| Alcohol dehydrogenase alpha chain |
Km |
= |
25.0 |
|
Michaelis-Menten constant against mammalian liver alcohol dehydrogenase (ADH) |
CHEMBL1127319 |
| Glutamate dehydrogenase |
Km |
= |
30.0 |
|
Michaelis-Menten constant against mammalian glutamate dehydrogenase (GDH) |
CHEMBL1127319 |
| L-lactate dehydrogenase A chain |
Km |
= |
141.0 |
|
Michaelis-Menten constant against mammalian lactate dehydrogenase (LDH) |
CHEMBL1127319 |
| Unchecked |
Km |
= |
32.0 |
|
Michaelis-Menten constant against mammalian malate dehydrogenase (MDH) |
CHEMBL1127319 |
| Glutamate dehydrogenase |
Km |
= |
20000.0 |
nM |
In vitro inhibitory activity against bovine liver glutamate dehydrogenase (GDH) |
CHEMBL1124735 |
| Alcohol dehydrogenase |
Km |
= |
22300.0 |
nM |
In vitro inhibitory activity against horse liver Alcohol dehydrogenase |
CHEMBL1124735 |
| L-lactate dehydrogenase B chain |
Km |
= |
84400.0 |
nM |
In vitro inhibitory activity against pig heart lactate dehydrogenase (LDH) |
CHEMBL1124735 |
| Malate dehydrogenase cytoplasmic |
Km |
= |
33900.0 |
nM |
In vitro inhibitory activity against pig heart cytoplasmic malate dehydrogenase (MDH), |
CHEMBL1124735 |
| Choline acetylase |
Ki |
|
|
nM |
Compound was tested for inhibition of choline acetyltransferase isolated from squid head ganglia; No inhibition at 10e-4 M |
CHEMBL1121773 |
| Estradiol 17-beta-dehydrogenase 1 |
K app |
= |
0.013 |
min-1 |
Tested by protection experiments to demonstrate the inactivation of estradiol dehydrogenase and the kinetic parameter Kapp was reported at a concentration of 20 uM |
CHEMBL1125169 |
| Ketopantoate reductase |
Kd |
= |
6900000.0 |
nM |
Binding affinity to Escherichia coli KPR |
CHEMBL1145346 |
| Ketopantoate reductase |
Inhibition |
= |
10.0 |
% |
Inhibition of Escherichia coli KPR at 20 mM |
CHEMBL1145346 |
| Inosine-5'-monophosphate dehydrogenase (IMPDH) |
Km |
= |
100000.0 |
nM |
Inhibition of human IMPDH |
CHEMBL1145329 |
| Hepatotoxicity |
Hepatotoxicity |
|
|
|
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans |
CHEMBL1697731 |
| Hepatotoxicity |
Hepatotoxicity |
|
|
|
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents |
CHEMBL1697731 |
| Hepatotoxicity |
Hepatotoxicity |
|
|
|
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents |
CHEMBL1697731 |
| NAD-dependent deacetylase sirtuin 1 |
Km |
= |
80000.0 |
nM |
Activity at human SIRT1 assessed as ADP-ribosyltransferase activity |
CHEMBL1773060 |
| Unchecked |
Km |
= |
46000.0 |
nM |
Activity at yeast SIRT2 assessed as ADP-ribosyltransferase activity |
CHEMBL1773060 |
| Solute carrier organic anion transporter family member 1B1 |
Inhibition |
= |
99.44 |
% |
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM |
CHEMBL3039007 |
| Solute carrier organic anion transporter family member 1B3 |
Inhibition |
= |
115.39 |
% |
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM |
CHEMBL3039007 |
| SARS-CoV-2 |
IC50 |
> |
20000.0 |
nM |
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging |
CHEMBL4651402 |
| SARS-CoV-2 |
IC50 |
< |
19952.62 |
nM |
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging |
CHEMBL4651402 |
