| Cyclin-dependent kinase 1/cyclin B |
IC50 |
= |
100.0 |
nM |
Inhibition of recombinant Cyclin-dependent kinase 1-cyclin B |
CHEMBL1134966 |
| MCF7 |
IC50 |
= |
12400.0 |
nM |
In vitro cytotoxic effect on MCF-7 cancer cell line |
CHEMBL1134966 |
| K562 |
IC50 |
= |
24000.0 |
nM |
In vitro cytotoxic effect on K562 cancer cell line |
CHEMBL1134966 |
| CCRF-CEM |
IC50 |
= |
10700.0 |
nM |
In vitro cytotoxic effect on CEM cancer cell line |
CHEMBL1134966 |
| HOS |
IC50 |
= |
17200.0 |
nM |
In vitro cytotoxic effect on HOS cancer cell line |
CHEMBL1134966 |
| G-361 |
IC50 |
= |
13300.0 |
nM |
In vitro cytotoxic effect on G361 cancer cell line |
CHEMBL1134966 |
| Cyclin-dependent kinase 1 |
IC50 |
= |
100.0 |
nM |
Inhibition of Cdk1 |
CHEMBL1145498 |
| Cyclin-dependent kinase 2 |
IC50 |
= |
80.0 |
nM |
Inhibition of Cdk2 |
CHEMBL1145498 |
| BJ |
Activity |
= |
85.0 |
% |
Cytotoxicity against human BJ cells assessed as cell viability at 30 uM after 72 hrs by fluorescence assay relative to control |
CHEMBL3421618 |
| Unchecked |
Activity |
= |
61.1 |
% |
Leshmanicidal activity against promastigote stage of Leishmania turanica MRHO/MN/08/BZ18 at 30 uM after 72 hrs by alamar blue staining-based fluorescence assay relative to control |
CHEMBL3421618 |
| Unchecked |
Inhibition |
= |
10.5 |
% |
Inhibition of Leishmania CRK3/CYC6 using histone H1/[gamma33-P]ATP as substrate at 30 uM after 30 mins relative to control |
CHEMBL3421618 |
| AMP-activated protein kinase, alpha-2 subunit |
Thermal melting change |
= |
0.2 |
degrees C |
Delta TM value showing the stabilisation of AMPKA2 produced by compound binding |
CHEMBL1145498 |
| CaM kinase I delta |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of CAMK1D produced by compound binding |
CHEMBL1145498 |
| CaM kinase I gamma |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of CAMK1G produced by compound binding |
CHEMBL1145498 |
| CaM kinase II alpha |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of CAMK2A produced by compound binding |
CHEMBL1145498 |
| CaM kinase II beta |
Thermal melting change |
= |
0.3 |
degrees C |
Delta TM value showing the stabilisation of CAMK2B produced by compound binding |
CHEMBL1145498 |
| CaM kinase II delta |
Thermal melting change |
= |
-0.1 |
degrees C |
Delta TM value showing the stabilisation of CAMK2D produced by compound binding |
CHEMBL1145498 |
| CaM kinase II gamma |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of CAMK2G produced by compound binding |
CHEMBL1145498 |
| CaM kinase IV |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of CAMK4 produced by compound binding |
CHEMBL1145498 |
| CaM-kinase kinase beta |
Thermal melting change |
= |
0.2 |
degrees C |
Delta TM value showing the stabilisation of CAMKK2 produced by compound binding |
CHEMBL1145498 |
| Cyclin-dependent kinase 2 |
Thermal melting change |
= |
1.2 |
degrees C |
Delta TM value showing the stabilisation of CDK2 produced by compound binding |
CHEMBL1145498 |
| Cyclin-dependent kinase 6 |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of CDK6 produced by compound binding |
CHEMBL1145498 |
| Cyclin-dependent kinase-like 1 |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of CDKL1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase Chk2 |
Thermal melting change |
= |
-0.4 |
degrees C |
Delta TM value showing the stabilisation of CHEK2 produced by compound binding |
CHEMBL1145498 |
| Dual specificty protein kinase CLK1 |
Thermal melting change |
= |
0.9 |
degrees C |
Delta TM value showing the stabilisation of CLK1 produced by compound binding |
CHEMBL1145498 |
| Dual specificity protein kinase CLK2 |
Thermal melting change |
= |
1.0 |
degrees C |
Delta TM value showing the stabilisation of CLK2 produced by compound binding |
CHEMBL1145498 |
| Dual specificity protein kinase CLK3 |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of CLK3 produced by compound binding |
CHEMBL1145498 |
| Casein kinase I gamma 1 |
Thermal melting change |
= |
0.5 |
degrees C |
Delta TM value showing the stabilisation of CK1G1 produced by compound binding |
CHEMBL1145498 |
| Casein kinase I gamma 2 |
Thermal melting change |
= |
0.7 |
degrees C |
Delta TM value showing the stabilisation of CK1G2 produced by compound binding |
CHEMBL1145498 |
| Casein kinase I isoform gamma-3 |
Thermal melting change |
= |
0.5 |
degrees C |
Delta TM value showing the stabilisation of CK1G3 produced by compound binding |
CHEMBL1145498 |
| Death-associated protein kinase 3 |
Thermal melting change |
= |
0.2 |
degrees C |
Delta TM value showing the stabilisation of DAPK3 produced by compound binding |
CHEMBL1145498 |
| Myotonin-protein kinase |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of DMPK1 produced by compound binding |
CHEMBL1145498 |
| Glycogen synthase kinase-3 beta |
Thermal melting change |
= |
0.3 |
degrees C |
Delta TM value showing the stabilisation of GSK3B produced by compound binding |
CHEMBL1145498 |
| Tyrosine-protein kinase JAK1 |
Thermal melting change |
= |
0.8 |
degrees C |
Delta TM value showing the stabilisation of JAK1~B produced by compound binding |
CHEMBL1145498 |
| Dual specificity mitogen-activated protein kinase kinase 2 |
Thermal melting change |
= |
-0.2 |
degrees C |
Delta TM value showing the stabilisation of MEK2 produced by compound binding |
CHEMBL1145498 |
| Dual specificity mitogen-activated protein kinase kinase 6 |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of MAP2K6 produced by compound binding |
CHEMBL1145498 |
| Mitogen-activated protein kinase kinase kinase 5 |
Thermal melting change |
= |
1.0 |
degrees C |
Delta TM value showing the stabilisation of ASK1 produced by compound binding |
CHEMBL1145498 |
| MAP kinase p38 beta |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of p38beta produced by compound binding |
CHEMBL1145498 |
| MAP kinase ERK1 |
Thermal melting change |
= |
0.4 |
degrees C |
Delta TM value showing the stabilisation of ERK1 produced by compound binding |
CHEMBL1145498 |
| Mitogen-activated protein kinase 6 |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of ERK3 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase MST4 |
Thermal melting change |
= |
0.4 |
degrees C |
Delta TM value showing the stabilisation of MST4(1) produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase NEK2 |
Thermal melting change |
= |
0.3 |
degrees C |
Delta TM value showing the stabilisation of NEK2 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase NEK6 |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of NEK6 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase OSR1 |
Thermal melting change |
= |
0.3 |
degrees C |
Delta TM value showing the stabilisation of OSR1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PAK 4 |
Thermal melting change |
= |
0.5 |
degrees C |
Delta TM value showing the stabilisation of PAK4 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PAK7 |
Thermal melting change |
= |
0.2 |
degrees C |
Delta TM value showing the stabilisation of PAK5 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PAK6 |
Thermal melting change |
= |
0.3 |
degrees C |
Delta TM value showing the stabilisation of PAK6 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PCTAIRE-1 |
Thermal melting change |
= |
-0.2 |
degrees C |
Delta TM value showing the stabilisation of PCTK1 produced by compound binding |
CHEMBL1145498 |
| 3-phosphoinositide dependent protein kinase-1 |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of PDK1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PIM1 |
Thermal melting change |
= |
-1.3 |
degrees C |
Delta TM value showing the stabilisation of PIM1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PIM2 |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of PIM2 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PIM3 |
Thermal melting change |
= |
0.4 |
degrees C |
Delta TM value showing the stabilisation of PIM3 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PLK1 |
Thermal melting change |
= |
0.5 |
degrees C |
Delta TM value showing the stabilisation of PLK1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase PLK4 |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of PLK4 produced by compound binding |
CHEMBL1145498 |
| cAMP-dependent protein kinase alpha-catalytic subunit |
Thermal melting change |
= |
0.2 |
degrees C |
Delta TM value showing the stabilisation of PRKACA produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase RIO2 |
Thermal melting change |
= |
-0.1 |
degrees C |
Delta TM value showing the stabilisation of RIOK2 produced by compound binding |
CHEMBL1145498 |
| Ribosomal protein S6 kinase alpha 3 |
Thermal melting change |
= |
0.9 |
degrees C |
Delta TM value showing the stabilisation of RSK2a produced by compound binding |
CHEMBL1145498 |
| Ribosomal protein S6 kinase alpha 3 |
Thermal melting change |
= |
0.7 |
degrees C |
Delta TM value showing the stabilisation of RSK2b produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase 2 |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of SLK produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase 10 |
Thermal melting change |
= |
0.5 |
degrees C |
Delta TM value showing the stabilisation of LOK produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase 16 |
Thermal melting change |
= |
1.2 |
degrees C |
Delta TM value showing the stabilisation of MPSK1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase 17A |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of DRAK1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase 38 |
Thermal melting change |
= |
0.3 |
degrees C |
Delta TM value showing the stabilisation of NDR1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase MST4 |
Thermal melting change |
= |
0.3 |
degrees C |
Delta TM value showing the stabilisation of MST4 (2) produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase MST1 |
Thermal melting change |
= |
0.3 |
degrees C |
Delta TM value showing the stabilisation of MST1 produced by compound binding |
CHEMBL1145498 |
| TRAF2- and NCK-interacting kinase |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of TNIK produced by compound binding |
CHEMBL1145498 |
| PDZ-binding kinase |
Thermal melting change |
= |
0.7 |
degrees C |
Delta TM value showing the stabilisation of PBK produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase VRK1 |
Thermal melting change |
= |
0.0 |
degrees C |
Delta TM value showing the stabilisation of VRK1 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase VRK2 |
Thermal melting change |
= |
0.6 |
degrees C |
Delta TM value showing the stabilisation of VRK2 produced by compound binding |
CHEMBL1145498 |
| Inactive serine/threonine-protein kinase VRK3 |
Thermal melting change |
= |
0.1 |
degrees C |
Delta TM value showing the stabilisation of VRK3 produced by compound binding |
CHEMBL1145498 |
| Serine/threonine-protein kinase 25 |
Thermal melting change |
= |
0.3 |
degrees C |
Delta TM value showing the stabilisation of YSK1 produced by compound binding |
CHEMBL1145498 |
