| CEM-SS |
CC50 |
> |
100000.0 |
nM |
Cytotoxic concentration required to inhibit the replication of HIV-1 in CEM-SS human T4 lymphoblastoid cell lines |
CHEMBL1135383 |
| CEM-SS |
EC50 |
= |
56000.0 |
nM |
Effective concentration required to inhibit the replication of HIV-1 in CEMSS human T4 lymphoblastoid cell lines |
CHEMBL1135383 |
| MT4 |
CC50 |
> |
100000.0 |
nM |
Cytotoxic concentration required to inhibit the replication of HIV-1 in MT-4 human T4 lymphoblastoid cell lines |
CHEMBL1135383 |
| MT4 |
EC50 |
> |
100000.0 |
nM |
Effective concentration required to inhibit the replication of HIV-1 in MT-4 human T4 lymphoblastoid cell lines |
CHEMBL1135383 |
| MT2 |
CC50 |
> |
100000.0 |
nM |
Cytotoxic concentration required to inhibit the replication of HIV-1 in MT-2 human T4 lymphoblastoid cell lines |
CHEMBL1135383 |
| MT2 |
EC50 |
> |
100000.0 |
nM |
Effective concentration required to inhibit the replication of HIV-1 in MT-2 human T4 lymphoblastoid cell lines |
CHEMBL1135383 |
| ATH-8 cell line |
IC50 |
= |
3000.0 |
nM |
Compound was evaluated for the inhibition of infectivity and cytopathic effect of HIV-1 in ATH8 cells |
CHEMBL1129608 |
| ATH-8 cell line |
EC50 |
= |
14000.0 |
nM |
Compound was evaluated for the inhibition of replication and cytopathic effect of HIV-1 in ATH8 cells |
CHEMBL1129608 |
| L1210 |
ID50 |
= |
150.0 |
uM |
Compound was evaluated for the clonogenic assay with murine leukemia L1210 cells |
CHEMBL1129608 |
| Human immunodeficiency virus 1 |
Inhibition |
|
|
% |
Antiviral activity against HIV-1 was determined; No inhibition |
CHEMBL1124905 |
| Human herpesvirus 5 |
Inhibition |
|
|
% |
Antiviral activity against HCMV was determined; No inhibition |
CHEMBL1124905 |
| Human immunodeficiency virus 1 |
IC50 |
= |
5800.0 |
nM |
Compound was tested for inhibition of HIV-1 |
CHEMBL1126199 |
| Adenosine deaminase |
Vmax |
= |
0.41 |
uM min-1 |
Vmax by adenosine deaminase |
CHEMBL1126199 |
| Adenosine deaminase |
Km |
= |
530000.0 |
nM |
Km by adenosine deaminase |
CHEMBL1126199 |
| Human immunodeficiency virus 1 |
IC50 |
> |
200000.0 |
nM |
Compound was tested for inhibition of HIV-1 |
CHEMBL1126199 |
| Adenosine deaminase |
Vmax |
= |
0.52 |
uM min-1 |
Vmax by adenosine deaminase |
CHEMBL1126199 |
| Adenosine deaminase |
Km |
= |
18500.0 |
nM |
Km by adenosine deaminase |
CHEMBL1126199 |
| Human immunodeficiency virus 1 |
IC50 |
= |
14000.0 |
nM |
Compound was tested for inhibition of HIV-1 |
CHEMBL1126199 |
| L1210 |
IC50 |
= |
150000.0 |
nM |
Inhibitory activity against murine leukemia L1210 cells |
CHEMBL1125745 |
| L1210 |
Cytotoxicity |
= |
160.0 |
|
Cytotoxicity was evaluated against L1210 leukemia cell line at 1000 ug/disk. |
CHEMBL1125745 |
| PO3 |
Cytotoxicity |
= |
0.0 |
|
Cytotoxicity was evaluated against PO3 cell line at 500 ug/disk. |
CHEMBL1125745 |
| Mus musculus |
EC50 |
= |
124000.0 |
nM |
Concentration that reduces Friend murine leukemia virus titer by 50% |
CHEMBL1125745 |
| Unchecked |
SI |
= |
1.4 |
|
Selectivity index is the ratio of IC50 to EC50 of F-MuLV. |
CHEMBL1125745 |
| Mus musculus |
EC50 |
= |
87300.0 |
nM |
Concentration that reduces Rauscher murine leukemia virus titer by 50% |
CHEMBL1125745 |
| Unchecked |
SI |
= |
1.9 |
|
Selectivity index which is the ratio of IC50 to EC50 of R-MuLV. |
CHEMBL1125745 |
| Mus musculus |
IC50 |
= |
168000.0 |
nM |
Cytotoxicity was evaluated |
CHEMBL1125745 |
| NON-PROTEIN TARGET |
Precursor inhibition |
= |
80.0 |
% |
Inhibition of incorporation of labeled precursor into macromolecules of noninfected SC-1 cells with the compound at a concentration 100 uM determined against thymidine |
CHEMBL1125745 |
| NON-PROTEIN TARGET |
Precursor inhibition |
= |
107.0 |
% |
Inhibition of incorporation of labeled precursor into macromolecules of noninfected SC-1 cells with the compound at a concentration 100 uM determined against uridine. |
CHEMBL1125745 |
| NON-PROTEIN TARGET |
Precursor inhibition |
= |
94.0 |
% |
Inhibition of incorporation of labeled precursor into macromolecules of noninfected SC-1 cells with the compound at a concentration 100 uM determined against leucine. |
CHEMBL1125745 |
| NON-PROTEIN TARGET |
Precursor inhibition |
= |
46.0 |
% |
Inhibition of incorporation of labeled precursor into macromolecules of noninfected SC-1 cells with the compound at a concentration 300 uM determined against thymidine |
CHEMBL1125745 |
| NON-PROTEIN TARGET |
Precursor inhibition |
= |
105.0 |
% |
Inhibition of incorporation of labeled precursor into macromolecules of noninfected SC-1 cells with the compound at a concentration 300 uM determined against uridine. |
CHEMBL1125745 |
| NON-PROTEIN TARGET |
Precursor inhibition |
= |
79.0 |
% |
Inhibition of incorporation of labeled precursor into macromolecules of noninfected SC-1 cells with the compound at a concentration 300 uM determined against leucine. |
CHEMBL1125745 |
| Prelamin-A/C |
Potency |
= |
5623.4 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Lysine-specific demethylase 4D-like |
Potency |
= |
25118.9 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) |
CHEMBL1201862 |
| Unchecked |
Potency |
= |
5.2 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Lipid Storage Modulators in Drosophila S3 Cells. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Thioredoxin glutathione reductase |
Potency |
= |
79432.8 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] |
CHEMBL1201862 |
| Putative fructose-1,6-bisphosphate aldolase |
Potency |
= |
8912.5 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] |
CHEMBL1201862 |
| Cellular tumor antigen p53 |
Potency |
|
35481.3 |
nM |
PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] |
CHEMBL1201862 |
| Chromobox protein homolog 1 |
Potency |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] |
CHEMBL1201862 |
| GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 |
Potency |
|
4610.9 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] |
CHEMBL1201862 |
| MDA-N |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SN12C |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NCI-H23 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| UO-31 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| HOP-92 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| DU-145 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SK-MEL-5 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Malme-3M |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| K562 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| OVCAR-3 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the OVCAR-3 Ovarian cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| A498 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| MOLT-4 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MOLT-4 Leukemia cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| HOP-62 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| U-251 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the U251 Central Nervous System cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NCI/ADR-RES |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI/ADR-RES Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| OVCAR-8 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the OVCAR-8 Ovarian cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| OVCAR-5 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the OVCAR-5 Ovarian cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SNB-19 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SNB-19 Central Nervous System cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SR |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SR Leukemia cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| MDA-MB-231 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-231/ATCC Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| TK-10 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the TK-10 Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SW-620 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SW-620 Colon cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| M14 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the M14 Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| KM12 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the KM12 Colon cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NCI-H322M |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H322M Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| RPMI-8226 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the RPMI-8226 Leukemia cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| OVCAR-4 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the OVCAR-4 Ovarian cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| LOX IMVI |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the LOX IMVI Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| BT-549 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SK-MEL-2 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-2 Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SNB-75 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SNB-75 Central Nervous System cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| HCC 2998 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Colon cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| HCT-15 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Colon cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| HCT-116 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Colon cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| MCF7 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MCF7 Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| PC-3 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the PC-3 Prostate cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| T47D |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the T-47D Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NCI-H460 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H460 Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| MDA-MB-435 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-435 Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| CAKI-1 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SF-295 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-295 Central Nervous System cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Hs-578T |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HS 578T Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| CCRF-CEM |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| UACC-257 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UACC-257 Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NCI-H226 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H226 Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| HT-29 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HT29 Colon cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SK-MEL-28 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-28 Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| COLO 205 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Colon cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| RXF 393 |
GI50 |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the RXF 393 Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Ataxin-2 |
Potency |
|
1000.0 |
nM |
PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Tyrosyl-DNA phosphodiesterase 1 |
Potency |
|
4109.5 |
nM |
PubChem BioAssay. qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Tyrosyl-DNA phosphodiesterase 1 |
Potency |
|
2592.9 |
nM |
PubChem BioAssay. qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Escherichia coli |
Inhibition |
= |
-2.59 |
% |
Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CAMBH media using NBS plates, by Resazurin F(560/590) |
CHEMBL4296182 |
| Klebsiella pneumoniae |
Inhibition |
= |
6.59 |
% |
Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); MIC in CAMBH media using NBS plates, by OD(600) |
CHEMBL4296182 |
| Pseudomonas aeruginosa |
Inhibition |
= |
-5.34 |
% |
Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 (CO-ADD:GN_042); MIC in CAMBH media using NBS plates, by OD(600) |
CHEMBL4296182 |
| Filobasidiella neoformans |
Inhibition |
= |
-2.86 |
% |
Antifungal activity against Cryptococcus neoformans H99 ATCC 208821 (CO-ADD:FG_002); MIC in YNB media using NBS plates, by Resazurin OD(600-570) |
CHEMBL4296182 |
| Staphylococcus aureus subsp. aureus |
Inhibition |
= |
13.44 |
% |
Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020); MIC in CAMBH media using NBS plates, by Resazurin F(560/590) |
CHEMBL4296182 |
| Acinetobacter baumannii |
Inhibition |
= |
8.12 |
% |
Antibacterial activity against Acinetobacter baumannii ATCC 19606 (CO-ADD:GN_034); MIC in CAMBH media using NBS plates, by Resazurin F(560/590) |
CHEMBL4296182 |
| Candida albicans |
Inhibition |
= |
1.58 |
% |
Antifungal activity against Candida albicans ATCC 90028 (CO-ADD:FG_001); MIC in YNB media using NBS plates, by OD630 |
CHEMBL4296182 |
