| HeLa |
MP |
= |
0.0 |
% |
Percentage of monophosphates (MP) formed in the first step of staggered assay compound was incubated with HSV-1 thymidine kinase for 4 hr |
CHEMBL1124020 |
| Human herpesvirus 1 DNA polymerase |
MP |
= |
0.0 |
% |
Percentage of monophosphates (MP) in the second step of staggered assay mixture from step 1 was incubated with GMP kinase and crude extract of HSV-1 infected HeLa cells over night |
CHEMBL1124020 |
| Human herpesvirus 1 DNA polymerase |
DP |
= |
0.0 |
% |
Percentage of diphosphates (DP) in the second step of staggered assay mixture from step 1 was incubated with GMP kinase and crude extract of HSV-1 infected HeLa cells over night |
CHEMBL1124020 |
| Human herpesvirus 1 DNA polymerase |
TP |
= |
0.0 |
% |
Percentage of triphosphates (TP) in the second step of staggered assay mixture from step 1 was incubated with GMP kinase and crude extract of HSV-1 infected HeLa cells over night |
CHEMBL1124020 |
| Human herpesvirus 1 DNA polymerase |
Inhibition |
= |
0.0 |
% |
Inhibition of DNA polymerase |
CHEMBL1124020 |
| Unchecked |
Inhibition |
= |
3.0 |
% |
Inhibition of DNA polymerase |
CHEMBL1124020 |
| Oryctolagus cuniculus |
|
|
|
|
Antiviral activity against HSV-1 cell line (concentration required to prevent viral cytopathic effect in half of primary rabbit kidney cell cultures); Not Active at 100 ug/mL |
CHEMBL1124020 |
| Oryctolagus cuniculus |
|
|
|
|
Antiviral activity against HSV-2 cell line (concentration required to prevent viral cytopathic effect in half of primary rabbit kidney cell cultures); Not Active at 100 ug/mL |
CHEMBL1124020 |
| Adenosylhomocysteinase |
Ki |
= |
125.0 |
nM |
Inhibition against bovine-liver S-Adenosyl-homocysteine (AdoHcy) hydrolase |
CHEMBL1124198 |
| Adenosylhomocysteinase |
IC50 |
|
|
nM |
Evaluated for the 50% inhibition of bovine-liver S-Adenosyl-homocysteine (AdoHcy) hydrolase; Not applicable |
CHEMBL1124198 |
| Adenosylhomocysteinase |
IC50 |
= |
145000.0 |
nM |
Evaluated for the 50% inhibition of S-Adenosyl-homocysteine (AdoHcy) hydrolase L929 lysate from murine L-929 cells |
CHEMBL1124198 |
| Vaccinia virus |
IC50 |
= |
108000.0 |
nM |
Evaluated for 50% plaque inhibition of vaccinia virus replication in murine L929 cells |
CHEMBL1124198 |
| MT4 |
ED50 |
|
|
|
Activity in HIV-l infected MT-4 cells cultures; No activity |
CHEMBL1127390 |
| L1210 |
IC50 |
= |
490000.0 |
nM |
Inhibitory activity against murine leukemia L1210 cells |
CHEMBL1125745 |
| L1210 |
Cytotoxicity |
= |
200.0 |
|
Cytotoxicity was evaluated against L1210 leukemia cell line at 250 ug/disk. |
CHEMBL1125745 |
| PO3 |
Cytotoxicity |
= |
260.0 |
|
Cytotoxicity was evaluated against PO3 cell line at 250 ug/disk. |
CHEMBL1125745 |
| NON-PROTEIN TARGET |
Cytotoxicity |
= |
240.0 |
|
Cytotoxicity was evaluated against low malignancy line at 250 ug/disk. |
CHEMBL1125745 |
| Mus musculus |
EC50 |
= |
175000.0 |
nM |
Concentration that reduces Friend murine leukemia virus titer by 50% |
CHEMBL1125745 |
| Unchecked |
SI |
> |
1.7 |
|
Selectivity index is the ratio of IC50 to EC50 of F-MuLV. |
CHEMBL1125745 |
| Mus musculus |
EC50 |
= |
124000.0 |
nM |
Concentration that reduces Rauscher murine leukemia virus titer by 50% |
CHEMBL1125745 |
| Unchecked |
SI |
> |
2.4 |
|
Selectivity index which is the ratio of IC50 to EC50 of R-MuLV. |
CHEMBL1125745 |
| Mus musculus |
IC50 |
> |
300000.0 |
nM |
Cytotoxicity was evaluated |
CHEMBL1125745 |
