
| Insulin receptor |
Ki |
< |
5011.87 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: INSR |
CHEMBL1201862 |
| Ephrin type-A receptor 2 |
Ki |
< |
3162.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: EPHA2 |
CHEMBL1201862 |
| Serine/threonine-protein kinase Chk2 |
Ki |
< |
5011.87 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CHEK2 |
CHEMBL1201862 |
| MAP kinase signal-integrating kinase 2 |
Ki |
< |
10000.0 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MKNK2 |
CHEMBL1201862 |
| Serine/threonine-protein kinase PAK 1 |
Ki |
< |
10000.0 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PAK1 |
CHEMBL1201862 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 4 |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: DYRK4 |
CHEMBL1201862 |
| Protein kinase N2 |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PKN2 |
CHEMBL1201862 |
| Protein kinase C gamma |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKCG |
CHEMBL1201862 |
| MAP kinase-activated protein kinase 3 |
Ki |
< |
10000.0 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAPKAPK3 |
CHEMBL1201862 |
| CaM kinase II beta |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CAMK2B |
CHEMBL1201862 |
| Homeodomain-interacting protein kinase 2 |
Ki |
< |
3162.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: HIPK2 |
CHEMBL1201862 |
| Protein kinase C iota |
Ki |
< |
5011.87 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKCI |
CHEMBL1201862 |
| CaM kinase II delta |
Ki |
< |
6309.57 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CAMK2D |
CHEMBL1201862 |
| Serine/threonine-protein kinase NEK2 |
Ki |
< |
10000.0 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: NEK2 |
CHEMBL1201862 |
| Serine/threonine-protein kinase PLK1 |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PLK1 |
CHEMBL1201862 |
| Vascular endothelial growth factor receptor 3 |
Ki |
< |
6309.57 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: FLT4 |
CHEMBL1201862 |
| Homeodomain-interacting protein kinase 4 |
Ki |
= |
1584.89 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: HIPK4 |
CHEMBL1201862 |
| Cell division protein kinase 8 |
Ki |
< |
3981.07 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK8 |
CHEMBL1201862 |
| MAP/microtubule affinity-regulating kinase 2 |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MARK2 |
CHEMBL1201862 |
| Cyclin-dependent kinase 7 |
Ki |
= |
79.43 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK7 |
CHEMBL1201862 |
| Cyclin-dependent kinase 1 |
Ki |
= |
1258.93 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDC2 |
CHEMBL1201862 |
| Glycogen synthase kinase-3 beta |
Ki |
< |
6309.57 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: GSK3B |
CHEMBL1201862 |
| Cyclin-dependent kinase 9 |
Ki |
= |
125.89 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK9 |
CHEMBL1201862 |
| cAMP-dependent protein kinase alpha-catalytic subunit |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKACA |
CHEMBL1201862 |
| Interleukin-1 receptor-associated kinase 4 |
Ki |
< |
10000.0 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: IRAK4 |
CHEMBL1201862 |
| Rho-associated protein kinase 1 |
Ki |
< |
10000.0 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ROCK1 |
CHEMBL1201862 |
| SK-MEL-2 |
GI50 |
|
20749.14 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-2 Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| MAP kinase p38 gamma |
Ki |
< |
6309.57 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAPK12 |
CHEMBL1201862 |
| Serine/threonine-protein kinase AKT |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: AKT1 |
CHEMBL1201862 |
| 3-phosphoinositide dependent protein kinase-1 |
Ki |
< |
3981.07 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PDPK1 |
CHEMBL1201862 |
| Serine/threonine-protein kinase 2 |
Ki |
< |
10000.0 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: SLK |
CHEMBL1201862 |
| Neurotrophic tyrosine kinase receptor type 2 |
Ki |
< |
5011.87 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: NTRK2 |
CHEMBL1201862 |
| CaM kinase I alpha |
Ki |
< |
6309.57 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CAMK1 |
CHEMBL1201862 |
| Dual specificity protein kinase CLK4 |
Ki |
= |
501.19 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CLK4 |
CHEMBL1201862 |
| Mitogen-activated protein kinase kinase kinase kinase 5 |
Ki |
< |
7943.28 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAP4K5 |
CHEMBL1201862 |
| Serine/threonine-protein kinase DCLK1 |
Ki |
< |
10000.0 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: DCAMKL1 |
CHEMBL1201862 |
| Fibroblast growth factor receptor 3 |
Ki |
< |
1995.26 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: FGFR3 |
CHEMBL1201862 |
| Receptor protein-tyrosine kinase erbB-4 |
Ki |
< |
3981.07 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ERBB4 |
CHEMBL1201862 |
| A549 |
GI50 |
|
23280.91 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SNB-75 |
GI50 |
|
13835.66 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SNB-75 Central Nervous System cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| HCC 2998 |
GI50 |
|
15275.66 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Colon cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| HCT-15 |
GI50 |
|
17906.06 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Colon cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SF-268 |
GI50 |
|
13740.42 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-268 Central Nervous System cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| HCT-116 |
GI50 |
|
8375.29 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Colon cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| MCF7 |
GI50 |
|
15739.83 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MCF7 Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| EKVX |
GI50 |
|
18238.96 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the EKVX Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| PC-3 |
GI50 |
|
17947.34 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the PC-3 Prostate cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SK-OV-3 |
GI50 |
|
57809.6 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-OV-3 Ovarian cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| T47D |
GI50 |
|
32809.53 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the T-47D Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| UACC-62 |
GI50 |
|
12793.81 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UACC-62 Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NCI-H460 |
GI50 |
|
16218.1 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H460 Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| CAKI-1 |
GI50 |
|
17378.01 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| MDA-MB-435 |
GI50 |
|
23388.37 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-435 Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SF-295 |
GI50 |
|
19275.25 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-295 Central Nervous System cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Hs-578T |
GI50 |
|
4581.42 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HS 578T Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| IGROV-1 |
GI50 |
|
14791.08 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Ovarian cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| 786-0 |
GI50 |
|
20230.19 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| UACC-257 |
GI50 |
|
30338.91 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UACC-257 Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| CCRF-CEM |
GI50 |
|
22594.36 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NCI-H226 |
GI50 |
|
15031.42 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H226 Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| HT-29 |
GI50 |
|
18836.49 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HT29 Colon cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SK-MEL-28 |
GI50 |
|
12793.81 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-28 Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| RXF 393 |
GI50 |
|
7655.97 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the RXF 393 Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| COLO 205 |
GI50 |
|
14996.85 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Colon cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Unchecked |
Potency |
|
935.0 |
nM |
PubChem BioAssay. Cell Proliferation Assay against the TMD8 Cell Line (Caspase readout at 16 hrs). (Class of assay: confirmatory) |
CHEMBL1201862 |
| Unchecked |
Potency |
|
11873.4 |
nM |
PubChem BioAssay. qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Unchecked |
Potency |
|
33173.4 |
nM |
PubChem BioAssay. Cell Proliferation Assay against the HBL1 Cell Line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Unchecked |
Potency |
|
18654.8 |
nM |
PubChem BioAssay. Cell Proliferation Assay against a hMSC Cell Line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NON-PROTEIN TARGET |
Potency |
|
37221.2 |
nM |
PubChem BioAssay. Cytotoxicity counterscreen for NFkB agonists and antagonists. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Unchecked |
Potency |
|
13206.6 |
nM |
PubChem BioAssay. Cell Proliferation Assay against the TMD8 Cell Line (Caspase readout at 8 hrs). (Class of assay: confirmatory) |
CHEMBL1201862 |
| Tyrosine-protein kinase YES |
Potency |
|
34499.3 |
nM |
PubChem BioAssay. qHTS for small molecule inhibitors of Yes1 kinase: Primary Screen. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NON-PROTEIN TARGET |
Potency |
|
11875.4 |
nM |
PubChem BioAssay. qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NON-PROTEIN TARGET |
Potency |
|
3346.9 |
nM |
PubChem BioAssay. qHTS profiling for inhibitors of Plasmodium falciparum (3D7) proliferation. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NON-PROTEIN TARGET |
Potency |
|
1332.4 |
nM |
PubChem BioAssay. qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation (Rep 2). (Class of assay: confirmatory) |
CHEMBL1201862 |
| NON-PROTEIN TARGET |
Potency |
|
8407.1 |
nM |
PubChem BioAssay. qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (HB3) proliferation. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NON-PROTEIN TARGET |
Potency |
|
9432.9 |
nM |
PubChem BioAssay. qHTS profiling for inhibitors of Plasmodium falciparum (DD2) proliferation. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Unchecked |
Potency |
|
8332.8 |
nM |
PubChem BioAssay. Immunotoxin (HA22) sensitization/mitigation study - treatment arm (low dose). (Class of assay: confirmatory) |
CHEMBL1201862 |
| Unchecked |
Potency |
|
3317.3 |
nM |
PubChem BioAssay. Immunotoxin (SS1P) sensitization/mitigation study - treatment arm. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Unchecked |
Potency |
|
23485.0 |
nM |
PubChem BioAssay. Immunotoxin (SS1P) sensitization/mitigation study. Vehicle arm (DMEM). (Class of assay: confirmatory) |
CHEMBL1201862 |
| Unchecked |
Potency |
|
20931.0 |
nM |
PubChem BioAssay. Immunotoxin (HA22) sensitization/mitigation study. Vehicle arm (PBS). (Class of assay: confirmatory) |
CHEMBL1201862 |
| Aldo-keto-reductase family 1 member C3 |
IC50 |
= |
2150.0 |
nM |
Inhibition of human AKR1C3 expressed in Escherichia coli incubated for 30 mins in presence of NADPH regeneration system by UHPLC analysis |
CHEMBL4665678 |
| Aldo-keto-reductase family 1 member C3 |
Ki |
= |
1400.0 |
nM |
Inhibition of human AKR1C3 expressed in Escherichia coli incubated for 30 mins in presence of NADPH regeneration system by UHPLC analysis |
CHEMBL4665678 |
