| Adenosine A1 receptor |
Ki |
= |
6.8 |
nM |
Inhibition of binding of [3H]N6-cyclohexyladenosine to adenosine A1 receptor of rat whole brain membranes. |
CHEMBL1124694 |
| Adenosine A2 receptor |
Ki |
= |
25.0 |
nM |
Inhibition of binding of [3H]NECA to adenosine A2 receptor of rat striatal membranes. |
CHEMBL1124694 |
| Adenosine receptors; A1 & A2 |
Ratio |
= |
3.6 |
|
Selectivity ratio for A1 receptor to that of A2 receptor in vitro in rat tissues |
CHEMBL1124694 |
| Phosphoglycerate kinase |
IC50 |
|
|
nM |
Inhibition of Trypanosoma brucei phosphoglycerate kinase (PGK); inactive at 4 mM |
CHEMBL1133593 |
| Adenosine A1 receptor |
Ki |
= |
6.8 |
nM |
Binding affinity to adenosine A1 receptor in rat whole brain membranes by [3H]N6-cyclohexyladenosine displacement. |
CHEMBL1123600 |
| Adenosine A2 receptor |
Ki |
= |
25.0 |
nM |
Binding affinity to A2 adenosine receptor in rat striatal membranes by [3H]NECA (1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide) displacement. |
CHEMBL1123600 |
| Mus musculus |
ED50 |
= |
1.3 |
mg.kg-1 |
Effect on Motor activity in mouse following i.p. administration. |
CHEMBL1123600 |
| Mus musculus |
ED50 |
= |
145.0 |
mg.kg-1 |
Effect on Ataxia in mouse following i.p. administration. |
CHEMBL1123600 |
| Rattus norvegicus |
ED50 |
= |
2.2 |
mg.kg-1 |
Effect on Motor activity(MA) in rat was measured as ED50 by perorally administration of compound. |
CHEMBL1123600 |
| Rattus norvegicus |
ED50 |
= |
31.0 |
mg.kg-1 |
Effect on Ataxia(ATX) in rat was measured as ED50 by perorally administration of compound. |
CHEMBL1123600 |
| Rattus norvegicus |
ED50 |
= |
2.5 |
mg.kg-1 |
Effect on Sidman conditioned avoidance in rat. |
CHEMBL1123600 |
| Adenosine A1 receptor |
Ki |
= |
6.8 |
nM |
Binding affinity at adenosine A1 receptor from rat brain membranes by [3H]N6-cyclohexyladenosine displacement. |
CHEMBL1124142 |
| Adenosine A2 receptor |
Ki |
= |
25.0 |
nM |
Binding affinity at adenosine A2 receptor from rat striatal membranes by [3H]NECA displacement. |
CHEMBL1124142 |
| Adenosine receptors; A1 & A2 |
Ratio |
= |
3.61 |
|
Ratio of binding affinity against A2 and A1 receptors |
CHEMBL1124142 |
| Adenosine A1 receptor |
Ki |
= |
6.8 |
nM |
Binding affinity towards adenosine A1 receptor on rat whole brain membrane using [3H]N6-cyclohexyladenosine |
CHEMBL1124304 |
| Adenosine A2 receptor |
Ki |
= |
25.0 |
nM |
Binding affinity towards adenosine A2 receptor on rat striatal membrane using [3H]NECA as radioligand |
CHEMBL1124304 |
| Adenosine A1 receptor |
EC25 |
= |
90.0 |
nM |
Reduction of heart rate (A1 response) in isolated rat heart preparation |
CHEMBL1124304 |
| Adenosine A2 receptor |
EC25 |
= |
10.0 |
nM |
Enhancement of coronary flow (A2 response) in isolated rat heart preparation |
CHEMBL1124304 |
| Adenosine receptors; A1 & A2 |
Ratio |
= |
3.7 |
|
Ratio of Ki at adenosine A2 and A1 receptors |
CHEMBL1124304 |
| Adenosine A1 receptor |
Ki |
= |
6.8 |
nM |
Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligand |
CHEMBL1125572 |
| Adenosine A2 receptor |
Ratio |
= |
25.0 |
nM |
Binding affinity against adenosine A2 receptor using [3H]- NECA as radioligand |
CHEMBL1125572 |
| Adenosine receptors; A1 & A2 |
Ratio |
= |
3.7 |
|
Ratio of A2 to A1. |
CHEMBL1125572 |
| ADMET |
k' |
= |
8.29 |
|
Index of hydrophobicity (k') |
CHEMBL1123294 |
| Adenosine A2 receptor |
Activity |
= |
30.8 |
M g-1 |
Binding affinity against A2 adenosine receptor |
CHEMBL1123294 |
| Adenosine A2 receptor |
K |
= |
83775.0 |
M-1 |
Association constant against A2 adenosine receptor |
CHEMBL1123294 |
| Adenosine A2 receptor |
MPR |
= |
0.71 |
|
Molar potency ratio (MPR) against adenosine A2 receptor of canine coronary artery |
CHEMBL1123294 |
| Adenosine A1 receptor |
Ki |
= |
50.0 |
nM |
Inhibition of [3H]R-PIA binding to human Adenosine A1 receptor expressed in CHO cells |
CHEMBL1142719 |
| Adenosine A2a receptor |
Ki |
= |
510.0 |
nM |
Inhibition of [3H]-CGS- 21680 binding to human Adenosine A2A receptor expressed in CHO cells |
CHEMBL1142719 |
| Adenosine A2b receptor |
Activation |
= |
70.0 |
% |
Relative activation of human Adenosine A2B receptor at 10 uM treatment compared to 10 uM Cl-IB-MECA |
CHEMBL1142719 |
| Adenosine A3 receptor |
Ki |
= |
3.9 |
nM |
Inhibition of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in CHO cells |
CHEMBL1142719 |
| Adenosine A3 receptor |
Activation |
= |
0.0 |
% |
Relative activation of human Adenosine A3 receptor expressed in CHO cells at 10 uM treatment compared to 10 uM Cl-IB-MECA |
CHEMBL1142719 |
| Adenosine A3 receptor |
Ki |
= |
540.0 |
nM |
Inhibition of [125I]AB-MECA binding to rat Adenosine A3 receptor expressed in CHO cells |
CHEMBL1142719 |
| Adenosine A2a receptor |
Ki |
= |
49.9 |
nM |
Binding affinity to A2A adenosine receptor |
CHEMBL1949672 |
| Adenosine A3 receptor |
IC50 |
|
|
|
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter |
CHEMBL2177029 |
| Adenosine A3 receptor |
Ki |
= |
538.0 |
nM |
Displacement of [125I]I-AB-MECA from human rat adenosine A3 receptor expressed in CHO cells after 60 mins by gamma counter |
CHEMBL2177029 |
| Adenosine A2a receptor |
Ki |
= |
510.0 |
nM |
Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in CHO cells after 60 mins by gamma counter |
CHEMBL2177029 |
| Unchecked |
Ratio Ki |
= |
131.0 |
|
Selectivity ratio of Ki for human recombinant adenosine A2A receptor to Ki for human recombinant adenosine A3 receptor expressed in CHO cells |
CHEMBL2177029 |
| Adenosine A2a receptor |
Ki |
= |
75.0 |
nM |
Displacement of [3H]CGS21680 from rat adenosine A2A receptor expressed in CHO cells after 60 mins by gamma counter |
CHEMBL2177029 |
| Adenosine A1 receptor |
Ki |
= |
50.0 |
nM |
Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells after 60 mins by gamma counter |
CHEMBL2177029 |
| Adenosine A1 receptor |
Ki |
= |
44.0 |
nM |
Displacement of [3H]CCPA from rat adenosine A1 receptor expressed in CHO cells after 60 mins by gamma counter |
CHEMBL2177029 |
| Adenosine receptors; A1 & A3 |
Ratio Ki |
= |
12.8 |
|
Selectivity ratio of Ki for human recombinant adenosine A1 receptor to Ki for human recombinant adenosine A3 receptor expressed in CHO cells |
CHEMBL2177029 |
| Unchecked |
Ratio Ki |
= |
12.0 |
|
Selectivity ratio of Ki for rat adenosine A1 receptor to Ki for rat adenosine A3 receptor expressed in CHO cells |
CHEMBL2177029 |
| Adenosine receptor A2a and A3 |
Ratio Ki |
= |
7.2 |
|
Selectivity ratio of Ki for rat adenosine A2A receptor to Ki for rat adenosine A3 receptor expressed in CHO cells |
CHEMBL2177029 |
| Adenosine A3 receptor |
Ki |
= |
3.9 |
nM |
Displacement of [125I]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells after 60 mins by gamma counter |
CHEMBL2177029 |
| Endoplasmin |
Activity |
|
|
|
Displacement of FITC-geldanamycin from GRP94 (unknown origin) at 50 uM after 24 hrs by fluorescence polarization assay relative to control |
CHEMBL4680372 |
| Heat shock protein HSP 90-alpha |
Activity |
|
|
|
Displacement of FITC-geldanamycin from HSP90alpha (unknown origin) at 50 uM after 24 hrs by fluorescence polarization assay relative to control |
CHEMBL4680372 |
| A549 |
Activity |
= |
77.0 |
% |
Antimigratory activity in human A549 cells assessed as wound closure at 2.5 uM after 24 hrs by scratch wound healing assay (Rvb = 59 %) |
CHEMBL4680372 |
| A549 |
Activity |
= |
91.0 |
% |
Antimigratory activity in human A549 cells assessed as wound closure at 2.5 uM after 36 hrs by scratch wound healing assay (Rvb = 88 %) |
CHEMBL4680372 |
| MDA-MB-231 |
Activity |
= |
62.0 |
% |
Antimigratory activity in human MDA-MB-231 cells assessed as wound closure at 2.5 uM after 24 hrs by scratch wound healing assay (Rvb = 64 %) |
CHEMBL4680372 |
| MDA-MB-231 |
Activity |
= |
90.0 |
% |
Antimigratory activity in human MDA-MB-231 cells assessed as wound closure at 2.5 uM after 48 hrs by scratch wound healing assay (Rvb = 93 %) |
CHEMBL4680372 |
| MDA-MB-231 |
Activity |
|
|
|
Antimigratory activity in human MDA-MB-231 cells assessed as rate of wound closure at 20 uM after 24 hrs by scratch wound healing assay |
CHEMBL4680372 |
| MDA-MB-231 |
Activity |
|
|
|
Antimigratory activity in human MDA-MB-231 cells assessed as rate of wound closure at 20 uM after 48 hrs by scratch wound healing assay |
CHEMBL4680372 |
| Adenosine A1 receptor |
Ki |
= |
49.9 |
nM |
Displacement of [3H]R-PIA from recombinant human A1AR measured after 60 mins by liquid scintillation counting method |
CHEMBL4680372 |
| Adenosine A2a receptor |
Ki |
= |
510.0 |
nM |
Displacement of [3H]CGS21680 from recombinant human A2AR measured after 60 mins by liquid scintillation counting method |
CHEMBL4680372 |
| Unchecked |
Ki |
= |
3.9 |
nM |
Displacement of [125I]-AB-MECA from human A3AR expressed in CHO cells measured after 60 mins by liquid scintillation counting method |
CHEMBL4680372 |
| Adenosine A2b receptor |
EC50 |
= |
485.0 |
nM |
Agonist activity at recombinant human A2BAR expressed in CHO cells assessed as stimulation of cAMP formation preincubated for 30 mins in presence of rolipram and adenosine deaminase followed by compound addition and measured after 20 mins by alphascreen cAMP assay |
CHEMBL4680372 |
