| Cyclin-dependent kinase 1 |
IC50 |
= |
4600.0 |
nM |
Inhibition of Cyclin-dependent kinase 1 |
CHEMBL1133758 |
| Cyclin-dependent kinase 2 |
IC50 |
= |
1200.0 |
nM |
Inhibition of Cyclin-dependent kinase 2 |
CHEMBL1133758 |
| Cyclin-dependent kinase 1/cyclin B1 |
IC50 |
= |
7000.0 |
nM |
Inhibition of Cyclin-dependent kinase 1-cyclin B1 |
CHEMBL1133502 |
| Cyclin-dependent kinase 2/cyclin E |
IC50 |
= |
7000.0 |
nM |
Inhibition of Cyclin-dependent kinase 2-cyclin E |
CHEMBL1133502 |
| Cyclin-dependent kinase 4/cyclin D1 |
IC50 |
= |
1000000.0 |
nM |
Inhibition of Cyclin-dependent kinase 4-cyclin D1 |
CHEMBL1133502 |
| Unchecked |
IC50 |
= |
30000.0 |
nM |
Inhibition of Mitogen-activated protein kinase |
CHEMBL1133502 |
| Unchecked |
IC50 |
= |
2000000.0 |
nM |
Inhibition of PKA kinase |
CHEMBL1133502 |
| Protein kinase C (PKC) |
IC50 |
= |
1000000.0 |
nM |
Inhibition of rat brain PKC kinase |
CHEMBL1133502 |
| Epidermal growth factor receptor erbB1 |
IC50 |
= |
440000.0 |
nM |
Inhibition of Epidermal growth factor receptor |
CHEMBL1133502 |
| Cyclin-dependent kinase 1 |
IC50 |
= |
6000.0 |
nM |
Inhibitory activity against purified cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis. |
CHEMBL1130316 |
| Cyclin-dependent kinase 1/cyclin B1 |
IC50 |
= |
7000.0 |
nM |
Inhibition of Cyclin-dependent kinase 1-cyclin B1 from starfish. |
CHEMBL1130775 |
| Cyclin-dependent kinase 1 |
IC50 |
= |
7000.0 |
nM |
Inhibition of Cyclin-dependent kinase 1 (CDK1) |
CHEMBL1133090 |
| Cyclin-dependent kinase 5 |
IC50 |
= |
3000.0 |
nM |
Inhibitory activity against Cyclin-dependent kinase 5 |
CHEMBL1133090 |
| Cyclin-dependent kinase 2/cyclin E |
IC50 |
= |
7000.0 |
nM |
Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E |
CHEMBL1129208 |
| Cyclin-dependent kinase 4 |
IC50 |
> |
200000.0 |
nM |
Inhibition of Cyclin-dependent kinase 4 (CDK4/cyclin Dl) |
CHEMBL1133408 |
| Cyclin-dependent kinase 2 |
IC50 |
= |
7000.0 |
nM |
Inhibition of Cyclin-dependent kinase 2 (CDK2/cyclin A) |
CHEMBL1133408 |
| A549 |
IC50 |
= |
57.0 |
ug.mL-1 |
Inhibition of A549 cancer cell proliferation |
CHEMBL1133408 |
| COLO1 |
IC50 |
= |
87.0 |
ug.mL-1 |
Inhibition of Col1 cancer cell proliferation |
CHEMBL1133408 |
| HL-60 |
IC50 |
= |
50.0 |
ug.mL-1 |
Inhibition of HL60 cancer cell proliferation |
CHEMBL1133408 |
| HepG2 |
IC50 |
|
|
ug.mL-1 |
Inhibition of HepG2 cancer cell proliferation (Not tested) |
CHEMBL1133408 |
| Cyclin-dependent kinase 1/cyclin B |
IC50 |
= |
7000.0 |
nM |
Inhibition of Cyclin B-cyclin-dependent kinase 1 |
CHEMBL1135432 |
| Cyclin-dependent kinase 2/cyclin A |
IC50 |
= |
7000.0 |
nM |
Inhibition of Cyclin A-cyclin-dependent kinase 2 |
CHEMBL1135432 |
| Cyclin-dependent kinase 2/cyclin E |
IC50 |
= |
7000.0 |
nM |
Inhibition of Cyclin E-cyclin-dependent kinase 2 |
CHEMBL1135432 |
| Cyclin-dependent kinase 4/cyclin D1 |
IC50 |
> |
1000000.0 |
nM |
Inhibition of Cyclin D1-cyclin-dependent kinase 4 |
CHEMBL1135432 |
| MAP kinase ERK1 |
IC50 |
= |
30000.0 |
nM |
Inhibition of Mitogen-activated protein kinase 3 (MAPK-ERK1) |
CHEMBL1135432 |
| MAP kinase ERK2 |
IC50 |
= |
7000.0 |
nM |
Inhibition of Mitogen-activated protein kinase 1 (MAPK-ERK2) |
CHEMBL1135432 |
| cAMP-dependent protein kinase (PKA) |
IC50 |
> |
2000000.0 |
nM |
Inhibition of cAMP-dependent protein kinase |
CHEMBL1135432 |
| Unchecked |
IC50 |
> |
2000000.0 |
nM |
Inhibition of cGMP-dependent protein kinase |
CHEMBL1135432 |
| Cyclin-dependent kinase 1/cyclin B |
IC50 |
= |
7000.0 |
nM |
Inhibition of recombinant Cyclin-dependent kinase 1-cyclin B |
CHEMBL1134966 |
| MCF7 |
IC50 |
= |
132000.0 |
nM |
In vitro cytotoxic effect on MCF-7 cancer cell line |
CHEMBL1134966 |
| K562 |
IC50 |
> |
167000.0 |
nM |
In vitro cytotoxic effect on K562 cancer cell line |
CHEMBL1134966 |
| CCRF-CEM |
IC50 |
= |
62000.0 |
nM |
In vitro cytotoxic effect on CEM cancer cell line |
CHEMBL1134966 |
| HOS |
IC50 |
= |
149000.0 |
nM |
In vitro cytotoxic effect on HOS cancer cell line |
CHEMBL1134966 |
| G-361 |
IC50 |
= |
160000.0 |
nM |
In vitro cytotoxic effect on G361 cancer cell line |
CHEMBL1134966 |
| Cyclin-dependent kinase 2/cyclin E |
IC50 |
= |
10000.0 |
nM |
Inhibition of Cyclin E-cyclin-dependent kinase 2 |
CHEMBL1133270 |
| Cyclin-dependent kinase 1/cyclin B |
IC50 |
= |
7000.0 |
nM |
In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes |
CHEMBL1132992 |
| Cyclin-dependent kinase 1/cyclin B |
IC50 |
= |
7000.0 |
nM |
Inhibitory concentration against Cyclin-dependent kinase 1-cyclin B |
CHEMBL1136198 |
| Cyclin-dependent kinase 1/cyclin B |
IC50 |
= |
163000.0 |
nM |
In vitro antiproliferative activity against myeloid leukemia K562 cell line |
CHEMBL1136198 |
| Cyclin-dependent kinase 1/cyclin B |
ID50 |
= |
7.0 |
uM |
Inhibition of Cyclin-dependent kinase 1-cyclin B |
CHEMBL1133166 |
| Cyclin-dependent kinase 2/cyclin E |
ID50 |
= |
7.0 |
uM |
Inhibition of Cyclin-dependent kinase 2-cyclin E |
CHEMBL1133166 |
| Cyclin-dependent kinase 4/cyclin D |
IA |
|
|
|
Inhibition of Cyclin-dependent kinase 4-cyclin D (Inactive) |
CHEMBL1133166 |
| Cyclin-dependent kinase 5/CDK5 activator 1 |
IC50 |
= |
7000.0 |
nM |
Inhibition of Cyclin-dependent kinase 5-p35nck5a |
CHEMBL1135277 |
| Protein kinase Pfmrk |
IC50 |
> |
1000000.0 |
nM |
Inhibitory activity against Plasmodium falciparum cyclin dependent protein kinase, Pfmrk |
CHEMBL1145071 |
| Plasmodium falciparum |
IC50 |
= |
8000.0 |
nM |
Inhibitory activity against Plasmodium falciparum W2 |
CHEMBL1145071 |
| Plasmodium falciparum |
IC50 |
= |
2700.0 |
nM |
Inhibitory activity against Plasmodium falciparum D6 |
CHEMBL1145071 |
| Protein kinase Pfmrk |
IC50 |
= |
1100000.0 |
nM |
Inhibition of Plasmodium falciparum cyclin-dependent kinase |
CHEMBL1138793 |
| Unchecked |
IC50 |
= |
7000.0 |
nM |
Inhibitory concentration against CDK1/Cyclin B complex from Marthasterias glacialis M-phase oocytes |
CHEMBL1140371 |
| Cyclin-dependent kinase 2/cyclin E |
IC50 |
= |
5000.0 |
nM |
Inhibition of CDK2/Cyclin E in presence of 15 uM ATP |
CHEMBL1137343 |
| MCF7 |
IC50 |
= |
134000.0 |
nM |
Antiproliferative activity against MCF7 cell line |
CHEMBL1137343 |
| HOS |
IC50 |
= |
144000.0 |
nM |
Antiproliferative activity against HOS cell line |
CHEMBL1137343 |
| G-361 |
IC50 |
= |
147000.0 |
nM |
Antiproliferative activity against G361 cell line |
CHEMBL1137343 |
| K562 |
IC50 |
= |
145000.0 |
nM |
Antiproliferative activity against K562 cell line |
CHEMBL1137343 |
| Cyclin-dependent kinase 1/cyclin B1 |
IC50 |
= |
7000.0 |
nM |
Inhibition of CDK1/cyclin B by MESACUP assay |
CHEMBL1141588 |
| Unchecked |
IC50 |
= |
7000.0 |
nM |
Inhibition of Cdk1/cyclin B |
CHEMBL1145498 |
| Unchecked |
IC50 |
= |
7000.0 |
nM |
Inhibition Cdk2/cyclin A |
CHEMBL1145498 |
| Unchecked |
IC50 |
= |
7000.0 |
nM |
Inhibition of p33cdk2/cyclin E |
CHEMBL1145498 |
| Unchecked |
IC50 |
= |
3000.0 |
nM |
Inhibition of Cdk5/p35 |
CHEMBL1145498 |
| Unchecked |
IC50 |
= |
25000.0 |
nM |
Inhibition of MAPK |
CHEMBL1145498 |
| Unchecked |
IC50 |
> |
1000000.0 |
nM |
Inhibition of Cdk4/cyclin D |
CHEMBL1145498 |
| CDK6/cyclin D3 |
IC50 |
> |
250000.0 |
nM |
Inhibition of Cdk6/cyclin D3 |
CHEMBL1145498 |
| Unchecked |
IC50 |
= |
1000000.0 |
nM |
Inhibition of cyclin dependent kinase |
CHEMBL1149915 |
| Unchecked |
Ki |
= |
1800000.0 |
nM |
Inhibition of Escherichia coli D-alanine-D-alanine ligase B after 15 mins by Lineweaver-Burke plot |
CHEMBL1140982 |
| Unchecked |
Inhibition |
= |
79.7 |
% |
Inhibition of ATP binding site of Escherichia coli D-alanine-D-alanine ligase B assessed as residual activity at 2 mM preincubated for 30 mins by ATP competitive malachite green assay |
CHEMBL1140982 |
| Unchecked |
IC50 |
= |
7000.0 |
nM |
Inhibition of CDK2/Cyclin A |
CHEMBL1140982 |
| Cyclin-dependent kinase 2 |
IC50 |
= |
7000.0 |
nM |
Inhibition of CDK2/Cyclin B |
CHEMBL1140982 |
| Cyclin-dependent kinase 2 |
IC50 |
= |
7000.0 |
nM |
Inhibition of CDK2/Cyclin E |
CHEMBL1140982 |
| MAP kinase ERK1 |
IC50 |
= |
25000.0 |
nM |
Inhibition of ERK1/MAPK |
CHEMBL1140982 |
| Simplexvirus |
IC50 |
= |
100000.0 |
nM |
Antiviral activity against Herpes simplex virus |
CHEMBL1136837 |
| Cyclin-dependent kinase 2/cyclin A |
IC50 |
= |
10000.0 |
nM |
Inhibition of recombinant CDK2/cyclin A |
CHEMBL1154643 |
| Cyclin-dependent kinase 2/cyclin E |
IC50 |
= |
10000.0 |
nM |
Inhibition of recombinant CDK2/cyclin E |
CHEMBL1154643 |
| NON-PROTEIN TARGET |
GI50 |
= |
65000.0 |
nM |
Antiproliferative activity against human HeLaS3 cells by sulforhodamine B assay |
CHEMBL1154643 |
| Cyclin-dependent kinase 2/cyclin A |
IC50 |
= |
7000.0 |
nM |
Inhibition of human recombinant CDK2/cyclin A expressed in baculovirus-infected insect Sf21 cells after 10 mins |
CHEMBL1154872 |
| SK-LU-1 |
IC50 |
= |
68100.0 |
nM |
Cytotoxicity against human SK-LU-1 cells after 48 hrs by SRB assay |
CHEMBL1154874 |
| MCF7 |
IC50 |
= |
55900.0 |
nM |
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay |
CHEMBL1154874 |
| HCT-15 |
IC50 |
= |
62500.0 |
nM |
Cytotoxicity against human HCT15 cells after 48 hrs by SRB assay |
CHEMBL1154874 |
| K562 |
IC50 |
= |
89300.0 |
nM |
Cytotoxicity against human K562 cells after 48 hrs by SRB assay |
CHEMBL1154874 |
| PC-3 |
IC50 |
= |
81000.0 |
nM |
Cytotoxicity against human PC3 cells after 48 hrs by SRB assay |
CHEMBL1154874 |
| U-251 |
IC50 |
= |
81500.0 |
nM |
Cytotoxicity against human U251 cells after 48 hrs by SRB assay |
CHEMBL1154874 |
| SK-LU-1 |
GI |
= |
36.9 |
% |
Cytotoxicity against human SK-LU-1 cells assessed as cell growth inhibition at 50 uM after 48 hrs by SRB assay |
CHEMBL1154874 |
| MCF7 |
GI |
= |
37.6 |
% |
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition at 50 uM after 48 hrs by SRB assay |
CHEMBL1154874 |
| HCT-15 |
GI |
= |
28.9 |
% |
Cytotoxicity against human HCT15 cells assessed as cell growth inhibition at 50 uM after 48 hrs by SRB assay |
CHEMBL1154874 |
| K562 |
GI |
= |
19.8 |
% |
Cytotoxicity against human K562 cells assessed as cell growth inhibition at 50 uM after 48 hrs by SRB assay |
CHEMBL1154874 |
| PC-3 |
GI |
= |
22.7 |
% |
Cytotoxicity against human PC3 cells assessed as cell growth inhibition at 50 uM after 48 hrs by SRB assay |
CHEMBL1154874 |
| U-251 |
GI |
= |
32.0 |
% |
Cytotoxicity against human U251 cells assessed as cell growth inhibition at 50 uM after 48 hrs by SRB assay |
CHEMBL1154874 |
| MCF7 |
Activity |
= |
60.6 |
% |
Cell cycle arrest in human MCF7 cells assessed as accumulation at G0/G1 phase at 2 times IC50 concentration after 24 hrs using propidium iodide staining by flow cytometry relative to control |
CHEMBL1154874 |
| MCF7 |
Activity |
= |
15.0 |
% |
Cell cycle arrest in human MCF7 cells assessed as accumulation at S phase at 2 times IC50 concentration after 24 hrs using propidium iodide staining by flow cytometry relative to control |
CHEMBL1154874 |
| MCF7 |
Activity |
= |
23.2 |
% |
Cell cycle arrest in human MCF7 cells assessed as accumulation at G2/M phase at 2 times IC50 concentration after 24 hrs using propidium iodide staining by flow cytometry relative to control |
CHEMBL1154874 |
| SK-LU-1 |
Activity |
= |
44.2 |
% |
Cell cycle arrest in human SK-LU-1 cells assessed as accumulation at G0/G1 phase at 2 times IC50 concentration after 24 hrs using propidium iodide staining by flow cytometry relative to control |
CHEMBL1154874 |
| SK-LU-1 |
Activity |
= |
19.7 |
% |
Cell cycle arrest in human SK-LU-1 cells assessed as accumulation at S phase at 2 times IC50 concentration after 24 hrs using propidium iodide staining by flow cytometry relative to control |
CHEMBL1154874 |
| SK-LU-1 |
Activity |
= |
31.8 |
% |
Cell cycle arrest in human SK-LU-1 cells assessed as accumulation at G2/M phase at 2 times IC50 concentration after 24 hrs using propidium iodide staining by flow cytometry relative to control |
CHEMBL1154874 |
| Cyclin-dependent kinase 1/cyclin B1 |
GI |
= |
50.0 |
% |
Inhibition of CDK1/cyclin B at 7 uM |
CHEMBL1154874 |
| Cyclin-dependent kinase 2/cyclin E1 |
GI |
= |
51.0 |
% |
Inhibition of CDK2/cyclin E at 7 uM |
CHEMBL1154874 |
| SK-LU-1 |
Activity |
= |
44.2 |
% |
Cell cycle arrest in human SK-LU-1 cells assessed as accumulation at G1 phase after 24 hrs by flow cytometry |
CHEMBL1153702 |
| SK-LU-1 |
Activity |
= |
19.7 |
% |
Cell cycle arrest in human SK-LU-1 cells assessed as accumulation at S phase after 24 hrs by flow cytometry |
CHEMBL1153702 |
| SK-LU-1 |
Activity |
= |
31.8 |
% |
Cell cycle arrest in human SK-LU-1 cells assessed as accumulation at G2/M phase after 24 hrs by flow cytometry |
CHEMBL1153702 |
| MCF7 |
Activity |
= |
60.6 |
% |
Cell cycle arrest in human MCF7 cells assessed as accumulation at G1 phase after 24 hrs by flow cytometry |
CHEMBL1153702 |
| MCF7 |
Activity |
= |
15.1 |
% |
Cell cycle arrest in human MCF7 cells assessed as accumulation at S phase after 24 hrs by flow cytometry |
CHEMBL1153702 |
| MCF7 |
Activity |
= |
23.2 |
% |
Cell cycle arrest in human MCF7 cells assessed as accumulation at G2/M phase after 24 hrs by flow cytometry |
CHEMBL1153702 |
| Cyclin-dependent kinase 1/cyclin B1 |
Inhibition |
= |
48.0 |
% |
Inhibition of human CDK1/cyclinB at 7 uM |
CHEMBL1153702 |
| Cyclin-dependent kinase 2/cyclin A |
Inhibition |
= |
43.0 |
% |
Inhibition of human CDK2/cyclinA at 7 uM |
CHEMBL1153702 |
| Cyclin-dependent kinase 1/cyclin B1 |
IC50 |
= |
7000.0 |
nM |
Inhibition of human CDK1/cyclinB |
CHEMBL1153702 |
| Plasmodium falciparum |
IC50 |
= |
3000.0 |
nM |
Antimicrobial activity against Plasmodium falciparum |
CHEMBL1212812 |
| Cyclin-dependent kinase 1/cyclin B1 |
IC50 |
= |
7000.0 |
nM |
Inhibition of human GST-CDK1/cyclin B1 expressed in baculovirus using [gamma-33P]ATP after 45 mins by liquid scintillation counting |
CHEMBL1240477 |
| Cyclin-dependent kinase 5 |
IC50 |
= |
3000.0 |
nM |
Inhibition of CDK5 |
CHEMBL1240533 |
| Cyclin-dependent kinase 4 |
IC50 |
> |
100000.0 |
nM |
Inhibition of CDK4 |
CHEMBL1240533 |
| Cyclin-dependent kinase 2 |
IC50 |
= |
7000.0 |
nM |
Inhibition of CDK2 |
CHEMBL1240533 |
| Cyclin-dependent kinase 1 |
IC50 |
= |
7000.0 |
nM |
Inhibition of CDK1 |
CHEMBL1240533 |
| Unchecked |
Inhibition |
|
|
% |
Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay |
CHEMBL1255231 |
| Plasmodium falciparum |
IC50 |
= |
6309.57 |
nM |
Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay |
CHEMBL1255382 |
| Plasmodium falciparum |
IC50 |
= |
10000.0 |
nM |
Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay |
CHEMBL1255382 |
| Nuclear factor NF-kappa-B p105 subunit |
Potency |
= |
6309.6 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Agonists for NFkB Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 895 ] |
CHEMBL1201862 |
| NON-PROTEIN TARGET |
Potency |
= |
4466.8 |
nM |
PUBCHEM_BIOASSAY: qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 3D7. (Class of assay: confirmatory) [Related PubChem assays: 1815 (Assay for Plasmodium falciparum line 7G8), 1816 (Assay for Plasmodium falciparum line GB4), 1828 (Summary assay)] |
CHEMBL1201862 |
| Lysine-specific demethylase 4D-like |
Potency |
= |
25118.9 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) |
CHEMBL1201862 |
| Survival motor neuron protein |
Potency |
= |
31622.8 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Survival motor neuron protein |
Potency |
= |
891.3 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Survival motor neuron protein |
Potency |
= |
25118.9 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Tyrosyl-DNA phosphodiesterase 1 |
Potency |
= |
89.1 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) |
CHEMBL1201862 |
| NON-PROTEIN TARGET |
Potency |
= |
8912.5 |
nM |
PUBCHEM_BIOASSAY: qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2. (Class of assay: confirmatory) [Related PubChem assays: 1815 (Assay for Plasmodium falciparum line 7G8), 1877 (Assay for Plasmodium falciparum line D10), 1816 (Assay for Plasmodium falciparum line GB4), 1876 (Assay for Plasmodium falciparum line 7D3), 1828 (Summary assay)] |
CHEMBL1201862 |
| Aldehyde dehydrogenase 1A1 |
Potency |
= |
44668.4 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] |
CHEMBL1201862 |
| NON-PROTEIN TARGET |
Potency |
= |
6309.6 |
nM |
PUBCHEM_BIOASSAY: qHTS for differential inhibitors of proliferation of Plasmodium falciparum line GB4. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Lysosomal alpha-glucosidase |
Potency |
= |
14125.4 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] |
CHEMBL1201862 |
| Arachidonate 15-lipoxygenase |
Potency |
= |
15848.9 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) |
CHEMBL1201862 |
| Microtubule-associated protein tau |
Potency |
= |
44668.4 |
nM |
PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] |
CHEMBL1201862 |
| NON-PROTEIN TARGET |
Potency |
= |
794.3 |
nM |
PUBCHEM_BIOASSAY: qHTS for differential inhibitors of proliferation of Plasmodium falciparum line D10. (Class of assay: confirmatory) [Related PubChem assays: 1815 (Assay for Plasmodium falciparum line 7G8), 1816 (Assay for Plasmodium falciparum line GB4), 1828 (Summary assay)] |
CHEMBL1201862 |
| Nuclear factor NF-kappa-B p105 subunit |
Potency |
= |
6309.6 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Anthrax lethal factor |
Potency |
= |
12589.3 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Cytochrome P450 2D6 |
Potency |
= |
1258.9 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] |
CHEMBL1201862 |
| NON-PROTEIN TARGET |
Potency |
= |
2818.4 |
nM |
PUBCHEM_BIOASSAY: qHTS for differential inhibitors of proliferation of Plasmodium falciparum line HB3. (Class of assay: confirmatory) [Related PubChem assays: 1815 (Assay for Plasmodium falciparum line 7G8), 1877 (Assay for Plasmodium falciparum line D10), 1816 (Assay for Plasmodium falciparum line GB4), 1876 (Assay for Plasmodium falciparum line 3D7), 1828 (Summary assay)] |
CHEMBL1201862 |
| Cytochrome P450 3A4 |
Potency |
= |
15848.9 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] |
CHEMBL1201862 |
| Cytochrome P450 2D6 |
Potency |
= |
3162.3 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] |
CHEMBL1201862 |
| Cytochrome P450 3A4 |
Potency |
= |
15848.9 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] |
CHEMBL1201862 |
| Unchecked |
Potency |
= |
2238.7 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Lipid Storage Modulators. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Dopamine D1 receptor |
Potency |
|
3.7 |
nM |
PUBCHEM_BIOASSAY: HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Potentiators. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488989, AID488993, AID488995] |
CHEMBL1201862 |
| Plasmodium falciparum |
Potency |
|
9285.0 |
nM |
PUBCHEM_BIOASSAY: Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774] |
CHEMBL1201862 |
| Plasmodium falciparum |
Potency |
|
8275.3 |
nM |
PUBCHEM_BIOASSAY: Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488774] |
CHEMBL1201862 |
| Cytochrome P450 2D6 |
AC50 |
= |
1258.93 |
nM |
PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active |
CHEMBL1201862 |
| Cytochrome P450 2C9 |
AC50 |
|
|
|
PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active |
CHEMBL1201862 |
| Cytochrome P450 2C19 |
AC50 |
|
|
|
PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active |
CHEMBL1201862 |
| Cytochrome P450 3A4 |
AC50 |
= |
15848.93 |
nM |
PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active |
CHEMBL1201862 |
| Cytochrome P450 1A2 |
AC50 |
= |
5011.87 |
nM |
PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active |
CHEMBL1201862 |
| Unchecked |
Potency |
|
14575.0 |
nM |
PUBCHEM_BIOASSAY: qHTS for inhibitors of binding or entry into cells for Marburg Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249, AID540278] |
CHEMBL1201862 |
| Unchecked |
Potency |
|
14575.0 |
nM |
PUBCHEM_BIOASSAY: qHTS for inhibitors of binding or entry into cells for Marburg Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249, AID540278] |
CHEMBL1201862 |
| Unchecked |
Potency |
|
14575.0 |
nM |
PUBCHEM_BIOASSAY: qHTS for inhibitors of binding or entry into cells for Marburg Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249, AID540278] |
CHEMBL1201862 |
| Unchecked |
Potency |
|
14575.0 |
nM |
PUBCHEM_BIOASSAY: qHTS for inhibitors of binding or entry into cells for Marburg Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249, AID540278] |
CHEMBL1201862 |
| Unchecked |
Potency |
|
14575.0 |
nM |
PUBCHEM_BIOASSAY: qHTS for inhibitors of binding or entry into cells for Marburg Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249, AID540278] |
CHEMBL1201862 |
| Unchecked |
Potency |
|
14575.0 |
nM |
PUBCHEM_BIOASSAY: qHTS for inhibitors of binding or entry into cells for Marburg Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249, AID540278] |
CHEMBL1201862 |
| Unchecked |
Potency |
|
14575.0 |
nM |
PUBCHEM_BIOASSAY: qHTS for inhibitors of binding or entry into cells for Marburg Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249, AID540278] |
CHEMBL1201862 |
| Unchecked |
Potency |
|
14575.0 |
nM |
PUBCHEM_BIOASSAY: qHTS for inhibitors of binding or entry into cells for Marburg Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249, AID540278] |
CHEMBL1201862 |
| Unchecked |
IC50 |
= |
45000.0 |
nM |
Inhibition of CDK4/cyclin D expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by radiometric assay |
CHEMBL1909587 |
| Cyclin-dependent kinase 2/cyclin A |
IC50 |
= |
7000.0 |
nM |
Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by radiometric assay |
CHEMBL1909587 |
| A-431 |
GI50 |
= |
16600.0 |
nM |
Growth inhibition of human A431 cells after 2 days by SRB assay |
CHEMBL1909587 |
| HCT-116 |
GI50 |
= |
16620.0 |
nM |
Growth inhibition of human SNU638 cells after 2 days by SRB assay |
CHEMBL1909587 |
| SNU-638 |
GI50 |
= |
12050.0 |
nM |
Growth inhibition of human HCT116 cells after 2 days by SRB assay |
CHEMBL1909587 |
| SN12C |
GI50 |
|
90157.11 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| MDA-N |
GI50 |
|
79432.82 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NCI-H23 |
GI50 |
|
59566.21 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| UO-31 |
GI50 |
|
31405.09 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| ACHN |
GI50 |
|
35892.19 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| HOP-92 |
GI50 |
|
61235.04 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| HL-60 |
GI50 |
|
36897.76 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SF-539 |
GI50 |
|
42169.65 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| DU-145 |
GI50 |
|
34119.29 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SK-MEL-5 |
GI50 |
|
40550.85 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Malme-3M |
GI50 |
|
98174.79 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| K562 |
GI50 |
|
106905.49 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| A498 |
GI50 |
|
102801.63 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| OVCAR-3 |
GI50 |
|
20749.14 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the OVCAR-3 Ovarian cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| MOLT-4 |
GI50 |
|
70145.53 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MOLT-4 Leukemia cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| HOP-62 |
GI50 |
|
29308.93 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NCI/ADR-RES |
GI50 |
|
93756.2 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI/ADR-RES Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| U-251 |
GI50 |
|
64416.93 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the U251 Central Nervous System cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| OVCAR-5 |
GI50 |
|
52966.34 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the OVCAR-5 Ovarian cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| OVCAR-8 |
GI50 |
|
66221.65 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the OVCAR-8 Ovarian cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| MDA-MB-231 |
GI50 |
|
92682.98 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-231/ATCC Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SNB-19 |
GI50 |
|
48640.72 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SNB-19 Central Nervous System cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| TK-10 |
GI50 |
|
63826.35 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the TK-10 Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SR |
GI50 |
|
29716.66 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SR Leukemia cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SW-620 |
GI50 |
|
43451.02 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SW-620 Colon cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NCI-H522 |
GI50 |
|
51404.37 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H522 Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| KM12 |
GI50 |
|
34994.52 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the KM12 Colon cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| M14 |
GI50 |
|
78886.01 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the M14 Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NCI-H322M |
GI50 |
|
76383.58 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H322M Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| RPMI-8226 |
GI50 |
|
53826.98 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the RPMI-8226 Leukemia cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| OVCAR-4 |
GI50 |
|
94188.96 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the OVCAR-4 Ovarian cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| LOX IMVI |
GI50 |
|
23988.33 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the LOX IMVI Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| BT-549 |
GI50 |
|
53088.44 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Cyclin-dependent kinase 2 |
Ki |
= |
3981.07 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK2 |
CHEMBL1201862 |
| Cyclin-dependent kinase 5 |
Ki |
= |
6309.57 |
nM |
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK5 |
CHEMBL1201862 |
| SK-MEL-2 |
GI50 |
|
98855.31 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-2 Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| A549 |
GI50 |
|
43853.07 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SNB-75 |
GI50 |
|
21281.39 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SNB-75 Central Nervous System cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| HCC 2998 |
GI50 |
|
79067.86 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Colon cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| HCT-15 |
GI50 |
|
41304.75 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Colon cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| HCT-116 |
GI50 |
|
34753.62 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Colon cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SF-268 |
GI50 |
|
48977.88 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-268 Central Nervous System cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| MCF7 |
GI50 |
|
39719.15 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MCF7 Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| EKVX |
GI50 |
|
94406.09 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the EKVX Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| PC-3 |
GI50 |
|
98174.79 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the PC-3 Prostate cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SK-OV-3 |
GI50 |
|
95499.26 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-OV-3 Ovarian cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| T47D |
GI50 |
|
50466.13 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the T-47D Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NCI-H460 |
GI50 |
|
104472.02 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H460 Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| UACC-62 |
GI50 |
|
32583.67 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UACC-62 Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| CAKI-1 |
GI50 |
|
33651.16 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| MDA-MB-435 |
GI50 |
|
78704.58 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-435 Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| IGROV-1 |
GI50 |
|
42266.86 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Ovarian cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SF-295 |
GI50 |
|
41114.97 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-295 Central Nervous System cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Hs-578T |
GI50 |
|
69502.43 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HS 578T Breast cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| UACC-257 |
GI50 |
|
95279.62 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UACC-257 Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| 786-0 |
GI50 |
|
60673.63 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| CCRF-CEM |
GI50 |
|
54575.79 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| NCI-H226 |
GI50 |
|
51286.14 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H226 Non-Small Cell Lung cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| SK-MEL-28 |
GI50 |
|
52844.53 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-28 Melanoma cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| HT-29 |
GI50 |
|
71449.63 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HT29 Colon cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| RXF 393 |
GI50 |
|
66988.46 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the RXF 393 Renal cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| COLO 205 |
GI50 |
|
30130.06 |
nM |
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Colon cell line. (Class of assay: confirmatory) |
CHEMBL1201862 |
| MCF7 |
IC50 |
= |
130000.0 |
nM |
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay |
CHEMBL2057204 |
| B16-F10 |
IC50 |
= |
105000.0 |
nM |
Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay |
CHEMBL2057204 |
| Cyclin-dependent kinase 2/cyclin E1 |
IC50 |
= |
5000.0 |
nM |
Inhibition of CDK2/cyclin E |
CHEMBL2057204 |
| Voltage-gated N-type calcium channel alpha-1B subunit |
EC50 |
> |
1000000.0 |
nM |
Agonist activity at N-type Cav2.2 channel expressed in tsA201 cell assessed as calcium current by whole-cell patch clamp method |
CHEMBL2203054 |
| Tyrosyl-DNA phosphodiesterase 1 |
Potency |
|
50118.7 |
nM |
PubChem BioAssay. qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Tyrosyl-DNA phosphodiesterase 1 |
Potency |
|
29855.4 |
nM |
PubChem BioAssay. qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Tyrosyl-DNA phosphodiesterase 1 |
Potency |
|
18356.4 |
nM |
PubChem BioAssay. qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Tyrosyl-DNA phosphodiesterase 1 |
Potency |
|
26608.6 |
nM |
PubChem BioAssay. qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Tyrosyl-DNA phosphodiesterase 1 |
Potency |
|
29092.9 |
nM |
PubChem BioAssay. qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Tyrosyl-DNA phosphodiesterase 1 |
Potency |
|
39810.7 |
nM |
PubChem BioAssay. qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Cyclin-dependent kinase 2 |
IC50 |
= |
7000.0 |
nM |
Inhibition of human N-terminal hexahistidine-tagged CDK2 expressed in baculovirus infected Sf21 cells using histone H1 as substrate after 10 mins in presence of [gamma-32P]-ATP |
CHEMBL2424530 |
| NON-PROTEIN TARGET |
IC50 |
= |
132000.0 |
nM |
Cytotoxicity against human H460 cells assessed as growth inhibition after 24 to 48 hrs by CCK8 assay |
CHEMBL2424530 |
| MCF7 |
IC50 |
= |
142000.0 |
nM |
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 24 to 48 hrs by CCK8 assay |
CHEMBL2424530 |
| A549 |
IC50 |
= |
130000.0 |
nM |
Cytotoxicity against human A549 cells assessed as growth inhibition after 24 to 48 hrs by CCK8 assay |
CHEMBL2424530 |
| Cerebroside-sulfatase |
Potency |
|
5358.2 |
nM |
PubChem BioAssay. qHTS screen for enhancers of Arylsulfatase A (ASA1): LOPAC Validation Assay. (Class of assay: confirmatory) |
CHEMBL1201862 |
| AMP-activated protein kinase, alpha-2 subunit |
Thermal melting change |
= |
0.2 |
degrees C |
Delta TM value showing the stabilisation of AMPKA2 produced by compound binding |
CHEMBL1145498 |
| CaM kinase I delta |
Thermal melting change |
= |
-0.1 |
degrees C |
Delta TM value showing the stabilisation of CAMK1D produced by compound binding |
CHEMBL1145498 |
| CaM kinase I gamma |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of CAMK1G produced by compound binding |
CHEMBL1145498 |
| CaM kinase II alpha |
Thermal melting change |
= |
-0.3 |
degrees C |
Delta TM value showing the stabilisation of CAMK2A produced by compound binding |
CHEMBL1145498 |
| CaM kinase II beta |
Thermal melting change |
= |
0.2 |
degrees C |
Delta TM value showing the stabilisation of CAMK2B produced by compound binding |
CHEMBL1145498 |
| CaM kinase II delta |
Thermal melting change |
= |
-0.2 |
degrees C |
Delta TM value showing the stabilisation of CAMK2D produced by compound binding |
CHEMBL1145498 |
| CaM kinase II gamma |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of CAMK2G produced by compound binding |
CHEMBL1145498 |
| CaM kinase IV |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of CAMK4 produced by compound binding |
CHEMBL1145498 |
| CaM-kinase kinase beta |
Thermal melting change |
= |
-0.2 |
degrees C |
Delta TM value showing the stabilisation of CAMKK2 produced by compound binding |
CHEMBL1145498 |
| Cyclin-dependent kinase 2 |
Thermal melting change |
= |
0.4 |
degrees C |
Delta TM value showing the stabilisation of CDK2 produced by compound binding |
CHEMBL1145498 |
| Cyclin-dependent kinase 6 |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of CDK6 produced by compound binding |
CHEMBL1145498 |
| Cyclin-dependent kinase-like 1 |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of CDKL1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase Chk2 |
Thermal melting change |
= |
-0.6 |
degrees C |
Delta TM value showing the stabilisation of CHEK2 produced by compound binding |
CHEMBL1145498 |
| Dual specificty protein kinase CLK1 |
Thermal melting change |
= |
-0.2 |
degrees C |
Delta TM value showing the stabilisation of CLK1 produced by compound binding |
CHEMBL1145498 |
| Dual specificity protein kinase CLK2 |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of CLK2 produced by compound binding |
CHEMBL1145498 |
| Dual specificity protein kinase CLK3 |
Thermal melting change |
= |
-0.1 |
degrees C |
Delta TM value showing the stabilisation of CLK3 produced by compound binding |
CHEMBL1145498 |
| Casein kinase I gamma 1 |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of CK1G1 produced by compound binding |
CHEMBL1145498 |
| Casein kinase I gamma 2 |
Thermal melting change |
= |
0.5 |
degrees C |
Delta TM value showing the stabilisation of CK1G2 produced by compound binding |
CHEMBL1145498 |
| Casein kinase I isoform gamma-3 |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of CK1G3 produced by compound binding |
CHEMBL1145498 |
| Death-associated protein kinase 3 |
Thermal melting change |
= |
-0.1 |
degrees C |
Delta TM value showing the stabilisation of DAPK3 produced by compound binding |
CHEMBL1145498 |
| Myotonin-protein kinase |
Thermal melting change |
= |
-0.1 |
degrees C |
Delta TM value showing the stabilisation of DMPK1 produced by compound binding |
CHEMBL1145498 |
| Glycogen synthase kinase-3 beta |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of GSK3B produced by compound binding |
CHEMBL1145498 |
| Tyrosine-protein kinase JAK1 |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of JAK1~B produced by compound binding |
CHEMBL1145498 |
| Dual specificity mitogen-activated protein kinase kinase 2 |
Thermal melting change |
= |
-0.4 |
degrees C |
Delta TM value showing the stabilisation of MEK2 produced by compound binding |
CHEMBL1145498 |
| Dual specificity mitogen-activated protein kinase kinase 6 |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of MAP2K6 produced by compound binding |
CHEMBL1145498 |
| Mitogen-activated protein kinase kinase kinase 5 |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of ASK1 produced by compound binding |
CHEMBL1145498 |
| MAP kinase p38 beta |
Thermal melting change |
= |
-0.1 |
degrees C |
Delta TM value showing the stabilisation of p38beta produced by compound binding |
CHEMBL1145498 |
| MAP kinase ERK1 |
Thermal melting change |
= |
0.2 |
degrees C |
Delta TM value showing the stabilisation of ERK1 produced by compound binding |
CHEMBL1145498 |
| Mitogen-activated protein kinase 6 |
Thermal melting change |
= |
0.2 |
degrees C |
Delta TM value showing the stabilisation of ERK3 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase MST4 |
Thermal melting change |
= |
0.2 |
degrees C |
Delta TM value showing the stabilisation of MST4(1) produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase NEK2 |
Thermal melting change |
= |
1.1 |
degrees C |
Delta TM value showing the stabilisation of NEK2 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase NEK6 |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of NEK6 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase OSR1 |
Thermal melting change |
= |
0.2 |
degrees C |
Delta TM value showing the stabilisation of OSR1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PAK 4 |
Thermal melting change |
= |
0.4 |
degrees C |
Delta TM value showing the stabilisation of PAK4 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PAK7 |
Thermal melting change |
= |
-0.1 |
degrees C |
Delta TM value showing the stabilisation of PAK5 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PAK6 |
Thermal melting change |
= |
-0.5 |
degrees C |
Delta TM value showing the stabilisation of PAK6 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PCTAIRE-1 |
Thermal melting change |
= |
-0.6 |
degrees C |
Delta TM value showing the stabilisation of PCTK1 produced by compound binding |
CHEMBL1145498 |
| 3-phosphoinositide dependent protein kinase-1 |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of PDK1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PIM1 |
Thermal melting change |
= |
-1.0 |
degrees C |
Delta TM value showing the stabilisation of PIM1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PIM2 |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of PIM2 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PIM3 |
Thermal melting change |
= |
-0.1 |
degrees C |
Delta TM value showing the stabilisation of PIM3 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PLK1 |
Thermal melting change |
= |
-0.9 |
degrees C |
Delta TM value showing the stabilisation of PLK1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PLK4 |
Thermal melting change |
= |
0.2 |
degrees C |
Delta TM value showing the stabilisation of PLK4 produced by compound binding |
CHEMBL1145498 |
| cAMP-dependent protein kinase alpha-catalytic subunit |
Thermal melting change |
= |
-0.1 |
degrees C |
Delta TM value showing the stabilisation of PRKACA produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase RIO2 |
Thermal melting change |
= |
0.3 |
degrees C |
Delta TM value showing the stabilisation of RIOK2 produced by compound binding |
CHEMBL1145498 |
| Ribosomal protein S6 kinase alpha 3 |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of RSK2a produced by compound binding |
CHEMBL1145498 |
| Ribosomal protein S6 kinase alpha 3 |
Thermal melting change |
= |
-0.2 |
degrees C |
Delta TM value showing the stabilisation of RSK2b produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase 2 |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of SLK produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase 10 |
Thermal melting change |
= |
0.5 |
degrees C |
Delta TM value showing the stabilisation of LOK produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase 16 |
Thermal melting change |
= |
0.7 |
degrees C |
Delta TM value showing the stabilisation of MPSK1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase 17A |
Thermal melting change |
= |
-0.1 |
degrees C |
Delta TM value showing the stabilisation of DRAK1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase 38 |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of NDR1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase MST4 |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of MST4 (2) produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase MST1 |
Thermal melting change |
= |
0.3 |
degrees C |
Delta TM value showing the stabilisation of MST1 produced by compound binding |
CHEMBL1145498 |
| TRAF2- and NCK-interacting kinase |
Thermal melting change |
= |
0.3 |
degrees C |
Delta TM value showing the stabilisation of TNIK produced by compound binding |
CHEMBL1145498 |
| PDZ-binding kinase |
Thermal melting change |
= |
0.4 |
degrees C |
Delta TM value showing the stabilisation of PBK produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase VRK1 |
Thermal melting change |
= |
0.4 |
degrees C |
Delta TM value showing the stabilisation of VRK1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase VRK2 |
Thermal melting change |
= |
0.2 |
degrees C |
Delta TM value showing the stabilisation of VRK2 produced by compound binding |
CHEMBL1145498 |
| Inactive serine/threonine-protein kinase VRK3 |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of VRK3 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase 25 |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of YSK1 produced by compound binding |
CHEMBL1145498 |
| Cyclin-dependent kinase 2/cyclin E1 |
IC50 |
= |
7079.46 |
nM |
Inhibition of CDK2/Cyclin E (unknown origin) |
CHEMBL3763042 |
| Cyclin-dependent kinase 1/cyclin B1 |
IC50 |
= |
7000.0 |
nM |
Inhibition of CDK1/CyclinB (unknown origin) |
CHEMBL4184194 |
| K562 |
IC50 |
= |
163000.0 |
nM |
Antiproliferative activity against human K562 cells |
CHEMBL4184194 |
| SARS-CoV-2 |
Inhibition |
= |
4.05 |
% |
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging |
CHEMBL4303101 |
| Replicase polyprotein 1ab |
Inhibition |
= |
2.494 |
% |
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate |
CHEMBL4495564 |
| SARS-CoV-2 |
Inhibition |
= |
0.0 |
% |
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging |
CHEMBL4495565 |
| SARS-CoV-2 |
Inhibition |
= |
0.0 |
% |
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging |
CHEMBL4495565 |
| Cyclin-dependent kinase 2 |
IC50 |
= |
7000.0 |
nM |
Inhibition of CDK2 (unknown origin) |
CHEMBL5131375 |
| Unchecked |
CC50 |
> |
15000.0 |
nM |
Cytotoxicity against human LU cells |
CHEMBL5131375 |
| Human herpesvirus 5 |
Inhibition |
= |
50.0 |
% |
Antiviral activity against HCMV assessed as inhibition of DNA synthesis at 10 uM relative to control |
CHEMBL5131375 |
