| Phosphatidylinositol 4-kinase, PI4K |
IC50 |
= |
28200.0 |
nM |
Inhibitory activity (IC50) against human phosphatidylinositol 4-kinase at the ATP binding site |
CHEMBL1124860 |
| Phosphatidylinositol 4-kinase, PI4K |
Ki |
= |
21200.0 |
nM |
Binding affinity (Ki) against human phosphatidylinositol 4-kinase |
CHEMBL1124860 |
| ADMET |
Vmax |
= |
25800.0 |
c.p.m. |
Vmax value was determined |
CHEMBL1124860 |
| Phosphatidylinositol 4-kinase, PI4K |
Km |
= |
261800.0 |
nM |
Inhibition of Phosphatidylinositol 4-kinase at the ATP binding site |
CHEMBL1124860 |
| Adenosine A1 receptor |
Ki |
= |
28000.0 |
nM |
Binding affinity against adenosine A1 receptor in rat cortex by using [3H]- PIA as a radioligand |
CHEMBL1125213 |
| Adenosine A2 receptor |
Ki |
= |
23000.0 |
nM |
Binding affinity against adenosine A2 receptor in rat striatum by using [3H]NECA as a radioligand |
CHEMBL1125213 |
| Adenosine A2 receptor |
Ki |
= |
2400.0 |
nM |
Tested for inhibition of rat PC12 adenylate cyclase stimulation by using NECA as a radioligand |
CHEMBL1125213 |
| ADMET |
k' |
= |
0.21 |
|
Hydrophobicity index |
CHEMBL1125213 |
| Adenosine receptors; A1 & A2 |
Selectivity ratio |
= |
0.82 |
|
It is the ratio of Ki value of A1 receptor to that of A2 receptor. |
CHEMBL1125213 |
| Unchecked |
IC50 |
= |
148000.0 |
nM |
Inhibition of adenylate cyclase |
CHEMBL1155111 |
| Unchecked |
Inhibition |
|
|
% |
Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay |
CHEMBL1255231 |
| NON-PROTEIN TARGET |
Potency |
= |
4466.8 |
nM |
PUBCHEM_BIOASSAY: qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2. (Class of assay: confirmatory) [Related PubChem assays: 1815 (Assay for Plasmodium falciparum line 7G8), 1877 (Assay for Plasmodium falciparum line D10), 1816 (Assay for Plasmodium falciparum line GB4), 1876 (Assay for Plasmodium falciparum line 7D3), 1828 (Summary assay)] |
CHEMBL1201862 |
| Cruzipain |
Potency |
= |
3981.1 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] |
CHEMBL1201862 |
| Aldehyde dehydrogenase 1A1 |
Potency |
= |
17782.8 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] |
CHEMBL1201862 |
| Menin/Histone-lysine N-methyltransferase MLL |
Potency |
= |
10000.0 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) |
CHEMBL1201862 |
| DNA-(apurinic or apyrimidinic site) lyase |
Potency |
= |
39810.7 |
nM |
PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) [Related pubchem assays: 1707, 1708 ] |
CHEMBL1201862 |
| Bloom syndrome protein |
Potency |
= |
398.1 |
nM |
PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 594 (Rhodamine region spectral profiling screen)] |
CHEMBL1201862 |
| Neuropeptide S receptor |
Potency |
= |
0.8 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Bloom syndrome protein |
Potency |
= |
398.1 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] |
CHEMBL1201862 |
| Thioredoxin reductase 1, cytoplasmic |
Potency |
|
4744.4 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771, AID488772] |
CHEMBL1201862 |
| Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 |
Potency |
|
1778.3 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] |
CHEMBL1201862 |
| 6-phospho-1-fructokinase |
Potency |
|
1069.1 |
nM |
PUBCHEM_BIOASSAY: qHTS Validation Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] |
CHEMBL1201862 |
| Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 |
Potency |
|
22387.2 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] |
CHEMBL1201862 |
| Chromobox protein homolog 1 |
Potency |
|
6.0 |
nM |
PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] |
CHEMBL1201862 |
| Unchecked |
Potency |
|
18356.4 |
nM |
PUBCHEM_BIOASSAY: qHTS Validation Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493014] |
CHEMBL1201862 |
| Importin subunit beta-1/Snurportin-1 |
Potency |
|
125892.5 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] |
CHEMBL1201862 |
| Thioredoxin reductase 1, cytoplasmic |
Potency |
|
4744.4 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] |
CHEMBL1201862 |
| Chromobox protein homolog 1 |
Potency |
|
63095.7 |
nM |
PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] |
CHEMBL1201862 |
| Thioredoxin reductase 1, cytoplasmic |
Potency |
|
2377.8 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] |
CHEMBL1201862 |
| Regulator of G-protein signaling 4 |
Potency |
|
37685.8 |
nM |
PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] |
CHEMBL1201862 |
| Unchecked |
Potency |
|
15848.9 |
nM |
PUBCHEM_BIOASSAY: qHTS for inhibitors of binding or entry into cells for Marburg Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249, AID540278] |
CHEMBL1201862 |
| Unchecked |
Potency |
|
5171.4 |
nM |
PUBCHEM_BIOASSAY: qHTS for inhibitors of binding or entry into cells for Marburg Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249, AID540278] |
CHEMBL1201862 |
| Unchecked |
Potency |
|
5171.4 |
nM |
PUBCHEM_BIOASSAY: qHTS for inhibitors of binding or entry into cells for Marburg Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249, AID540278] |
CHEMBL1201862 |
| Unchecked |
Potency |
|
5171.4 |
nM |
PUBCHEM_BIOASSAY: qHTS for inhibitors of binding or entry into cells for Marburg Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249, AID540278] |
CHEMBL1201862 |
| Unchecked |
Potency |
|
5171.4 |
nM |
PUBCHEM_BIOASSAY: qHTS for inhibitors of binding or entry into cells for Marburg Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249, AID540278] |
CHEMBL1201862 |
| Unchecked |
Potency |
|
5171.4 |
nM |
PUBCHEM_BIOASSAY: qHTS for inhibitors of binding or entry into cells for Marburg Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249, AID540278] |
CHEMBL1201862 |
| Unchecked |
Potency |
|
5171.4 |
nM |
PUBCHEM_BIOASSAY: qHTS for inhibitors of binding or entry into cells for Marburg Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249, AID540278] |
CHEMBL1201862 |
| HEK293 |
Potency |
|
23099.9 |
nM |
PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] |
CHEMBL1201862 |
| Unchecked |
Potency |
|
5171.4 |
nM |
PUBCHEM_BIOASSAY: qHTS for inhibitors of binding or entry into cells for Marburg Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249, AID540278] |
CHEMBL1201862 |
| TAR DNA-binding protein 43 |
Potency |
|
35481.3 |
nM |
PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Cerebroside-sulfatase |
Potency |
|
2685.5 |
nM |
PubChem BioAssay. qHTS screen for enhancers of Arylsulfatase A (ASA1): LOPAC Validation Assay. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SARS-CoV-2 |
Inhibition |
= |
40.52 |
% |
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging |
CHEMBL4303101 |
| Replicase polyprotein 1ab |
Inhibition |
= |
11.63 |
% |
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate |
CHEMBL4495564 |
| SARS-CoV-2 |
Inhibition |
= |
0.12 |
% |
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging |
CHEMBL4495565 |
| SARS-CoV-2 |
Inhibition |
= |
0.12 |
% |
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging |
CHEMBL4495565 |
| Unchecked |
IC50 |
|
|
|
Inhibition of Bordetella pertussis ACT exposed to mouse J774.A1 cells assessed as inhibition of ACT-induced cAMP accumulation cells pretreated for 5 hrs measured after 30 mins followed by enzyme addition by immunoassay |
CHEMBL4823269 |
| J774.A1 |
Activity |
|
|
|
Cytotoxicity against mouse J774.A1 cells assessed as reduction in cell viability at 10 uM measured after 5 hrs by Cell TiterGlo Luminescent assay relative to control |
CHEMBL4823269 |
| Brain adenylate cyclase 1 |
Activity |
= |
46.0 |
% |
Inhibition of human AC1 expressed in HEK293 cells assessed as remaining activity by measuring cAMP level at 30 uM relative to control |
CHEMBL4823269 |
| Adenylate cyclase type II |
Activity |
= |
27.0 |
% |
Inhibition of human AC2 expressed in HEK293 cells assessed as remaining activity by measuring cAMP level at 30 uM relative to control |
CHEMBL4823269 |
| Adenylate cyclase type III |
Activity |
= |
45.0 |
% |
Inhibition of human AC3 expressed in HEK293 cells assessed as remaining activity by measuring cAMP level at 30 uM relative to control |
CHEMBL4823269 |
