| Phosphatidylinositol 4-kinase, PI4K |
IC50 |
= |
8700.0 |
nM |
Inhibitory activity (IC50) against human phosphatidylinositol 4-kinase at the ATP binding site |
CHEMBL1124860 |
| Phosphatidylinositol 4-kinase, PI4K |
Ki |
= |
6000.0 |
nM |
Binding affinity (Ki) against human phosphatidylinositol 4-kinase |
CHEMBL1124860 |
| Adenosine A1 receptor |
Ki |
= |
1800.0 |
nM |
Binding affinity against adenosine A1 receptor in rat cortex by using [3H]- PIA as a radioligand |
CHEMBL1125213 |
| Adenosine A2 receptor |
Ki |
= |
8200.0 |
nM |
Binding affinity against adenosine A2 receptor in rat striatum by using [3H]NECA as a radioligand |
CHEMBL1125213 |
| Adenosine A2 receptor |
Ki |
= |
3400.0 |
nM |
Tested for inhibition of rat PC12 adenylate cyclase stimulation by using NECA as a radioligand |
CHEMBL1125213 |
| ADMET |
k' |
= |
1.94 |
|
Hydrophobicity index |
CHEMBL1125213 |
| Adenosine receptors; A1 & A2 |
Selectivity ratio |
= |
4.6 |
|
It is the ratio of Ki value of A1 receptor to that of A2 receptor. |
CHEMBL1125213 |
| Adenosine A1 receptor |
Ki |
= |
10000.0 |
nM |
Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells |
CHEMBL1153377 |
| Adenosine A2a receptor |
Ki |
= |
1800.0 |
nM |
Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cells |
CHEMBL1153377 |
| Adenosine A2b receptor |
Ki |
> |
30000.0 |
nM |
Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity |
CHEMBL1153377 |
| Adenosine A3 receptor |
Ki |
= |
13000.0 |
nM |
Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cells |
CHEMBL1153377 |
| Staphylococcus aureus |
MIC |
= |
50.0 |
ug.mL-1 |
Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 to 24 hrs by tube dilution method |
CHEMBL1136859 |
| Staphylococcus aureus |
MIC |
= |
50.0 |
ug.mL-1 |
Antibacterial activity against methicillin-resistant Staphylococcus aureus 431300 after 18 to 24 hrs by tube dilution method |
CHEMBL1136859 |
| Staphylococcus aureus |
MIC |
= |
50.0 |
ug.mL-1 |
Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate after 18 to 24 hrs by tube dilution method |
CHEMBL1136859 |
| Escherichia coli |
MIC |
= |
50.0 |
ug.mL-1 |
Antibacterial activity against Escherichia coli 25922 after 18 to 24 hrs by tube dilution method |
CHEMBL1136859 |
| Bacillus subtilis |
MIC |
= |
25.0 |
ug.mL-1 |
Antibacterial activity against Bacillus subtilis 6633 after 18 to 24 hrs by tube dilution method |
CHEMBL1136859 |
| Candida albicans |
MIC |
= |
12.5 |
ug.mL-1 |
Antifungal activity against Candida albicans 10145 after 2 to 5 days by tube dilution method |
CHEMBL1136859 |
| Unchecked |
Inhibition |
|
|
% |
Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay |
CHEMBL1255231 |
| Plasmodium falciparum |
IC50 |
= |
7943.28 |
nM |
Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay |
CHEMBL1255382 |
| ATPase family AAA domain-containing protein 5 |
Potency |
|
2310.0 |
nM |
PUBCHEM_BIOASSAY: Validation screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493143, AID504466] |
CHEMBL1201862 |
| Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 |
Potency |
|
29934.9 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] |
CHEMBL1201862 |
| 6-phospho-1-fructokinase |
Potency |
|
12.0 |
nM |
PUBCHEM_BIOASSAY: qHTS Validation Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] |
CHEMBL1201862 |
| Unchecked |
Potency |
|
6309.6 |
nM |
PUBCHEM_BIOASSAY: qHTS for inhibitors of binding or entry into cells for Marburg Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249, AID540278] |
CHEMBL1201862 |
