| K562 |
Effect |
= |
35.0 |
% |
Compound effect on differentiation of K562 cells, % of benzidine positive cells at 14 uM |
CHEMBL1135710 |
| K562 |
Effect |
= |
2.5 |
% |
Compound effect on differentiation of K562 cells, % of benzidine positive cells at 1.0 uM |
CHEMBL1135710 |
| K562 |
IC50 |
= |
3700.0 |
nM |
Tested for inhibition of growth in human erythroleukemia K-562 cells. |
CHEMBL1130411 |
| K562 |
Control |
= |
80.0 |
% |
Inhibition of growth in human erythroleukemia K-562 cells (% of untreated control) |
CHEMBL1130411 |
| K562 |
Benzidine positive cells |
= |
50.0 |
% |
Differentiation of K-562 cells at 7.5 uM with out coadministration of guanosine |
CHEMBL1130411 |
| K562 |
Benzidine positive cells |
= |
15.0 |
% |
Differentiation of K-562 cells at 7.5 uM with coadministration of guanosine |
CHEMBL1130411 |
| K562 |
Benzidine positive cells |
= |
70.0 |
% |
Differentiation of K-562 cells at 15 uM with out coadministration of guanosine |
CHEMBL1130411 |
| K562 |
Benzidine positive cells |
= |
30.0 |
% |
Differentiation of K-562 cells at 15 uM with coadministration of guanosine |
CHEMBL1130411 |
| Unchecked |
Ki |
= |
300.0 |
nM |
Inhibition of partially purified preparation of Inosine-5'-monophosphate dehydrogenase from P388 leukemic cells with enzymatically synthesized dinucleotide |
CHEMBL1122493 |
| Unchecked |
Ki |
= |
120.0 |
nM |
Inhibition of partially purified preparation of Inosine-5'-monophosphate dehydrogenase from P388 leukemic cells with chemically synthesized dinucleotide |
CHEMBL1122493 |
| P388 |
IC50 |
= |
2100.0 |
nM |
Cytotoxicity against P388 cells with enzymatically synthesized dinucleotide |
CHEMBL1122493 |
| P388 |
IC50 |
= |
3100.0 |
nM |
Cytotoxicity against P388 cells with chemically synthesized dinucleotide |
CHEMBL1122493 |
| Mus musculus |
Survival days |
= |
12.6 |
|
In vivo antitumor activity against mice bearing P388 cells |
CHEMBL1122493 |
| Unchecked |
T/C |
= |
135.0 |
% |
Tested for in vivo antitumor activity in mice expressed as percentage of treated/control |
CHEMBL1122493 |
| P388 |
ID50 |
= |
2.1 |
uM |
The cytotoxic concentration against P388 leukemia cell |
CHEMBL1123434 |
| Inosine-5'-monophosphate dehydrogenase 2 |
Ki |
= |
240.0 |
nM |
Compound was tested for inhibitory activity against Inosine-5'-monophosphate dehydrogenase, the type of inhibition in not competitive |
CHEMBL1123434 |
| Unchecked |
TAD |
= |
100.0 |
% |
Compound was tested for its degradation by TAD-phosphodiesterase |
CHEMBL1123434 |
| Unchecked |
TAD |
= |
100.0 |
% |
Compound was tested for its degradation by venom phosphodiesterase |
CHEMBL1123434 |
| Unchecked |
Activity |
|
|
|
Compound tested for the inhibition of IMP-dehydrogenase causing a profound depletion of GMP anf accumulation of IMP; Active |
CHEMBL1123746 |
| Glutamate dehydrogenase |
Ki |
= |
4500.0 |
nM |
In vitro inhibitory activity against bovine liver glutamate dehydrogenase (GDH) |
CHEMBL1124735 |
| Alcohol dehydrogenase |
Ki |
= |
26500.0 |
nM |
In vitro inhibitory activity against horse liver Alcohol dehydrogenase (ADH) |
CHEMBL1124735 |
| L-lactate dehydrogenase B chain |
Ki |
= |
25200.0 |
nM |
In vitro inhibitory activity against pig heart lactate dehydrogenase (LDH) |
CHEMBL1124735 |
| Malate dehydrogenase cytoplasmic |
Ki |
= |
36300.0 |
nM |
In vitro inhibitory activity against pig heart cytoplasmic malate dehydrogenase (MDH) |
CHEMBL1124735 |
| Alcohol dehydrogenase |
Kd |
= |
27000.0 |
nM |
Dissociation constant from Alcohol dehydrogenase |
CHEMBL1124735 |
| P388 |
ID50 |
= |
7.5 |
uM |
Cytotoxicity against P388 cells in culture |
CHEMBL1122938 |
| Unchecked |
Ki |
= |
130.0 |
nM |
Uncompetitive Inhibitory activity against Inosine-5'-monophosphate dehydrogenase using IMP as viable substrate |
CHEMBL1122938 |
| Unchecked |
Ki |
= |
240.0 |
nM |
Noncompetitive inhibitory activity against Inosine-5'-monophosphate dehydrogenase using NAD as viable substrate |
CHEMBL1122938 |
| Inosine-5'-monophosphate dehydrogenase 2 |
Kii |
= |
0.19 |
uM |
Inhibitory binding constant was determined against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II) from intercept of Michaelis-Menten plot |
CHEMBL1128279 |
| Inosine-5'-monophosphate dehydrogenase 2 |
Kis |
= |
0.3 |
uM |
Inhibitory binding constant was determined against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II) from slope of Michaelis-Menten plot |
CHEMBL1128279 |
| Inosine-5'-monophosphate dehydrogenase 1 |
Ki |
= |
710.0 |
nM |
The compound was tested for the inhibition towards IMP(Inosine 5'-monophosphate) substrate of Inosine-5'-monophosphate dehydrogenase 1 |
CHEMBL1131220 |
| Inosine-5'-monophosphate dehydrogenase 1 |
Ki |
= |
470.0 |
nM |
The compound was tested for the inhibition towards NMD (Nicotinamide adenine dinucleotide) substrate of Inosine-5'-monophosphate dehydrogenase 1 |
CHEMBL1131220 |
| Inosine-5'-monophosphate dehydrogenase 2 |
Ki |
= |
430.0 |
nM |
The compound was tested for the inhibition towards IMP(Inosine 5'-monophosphate) substrate of Inosine-5'-monophosphate dehydrogenase 2 |
CHEMBL1131220 |
| Inosine-5'-monophosphate dehydrogenase 2 |
Ki |
= |
440.0 |
nM |
The compound was tested for the inhibition towards NMD (Nicotinamide adenine dinucleotide) substrate of Inosine-5'-monophosphate dehydrogenase 2 |
CHEMBL1131220 |
| Unchecked |
Ki |
= |
120.0 |
nM |
Inhibition of inosine monophosphate dehydrogenase (IMPDH) enzyme by Non-competitive inhibition |
CHEMBL1126721 |
| Inosine-5'-monophosphate dehydrogenase 2 |
IC50 |
= |
90.0 |
nM |
The compound was assayed to determine the inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 |
CHEMBL1130108 |
| K562 |
IC50 |
= |
3700.0 |
nM |
Antiproliferative activity against K562 erythroid leukemic cells was determined. |
CHEMBL1130108 |
| K562 |
Concentration |
= |
15.0 |
uM |
The concentration used to induce differentiation in K562 cells |
CHEMBL1130108 |
| K562 |
Positive cells |
= |
70.0 |
% |
The ability to induce differentiation in K562 cells was estimated by determining the fraction of benzidine positive cells converted following incubation with the compound. |
CHEMBL1130108 |
| Unchecked |
Concentration |
= |
7.7 |
% |
Percentage of benzidine positive cells is divided by the concentration used. |
CHEMBL1130108 |
| Inosine-5'-monophosphate dehydrogenase (IMPDH) |
Km |
= |
110.0 |
nM |
Inhibition of human IMPDH |
CHEMBL1145329 |
| Inosine-5'-monophosphate dehydrogenase 1 |
Ki |
= |
110.0 |
nM |
Inhibition of human IMPDH1 by Spectrophotometry |
CHEMBL1681750 |
| Inosine-5'-monophosphate dehydrogenase 2 |
Ki |
= |
110.0 |
nM |
Inhibition of human IMPDH2 by Spectrophotometer |
CHEMBL1681750 |
| K562 |
IC50 |
= |
3700.0 |
nM |
Antiproliferative activity against human K562 cells assessed as release of tiazofurin after 72 hrs |
CHEMBL1681750 |
