| Cyclin-dependent kinase 2/cyclin E |
IC50 |
= |
500.0 |
nM |
Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E |
CHEMBL1129208 |
| Cyclin-dependent kinase 1 |
IC50 |
= |
330000.0 |
nM |
Binding affinity to cyclin-dependent kinase 1 (CDK1) |
CHEMBL1135432 |
| Unchecked |
IC50 |
= |
500.0 |
nM |
Inhibition Cdk2/cyclin A |
CHEMBL1145498 |
| Unchecked |
IC50 |
= |
500.0 |
nM |
Inhibition of cdk2/cyclin E |
CHEMBL1145498 |
| Unchecked |
IC50 |
= |
4200.0 |
nM |
Inhibition of Cdk1/cyclin B |
CHEMBL1145498 |
| Unchecked |
IC50 |
= |
215000.0 |
nM |
Inhibition of Cdk4/cyclin D1 |
CHEMBL1145498 |
| Unchecked |
IC50 |
> |
1250000.0 |
nM |
Inhibition of MAPK |
CHEMBL1145498 |
| Unchecked |
IC50 |
> |
1250000.0 |
nM |
Inhibition of PKA |
CHEMBL1145498 |
| Unchecked |
IC50 |
> |
1250000.0 |
nM |
Inhibition of PKC |
CHEMBL1145498 |
| MRC5 |
Activity |
|
|
|
Cell cycle arrest in human MRC5 cells assessed as accumulation at G1/S phase at high concentration after 18 hrs by FACS analysis |
CHEMBL1153829 |
| MRC5 |
Activity |
|
|
|
Cell cycle arrest in human MRC5 cells assessed as accumulation at G2/M phase at high concentration after 18 hrs by FACS analysis |
CHEMBL1153829 |
| MRC5 |
Activity |
|
|
|
Cell cycle arrest in human MRC5 cells assessed as accumulation at G1/S phase at low concentration after 18 hrs by FACS analysis |
CHEMBL1153829 |
| Serine/threonine-protein kinase MARK1 |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of MARK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase SRPK3 |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of SRPK3 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase NEK6 |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of NEK6 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase NEK7 |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of NEK7 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase ABL2 |
Residual Activity |
= |
113.0 |
% |
Millipore: Percentage of residual kinase activity of ABL2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase ABL2 |
Residual Activity |
= |
76.0 |
% |
Millipore: Percentage of residual kinase activity of ABL2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Cyclin-dependent kinase 2/cyclin A |
Residual Activity |
= |
3.0 |
% |
Millipore: Percentage of residual kinase activity of CDK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase I isoform gamma-3 |
Residual Activity |
= |
17.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK1G3 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| CaM kinase I delta |
Residual Activity |
= |
50.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK1D at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| Death-associated protein kinase 1 |
Residual Activity |
= |
93.0 |
% |
Millipore: Percentage of residual kinase activity of DAPK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-A receptor 4 |
Residual Activity |
= |
110.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA4 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Fibroblast growth factor receptor 3 |
Residual Activity |
= |
109.0 |
% |
Millipore: Percentage of residual kinase activity of FGFR3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase FYN |
Residual Activity |
= |
70.0 |
% |
Millipore: Percentage of residual kinase activity of FYN at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4 |
CHEMBL2218924 |
| Tyrosine-protein kinase FYN |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of FYN at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4 |
CHEMBL2218924 |
| Tyrosine-protein kinase HCK |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of HCK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Inhibitor of nuclear factor kappa B kinase alpha subunit |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of CHUK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Inhibitor of nuclear factor kappa B kinase alpha subunit |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of CHUK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| c-Jun N-terminal kinase 3 |
Residual Activity |
= |
75.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK10 at 1uM relative to control. Control inhibitor: JAK Inhibitor I at 30.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| c-Jun N-terminal kinase 3 |
Residual Activity |
= |
70.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK10 at 10uM relative to control. Control inhibitor: JAK Inhibitor I at 30.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Serine/threonine-protein kinase MARK1 |
Residual Activity |
= |
72.0 |
% |
Millipore: Percentage of residual kinase activity of MARK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Dual specificity mitogen-activated protein kinase kinase 1 |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of MAP2K1 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 50 mM Tris pH 7.5, 0.2 mM EGTA, 0.1% ?-mercaptoethanol, 0.01% Brij-35 |
CHEMBL2218924 |
| Serine/threonine-protein kinase SRPK3 |
Residual Activity |
= |
84.0 |
% |
Millipore: Percentage of residual kinase activity of SRPK3 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase MST1 |
Residual Activity |
= |
74.0 |
% |
Millipore: Percentage of residual kinase activity of STK4 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase NEK7 |
Residual Activity |
= |
86.0 |
% |
Millipore: Percentage of residual kinase activity of NEK7 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Aurora-A |
Residual Activity |
= |
89.0 |
% |
Millipore: Percentage of residual kinase activity of AURKA at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl, 0.1% v/v Triton-X-100 |
CHEMBL2218924 |
| Cyclin-dependent kinase 2/cyclin E |
Residual Activity |
= |
18.0 |
% |
Millipore: Percentage of residual kinase activity of CDK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Cyclin-dependent kinase 2/cyclin E |
Residual Activity |
= |
0.0 |
% |
Millipore: Percentage of residual kinase activity of CDK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase I delta |
Residual Activity |
= |
40.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK1D at 1uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase I delta |
Residual Activity |
= |
6.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK1D at 10uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Death-associated protein kinase 1 |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of DAPK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-A receptor 5 |
Residual Activity |
= |
126.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 2.5 mM MnCl2 |
CHEMBL2218924 |
| Ephrin type-A receptor 5 |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 2.5 mM MnCl2 |
CHEMBL2218924 |
| Fibroblast growth factor receptor 4 |
Residual Activity |
= |
116.0 |
% |
Millipore: Percentage of residual kinase activity of FGFR4 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Fibroblast growth factor receptor 4 |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of FGFR4 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Mitogen-activated protein kinase kinase kinase kinase 2 |
Residual Activity |
= |
78.0 |
% |
Millipore: Percentage of residual kinase activity of GCK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 200 mM NaCl, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase HCK |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of HCK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Insulin-like growth factor I receptor |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of IGF1R at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Inhibitor of nuclear factor kappa B kinase beta subunit |
Residual Activity |
= |
112.0 |
% |
Millipore: Percentage of residual kinase activity of IKBKB at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Vascular endothelial growth factor receptor 2 |
Residual Activity |
= |
79.0 |
% |
Millipore: Percentage of residual kinase activity of KDR at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Dual specificity mitogen-activated protein kinase kinase 1 |
Residual Activity |
= |
120.0 |
% |
Millipore: Percentage of residual kinase activity of MAP2K1 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 50 mM Tris pH 7.5, 0.2 mM EGTA, 0.1% ?-mercaptoethanol, 0.01% Brij-35 |
CHEMBL2218924 |
| Serine/threonine-protein kinase MST1 |
Residual Activity |
= |
112.0 |
% |
Millipore: Percentage of residual kinase activity of STK4 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine protein kinase NLK |
Residual Activity |
= |
89.0 |
% |
Millipore: Percentage of residual kinase activity of NLK at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine protein kinase NLK |
Residual Activity |
= |
86.0 |
% |
Millipore: Percentage of residual kinase activity of NLK at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Aurora-A |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of AURKA at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl, 0.1% v/v Triton-X-100 |
CHEMBL2218924 |
| Serine/threonine-protein kinase Aurora-B |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of AURKB at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl, 0.1% v/v Triton-X-100 |
CHEMBL2218924 |
| CDK3/cyclin E |
Residual Activity |
= |
52.0 |
% |
Millipore: Percentage of residual kinase activity of CDK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase II |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK2A1 at 1uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 20 mM HEPES pH 7.6, 0.15 M NaCl, 0.1 mM EDTA, 5 mM DTT, 0.1% Triton X-100 |
CHEMBL2218924 |
| Death-associated protein kinase 2 |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of DAPK2 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Death-associated protein kinase 2 |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of DAPK2 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-A receptor 7 |
Residual Activity |
= |
92.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA7 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase FER |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of FER at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM MnCl2 |
CHEMBL2218924 |
| Mitogen-activated protein kinase kinase kinase kinase 2 |
Residual Activity |
= |
78.0 |
% |
Millipore: Percentage of residual kinase activity of GCK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 200 mM NaCl, 0.2 mM EDTA |
CHEMBL2218924 |
| G protein-coupled receptor kinase 5 |
Residual Activity |
= |
89.0 |
% |
Millipore: Percentage of residual kinase activity of GRK5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Insulin-like growth factor I receptor |
Residual Activity |
= |
129.0 |
% |
Millipore: Percentage of residual kinase activity of IGF1R at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Inhibitor of nuclear factor kappa B kinase beta subunit |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of IKBKB at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Insulin receptor |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of INSR at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Vascular endothelial growth factor receptor 2 |
Residual Activity |
= |
74.0 |
% |
Millipore: Percentage of residual kinase activity of KDR at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| LIM domain kinase 1 |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of LIMK1 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Maternal embryonic leucine zipper kinase |
Residual Activity |
= |
77.0 |
% |
Millipore: Percentage of residual kinase activity of MELK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Maternal embryonic leucine zipper kinase |
Residual Activity |
= |
38.0 |
% |
Millipore: Percentage of residual kinase activity of MELK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase MST2 |
Residual Activity |
= |
107.0 |
% |
Millipore: Percentage of residual kinase activity of STK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase MST2 |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of STK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PAK 2 |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of PAK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Aurora-B |
Residual Activity |
= |
73.0 |
% |
Millipore: Percentage of residual kinase activity of AURKB at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl, 0.1% v/v Triton-X-100 |
CHEMBL2218924 |
| Serine/threonine-protein kinase Aurora-C |
Residual Activity |
= |
75.0 |
% |
Millipore: Percentage of residual kinase activity of AURKC at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl, 0.1% v/v Triton-X-100 |
CHEMBL2218924 |
| CDK3/cyclin E |
Residual Activity |
= |
9.0 |
% |
Millipore: Percentage of residual kinase activity of CDK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Cyclin-dependent kinase 5/CDK5 activator 1 |
Residual Activity |
= |
11.0 |
% |
Millipore: Percentage of residual kinase activity of CDK5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase II |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK2A1 at 10uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 20 mM HEPES pH 7.6, 0.15 M NaCl, 0.1 mM EDTA, 5 mM DTT, 0.1% Triton X-100 |
CHEMBL2218924 |
| Casein kinase II alpha (prime) |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK2A2 at 1uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 20 mM HEPES pH 7.6, 0.15 M NaCl, 0.1 mM EDTA, 5 mM DTT, 0.1% Triton X-100 |
CHEMBL2218924 |
| Serine/threonine-protein kinase DCLK2 |
Residual Activity |
= |
94.0 |
% |
Millipore: Percentage of residual kinase activity of DCLK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-A receptor 7 |
Residual Activity |
= |
73.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA7 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-A receptor 8 |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA8 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| G protein-coupled receptor kinase 5 |
Residual Activity |
= |
93.0 |
% |
Millipore: Percentage of residual kinase activity of GRK5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Insulin receptor |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of INSR at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| LIM domain kinase 1 |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of LIMK1 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Misshapen-like kinase 1 |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of MINK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase 24 |
Residual Activity |
= |
65.0 |
% |
Millipore: Percentage of residual kinase activity of STK24 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PAK 2 |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of PAK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PAK 3 |
Residual Activity |
= |
84.0 |
% |
Millipore: Percentage of residual kinase activity of PAK3 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Aurora-C |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of AURKC at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl, 0.1% v/v Triton-X-100 |
CHEMBL2218924 |
| Cyclin-dependent kinase 5/CDK5 activator 1 |
Residual Activity |
= |
2.0 |
% |
Millipore: Percentage of residual kinase activity of CDK5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase II alpha (prime) |
Residual Activity |
= |
107.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK2A2 at 10uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 20 mM HEPES pH 7.6, 0.15 M NaCl, 0.1 mM EDTA, 5 mM DTT, 0.1% Triton X-100 |
CHEMBL2218924 |
| Serine/threonine-protein kinase DCLK2 |
Residual Activity |
= |
80.0 |
% |
Millipore: Percentage of residual kinase activity of DCLK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Discoidin domain-containing receptor 2 |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of DDR2 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Ephrin type-A receptor 8 |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA8 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| G protein-coupled receptor kinase 6 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of GRK6 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| G protein-coupled receptor kinase 6 |
Residual Activity |
= |
86.0 |
% |
Millipore: Percentage of residual kinase activity of GRK6 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Insulin receptor |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of INSR at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM Na3VO4, 5 mM Na-?-glycerophosphate |
CHEMBL2218924 |
| Insulin receptor |
Residual Activity |
= |
77.0 |
% |
Millipore: Percentage of residual kinase activity of INSR at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM Na3VO4, 5 mM Na-?-glycerophosphate |
CHEMBL2218924 |
| Serine/threonine-protein kinase 11 |
Residual Activity |
= |
126.0 |
% |
Millipore: Percentage of residual kinase activity of STK11 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.1% v/v Triton X-100 |
CHEMBL2218924 |
| Serine/threonine-protein kinase 11 |
Residual Activity |
= |
73.0 |
% |
Millipore: Percentage of residual kinase activity of STK11 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.1% v/v Triton X-100 |
CHEMBL2218924 |
| Misshapen-like kinase 1 |
Residual Activity |
= |
92.0 |
% |
Millipore: Percentage of residual kinase activity of MINK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Dual specificity mitogen-activated protein kinase kinase 6 |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of MAP2K6 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol, 0.1 mM Na3VO4, 1 mg/mL BSA |
CHEMBL2218924 |
| Serine/threonine-protein kinase 24 |
Residual Activity |
= |
60.0 |
% |
Millipore: Percentage of residual kinase activity of STK24 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Proto-oncogene tyrosine-protein kinase MER |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of MERTK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: mM MOPS pH 7.0, 0.2 mM EDTA, 30 mM NaCl |
CHEMBL2218924 |
| Tyrosine kinase non-receptor protein 2 |
Residual Activity |
= |
70.0 |
% |
Millipore: Percentage of residual kinase activity of TNK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase receptor UFO |
Residual Activity |
= |
92.0 |
% |
Millipore: Percentage of residual kinase activity of AXL at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase receptor UFO |
Residual Activity |
= |
75.0 |
% |
Millipore: Percentage of residual kinase activity of AXL at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Cyclin-dependent kinase 5/CDK5 activator 1 |
Residual Activity |
= |
18.0 |
% |
Millipore: Percentage of residual kinase activity of CDK5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Cyclin-dependent kinase 5/CDK5 activator 1 |
Residual Activity |
= |
2.0 |
% |
Millipore: Percentage of residual kinase activity of CDK5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Dual specificity protein kinase CLK2 |
Residual Activity |
= |
48.0 |
% |
Millipore: Percentage of residual kinase activity of CLK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Dual specificity protein kinase CLK2 |
Residual Activity |
= |
18.0 |
% |
Millipore: Percentage of residual kinase activity of CLK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Discoidin domain-containing receptor 2 |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of DDR2 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Ephrin type-B receptor 1 |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of EPHB1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-B receptor 1 |
Residual Activity |
= |
77.0 |
% |
Millipore: Percentage of residual kinase activity of EPHB1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| G protein-coupled receptor kinase 7 |
Residual Activity |
= |
76.0 |
% |
Millipore: Percentage of residual kinase activity of GRK7 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Interleukin-1 receptor-associated kinase 1 |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of IRAK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase 10 |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of STK10 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Dual specificity mitogen-activated protein kinase kinase 6 |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of MAP2K6 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol, 0.1 mM Na3VO4, 1 mg/mL BSA |
CHEMBL2218924 |
| Proto-oncogene tyrosine-protein kinase MER |
Residual Activity |
= |
60.0 |
% |
Millipore: Percentage of residual kinase activity of MERTK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: mM MOPS pH 7.0, 0.2 mM EDTA, 30 mM NaCl |
CHEMBL2218924 |
| Tyrosine kinase non-receptor protein 2 |
Residual Activity |
= |
51.0 |
% |
Millipore: Percentage of residual kinase activity of TNK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| ALK tyrosine kinase receptor |
Residual Activity |
= |
80.0 |
% |
Millipore: Percentage of residual kinase activity of ALK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase BRK |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of PTK6 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 5 mM MnCl2 |
CHEMBL2218924 |
| CDK6/cyclin D3 |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of CDK6 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Dual specificity protein kinase CLK3 |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of CLK3 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Myotonin-protein kinase |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of DMPK at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Myotonin-protein kinase |
Residual Activity |
= |
73.0 |
% |
Millipore: Percentage of residual kinase activity of DMPK at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-B receptor 2 |
Residual Activity |
= |
113.0 |
% |
Millipore: Percentage of residual kinase activity of EPHB2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| G protein-coupled receptor kinase 7 |
Residual Activity |
= |
69.0 |
% |
Millipore: Percentage of residual kinase activity of GRK7 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Glycogen synthase kinase-3 alpha |
Residual Activity |
= |
74.0 |
% |
Millipore: Percentage of residual kinase activity of GSK3A at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Interleukin-1 receptor-associated kinase 1 |
Residual Activity |
= |
107.0 |
% |
Millipore: Percentage of residual kinase activity of IRAK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Interleukin-1 receptor-associated kinase 4 |
Residual Activity |
= |
71.0 |
% |
Millipore: Percentage of residual kinase activity of IRAK4 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase 10 |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of STK10 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase LCK |
Residual Activity |
= |
62.0 |
% |
Millipore: Percentage of residual kinase activity of LCK at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4 |
CHEMBL2218924 |
| Dual specificity mitogen-activated protein kinase kinase 7 |
Residual Activity |
= |
86.0 |
% |
Millipore: Percentage of residual kinase activity of MAP2K7 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol, 0.1 mM Na3VO4 |
CHEMBL2218924 |
| Dual specificity mitogen-activated protein kinase kinase 7 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of MAP2K7 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol, 0.1 mM Na3VO4 |
CHEMBL2218924 |
| Hepatocyte growth factor receptor |
Residual Activity |
= |
122.0 |
% |
Millipore: Percentage of residual kinase activity of MET at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Hepatocyte growth factor receptor |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of MET at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| ALK tyrosine kinase receptor |
Residual Activity |
= |
61.0 |
% |
Millipore: Percentage of residual kinase activity of ALK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase BRK |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of PTK6 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 5 mM MnCl2 |
CHEMBL2218924 |
| Tyrosine-protein kinase BTK |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of BTK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| CDK6/cyclin D3 |
Residual Activity |
= |
77.0 |
% |
Millipore: Percentage of residual kinase activity of CDK6 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Cyclin-dependent kinase 7/ cyclin H |
Residual Activity |
= |
94.0 |
% |
Millipore: Percentage of residual kinase activity of CDK7 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Dual specificity protein kinase CLK3 |
Residual Activity |
= |
62.0 |
% |
Millipore: Percentage of residual kinase activity of CLK3 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase CSK |
Residual Activity |
= |
106.0 |
% |
Millipore: Percentage of residual kinase activity of CSK at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol, 10 mM MnCl2 |
CHEMBL2218924 |
| Serine/threonine-protein kinase 17A |
Residual Activity |
= |
106.0 |
% |
Millipore: Percentage of residual kinase activity of STK17A at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-B receptor 2 |
Residual Activity |
= |
106.0 |
% |
Millipore: Percentage of residual kinase activity of EPHB2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Ephrin type-B receptor 3 |
Residual Activity |
= |
113.0 |
% |
Millipore: Percentage of residual kinase activity of EPHB3 at 1uM relative to control. Control inhibitor: PP2 at 30.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Tyrosine-protein kinase FER |
Residual Activity |
= |
86.0 |
% |
Millipore: Percentage of residual kinase activity of FER at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM MnCl2 |
CHEMBL2218924 |
| Glycogen synthase kinase-3 alpha |
Residual Activity |
= |
75.0 |
% |
Millipore: Percentage of residual kinase activity of GSK3A at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Interleukin-1 receptor-associated kinase 4 |
Residual Activity |
= |
71.0 |
% |
Millipore: Percentage of residual kinase activity of IRAK4 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase LCK |
Residual Activity |
= |
77.0 |
% |
Millipore: Percentage of residual kinase activity of LCK at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4 |
CHEMBL2218924 |
| Myosin light chain kinase, smooth muscle |
Residual Activity |
= |
108.0 |
% |
Millipore: Percentage of residual kinase activity of MYLK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| MAP kinase signal-integrating kinase 2 |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of MKNK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Activin receptor type-1B |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of ACVR1B at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Activin receptor type-1B |
Residual Activity |
= |
118.0 |
% |
Millipore: Percentage of residual kinase activity of ACVR1B at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase BTK |
Residual Activity |
= |
86.0 |
% |
Millipore: Percentage of residual kinase activity of BTK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Cyclin-dependent kinase 7/ cyclin H |
Residual Activity |
= |
36.0 |
% |
Millipore: Percentage of residual kinase activity of CDK7 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase CSK |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of CSK at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol, 10 mM MnCl2 |
CHEMBL2218924 |
| Serine/threonine-protein kinase 17A |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of STK17A at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Dual-specificity tyrosine-phosphorylation regulated kinase 2 |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of DYRK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-B receptor 3 |
Residual Activity |
= |
107.0 |
% |
Millipore: Percentage of residual kinase activity of EPHB3 at 10uM relative to control. Control inhibitor: PP2 at 30.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Tyrosine-protein kinase FES |
Residual Activity |
= |
62.0 |
% |
Millipore: Percentage of residual kinase activity of FES at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase FES |
Residual Activity |
= |
23.0 |
% |
Millipore: Percentage of residual kinase activity of FES at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Glycogen synthase kinase-3 beta |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of GSK3B at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Glycogen synthase kinase-3 beta |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of GSK3B at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Insulin receptor-related protein |
Residual Activity |
= |
92.0 |
% |
Millipore: Percentage of residual kinase activity of INSRR at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Insulin receptor-related protein |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of INSRR at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase LCK |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of LCK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Myosin light chain kinase, smooth muscle |
Residual Activity |
= |
68.0 |
% |
Millipore: Percentage of residual kinase activity of MYLK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| Mitogen-activated protein kinase kinase kinase 9 |
Residual Activity |
= |
82.0 |
% |
Millipore: Percentage of residual kinase activity of MAP3K9 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| MAP kinase signal-integrating kinase 2 |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of MKNK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Muscle, skeletal receptor tyrosine protein kinase |
Residual Activity |
= |
86.0 |
% |
Millipore: Percentage of residual kinase activity of MUSK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 5 mM MnCl2 |
CHEMBL2218924 |
| AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of PRKAA1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP |
CHEMBL2218924 |
| Tyrosine-protein kinase BLK |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of BLK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Tyrosine-protein kinase BLK |
Residual Activity |
= |
83.0 |
% |
Millipore: Percentage of residual kinase activity of BLK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| CDK9/cyclin T1 |
Residual Activity |
= |
29.0 |
% |
Millipore: Percentage of residual kinase activity of CDK9 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| CDK9/cyclin T1 |
Residual Activity |
= |
0.0 |
% |
Millipore: Percentage of residual kinase activity of CDK9 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| CaM kinase I alpha |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| CaM kinase I alpha |
Residual Activity |
= |
55.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| Dual-specificity tyrosine-phosphorylation regulated kinase 2 |
Residual Activity |
= |
67.0 |
% |
Millipore: Percentage of residual kinase activity of DYRK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-B receptor 4 |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of EPHB4 at 1uM relative to control. Control inhibitor: PP2 at 30.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Ephrin type-B receptor 4 |
Residual Activity |
= |
77.0 |
% |
Millipore: Percentage of residual kinase activity of EPHB4 at 10uM relative to control. Control inhibitor: PP2 at 30.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Tyrosine-protein kinase FGR |
Residual Activity |
= |
77.0 |
% |
Millipore: Percentage of residual kinase activity of FGR at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Homeodomain-interacting protein kinase 1 |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of HIPK1 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase ITK/TSK |
Residual Activity |
= |
94.0 |
% |
Millipore: Percentage of residual kinase activity of ITK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase LCK |
Residual Activity |
= |
79.0 |
% |
Millipore: Percentage of residual kinase activity of LCK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase Lyn |
Residual Activity |
= |
74.0 |
% |
Millipore: Percentage of residual kinase activity of LYN at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Mitogen-activated protein kinase kinase kinase 9 |
Residual Activity |
= |
41.0 |
% |
Millipore: Percentage of residual kinase activity of MAP3K9 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Muscle, skeletal receptor tyrosine protein kinase |
Residual Activity |
= |
73.0 |
% |
Millipore: Percentage of residual kinase activity of MUSK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 5 mM MnCl2 |
CHEMBL2218924 |
| AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 |
Residual Activity |
= |
80.0 |
% |
Millipore: Percentage of residual kinase activity of PRKAA1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP |
CHEMBL2218924 |
| AMP-activated protein kinase, AMPK |
Residual Activity |
= |
86.0 |
% |
Millipore: Percentage of residual kinase activity of PRKAA2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP |
CHEMBL2218924 |
| Tyrosine-protein kinase BMX |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of BMX at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Chk1 |
Residual Activity |
= |
93.0 |
% |
Millipore: Percentage of residual kinase activity of CHEK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| CaM kinase II beta |
Residual Activity |
= |
89.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK2B at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| CaM kinase II beta |
Residual Activity |
= |
55.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK2B at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| Epidermal growth factor receptor erbB1 |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of EGFR at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Epidermal growth factor receptor erbB1 |
Residual Activity |
= |
116.0 |
% |
Millipore: Percentage of residual kinase activity of EGFR at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Receptor protein-tyrosine kinase erbB-4 |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of ERBB4 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 2.5 mM MnCl2 |
CHEMBL2218924 |
| Tyrosine-protein kinase FGR |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of FGR at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Vascular endothelial growth factor receptor 1 |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of FLT1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Homeodomain-interacting protein kinase 1 |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of HIPK1 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Homeodomain-interacting protein kinase 2 |
Residual Activity |
= |
98.0 |
% |
Millipore: Percentage of residual kinase activity of HIPK2 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase ITK/TSK |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of ITK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase JAK2 |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of JAK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase Lyn |
Residual Activity |
= |
78.0 |
% |
Millipore: Percentage of residual kinase activity of LYN at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Serine/threonine-protein kinase MRCK-A |
Residual Activity |
= |
108.0 |
% |
Millipore: Percentage of residual kinase activity of CDC42BPA at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase MRCK-A |
Residual Activity |
= |
89.0 |
% |
Millipore: Percentage of residual kinase activity of CDC42BPA at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Nek11 |
Residual Activity |
= |
53.0 |
% |
Millipore: Percentage of residual kinase activity of NEK11 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Nek11 |
Residual Activity |
= |
64.0 |
% |
Millipore: Percentage of residual kinase activity of NEK11 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| AMP-activated protein kinase, AMPK |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of PRKAA2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP |
CHEMBL2218924 |
| Tyrosine-protein kinase BMX |
Residual Activity |
= |
83.0 |
% |
Millipore: Percentage of residual kinase activity of BMX at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| BR serine/threonine-protein kinase 1 |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of BRSK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Chk1 |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of CHEK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Chk2 |
Residual Activity |
= |
77.0 |
% |
Millipore: Percentage of residual kinase activity of CHEK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| CaM kinase II gamma |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK2G at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| Ephrin type-A receptor 1 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Receptor protein-tyrosine kinase erbB-4 |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of ERBB4 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 2.5 mM MnCl2 |
CHEMBL2218924 |
| Focal adhesion kinase 1 |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of PTK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Vascular endothelial growth factor receptor 1 |
Residual Activity |
= |
55.0 |
% |
Millipore: Percentage of residual kinase activity of FLT1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Homeodomain-interacting protein kinase 2 |
Residual Activity |
= |
82.0 |
% |
Millipore: Percentage of residual kinase activity of HIPK2 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase JAK2 |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of JAK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| MAP kinase ERK1 |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK3 at 1uM relative to control. Control inhibitor: ERK Inhibitor II at 30.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| MAP kinase ERK1 |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK3 at 10uM relative to control. Control inhibitor: ERK Inhibitor II at 30.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase MRCK beta |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of CDC42BPB at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase NEK2 |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of NEK2 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| NUAK family SNF1-like kinase 1 |
Residual Activity |
= |
107.0 |
% |
Millipore: Percentage of residual kinase activity of NUAK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| NUAK family SNF1-like kinase 1 |
Residual Activity |
= |
77.0 |
% |
Millipore: Percentage of residual kinase activity of NUAK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| BR serine/threonine-protein kinase 1 |
Residual Activity |
= |
92.0 |
% |
Millipore: Percentage of residual kinase activity of BRSK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Chk2 |
Residual Activity |
= |
33.0 |
% |
Millipore: Percentage of residual kinase activity of CHEK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| CaM kinase II gamma |
Residual Activity |
= |
63.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK2G at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| CaM kinase II delta |
Residual Activity |
= |
92.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK2D at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| Ephrin type-A receptor 1 |
Residual Activity |
= |
81.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-A receptor 2 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Focal adhesion kinase 1 |
Residual Activity |
= |
64.0 |
% |
Millipore: Percentage of residual kinase activity of PTK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase receptor FLT3 |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of FLT3 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase receptor FLT3 |
Residual Activity |
= |
74.0 |
% |
Millipore: Percentage of residual kinase activity of FLT3 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Homeodomain-interacting protein kinase 3 |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of HIPK3 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Homeodomain-interacting protein kinase 3 |
Residual Activity |
= |
98.0 |
% |
Millipore: Percentage of residual kinase activity of HIPK3 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase JAK3 |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of JAK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase JAK3 |
Residual Activity |
= |
107.0 |
% |
Millipore: Percentage of residual kinase activity of JAK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| MAP kinase ERK2 |
Residual Activity |
= |
123.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK1 at 1uM relative to control. Control inhibitor: ERK Inhibitor II at 30.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase MRCK beta |
Residual Activity |
= |
83.0 |
% |
Millipore: Percentage of residual kinase activity of CDC42BPB at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 5 |
Residual Activity |
= |
92.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase NEK2 |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of NEK2 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Mitogen-activated protein kinase kinase kinase 5 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of MAP3K5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| BR serine/threonine-protein kinase 2 |
Residual Activity |
= |
114.0 |
% |
Millipore: Percentage of residual kinase activity of BRSK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| BR serine/threonine-protein kinase 2 |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of BRSK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase I gamma 1 |
Residual Activity |
= |
67.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK1G1 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase I gamma 1 |
Residual Activity |
= |
29.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK1G1 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| CaM kinase II delta |
Residual Activity |
= |
54.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK2D at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| Ephrin type-A receptor 2 |
Residual Activity |
= |
117.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Fibroblast growth factor receptor 1 |
Residual Activity |
= |
89.0 |
% |
Millipore: Percentage of residual kinase activity of FGFR1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Fibroblast growth factor receptor 1 |
Residual Activity |
= |
67.0 |
% |
Millipore: Percentage of residual kinase activity of FGFR1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Vascular endothelial growth factor receptor 3 |
Residual Activity |
= |
62.0 |
% |
Millipore: Percentage of residual kinase activity of FLT4 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase haspin |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of GSG2 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| c-Jun N-terminal kinase 1 |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK8 at 1uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ? -mercaptoethanol |
CHEMBL2218924 |
| MAP kinase ERK2 |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK1 at 10uM relative to control. Control inhibitor: ERK Inhibitor II at 30.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| MAP kinase-activated protein kinase 2 |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of MAPKAPK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Na-?-glycerophosphate pH 7.5, 0.1 mM EGTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 5 |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Nek3 |
Residual Activity |
= |
71.0 |
% |
Millipore: Percentage of residual kinase activity of NEK3 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Nek3 |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of NEK3 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Mitogen-activated protein kinase kinase kinase 5 |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of MAP3K5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase ABL |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of ABL1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Cyclin-dependent kinase 1/cyclin B1 |
Residual Activity |
= |
81.0 |
% |
Millipore: Percentage of residual kinase activity of CDK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase I gamma 2 |
Residual Activity |
= |
53.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK1G2 at 1uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| CaM kinase IV |
Residual Activity |
= |
113.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK4 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 40 mM HEPES pH 7.4, 5 mM CaCl2, 30 ug/mL calmodulin |
CHEMBL2218924 |
| CaM kinase IV |
Residual Activity |
= |
78.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK4 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 40 mM HEPES pH 7.4, 5 mM CaCl2, 30 ug/mL calmodulin |
CHEMBL2218924 |
| Ephrin type-A receptor 3 |
Residual Activity |
= |
82.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Fibroblast growth factor receptor 2 |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of FGFR2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 2.5 mM MnCl2 |
CHEMBL2218924 |
| Vascular endothelial growth factor receptor 3 |
Residual Activity |
= |
30.0 |
% |
Millipore: Percentage of residual kinase activity of FLT4 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Macrophage colony stimulating factor receptor |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of CSF1R at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase haspin |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of GSG2 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase HCK |
Residual Activity |
= |
62.0 |
% |
Millipore: Percentage of residual kinase activity of HCK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Insulin-like growth factor I receptor |
Residual Activity |
= |
94.0 |
% |
Millipore: Percentage of residual kinase activity of IGF1R at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM Na3VO4, 5 mM Na-?-glycerophosphate |
CHEMBL2218924 |
| c-Jun N-terminal kinase 1 |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK8 at 10uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ? -mercaptoethanol |
CHEMBL2218924 |
| c-Jun N-terminal kinase 2 |
Residual Activity |
= |
83.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK9 at 1uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| MAP kinase-activated protein kinase 2 |
Residual Activity |
= |
81.0 |
% |
Millipore: Percentage of residual kinase activity of MAPKAPK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Na-?-glycerophosphate pH 7.5, 0.1 mM EGTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 4 |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA4 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 4 |
Residual Activity |
= |
82.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA4 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase NEK6 |
Residual Activity |
= |
107.0 |
% |
Millipore: Percentage of residual kinase activity of NEK6 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase ABL |
Residual Activity |
= |
73.0 |
% |
Millipore: Percentage of residual kinase activity of ABL1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Cyclin-dependent kinase 1/cyclin B1 |
Residual Activity |
= |
26.0 |
% |
Millipore: Percentage of residual kinase activity of CDK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Cyclin-dependent kinase 2/cyclin A |
Residual Activity |
= |
24.0 |
% |
Millipore: Percentage of residual kinase activity of CDK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase I gamma 2 |
Residual Activity |
= |
5.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK1G2 at 10uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase I isoform gamma-3 |
Residual Activity |
= |
67.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK1G3 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| CaM kinase I delta |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK1D at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| Ephrin type-A receptor 3 |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-A receptor 4 |
Residual Activity |
= |
110.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA4 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Fibroblast growth factor receptor 2 |
Residual Activity |
= |
80.0 |
% |
Millipore: Percentage of residual kinase activity of FGFR2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 2.5 mM MnCl2 |
CHEMBL2218924 |
| Fibroblast growth factor receptor 3 |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of FGFR3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Macrophage colony stimulating factor receptor |
Residual Activity |
= |
69.0 |
% |
Millipore: Percentage of residual kinase activity of CSF1R at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase HCK |
Residual Activity |
= |
56.0 |
% |
Millipore: Percentage of residual kinase activity of HCK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Insulin-like growth factor I receptor |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of IGF1R at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM Na3VO4, 5 mM Na-?-glycerophosphate |
CHEMBL2218924 |
| c-Jun N-terminal kinase 2 |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK9 at 10uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| MAP kinase-activated protein kinase 3 |
Residual Activity |
= |
110.0 |
% |
Millipore: Percentage of residual kinase activity of MAPKAPK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Na-?-glycerophosphate pH 7.5, 0.1 mM EGTA |
CHEMBL2218924 |
| MAP kinase-activated protein kinase 3 |
Residual Activity |
= |
98.0 |
% |
Millipore: Percentage of residual kinase activity of MAPKAPK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Na-?-glycerophosphate pH 7.5, 0.1 mM EGTA |
CHEMBL2218924 |
| 3-phosphoinositide dependent protein kinase-1 |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of PDPK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| cAMP-dependent protein kinase alpha-catalytic subunit |
Residual Activity |
= |
93.0 |
% |
Millipore: Percentage of residual kinase activity of PRKACA at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C eta |
Residual Activity |
= |
83.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCH at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| Serine/threonine-protein kinase PIM2 |
Residual Activity |
= |
130.0 |
% |
Millipore: Percentage of residual kinase activity of PIM2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase receptor TYRO3 |
Residual Activity |
= |
116.0 |
% |
Millipore: Percentage of residual kinase activity of TYRO3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM MnCl2 |
CHEMBL2218924 |
| Tyrosine-protein kinase receptor TYRO3 |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of TYRO3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM MnCl2 |
CHEMBL2218924 |
| Serine/threonine-protein kinase SIK1 |
Residual Activity |
= |
93.0 |
% |
Millipore: Percentage of residual kinase activity of SIK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase SIK1 |
Residual Activity |
= |
78.0 |
% |
Millipore: Percentage of residual kinase activity of SIK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase tousled-like 2 |
Residual Activity |
= |
83.0 |
% |
Millipore: Percentage of residual kinase activity of TLK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase WNK3 |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of WNK3 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| cAMP-dependent protein kinase alpha-catalytic subunit |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of PRKACA at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C theta |
Residual Activity |
= |
4.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCQ at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C theta |
Residual Activity |
= |
5.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCQ at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PIM3 |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of PIM3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.1% Triton X-100 |
CHEMBL2218924 |
| Serine/threonine-protein kinase PIM3 |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of PIM3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.1% Triton X-100 |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 1 |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase SRPK1 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of SRPK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase tousled-like 2 |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of TLK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Testis-specific serine/threonine-protein kinase 1 |
Residual Activity |
= |
86.0 |
% |
Millipore: Percentage of residual kinase activity of TSSK1B at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase WNK3 |
Residual Activity |
= |
93.0 |
% |
Millipore: Percentage of residual kinase activity of WNK3 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase YES |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of YES1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase AKT |
Residual Activity |
= |
118.0 |
% |
Millipore: Percentage of residual kinase activity of AKT1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase AKT |
Residual Activity |
= |
111.0 |
% |
Millipore: Percentage of residual kinase activity of AKT1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C iota |
Residual Activity |
= |
112.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCI at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100 |
CHEMBL2218924 |
| Serine/threonine-protein kinase PLK1 |
Residual Activity |
= |
69.0 |
% |
Millipore: Percentage of residual kinase activity of PLK1 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 20 mM DTT |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 1 |
Residual Activity |
= |
59.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 3 |
Residual Activity |
= |
31.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase SRPK1 |
Residual Activity |
= |
67.0 |
% |
Millipore: Percentage of residual kinase activity of SRPK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase SRPK2 |
Residual Activity |
= |
86.0 |
% |
Millipore: Percentage of residual kinase activity of SRPK2 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Testis-specific serine/threonine-protein kinase 1 |
Residual Activity |
= |
70.0 |
% |
Millipore: Percentage of residual kinase activity of TSSK1B at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase YES |
Residual Activity |
= |
89.0 |
% |
Millipore: Percentage of residual kinase activity of YES1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase AKT2 |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of AKT2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C iota |
Residual Activity |
= |
108.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCI at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100 |
CHEMBL2218924 |
| Protein kinase C mu |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of PRKD1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: mM HEPES pH 7.4, 0.03% Triton X-100 |
CHEMBL2218924 |
| Serine/threonine-protein kinase PLK1 |
Residual Activity |
= |
58.0 |
% |
Millipore: Percentage of residual kinase activity of PLK1 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 20 mM DTT |
CHEMBL2218924 |
| Serine/threonine-protein kinase PLK3 |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of PLK3 at 1uM relative to control. Control inhibitor: Wortmannin at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 3 |
Residual Activity |
= |
22.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase SRPK2 |
Residual Activity |
= |
65.0 |
% |
Millipore: Percentage of residual kinase activity of SRPK2 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Testis-specific serine/threonine-protein kinase 2 |
Residual Activity |
= |
98.0 |
% |
Millipore: Percentage of residual kinase activity of TSSK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Testis-specific serine/threonine-protein kinase 2 |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of TSSK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase ZAP-70 |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of ZAP70 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Tyrosine-protein kinase ZAP-70 |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of ZAP70 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Serine/threonine-protein kinase AKT2 |
Residual Activity |
= |
108.0 |
% |
Millipore: Percentage of residual kinase activity of AKT2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase AKT3 |
Residual Activity |
= |
72.0 |
% |
Millipore: Percentage of residual kinase activity of AKT3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C mu |
Residual Activity |
= |
71.0 |
% |
Millipore: Percentage of residual kinase activity of PRKD1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: mM HEPES pH 7.4, 0.03% Triton X-100 |
CHEMBL2218924 |
| Serine/threonine-protein kinase PLK3 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of PLK3 at 10uM relative to control. Control inhibitor: Wortmannin at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 2 |
Residual Activity |
= |
11.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 2 |
Residual Activity |
= |
5.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase 33 |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of STK33 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase 33 |
Residual Activity |
= |
83.0 |
% |
Millipore: Percentage of residual kinase activity of STK33 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase TEC |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of TEC at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM Na3VO4, 5 mM Na-?-glycerophosphate |
CHEMBL2218924 |
| Death-associated protein kinase 3 |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of DAPK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PAK 3 |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of PAK3 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase AKT3 |
Residual Activity |
= |
69.0 |
% |
Millipore: Percentage of residual kinase activity of AKT3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase D2 |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of PRKD2 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100 |
CHEMBL2218924 |
| Serine/threonine-protein kinase D2 |
Residual Activity |
= |
93.0 |
% |
Millipore: Percentage of residual kinase activity of PRKD2 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100 |
CHEMBL2218924 |
| Serine/threonine-protein kinase PRKX |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of PRKX at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PRKX |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of PRKX at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 6 |
Residual Activity |
= |
84.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA6 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 30 mM NaCl |
CHEMBL2218924 |
| Serine/threonine-protein kinase PLK2 |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of PLK2 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase TEC |
Residual Activity |
= |
79.0 |
% |
Millipore: Percentage of residual kinase activity of TEC at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM Na3VO4, 5 mM Na-?-glycerophosphate |
CHEMBL2218924 |
| Tyrosine-protein kinase TIE-2 |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of TEK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM MnCl2 |
CHEMBL2218924 |
| Death-associated protein kinase 3 |
Residual Activity |
= |
92.0 |
% |
Millipore: Percentage of residual kinase activity of DAPK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase RAF |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of RAF1 at 1uM relative to control. Control inhibitor: SB203580 at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PAK 4 |
Residual Activity |
= |
89.0 |
% |
Millipore: Percentage of residual kinase activity of PAK4 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PAK 4 |
Residual Activity |
= |
56.0 |
% |
Millipore: Percentage of residual kinase activity of PAK4 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C alpha |
Residual Activity |
= |
34.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCA at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| Protein kinase C alpha |
Residual Activity |
= |
13.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCA at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| cGMP-dependent protein kinase 1 beta |
Residual Activity |
= |
93.0 |
% |
Millipore: Percentage of residual kinase activity of PRKG1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 uM cGMP |
CHEMBL2218924 |
| Protein tyrosine kinase 2 beta |
Residual Activity |
= |
83.0 |
% |
Millipore: Percentage of residual kinase activity of PTK2B at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 6 |
Residual Activity |
= |
56.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA6 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 30 mM NaCl |
CHEMBL2218924 |
| MAP kinase p38 alpha |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK14 at 1uM relative to control. Control inhibitor: SB203580 at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PLK2 |
Residual Activity |
= |
94.0 |
% |
Millipore: Percentage of residual kinase activity of PLK2 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase SYK |
Residual Activity |
= |
94.0 |
% |
Millipore: Percentage of residual kinase activity of SYK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Tyrosine-protein kinase TIE-2 |
Residual Activity |
= |
80.0 |
% |
Millipore: Percentage of residual kinase activity of TEK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM MnCl2 |
CHEMBL2218924 |
| Serine/threonine-protein kinase RAF |
Residual Activity |
= |
69.0 |
% |
Millipore: Percentage of residual kinase activity of RAF1 at 10uM relative to control. Control inhibitor: SB203580 at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PAK7 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of PAK7 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C beta |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCB at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| cGMP-dependent protein kinase 1 beta |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of PRKG1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 uM cGMP |
CHEMBL2218924 |
| cGMP-dependent protein kinase 1 beta |
Residual Activity |
= |
109.0 |
% |
Millipore: Percentage of residual kinase activity of PRKG1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 uM cGMP |
CHEMBL2218924 |
| Protein tyrosine kinase 2 beta |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of PTK2B at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase RIPK2 |
Residual Activity |
= |
83.0 |
% |
Millipore: Percentage of residual kinase activity of RIPK2 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| MAP kinase p38 alpha |
Residual Activity |
= |
89.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK14 at 10uM relative to control. Control inhibitor: SB203580 at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| Tyrosine-protein kinase SYK |
Residual Activity |
= |
114.0 |
% |
Millipore: Percentage of residual kinase activity of SYK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Nerve growth factor receptor Trk-A |
Residual Activity |
= |
75.0 |
% |
Millipore: Percentage of residual kinase activity of NTRK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Nerve growth factor receptor Trk-A |
Residual Activity |
= |
56.0 |
% |
Millipore: Percentage of residual kinase activity of NTRK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Stem cell growth factor receptor |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of KIT at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Stem cell growth factor receptor |
Residual Activity |
= |
66.0 |
% |
Millipore: Percentage of residual kinase activity of KIT at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Serine/threonine-protein kinase PAK7 |
Residual Activity |
= |
66.0 |
% |
Millipore: Percentage of residual kinase activity of PAK7 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PAK6 |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of PAK6 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C beta |
Residual Activity |
= |
86.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCB at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| Protein kinase C beta |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCB at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| cGMP-dependent protein kinase 1 beta |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of PRKG1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 uM cGMP |
CHEMBL2218924 |
| Serine/threonine-protein kinase RIPK2 |
Residual Activity |
= |
78.0 |
% |
Millipore: Percentage of residual kinase activity of RIPK2 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| MAP kinase p38 beta |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK11 at 1uM relative to control. Control inhibitor: SB203580 at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| MAP kinase p38 beta |
Residual Activity |
= |
92.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK11 at 10uM relative to control. Control inhibitor: SB203580 at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| Mitogen-activated protein kinase kinase kinase 7 |
Residual Activity |
= |
92.0 |
% |
Millipore: Percentage of residual kinase activity of MAP3K7 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Mitogen-activated protein kinase kinase kinase 7 |
Residual Activity |
= |
82.0 |
% |
Millipore: Percentage of residual kinase activity of MAP3K7 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Neurotrophic tyrosine kinase receptor type 2 |
Residual Activity |
= |
72.0 |
% |
Millipore: Percentage of residual kinase activity of NTRK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase SRC |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of SRC at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PAK6 |
Residual Activity |
= |
63.0 |
% |
Millipore: Percentage of residual kinase activity of PAK6 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C beta |
Residual Activity |
= |
79.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCB at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| MAP kinase-activated protein kinase 5 |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of MAPKAPK5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Na-?-glycerophosphate pH 7.5, 0.1 mM EGTA |
CHEMBL2218924 |
| MAP kinase-activated protein kinase 5 |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of MAPKAPK5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Na-?-glycerophosphate pH 7.5, 0.1 mM EGTA |
CHEMBL2218924 |
| Rho-associated protein kinase 1 |
Residual Activity |
= |
121.0 |
% |
Millipore: Percentage of residual kinase activity of ROCK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| MAP kinase p38 gamma |
Residual Activity |
= |
109.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK12 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase TAO1 |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of TAOK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl |
CHEMBL2218924 |
| Neurotrophic tyrosine kinase receptor type 2 |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of NTRK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase TXK |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of TXK at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase SRC |
Residual Activity |
= |
82.0 |
% |
Millipore: Percentage of residual kinase activity of SRC at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase EEF2K |
Residual Activity |
= |
106.0 |
% |
Millipore: Percentage of residual kinase activity of EEF2K at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| MAP/microtubule affinity-regulating kinase 2 |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of MARK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| MAP/microtubule affinity-regulating kinase 2 |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of MARK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C gamma |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCG at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| Protein kinase N2 |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of PKN2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Rho-associated protein kinase 1 |
Residual Activity |
= |
109.0 |
% |
Millipore: Percentage of residual kinase activity of ROCK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Rho-associated protein kinase 2 |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of ROCK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA |
CHEMBL2218924 |
| MAP kinase p38 gamma |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK12 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| MAP kinase p38 delta |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK13 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase TAO1 |
Residual Activity |
= |
81.0 |
% |
Millipore: Percentage of residual kinase activity of TAOK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl |
CHEMBL2218924 |
| Serine/threonine-protein kinase TAO2 |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of TAOK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase TXK |
Residual Activity |
= |
89.0 |
% |
Millipore: Percentage of residual kinase activity of TXK at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase EEF2K |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of EEF2K at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| PAS domain-containing serine/threonine-protein kinase |
Residual Activity |
= |
117.0 |
% |
Millipore: Percentage of residual kinase activity of PASK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C gamma |
Residual Activity |
= |
86.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCG at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| Protein kinase C delta |
Residual Activity |
= |
60.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCD at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| Protein kinase N2 |
Residual Activity |
= |
77.0 |
% |
Millipore: Percentage of residual kinase activity of PKN2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Tyrosine-protein kinase FRK |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of FRK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Rho-associated protein kinase 2 |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of ROCK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA |
CHEMBL2218924 |
| MAP kinase p38 delta |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK13 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase TAO2 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of TAOK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase ULK2 |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of ULK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase ULK2 |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of ULK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase mTOR |
Residual Activity |
= |
106.0 |
% |
Millipore: Percentage of residual kinase activity of MTOR at 1uM relative to control. Control inhibitor: PI-103 at 30.0uM. Buffer: 50 mM HEPES pH 7.5, 1 mM EGTA, 0.01% Tween 20 |
CHEMBL2218924 |
| Serine/threonine-protein kinase mTOR |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of MTOR at 10uM relative to control. Control inhibitor: PI-103 at 30.0uM. Buffer: 50 mM HEPES pH 7.5, 1 mM EGTA, 0.01% Tween 20 |
CHEMBL2218924 |
| PAS domain-containing serine/threonine-protein kinase |
Residual Activity |
= |
129.0 |
% |
Millipore: Percentage of residual kinase activity of PASK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Platelet-derived growth factor receptor alpha |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of PDGFRA at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C delta |
Residual Activity |
= |
27.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCD at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| Tyrosine-protein kinase FRK |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of FRK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase receptor RET |
Residual Activity |
= |
108.0 |
% |
Millipore: Percentage of residual kinase activity of RET at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase receptor RET |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of RET at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Sgk1 |
Residual Activity |
= |
73.0 |
% |
Millipore: Percentage of residual kinase activity of SGK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Sgk1 |
Residual Activity |
= |
116.0 |
% |
Millipore: Percentage of residual kinase activity of SGK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase TAO3 |
Residual Activity |
= |
92.0 |
% |
Millipore: Percentage of residual kinase activity of TAOK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 200 mM NaCl, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase TAO3 |
Residual Activity |
= |
71.0 |
% |
Millipore: Percentage of residual kinase activity of TAOK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 200 mM NaCl, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase ULK3 |
Residual Activity |
= |
81.0 |
% |
Millipore: Percentage of residual kinase activity of ULK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase mTOR |
Residual Activity |
= |
128.0 |
% |
Millipore: Percentage of residual kinase activity of MTOR at 1uM relative to control. Control inhibitor: Rapamycin at 10.0uM. Buffer: 50 mM HEPES pH 7.5, 1 mM EGTA, 0.01% Tween 20, 10 uM FKBP12 |
CHEMBL2218924 |
| Platelet-derived growth factor receptor alpha |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of PDGFRA at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C epsilon |
Residual Activity |
= |
115.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCE at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| Protein kinase C epsilon |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCE at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| Phosphorylase kinase gamma subunit 2 |
Residual Activity |
= |
122.0 |
% |
Millipore: Percentage of residual kinase activity of PHKG2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Phosphorylase kinase gamma subunit 2 |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of PHKG2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Macrophage-stimulating protein receptor |
Residual Activity |
= |
76.0 |
% |
Millipore: Percentage of residual kinase activity of MST1R at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Sgk2 |
Residual Activity |
= |
107.0 |
% |
Millipore: Percentage of residual kinase activity of SGK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase TBK1 |
Residual Activity |
= |
69.0 |
% |
Millipore: Percentage of residual kinase activity of TBK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase ULK3 |
Residual Activity |
= |
82.0 |
% |
Millipore: Percentage of residual kinase activity of ULK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase VRK2 |
Residual Activity |
= |
79.0 |
% |
Millipore: Percentage of residual kinase activity of VRK2 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase mTOR |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of MTOR at 10uM relative to control. Control inhibitor: Rapamycin at 10.0uM. Buffer: 50 mM HEPES pH 7.5, 1 mM EGTA, 0.01% Tween 20, 10 uM FKBP12 |
CHEMBL2218924 |
| Ribosomal protein S6 kinase 1 |
Residual Activity |
= |
74.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KB1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Platelet-derived growth factor receptor beta |
Residual Activity |
= |
93.0 |
% |
Millipore: Percentage of residual kinase activity of PDGFRB at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Platelet-derived growth factor receptor beta |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of PDGFRB at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C zeta |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCZ at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PIM1 |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of PIM1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Macrophage-stimulating protein receptor |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of MST1R at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Proto-oncogene tyrosine-protein kinase ROS |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of ROS1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Serine/threonine-protein kinase Sgk2 |
Residual Activity |
= |
80.0 |
% |
Millipore: Percentage of residual kinase activity of SGK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Sgk3 |
Residual Activity |
= |
114.0 |
% |
Millipore: Percentage of residual kinase activity of SGK3 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase TBK1 |
Residual Activity |
= |
55.0 |
% |
Millipore: Percentage of residual kinase activity of TBK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase VRK2 |
Residual Activity |
= |
46.0 |
% |
Millipore: Percentage of residual kinase activity of VRK2 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase 1 |
Residual Activity |
= |
49.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KB1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| 3-phosphoinositide dependent protein kinase-1 |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of PDPK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Protein kinase C zeta |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCZ at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C eta |
Residual Activity |
= |
83.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCH at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| Serine/threonine-protein kinase PIM1 |
Residual Activity |
= |
69.0 |
% |
Millipore: Percentage of residual kinase activity of PIM1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PIM2 |
Residual Activity |
= |
134.0 |
% |
Millipore: Percentage of residual kinase activity of PIM2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Proto-oncogene tyrosine-protein kinase ROS |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of ROS1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Serine/threonine-protein kinase Sgk3 |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of SGK3 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| TGF-beta receptor type I |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of TGFBR1 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM MnCl2 |
CHEMBL2218924 |
| TGF-beta receptor type I |
Residual Activity |
= |
74.0 |
% |
Millipore: Percentage of residual kinase activity of TGFBR1 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM MnCl2 |
CHEMBL2218924 |
| Serine/threonine-protein kinase WNK2 |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of WNK2 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase WNK2 |
Residual Activity |
= |
86.0 |
% |
Millipore: Percentage of residual kinase activity of WNK2 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| AMP-activated protein kinase, alpha-2 subunit |
Thermal melting change |
= |
0.6 |
degrees C |
Delta TM value showing the stabilisation of AMPKA2 produced by compound binding |
CHEMBL1145498 |
| CaM kinase I delta |
Thermal melting change |
= |
0.3 |
degrees C |
Delta TM value showing the stabilisation of CAMK1D produced by compound binding |
CHEMBL1145498 |
| CaM kinase I gamma |
Thermal melting change |
= |
0.6 |
degrees C |
Delta TM value showing the stabilisation of CAMK1G produced by compound binding |
CHEMBL1145498 |
| CaM kinase II alpha |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of CAMK2A produced by compound binding |
CHEMBL1145498 |
| CaM kinase II beta |
Thermal melting change |
= |
0.3 |
degrees C |
Delta TM value showing the stabilisation of CAMK2B produced by compound binding |
CHEMBL1145498 |
| CaM kinase II delta |
Thermal melting change |
= |
-0.3 |
degrees C |
Delta TM value showing the stabilisation of CAMK2D produced by compound binding |
CHEMBL1145498 |
| CaM kinase II gamma |
Thermal melting change |
= |
0.3 |
degrees C |
Delta TM value showing the stabilisation of CAMK2G produced by compound binding |
CHEMBL1145498 |
| CaM kinase IV |
Thermal melting change |
= |
0.4 |
degrees C |
Delta TM value showing the stabilisation of CAMK4 produced by compound binding |
CHEMBL1145498 |
| CaM-kinase kinase beta |
Thermal melting change |
= |
1.2 |
degrees C |
Delta TM value showing the stabilisation of CAMKK2 produced by compound binding |
CHEMBL1145498 |
| Cyclin-dependent kinase 2 |
Thermal melting change |
= |
1.6 |
degrees C |
Delta TM value showing the stabilisation of CDK2 produced by compound binding |
CHEMBL1145498 |
| Cyclin-dependent kinase 6 |
Thermal melting change |
= |
-0.1 |
degrees C |
Delta TM value showing the stabilisation of CDK6 produced by compound binding |
CHEMBL1145498 |
| Cyclin-dependent kinase-like 1 |
Thermal melting change |
= |
0.3 |
degrees C |
Delta TM value showing the stabilisation of CDKL1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase Chk2 |
Thermal melting change |
= |
0.9 |
degrees C |
Delta TM value showing the stabilisation of CHEK2 produced by compound binding |
CHEMBL1145498 |
| Dual specificty protein kinase CLK1 |
Thermal melting change |
= |
2.4 |
degrees C |
Delta TM value showing the stabilisation of CLK1 produced by compound binding |
CHEMBL1145498 |
| Dual specificity protein kinase CLK2 |
Thermal melting change |
= |
2.4 |
degrees C |
Delta TM value showing the stabilisation of CLK2 produced by compound binding |
CHEMBL1145498 |
| Dual specificity protein kinase CLK3 |
Thermal melting change |
= |
0.6 |
degrees C |
Delta TM value showing the stabilisation of CLK3 produced by compound binding |
CHEMBL1145498 |
| Casein kinase I gamma 1 |
Thermal melting change |
= |
1.8 |
degrees C |
Delta TM value showing the stabilisation of CK1G1 produced by compound binding |
CHEMBL1145498 |
| Casein kinase I gamma 2 |
Thermal melting change |
= |
1.6 |
degrees C |
Delta TM value showing the stabilisation of CK1G2 produced by compound binding |
CHEMBL1145498 |
| Casein kinase I isoform gamma-3 |
Thermal melting change |
= |
1.7 |
degrees C |
Delta TM value showing the stabilisation of CK1G3 produced by compound binding |
CHEMBL1145498 |
| Death-associated protein kinase 3 |
Thermal melting change |
= |
0.7 |
degrees C |
Delta TM value showing the stabilisation of DAPK3 produced by compound binding |
CHEMBL1145498 |
| Myotonin-protein kinase |
Thermal melting change |
= |
-0.1 |
degrees C |
Delta TM value showing the stabilisation of DMPK1 produced by compound binding |
CHEMBL1145498 |
| Glycogen synthase kinase-3 beta |
Thermal melting change |
= |
0.8 |
degrees C |
Delta TM value showing the stabilisation of GSK3B produced by compound binding |
CHEMBL1145498 |
| Tyrosine-protein kinase JAK1 |
Thermal melting change |
= |
0.2 |
degrees C |
Delta TM value showing the stabilisation of JAK1~B produced by compound binding |
CHEMBL1145498 |
| Dual specificity mitogen-activated protein kinase kinase 2 |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of MEK2 produced by compound binding |
CHEMBL1145498 |
| Dual specificity mitogen-activated protein kinase kinase 6 |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of MAP2K6 produced by compound binding |
CHEMBL1145498 |
| Mitogen-activated protein kinase kinase kinase 5 |
Thermal melting change |
= |
2.0 |
degrees C |
Delta TM value showing the stabilisation of ASK1 produced by compound binding |
CHEMBL1145498 |
| MAP kinase p38 beta |
Thermal melting change |
= |
1.2 |
degrees C |
Delta TM value showing the stabilisation of p38beta produced by compound binding |
CHEMBL1145498 |
| MAP kinase ERK1 |
Thermal melting change |
= |
0.2 |
degrees C |
Delta TM value showing the stabilisation of ERK1 produced by compound binding |
CHEMBL1145498 |
| Mitogen-activated protein kinase 6 |
Thermal melting change |
= |
-0.4 |
degrees C |
Delta TM value showing the stabilisation of ERK3 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase MST4 |
Thermal melting change |
= |
0.8 |
degrees C |
Delta TM value showing the stabilisation of MST4(1) produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase NEK2 |
Thermal melting change |
= |
1.0 |
degrees C |
Delta TM value showing the stabilisation of NEK2 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase NEK6 |
Thermal melting change |
= |
0.3 |
degrees C |
Delta TM value showing the stabilisation of NEK6 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase OSR1 |
Thermal melting change |
= |
0.4 |
degrees C |
Delta TM value showing the stabilisation of OSR1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PAK 4 |
Thermal melting change |
= |
1.7 |
degrees C |
Delta TM value showing the stabilisation of PAK4 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PAK7 |
Thermal melting change |
= |
1.1 |
degrees C |
Delta TM value showing the stabilisation of PAK5 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PAK6 |
Thermal melting change |
= |
1.2 |
degrees C |
Delta TM value showing the stabilisation of PAK6 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PCTAIRE-1 |
Thermal melting change |
= |
-0.3 |
degrees C |
Delta TM value showing the stabilisation of PCTK1 produced by compound binding |
CHEMBL1145498 |
| 3-phosphoinositide dependent protein kinase-1 |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of PDK1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PIM1 |
Thermal melting change |
= |
-1.0 |
degrees C |
Delta TM value showing the stabilisation of PIM1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PIM2 |
Thermal melting change |
= |
0.3 |
degrees C |
Delta TM value showing the stabilisation of PIM2 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PIM3 |
Thermal melting change |
= |
0.2 |
degrees C |
Delta TM value showing the stabilisation of PIM3 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PLK1 |
Thermal melting change |
= |
0.9 |
degrees C |
Delta TM value showing the stabilisation of PLK1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PLK4 |
Thermal melting change |
= |
0.5 |
degrees C |
Delta TM value showing the stabilisation of PLK4 produced by compound binding |
CHEMBL1145498 |
| cAMP-dependent protein kinase alpha-catalytic subunit |
Thermal melting change |
= |
0.5 |
degrees C |
Delta TM value showing the stabilisation of PRKACA produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase RIO2 |
Thermal melting change |
= |
0.3 |
degrees C |
Delta TM value showing the stabilisation of RIOK2 produced by compound binding |
CHEMBL1145498 |
| Ribosomal protein S6 kinase alpha 3 |
Thermal melting change |
= |
1.3 |
degrees C |
Delta TM value showing the stabilisation of RSK2a produced by compound binding |
CHEMBL1145498 |
| Ribosomal protein S6 kinase alpha 3 |
Thermal melting change |
= |
1.7 |
degrees C |
Delta TM value showing the stabilisation of RSK2b produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase 2 |
Thermal melting change |
= |
0.3 |
degrees C |
Delta TM value showing the stabilisation of SLK produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase 10 |
Thermal melting change |
= |
0.7 |
degrees C |
Delta TM value showing the stabilisation of LOK produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase 16 |
Thermal melting change |
= |
2.3 |
degrees C |
Delta TM value showing the stabilisation of MPSK1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase 17A |
Thermal melting change |
= |
-0.2 |
degrees C |
Delta TM value showing the stabilisation of DRAK1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase 38 |
Thermal melting change |
= |
0.4 |
degrees C |
Delta TM value showing the stabilisation of NDR1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase MST4 |
Thermal melting change |
= |
1.0 |
degrees C |
Delta TM value showing the stabilisation of MST4 (2) produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase MST1 |
Thermal melting change |
= |
0.4 |
degrees C |
Delta TM value showing the stabilisation of MST1 produced by compound binding |
CHEMBL1145498 |
| TRAF2- and NCK-interacting kinase |
Thermal melting change |
= |
0.5 |
degrees C |
Delta TM value showing the stabilisation of TNIK produced by compound binding |
CHEMBL1145498 |
| PDZ-binding kinase |
Thermal melting change |
= |
0.7 |
degrees C |
Delta TM value showing the stabilisation of PBK produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase VRK1 |
Thermal melting change |
= |
0.7 |
degrees C |
Delta TM value showing the stabilisation of VRK1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase VRK2 |
Thermal melting change |
= |
1.4 |
degrees C |
Delta TM value showing the stabilisation of VRK2 produced by compound binding |
CHEMBL1145498 |
| Inactive serine/threonine-protein kinase VRK3 |
Thermal melting change |
= |
0.4 |
degrees C |
Delta TM value showing the stabilisation of VRK3 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase 25 |
Thermal melting change |
= |
1.5 |
degrees C |
Delta TM value showing the stabilisation of YSK1 produced by compound binding |
CHEMBL1145498 |
| Cyclin-dependent kinase 1/cyclin B1 |
IC50 |
= |
3700.0 |
nM |
Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay |
CHEMBL4308846 |
| Cyclin-dependent kinase 2/cyclin E1 |
IC50 |
= |
176.0 |
nM |
Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay |
CHEMBL4308846 |
| CDK2/Cyclin A2 |
IC50 |
= |
220.0 |
nM |
Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay |
CHEMBL4308846 |
| Cyclin-dependent kinase 4/cyclin D1 |
IC50 |
> |
20000.0 |
nM |
Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay |
CHEMBL4308846 |
| Cyclin-dependent kinase 5/CDK5 activator 1 |
IC50 |
= |
419.0 |
nM |
Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay |
CHEMBL4308846 |
| CDK7/Cyclin H/MNAT1 |
IC50 |
= |
9200.0 |
nM |
Inhibition of GST-tagged CDK7/cyclinH/MAT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay |
CHEMBL4308846 |
| CDK9/cyclin T1 |
IC50 |
= |
2300.0 |
nM |
Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay |
CHEMBL4308846 |
| HCT-116 |
Activity |
<= |
30.0 |
% |
Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G2/M phase after 24 hrs by propidium iodide-staining based flow cytometry |
CHEMBL4308846 |
| Replicase polyprotein 1ab |
Inhibition |
= |
8.96 |
% |
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate |
CHEMBL4495564 |
| SARS-CoV-2 |
Inhibition |
= |
13.26 |
% |
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging |
CHEMBL4495565 |
| SARS-CoV-2 |
IC50 |
= |
7950.0 |
nM |
Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of VERO-E6 cells after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging |
CHEMBL4495565 |
| Vero C1008 |
CC50 |
= |
6490.0 |
nM |
Toxicity CC50 against VERO-E6 cells determined at 48 hours by high content imaging (same conditions as 2_LEY without exposure to 0.01 MOI SARS CoV-2 virus) |
CHEMBL4495565 |
| ADMET |
Selectivity index |
= |
0.82 |
|
Cytotoxicity index (CI): selectivity for inhibition of SARS-CoV-2 induced cytotoxicity of VERO-E6 cells versus toxicity against VERO-E6 cells (CC50/IC50) |
CHEMBL4495565 |
| SARS-CoV-2 |
Inhibition |
= |
13.26 |
% |
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging |
CHEMBL4495565 |
| ADMET |
Selectivity index |
= |
0.82 |
|
Cytotoxicity index (CI): selectivity for inhibition of SARS-CoV-2 induced cytotoxicity of VERO-E6 cells versus toxicity against VERO-E6 cells (CC50/IC50) |
CHEMBL4495565 |
| SARS-CoV-2 |
IC50 |
= |
7950.0 |
nM |
Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of VERO-E6 cells after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging |
CHEMBL4495565 |
| Vero C1008 |
CC50 |
= |
6490.0 |
nM |
Toxicity CC50 against VERO-E6 cells determined at 48 hours by high content imaging (same conditions as 2_LEY without exposure to 0.01 MOI SARS CoV-2 virus) |
CHEMBL4495565 |
