| MAP kinase p38 alpha |
Inhibition |
= |
10.0 |
% |
Inhibition of p38alpha (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Glycogen synthase kinase-3 beta |
Inhibition |
= |
21.0 |
% |
Inhibition of GSK3beta (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| MAP kinase ERK2 |
Inhibition |
= |
74.0 |
% |
Inhibition of ERK2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| MAP kinase ERK1 |
Inhibition |
= |
66.0 |
% |
Inhibition of ERK1 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Serine/threonine-protein kinase Chk2 |
Inhibition |
= |
98.0 |
% |
Inhibition of CHK2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Serine/threonine-protein kinase Chk1 |
Inhibition |
= |
84.0 |
% |
Inhibition of CHK1 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Serine/threonine-protein kinase D2 |
Inhibition |
= |
84.0 |
% |
Inhibition of PKD2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| MAP kinase-activated protein kinase 5 |
Inhibition |
= |
8.0 |
% |
Inhibition of MAPKAPK5 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| MAP kinase-activated protein kinase 2 |
Inhibition |
= |
3.0 |
% |
Inhibition of MK2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Protein kinase C (PKC) |
Inhibition |
= |
0.0 |
% |
Inhibition of PKC (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Ribosomal protein S6 kinase alpha 1 |
Inhibition |
= |
90.0 |
% |
Inhibition of RSK1 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Ribosomal protein S6 kinase alpha 5 |
Inhibition |
= |
100.0 |
% |
Inhibition of MSK1 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Serine/threonine-protein kinase AKT2 |
Inhibition |
= |
98.0 |
% |
Inhibition of AKT2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Serine/threonine-protein kinase AKT |
Inhibition |
= |
101.0 |
% |
Inhibition of AKT1 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Unchecked |
Inhibition |
= |
101.0 |
% |
Inhibition of PKA (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Insulin receptor |
Inhibition |
= |
0.0 |
% |
Inhibition of INSR (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Serine/threonine-protein kinase NEK2 |
Inhibition |
= |
11.0 |
% |
Inhibition of NEK2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Inhibitor of nuclear factor kappa B kinase beta subunit |
Inhibition |
= |
95.0 |
% |
Inhibition of IKKbeta (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Serine/threonine-protein kinase Aurora-C |
Inhibition |
= |
46.0 |
% |
Inhibition of AURC (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Serine/threonine-protein kinase Aurora-B |
Inhibition |
= |
66.0 |
% |
Inhibition of AURB (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Unchecked |
Inhibition |
= |
7.0 |
% |
Inhibition of DYRK1 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Unchecked |
Inhibition |
= |
11.0 |
% |
Inhibition of CSNK1 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Mitogen-activated protein kinase kinase kinase kinase 4 |
Inhibition |
= |
2.0 |
% |
Inhibition of HGK (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Serine/threonine-protein kinase MST2 |
Inhibition |
= |
10.0 |
% |
Inhibition of MST2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Serine/threonine-protein kinase PAK 2 |
Inhibition |
= |
19.0 |
% |
Inhibition of PAK2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Unchecked |
Inhibition |
= |
55.0 |
% |
Inhibition of c-TAK (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Serine/threonine-protein kinase RAF |
Inhibition |
= |
15.0 |
% |
Inhibition of c-RAF (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Interleukin-1 receptor-associated kinase 4 |
Inhibition |
= |
8.0 |
% |
Inhibition of IRAK4 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Tyrosine-protein kinase FER |
Inhibition |
= |
2.0 |
% |
Inhibition of FER (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Tyrosine-protein kinase receptor FLT3 |
Inhibition |
= |
22.0 |
% |
Inhibition of FLT3 D835Y mutant (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Tyrosine-protein kinase receptor FLT3 |
Inhibition |
= |
10.0 |
% |
Inhibition of FLT3 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Tyrosine-protein kinase SYK |
Inhibition |
= |
8.0 |
% |
Inhibition of SYK (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Platelet-derived growth factor receptor |
Inhibition |
= |
20.0 |
% |
Inhibition of PDGFR (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Vascular endothelial growth factor receptor 2 |
Inhibition |
= |
11.0 |
% |
Inhibition of KDR (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Fibroblast growth factor receptor 4 |
Inhibition |
= |
0.0 |
% |
Inhibition of FGFR4 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Fibroblast growth factor receptor 2 |
Inhibition |
= |
22.0 |
% |
Inhibition of FGFR2 N549H mutant (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Fibroblast growth factor receptor 2 |
Inhibition |
= |
18.0 |
% |
Inhibition of FGFR2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Fibroblast growth factor receptor 3 |
Inhibition |
= |
7.0 |
% |
Inhibition of FGFR3 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Fibroblast growth factor receptor 1 |
Inhibition |
= |
44.0 |
% |
Inhibition of FGFR1 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Insulin-like growth factor I receptor |
Inhibition |
= |
5.0 |
% |
Inhibition of IGF1R (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Epidermal growth factor receptor erbB1 |
Inhibition |
= |
3.0 |
% |
Inhibition of EGFR (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Tyrosine-protein kinase HCK |
Inhibition |
= |
22.0 |
% |
Inhibition of HCK (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Tyrosine-protein kinase BMX |
Inhibition |
= |
8.0 |
% |
Inhibition of BMX (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Tyrosine-protein kinase BTK |
Inhibition |
= |
11.0 |
% |
Inhibition of BTK (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Tyrosine-protein kinase ABL2 |
Inhibition |
= |
13.0 |
% |
Inhibition of ARG (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Tyrosine-protein kinase ABL |
Inhibition |
= |
15.0 |
% |
Inhibition of ABL H396P mutant (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Tyrosine-protein kinase ABL |
Inhibition |
= |
17.0 |
% |
Inhibition of ABL T315I mutant (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Tyrosine-protein kinase ABL |
Inhibition |
= |
12.0 |
% |
Inhibition of ABL Q252H mutant (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| MAP kinase p38 gamma |
Inhibition |
= |
11.0 |
% |
Inhibition of p38gamma (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| MAP kinase p38 delta |
Inhibition |
= |
23.0 |
% |
Inhibition of p38delta (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| MAP kinase p38 beta |
Inhibition |
= |
8.0 |
% |
Inhibition of p38beta-2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Cyclin-dependent kinase 2 |
Inhibition |
= |
21.0 |
% |
Inhibition of CDK2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| AMP-activated protein kinase, AMPK |
Inhibition |
= |
78.0 |
% |
Inhibition of AMPK (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Protein kinase C nu |
Inhibition |
= |
81.0 |
% |
Inhibition of PKD3 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Serine/threonine-protein kinase PIM1 |
Inhibition |
= |
8.0 |
% |
Inhibition of PIM1 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Testis-specific serine/threonine-protein kinase 1 |
Inhibition |
= |
97.0 |
% |
Inhibition of TSSK1 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Testis-specific serine/threonine-protein kinase 2 |
Inhibition |
= |
32.0 |
% |
Inhibition of TSSK2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Serine/threonine-protein kinase PIM2 |
Inhibition |
= |
21.0 |
% |
Inhibition of PIM2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| MAP/microtubule affinity-regulating kinase 2 |
Inhibition |
= |
60.0 |
% |
Inhibition of MARK2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Serine/threonine-protein kinase MARK1 |
Inhibition |
= |
99.0 |
% |
Inhibition of MARK1 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| BR serine/threonine-protein kinase 1 |
Inhibition |
= |
16.0 |
% |
Inhibition of BRSK1 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| BR serine/threonine-protein kinase 2 |
Inhibition |
= |
0.0 |
% |
Inhibition of BRSK2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| MAP kinase-activated protein kinase 5 |
Inhibition |
= |
8.0 |
% |
Inhibition of PRAK (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| MAP kinase ERK1 |
Inhibition |
= |
9.0 |
% |
Inhibition of MAPK3 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| MAP kinase ERK2 |
Inhibition |
= |
6.0 |
% |
Inhibition of MAPK2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Unchecked |
Inhibition |
= |
20.0 |
% |
Inhibition of DCAMK (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| CaM kinase II delta |
Inhibition |
= |
17.0 |
% |
Inhibition of CAMK2gamma (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| CaM kinase II beta |
Inhibition |
= |
29.0 |
% |
Inhibition of CAMK2beta (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Unchecked |
Inhibition |
= |
17.0 |
% |
Inhibition of CAMK2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| CaM kinase IV |
Inhibition |
= |
14.0 |
% |
Inhibition of CAMK4 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Protein kinase C mu |
Inhibition |
= |
72.0 |
% |
Inhibition of PKD1 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Rho-associated protein kinase 2 |
Inhibition |
= |
98.0 |
% |
Inhibition of ROCK2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Unchecked |
Inhibition |
= |
98.0 |
% |
Inhibition of PKGbeta (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Unchecked |
Inhibition |
= |
99.0 |
% |
Inhibition of PKGalpha (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Ribosomal protein S6 kinase 1 |
Inhibition |
= |
98.0 |
% |
Inhibition of p70S6K (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Protein kinase C zeta |
Inhibition |
= |
0.0 |
% |
Inhibition of PKCzeta (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Protein kinase C theta |
Inhibition |
= |
75.0 |
% |
Inhibition of PKCtheta (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Protein kinase C delta |
Inhibition |
= |
75.0 |
% |
Inhibition of PKCdelta (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Protein kinase C epsilon |
Inhibition |
= |
64.0 |
% |
Inhibition of PKCepsilon (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Protein kinase C eta |
Inhibition |
= |
71.0 |
% |
Inhibition of PKCeta (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Protein kinase C gamma |
Inhibition |
= |
86.0 |
% |
Inhibition of PKCgamma (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Protein kinase C beta |
Inhibition |
= |
60.0 |
% |
Inhibition of PKCbeta-2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Protein kinase C beta |
Inhibition |
= |
76.0 |
% |
Inhibition of PKCbeta-1 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Protein kinase C alpha |
Inhibition |
= |
78.0 |
% |
Inhibition of PKCalpha (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Serine/threonine-protein kinase Sgk2 |
Inhibition |
= |
59.0 |
% |
Inhibition of SGK2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Serine/threonine-protein kinase Sgk3 |
Inhibition |
= |
94.0 |
% |
Inhibition of SGK3 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Serine/threonine-protein kinase Sgk1 |
Inhibition |
= |
64.0 |
% |
Inhibition of SGK1 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Ribosomal protein S6 kinase alpha 4 |
Inhibition |
= |
100.0 |
% |
Inhibition of MSK2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Ribosomal protein S6 kinase alpha 2 |
Inhibition |
= |
91.0 |
% |
Inhibition of RSK3 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Ribosomal protein S6 kinase alpha 3 |
Inhibition |
= |
94.0 |
% |
Inhibition of RSK2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Serine/threonine-protein kinase AKT3 |
Inhibition |
= |
101.0 |
% |
Inhibition of AKT3 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Unchecked |
IC50 |
= |
31.0 |
nM |
Inhibition of PKA (unknown origin) using LRRASLG as substrate after 1 hr by fluorescence assay |
CHEMBL2417369 |
| Serine/threonine-protein kinase Aurora-A |
Inhibition |
= |
64.0 |
% |
Inhibition of AURA (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Casein kinase I delta |
Inhibition |
= |
15.0 |
% |
Inhibition of CK1delta (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Tyrosine-protein kinase SRC |
Inhibition |
= |
64.0 |
% |
Inhibition of SRC (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Hepatocyte growth factor receptor |
Inhibition |
= |
6.0 |
% |
Inhibition of MET (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Tyrosine-protein kinase LCK |
Inhibition |
= |
60.0 |
% |
Inhibition of LCK (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Tyrosine-protein kinase Lyn |
Inhibition |
= |
50.0 |
% |
Inhibition of LYN (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Tyrosine-protein kinase FYN |
Inhibition |
= |
28.0 |
% |
Inhibition of FYN (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
| Tyrosine-protein kinase ABL |
Inhibition |
= |
16.0 |
% |
Inhibition of ABL (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control |
CHEMBL2417369 |
