| Adenosine A1 receptor |
Ki |
= |
3070.0 |
nM |
Displacement of [3H]CCPA form human adenosine A1 receptor expressed in CHO cells |
CHEMBL1144175 |
| Adenosine A2a receptor |
Ki |
= |
4510.0 |
nM |
Displacement of [3H]R-PIA form human adenosine A2A receptor expressed in HEK cells |
CHEMBL1144175 |
| Adenosine A3 receptor |
Ki |
= |
1.06 |
nM |
Displacement of [3H]CGS21680 form human adenosine A3 receptor expressed in CHO cells |
CHEMBL1144175 |
| Adenosine A3 receptor |
Efficacy |
= |
2.9 |
% |
Antagonist activity at human adenosine A3 receptor expressed in CHO cells at 10 uM by [35S]GTPgammaS binding assay relative to NECA |
CHEMBL1144175 |
| Adenosine receptors; A1 & A3 |
FC |
= |
2900.0 |
|
Selectivity for human adenosine A3 receptor over human adenosine A1 receptor expressed in CHO cells |
CHEMBL1144175 |
| Unchecked |
FC |
= |
4250.0 |
|
Selectivity for human adenosine A3 receptor expressed in CHO cells over human adenosine A2A receptor expressed in HEK cells |
CHEMBL1144175 |
| Adenosine A3 receptor |
Ki |
= |
1.06 |
nM |
Displacement of [125I]AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells after 60 mins by liquid scintillation counting |
CHEMBL1154768 |
| Adenosine A2a receptor |
Ki |
= |
4510.0 |
nM |
Displacement of [3H]CGS21680 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting |
CHEMBL1154768 |
| Adenosine A1 receptor |
Ki |
= |
3070.0 |
nM |
Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells after 60 mins by liquid scintillation counting |
CHEMBL1154768 |
| Adenosine A3 receptor |
Efficacy |
= |
2.9 |
% |
Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding at 10 uM relative to NECA |
CHEMBL1154768 |
| Serotonin 1a (5-HT1a) receptor |
Inhibition |
< |
50.0 |
% |
Displacement of [3H]WAY100635 from human 5-HT1AR expressed in CHO cell membranes at 10 uM incubated for 90 mins under dark condition by microbeta scintillation counting method relative to control |
CHEMBL3862033 |
| Serotonin 1d (5-HT1d) receptor |
Inhibition |
< |
50.0 |
% |
Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK-T cell membranes at 10 uM incubated for 90 mins under dark condition by microbeta scintillation counting method relative to control |
CHEMBL3862033 |
| Serotonin 1b (5-HT1b) receptor |
Inhibition |
< |
50.0 |
% |
Displacement of [3H]5-CT from human 5-HT1BR expressed in HEK cell membranes at 10 uM incubated for 90 mins under dark condition by microbeta scintillation counting method relative to control |
CHEMBL3862033 |
| Serotonin 1e (5-HT1e) receptor |
Inhibition |
< |
50.0 |
% |
Displacement of [3H]5-HT from human 5-HT1E receptor expressed in HEK cell membranes at 10 uM incubated for 90 mins under dark condition by microbeta scintillation counting method relative to control |
CHEMBL3862033 |
| Serotonin 4 (5-HT4) receptor |
Inhibition |
< |
50.0 |
% |
Displacement of [3H]GR113808 from human 5-HT4 receptor at 10 uM incubated for 90 mins under dark condition by microbeta scintillation counting method relative to control |
CHEMBL3862033 |
| Serotonin 6 (5-HT6) receptor |
Inhibition |
< |
50.0 |
% |
Displacement of [3H]LSD from human 5-HT6 receptor expressed in HEK cell membranes at 10 uM incubated for 90 mins under dark condition by microbeta scintillation counting method relative to control |
CHEMBL3862033 |
| Serotonin 7 (5-HT7) receptor |
Inhibition |
< |
50.0 |
% |
Displacement of [3H]LSD from human 5-HT7A receptor expressed in HEK cell membranes at 10 uM incubated for 90 mins under dark condition by microbeta scintillation counting method relative to control |
CHEMBL3862033 |
| Serotonin 2a (5-HT2a) receptor |
Ki |
> |
10000.0 |
nM |
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK-T cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting method |
CHEMBL3862033 |
| Serotonin 3a (5-HT3a) receptor |
Ki |
= |
3260.0 |
nM |
Displacement of [3H]GR65630 from human 5-HT3 receptor expressed in HEK-T cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting method |
CHEMBL3862033 |
| Serotonin 2a (5-HT2a) receptor |
Inhibition |
< |
10.0 |
% |
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK-T cell membranes at 10 uM incubated for 90 mins under dark condition by microbeta scintillation counting method relative to control |
CHEMBL3862033 |
| Serotonin 2b (5-HT2b) receptor |
Ki |
= |
2390.0 |
nM |
Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method |
CHEMBL3862033 |
| Serotonin 2b (5-HT2b) receptor |
Inhibition |
> |
50.0 |
% |
Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes at 10 uM incubated for 90 mins under dark condition by microbeta scintillation counting method relative to control |
CHEMBL3862033 |
| Serotonin 2c (5-HT2c) receptor |
Ki |
= |
4100.0 |
nM |
Displacement of [3H]mesulergine from human 5-HT2CR expressed in Flp-In HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting method |
CHEMBL3862033 |
| Serotonin 2c (5-HT2c) receptor |
Inhibition |
> |
50.0 |
% |
Displacement of [3H]mesulergine from human 5-HT2CR expressed in Flp-In HEK cell membranes at 10 uM incubated for 90 mins under dark condition by microbeta scintillation counting method relative to control |
CHEMBL3862033 |
| Adenosine A1 receptor |
Ki |
= |
1600.0 |
nM |
Displacement of [3H]N6-phenylisopropyladenosine from recombinant human A1AR expressed in CHO cell membranes after 60 mins by liquid scintillation counting method |
CHEMBL3862033 |
| Adenosine A2a receptor |
Ki |
= |
4520.0 |
nM |
Displacement of [3 H]2-[p-(2-carboxyethyl)phenyl-ethylamino]-5'-N-ethylcarboxamidoadenosine from recombinant human adenosine receptor A2A expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting method |
CHEMBL3862033 |
| Adenosine A2a receptor |
Inhibition |
> |
50.0 |
% |
Displacement of [3 H]2-[p-(2-carboxyethyl)phenyl-ethylamino]-5'-N-ethylcarboxamidoadenosine from recombinant human adenosine receptor A2A expressed in HEK293 cell membranes at 10 uM after 60 mins by liquid scintillation counting method relative to control |
CHEMBL3862033 |
| Transmembrane domain-containing protein TMIGD3 |
Ki |
= |
4900.0 |
nM |
Displacement of [125l]N 6-(4-amino-3-iodobenzyl)adenosine-5'-N-methyluronamide from recombinant human A3AR expressed in CHO cell membranes after 60 mins by gamma counting method |
CHEMBL3862033 |
| Serotonin 5a (5-HT5a) receptor |
Inhibition |
< |
50.0 |
% |
Displacement of [3H]LSD from human 5-HT5A receptor expressed in Flp-In-CHO cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting method relative to control |
CHEMBL3862033 |
