| Misshapen-like kinase 1 |
Activity |
= |
64.0 |
% |
Inhibition of recombinant MINK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Aurora kinase A/B |
Ratio |
= |
0.08 |
|
Activity at Aurora kinase A/B in human MCF7 cells assessed as histone H3 phosphorylation at Ser10 at 100 uM after 24 hrs by flow cytometry relative to untreated control |
CHEMBL2331324 |
| Tyrosine-protein kinase ZAP-70 |
Activity |
= |
86.0 |
% |
Inhibition of recombinant ZAP70 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Tyrosine-protein kinase YES |
Activity |
= |
13.0 |
% |
Inhibition of recombinant YES1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Unchecked |
Activity |
= |
6.0 |
% |
Inhibition of recombinant VEGFR (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Dual specificity protein kinase TTK |
Activity |
= |
40.0 |
% |
Inhibition of recombinant TTK (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Nerve growth factor receptor Trk-A |
Activity |
= |
24.0 |
% |
Inhibition of recombinant TRKA (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase tousled-like 1 |
Activity |
= |
9.0 |
% |
Inhibition of recombinant TLK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Tyrosine-protein kinase TIE-2 |
Activity |
= |
39.0 |
% |
Inhibition of recombinant TIE2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase TBK1 |
Activity |
= |
92.0 |
% |
Inhibition of recombinant TBK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase TAO1 |
Activity |
= |
9.0 |
% |
Inhibition of recombinant TAO1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Mitogen-activated protein kinase kinase kinase 7 |
Activity |
= |
7.0 |
% |
Inhibition of recombinant TAK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Tyrosine-protein kinase SYK |
Activity |
= |
58.0 |
% |
Inhibition of recombinant SYK (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase 33 |
Activity |
= |
11.0 |
% |
Inhibition of recombinant STK33 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase SRPK1 |
Activity |
= |
22.0 |
% |
Inhibition of recombinant SRPK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Tyrosine-protein kinase SRC |
Activity |
= |
22.0 |
% |
Inhibition of recombinant SRC (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Myosin light chain kinase, smooth muscle |
Activity |
= |
49.0 |
% |
Inhibition of recombinant SMMLCK (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase Sgk1 |
Activity |
= |
60.0 |
% |
Inhibition of recombinant SGK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Ribosomal protein S6 kinase 1 |
Activity |
= |
49.0 |
% |
Inhibition of recombinant S6K1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Ribosomal protein S6 kinase alpha 3 |
Activity |
= |
35.0 |
% |
Inhibition of recombinant RSK2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Ribosomal protein S6 kinase alpha 1 |
Activity |
= |
18.0 |
% |
Inhibition of recombinant RSK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Rho-associated protein kinase 2 |
Activity |
= |
61.0 |
% |
Inhibition of recombinant ROCK2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase RIPK2 |
Activity |
= |
72.0 |
% |
Inhibition of recombinant RIPK2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Protein kinase N2 |
Activity |
= |
85.0 |
% |
Inhibition of recombinant PRK2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| MAP kinase-activated protein kinase 5 |
Activity |
= |
76.0 |
% |
Inhibition of recombinant PRAK (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase PLK1 |
Activity |
= |
108.0 |
% |
Inhibition of recombinant PLK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Protein kinase C mu |
Activity |
= |
17.0 |
% |
Inhibition of recombinant PKD1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Protein kinase C gamma |
Activity |
= |
73.0 |
% |
Inhibition of recombinant PKCgamma (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Protein kinase C zeta |
Activity |
= |
68.0 |
% |
Inhibition of recombinant PKCzeta (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Protein kinase C alpha |
Activity |
= |
71.0 |
% |
Inhibition of recombinant PKCalpha (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase AKT2 |
Activity |
= |
111.0 |
% |
Inhibition of recombinant PKB beta (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase AKT |
Activity |
= |
99.0 |
% |
Inhibition of recombinant PKB alpha (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Unchecked |
Activity |
= |
90.0 |
% |
Inhibition of recombinant PKA (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase PIM3 |
Activity |
= |
64.0 |
% |
Inhibition of recombinant PIM3 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase PIM2 |
Activity |
= |
88.0 |
% |
Inhibition of recombinant PIM2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase PIM1 |
Activity |
= |
85.0 |
% |
Inhibition of recombinant PIM1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Phosphorylase kinase |
Activity |
= |
14.0 |
% |
Inhibition of recombinant PHK (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Pyruvate dehydrogenase kinase isoform 1 |
Activity |
= |
68.0 |
% |
Inhibition of recombinant PDK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase PAK6 |
Activity |
= |
26.0 |
% |
Inhibition of recombinant PAK6 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase PAK6 |
Activity |
= |
18.0 |
% |
Inhibition of recombinant PAK5 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase PAK 4 |
Activity |
= |
15.0 |
% |
Inhibition of recombinant PAK4 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase PAK 2 |
Activity |
= |
45.0 |
% |
Inhibition of recombinant PAK2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| MAP kinase p38 gamma |
Activity |
= |
77.0 |
% |
Inhibition of recombinant p38 MAPKgamma (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| MAP kinase p38 delta |
Activity |
= |
37.0 |
% |
Inhibition of recombinant p38 MAPKdelta (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| MAP kinase p38 beta |
Activity |
= |
64.0 |
% |
Inhibition of recombinant p38 MAPKbeta (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| MAP kinase p38 alpha |
Activity |
= |
87.0 |
% |
Inhibition of recombinant p38 MAPKalpha (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase OSR1 |
Activity |
= |
16.0 |
% |
Inhibition of recombinant OSR1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| NUAK family SNF1-like kinase 1 |
Activity |
= |
8.0 |
% |
Inhibition of recombinant NUAK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase NEK6 |
Activity |
= |
95.0 |
% |
Inhibition of recombinant NEK6 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase NEK2 |
Activity |
= |
73.0 |
% |
Inhibition of recombinant NEK2a (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase MST4 |
Activity |
= |
42.0 |
% |
Inhibition of recombinant MST4 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase MST2 |
Activity |
= |
35.0 |
% |
Inhibition of recombinant MST2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Ribosomal protein S6 kinase alpha 5 |
Activity |
= |
46.0 |
% |
Inhibition of recombinant MSK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase 16 |
Activity |
= |
36.0 |
% |
Inhibition of recombinant MPSK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| MAP kinase signal-integrating kinase 2 |
Activity |
= |
119.0 |
% |
Inhibition of recombinant MNK2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| MAP kinase-interacting serine/threonine-protein kinase MNK1 |
Activity |
= |
173.0 |
% |
Inhibition of recombinant MNK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Mitogen-activated protein kinase kinase kinase 11 |
Activity |
= |
37.0 |
% |
Inhibition of recombinant MLK3 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Mitogen-activated protein kinase kinase kinase 9 |
Activity |
= |
25.0 |
% |
Inhibition of recombinant MLK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Dual specificity mitogen-activated protein kinase kinase 6 |
Activity |
= |
72.0 |
% |
Inhibition of recombinant MKK6 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Dual specificity mitogen-activated protein kinase kinase 2 |
Activity |
= |
53.0 |
% |
Inhibition of recombinant MKK2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Dual specificity mitogen-activated protein kinase kinase 1 |
Activity |
= |
41.0 |
% |
Inhibition of recombinant MKK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Maternal embryonic leucine zipper kinase |
Activity |
= |
27.0 |
% |
Inhibition of recombinant MELK (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Mitogen-activated protein kinase kinase kinase 1 |
Activity |
= |
91.0 |
% |
Inhibition of recombinant MEKK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| MAP/microtubule affinity-regulating kinase 4 |
Activity |
= |
38.0 |
% |
Inhibition of recombinant MARK4 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase c-TAK1 |
Activity |
= |
24.0 |
% |
Inhibition of recombinant MARK3 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| MAP/microtubule affinity-regulating kinase 2 |
Activity |
= |
45.0 |
% |
Inhibition of recombinant MARK2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase MARK1 |
Activity |
= |
31.0 |
% |
Inhibition of recombinant MARK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| MAP kinase-activated protein kinase 3 |
Activity |
= |
80.0 |
% |
Inhibition of recombinant MAPKAPK3 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| MAP kinase-activated protein kinase 2 |
Activity |
= |
41.0 |
% |
Inhibition of recombinant MAPKAPK2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase 11 |
Activity |
= |
13.0 |
% |
Inhibition of recombinant LKB1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Tyrosine-protein kinase LCK |
Activity |
= |
13.0 |
% |
Inhibition of recombinant LCK (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| c-Jun N-terminal kinase 3 |
Activity |
= |
96.0 |
% |
Inhibition of recombinant JNK3 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| c-Jun N-terminal kinase 2 |
Activity |
= |
85.0 |
% |
Inhibition of recombinant JNK2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| c-Jun N-terminal kinase 1 |
Activity |
= |
88.0 |
% |
Inhibition of recombinant JNK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Tyrosine-protein kinase JAK2 |
Activity |
= |
16.0 |
% |
Inhibition of recombinant JAK2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Insulin receptor-related protein |
Activity |
= |
19.0 |
% |
Inhibition of recombinant IRR (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Interleukin-1 receptor-associated kinase 4 |
Activity |
= |
21.0 |
% |
Inhibition of recombinant IRAK4 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Interleukin-1 receptor-associated kinase 1 |
Activity |
= |
26.0 |
% |
Inhibition of recombinant IRAK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Insulin receptor |
Activity |
= |
5.0 |
% |
Inhibition of recombinant IR (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Inhibitor of nuclear factor kappa B kinase epsilon subunit |
Activity |
= |
66.0 |
% |
Inhibition of recombinant IKKepsilon (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Inhibitor of nuclear factor kappa B kinase beta subunit |
Activity |
= |
74.0 |
% |
Inhibition of recombinant IKKbeta (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Insulin-like growth factor I receptor |
Activity |
= |
10.0 |
% |
Inhibition of recombinant IGF-1R (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase Chk2 |
Activity |
= |
59.0 |
% |
Inhibition of recombinant CHK2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase Chk1 |
Activity |
= |
58.0 |
% |
Inhibition of recombinant CHK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Homeodomain-interacting protein kinase 3 |
Activity |
= |
38.0 |
% |
Inhibition of recombinant HIPK3 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Homeodomain-interacting protein kinase 2 |
Activity |
= |
8.0 |
% |
Inhibition of recombinant HIPK2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Homeodomain-interacting protein kinase 1 |
Activity |
= |
15.0 |
% |
Inhibition of recombinant HIPK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Receptor protein-tyrosine kinase erbB-4 |
Activity |
= |
27.0 |
% |
Inhibition of recombinant HER4 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Glycogen synthase kinase-3 beta |
Activity |
= |
37.0 |
% |
Inhibition of recombinant GSK3b (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Mitogen-activated protein kinase kinase kinase kinase 2 |
Activity |
= |
15.0 |
% |
Inhibition of recombinant GCK (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Fibroblast growth factor receptor 1 |
Activity |
= |
4.0 |
% |
Inhibition of recombinant FGF-R1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Mitogen-activated protein kinase 15 |
Activity |
= |
16.0 |
% |
Inhibition of recombinant ERK8 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| MAP kinase ERK2 |
Activity |
= |
32.0 |
% |
Inhibition of recombinant ERK2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| MAP kinase ERK1 |
Activity |
= |
50.0 |
% |
Inhibition of recombinant ERK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Ephrin type-B receptor 4 |
Activity |
= |
6.0 |
% |
Inhibition of recombinant EPH-B4 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Ephrin type-B receptor 2 |
Activity |
= |
2.0 |
% |
Inhibition of recombinant EPH-B2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Ephrin type-B receptor 1 |
Activity |
= |
8.0 |
% |
Inhibition of recombinant EPH-B1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Ephrin type-A receptor 4 |
Activity |
= |
22.0 |
% |
Inhibition of recombinant EPH-A4 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Ephrin type-A receptor 2 |
Activity |
= |
22.0 |
% |
Inhibition of recombinant EPH-A2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Eukaryotic translation initiation factor 2-alpha kinase 3 |
Activity |
= |
17.0 |
% |
Inhibition of recombinant EIF2AK3 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase EEF2K |
Activity |
= |
94.0 |
% |
Inhibition of recombinant EF2K (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Dual-specificity tyrosine-phosphorylation regulated kinase 3 |
Activity |
= |
18.0 |
% |
Inhibition of recombinant DYRK3 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Dual-specificity tyrosine-phosphorylation regulated kinase 2 |
Activity |
= |
27.0 |
% |
Inhibition of recombinant DYRK2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Dual-specificity tyrosine-phosphorylation regulated kinase 1A |
Activity |
= |
1.0 |
% |
Inhibition of recombinant DYRK1A (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Death-associated protein kinase 1 |
Activity |
= |
54.0 |
% |
Inhibition of recombinant DAPK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Tyrosine-protein kinase CSK |
Activity |
= |
58.0 |
% |
Inhibition of recombinant CSK (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Dual specificity protein kinase CLK2 |
Activity |
= |
4.0 |
% |
Inhibition of recombinant CLK2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Casein kinase II |
Activity |
= |
43.0 |
% |
Inhibition of recombinant CK2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Unchecked |
Activity |
= |
15.0 |
% |
Inhibition of recombinant CK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Cyclin-dependent kinase 2/cyclin A |
Activity |
= |
5.0 |
% |
Inhibition of recombinant CDK2/cyclin A (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| CaM-kinase kinase beta |
Activity |
= |
17.0 |
% |
Inhibition of recombinant CAMKKbeta (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| CaM kinase I alpha |
Activity |
= |
35.0 |
% |
Inhibition of recombinant CAMK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Tyrosine-protein kinase BTK |
Activity |
= |
53.0 |
% |
Inhibition of recombinant BTK (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| BR serine/threonine-protein kinase 2 |
Activity |
= |
77.0 |
% |
Inhibition of recombinant BRSK2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| BR serine/threonine-protein kinase 1 |
Activity |
= |
44.0 |
% |
Inhibition of recombinant BRSK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Tyrosine-protein kinase BRK |
Activity |
= |
50.0 |
% |
Inhibition of recombinant BRK (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase Aurora-B |
Activity |
= |
47.0 |
% |
Inhibition of recombinant AURB (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Serine/threonine-protein kinase Aurora-A |
Activity |
= |
39.0 |
% |
Inhibition of recombinant AURA (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Mitogen-activated protein kinase kinase kinase 5 |
Activity |
= |
100.0 |
% |
Inhibition of recombinant ASK1 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| AMP-activated protein kinase, alpha-2 subunit |
Activity |
= |
29.0 |
% |
Inhibition of recombinant AMPK (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| Tyrosine-protein kinase ABL |
Activity |
= |
5.0 |
% |
Inhibition of recombinant ABL (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM |
CHEMBL2331324 |
| MCF7 |
Ratio |
= |
1.8 |
|
Cell cycle arrest in human MCF7 cells assessed as accumulation of cells in G2+M phase at 100 uM after 24 hrs by propidium iodide staining based flow cytometry relative to untreated control |
CHEMBL2331324 |
| MCF7 |
IC50 |
= |
4500.0 |
nM |
Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by calcien AM dye based fluorescence analysis |
CHEMBL2331324 |
| Cyclin-dependent kinase 2/cyclin E1 |
IC50 |
= |
140.0 |
nM |
Inhibition of recombinant CDK2/cyclin E (unknown origin) using histone H1 as substrate in presence of [gamma-33P]ATP |
CHEMBL2331324 |
| Cyclin-dependent kinase 1/cyclin B1 |
IC50 |
= |
2100.0 |
nM |
Inhibition of recombinant CDK1/cyclin B (unknown origin) using histone H1 as substrate in presence of [gamma-33P]ATP |
CHEMBL2331324 |
