| L1210 |
IC50 |
= |
35.0 |
nM |
Tested in vitro for cytotoxicity against murine L1210 leukemic cells |
CHEMBL1133023 |
| KB |
IC50 |
> |
100000.0 |
nM |
Inhibition of KB cell growth was assessed |
CHEMBL1133023 |
| HFF |
IC50 |
= |
100000.0 |
nM |
Tested for visual cytotoxicity on uninfected HFF cells |
CHEMBL1133023 |
| CEM-SS |
IC50 |
> |
100000.0 |
nM |
Tested for visual cytotoxicity on uninfected CEM-SS cells |
CHEMBL1133023 |
| Human immunodeficiency virus type 1 reverse transcriptase |
IC50 |
= |
40.0 |
nM |
Antiviral activity was tested in cells acutely infected with HIV-1 RT (reverse transcriptase) |
CHEMBL1133023 |
| ADMET |
IC50 |
= |
23000.0 |
nM |
Antiviral activity was tested using an enzyme-linked immunosorbent assay (ELISA) to detect HSV-1 (herpes simplex virus type 1) using BSC-1 cells |
CHEMBL1133023 |
| HFF |
IC50 |
= |
2500.0 |
nM |
HCMV plaque assay was performed using HFF cells and effect was calculated as a percentage of reduction in number of plaques |
CHEMBL1133023 |
| CEM-SS |
Concentration |
= |
286.0 |
uM |
Intracellular phosphorylation (10 uM) in uninfected CEM-SS cells after 5 hrs of incubation time |
CHEMBL1133023 |
| CEM-SS |
Concentration |
= |
323.0 |
uM |
Intracellular phosphorylation (100 uM) in uninfected CEM-SS cells after 5 hrs of incubation time |
CHEMBL1133023 |
| CEM-SS |
Concentration |
= |
775.0 |
uM |
Intracellular phosphorylation (330 uM) in uninfected CEM-SS cells after 5 hrs of incubation time |
CHEMBL1133023 |
| CEM-SS |
Concentration |
= |
176.0 |
uM |
Intracellular phosphorylation (10 uM) in uninfected CEM-SS cells after 12 hrs of incubation time |
CHEMBL1133023 |
| CEM-SS |
Concentration |
= |
307.0 |
uM |
Intracellular phosphorylation (100 uM) in uninfected CEM-SS cells after 12 hrs of incubation time |
CHEMBL1133023 |
| CEM-SS |
Concentration |
= |
390.0 |
uM |
Intracellular phosphorylation (330 uM) in uninfected CEM-SS cells after 12 hrs of incubation time |
CHEMBL1133023 |
| Huh-7 |
EC50 |
= |
2000.0 |
nM |
Compound was tested for its ability to inhibit hepatitis C viral RNA replication in Huh-7 cells (human hepatoma cells) |
CHEMBL1147474 |
| Huh-7 |
CC50 |
> |
300000.0 |
nM |
Cytotoxicity using HCV replicon assay |
CHEMBL1147474 |
| Human immunodeficiency virus type 1 reverse transcriptase |
IC50 |
= |
40.0 |
nM |
Antiviral activity was evaluated by RT (reverse transcriptase) activity in cells acutely infected with HIV-1 |
CHEMBL1133753 |
| ADMET |
IC50 |
= |
23000.0 |
nM |
Antiviral activity against HSV-1 was determined using BSC-1 cells by an enzyme-linked immunosorbent assay (ELISA) |
CHEMBL1133753 |
| HFF |
IC50 |
= |
2500.0 |
nM |
Antiviral activity against HCMV was determined by plaque reduction assay using HFF cells |
CHEMBL1133753 |
| ADMET |
IC50 |
> |
100000.0 |
nM |
Cytotoxicity measured as Inhibition of KB cell growth was assessed. |
CHEMBL1133753 |
| HFF |
IC50 |
= |
100000.0 |
nM |
Visual cytotoxicity was scored on uninfected HFF cells |
CHEMBL1133753 |
| CEM-SS |
IC50 |
> |
100000.0 |
nM |
Visual cytotoxicity was scored on CEM-SS cells |
CHEMBL1133753 |
| CEM-SS |
Concentration |
= |
286.0 |
uM |
Intracellular phosphorylation (10 uM) in uninfected CEM-SS cells was studied after 5 hrs of Incubation. |
CHEMBL1133753 |
| CEM-SS |
Concentration |
= |
323.0 |
uM |
Intracellular phosphorylation (100 uM) in uninfected CEM-SS cells was studied after 5 hrs of Incubation. |
CHEMBL1133753 |
| CEM-SS |
Concentration |
= |
318.0 |
uM |
Intracellular phosphorylation (100 uM) in uninfected CEM-SS cells was studied after 5 hrs of Incubation. |
CHEMBL1133753 |
| Unchecked |
Concentration |
= |
9.0 |
uM |
Intracellular phosphorylation (100 uM) in uninfected AA2 cells was studied after 5 hrs of Incubation. |
CHEMBL1133753 |
| Human herpesvirus 5 |
IC50 |
= |
2500.0 |
nM |
Inhibitory concentration against human cytomegalovirus using plaque assay |
CHEMBL1144445 |
| Human herpesvirus 1 |
IC50 |
= |
23000.0 |
nM |
Inhibitory concentration against human herpes simplex virus type 1 using ELISA test |
CHEMBL1144445 |
| Human immunodeficiency virus type 1 reverse transcriptase |
IC50 |
= |
40.0 |
nM |
Inhibitory concentration against human immunodeficiency virus type 1 reverse transcriptase |
CHEMBL1144445 |
| HFF |
IC50 |
= |
100000.0 |
nM |
Visual cytotoxicity was determined in uninfected HFF cells using plaque assay |
CHEMBL1144445 |
| KB |
IC50 |
= |
100000.0 |
nM |
Inhibitory concentration was determined for KB cell growth |
CHEMBL1144445 |
| Human immunodeficiency virus type 1 reverse transcriptase |
IC50 |
= |
20.0 |
nM |
Inhibitory concentration against human immunodeficiency virus type 1 reverse transcriptase |
CHEMBL1144445 |
| MCF7 |
Activity |
= |
1.0 |
% |
Cytotoxicity against human MCF7 cells in presence of 20 uM chloroquine by SRB assay relative to control |
CHEMBL1139398 |
| ADMET |
GI50 |
= |
40000.0 |
nM |
Cytotoxicity against human 184B5 cells by SRB assay |
CHEMBL1139398 |
| ADMET |
GI50 |
= |
34000.0 |
nM |
Cytotoxicity against human 184B5 cells at 10 uM chloroquine by SRB assay |
CHEMBL1139398 |
| ADMET |
Activity |
= |
85.0 |
% |
Cytotoxicity against human 184B5 cells at 10 uM chloroquine by SRB assay relative to control |
CHEMBL1139398 |
| ADMET |
GI50 |
= |
16960.0 |
nM |
Cytotoxicity against human 184B5 cells at 20 uM chloroquine by SRB assay |
CHEMBL1139398 |
| ADMET |
Activity |
= |
42.0 |
% |
Cytotoxicity against human 184B5 cells at 20 uM chloroquine by SRB assay relative to control |
CHEMBL1139398 |
| MDA-MB-231 |
RatioGI50 |
= |
0.78 |
|
Ratio of GI50 for human 184B5 cells to GI50 for human MDA-MB-231 cells |
CHEMBL1139398 |
| MDA-MB-231 |
RatioGI50 |
= |
24.58 |
|
Ratio of GI50 for human 184B5 cells to GI50 for human MDA-MB-231 cells in presence of 20 uM chloroquine |
CHEMBL1139398 |
| MDA-MB-468 |
GI50 |
= |
43530.0 |
nM |
Cytotoxicity against human MDA-MB-468 cells by SRB assay |
CHEMBL1139398 |
| MDA-MB-468 |
GI50 |
= |
20450.0 |
nM |
Cytotoxicity against human MDA-MB-468 cells in presence of 10 uM chloroquine by SRB assay |
CHEMBL1139398 |
| MDA-MB-468 |
Activity |
= |
47.0 |
% |
Cytotoxicity against human MDA-MB-468 cells in presence of 10 uM chloroquine by SRB assay relative to control |
CHEMBL1139398 |
| MDA-MB-468 |
GI50 |
= |
10290.0 |
nM |
Cytotoxicity against human MDA-MB-468 cells in presence of 20 uM chloroquine by SRB assay |
CHEMBL1139398 |
| MDA-MB-468 |
Activity |
= |
24.0 |
% |
Cytotoxicity against human MDA-MB-468 cells in presence of 20 uM chloroquine by SRB assay relative to control |
CHEMBL1139398 |
| MDA-MB-231 |
GI50 |
= |
50150.0 |
nM |
Cytotoxicity against human MDA-MB-231 cells by SRB assay |
CHEMBL1139398 |
| MDA-MB-231 |
GI50 |
= |
37000.0 |
nM |
Cytotoxicity against human MDA-MB-231 cells in presence of 10 uM chloroquine by SRB assay |
CHEMBL1139398 |
| MDA-MB-231 |
Activity |
= |
74.0 |
% |
Cytotoxicity against human MDA-MB-231 cells in presence of 10 uM chloroquine by SRB assay relative to control |
CHEMBL1139398 |
| MDA-MB-231 |
GI50 |
= |
690.0 |
nM |
Cytotoxicity against human MDA-MB-231 cells in presence of 20 uM chloroquine by SRB assay |
CHEMBL1139398 |
| MDA-MB-231 |
Activity |
= |
1.0 |
% |
Cytotoxicity against human MDA-MB-231 cells in presence of 20 uM chloroquine by SRB assay relative to control |
CHEMBL1139398 |
| MCF7 |
GI50 |
= |
3640.0 |
nM |
Cytotoxicity against human MCF7 cells by SRB assay |
CHEMBL1139398 |
| MCF7 |
GI50 |
= |
560.0 |
nM |
Cytotoxicity against human MCF7 cells in presence of 10 uM chloroquine by SRB assay |
CHEMBL1139398 |
| MCF7 |
Activity |
= |
25.0 |
% |
Cytotoxicity against human MCF7 cells in presence of 10 uM chloroquine by SRB assay relative to control |
CHEMBL1139398 |
| MCF7 |
GI50 |
= |
50.0 |
nM |
Cytotoxicity against human MCF7 cells in presence of 20 uM chloroquine by SRB assay |
CHEMBL1139398 |
| Monoamine oxidase A |
Activity |
|
|
|
Inhibition of mouse brain MAOA |
CHEMBL1152129 |
| Monoamine oxidase B |
Activity |
|
|
|
Inhibition of mouse brain MAOB |
CHEMBL1152129 |
| Nucleic Acid |
Kd |
= |
118000.0 |
nM |
Binding affinity to unlabeled 14mer stem loop 3 HIV1 RNA of packaging element psi by titration method |
CHEMBL1154238 |
| Nucleic Acid |
Activity |
|
|
|
Binding affinity to fluorescein-labeled 20mer stem loop 3 HIV1 RNA of packaging element psi by titration method |
CHEMBL1154238 |
| Ferritin light chain |
Potency |
= |
31622.8 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] |
CHEMBL1201862 |
| Human immunodeficiency virus 1 |
IC50 |
= |
300.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 ROJO infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
50.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 SLKA infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
90.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 TEKI infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
10.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 WEJO infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
80.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 MDR 769 infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
2.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 subtype A RW/92/016 infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
10.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 subtype B 302056 infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
20.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 subtype C BR/92/025 infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
50.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 subtype D UG/92/046 infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
90.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 subtype E CMU02 infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
50.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 subtype F BR/93/020 infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
30.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 subtype G JV 1083 infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
> |
10000.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 subtype O BCF01 infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
1740.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 subtype O BCF02 infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
200.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 subtype O BCF03 infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 2 |
IC50 |
= |
6.0 |
nM |
Antiviral activity against Human immunodeficiency virus 2 CDC 310319 infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 2 |
IC50 |
= |
20.0 |
nM |
Antiviral activity against Human immunodeficiency virus 2 CDC 310342 infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Simian immunodeficiency virus |
IC50 |
= |
60.0 |
nM |
Antiviral activity against simian immunodeficiency virus Mac251 infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Simian immunodeficiency virus |
IC50 |
= |
40.0 |
nM |
Antiviral activity against simian immunodeficiency virus 69R infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| PBMC |
Activity |
|
|
|
Cytotoxicity against human PBMC assessed as cell viability at 10 uM by MTS assay |
CHEMBL1671682 |
| PBMC |
Activity |
|
|
|
Cytotoxicity against human PBMC assessed as cell viability at 1 uM by MTS assay |
CHEMBL1671682 |
| PBMC |
TC50 |
> |
31.0 |
uM |
Cytotoxicity against human PBMC by MTS assay |
CHEMBL1671682 |
| CEM-SS |
CC50 |
= |
85800.0 |
nM |
Cytotoxicity against human CEM-SS cells by MTS assay |
CHEMBL1671682 |
| CEM-SS |
IC50 |
> |
3130.0 |
nM |
Cytotoxicity against human CEM-SS cells by MTS assay |
CHEMBL1671682 |
| CEM-SS |
CC50 |
= |
88500.0 |
nM |
Cytotoxicity against human CEM-SS cells infected with Human immunodeficiency virus 1 SK1 by MTS assay |
CHEMBL1671682 |
| CEM-SS |
CC50 |
= |
77300.0 |
nM |
Cytotoxicity against human CEM-SS cells infected with Human immunodeficiency virus 2 ROD by MTS assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
130.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 SK1 infected in human CEM-SS cells assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus type 2 (ISOLATE ROD) |
IC50 |
= |
1400.0 |
nM |
Antiviral activity against Human immunodeficiency virus 2 ROD infected in human CEM-SS cells assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| H9 |
CC50 |
= |
19600.0 |
nM |
Cytotoxicity against human H9 cells by MTS assay |
CHEMBL1671682 |
| H9 |
IC50 |
= |
16300.0 |
nM |
Cytotoxicity against human H9 cells by MTS assay |
CHEMBL1671682 |
| H9 |
CC50 |
|
|
|
Cytotoxicity against human H9 cells infected with Human immunodeficiency virus 1 SK1 by MTS assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
36.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 SK1 infected in human H9 cells assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| U1 |
CC50 |
= |
280.0 |
nM |
Cytotoxicity against human U1 cells infected with latent Human immunodeficiency virus 1 by MTS assay |
CHEMBL1671682 |
| U1 |
CC50 |
= |
280.0 |
nM |
Cytotoxicity against human U1 cells infected with latent Human immunodeficiency virus 1 by MTS assay in presence of tumor necrosis factor alpha |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
230.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 infected in human U1 cells assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| ADMET |
CC50 |
= |
10.0 |
nM |
Cytotoxicity against human ACH2 cells infected with latent Human immunodeficiency virus 1 by MTS assay |
CHEMBL1671682 |
| ADMET |
CC50 |
= |
10.0 |
nM |
Cytotoxicity against human ACH2 cells infected with latent Human immunodeficiency virus 1 by MTS assay in presence of tumor necrosis factor alpha |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
150.0 |
nM |
Antiviral activity against 5 x 10'3 cells/well Human immunodeficiency virus 1 infected in human ACH2 cells assessed as inhibition of viral Reverse transcriptase after 3 days by [3H]TTP incorporation assay in presence of 5 ng/ml tumor necrosis factor alpha |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
6.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 ADA infected in human MDM cells assessed as expression of p24 antigen after 6 days postinfection by ELISA |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
18.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 BAL infected in human MDM cells assessed as expression of p24 antigen after 6 days postinfection by ELISA |
CHEMBL1671682 |
| ADMET |
TC50 |
> |
0.66 |
uM |
Cytotoxicity against human MDM cells infected with Human immunodeficiency virus 1 ADA by MTS assay |
CHEMBL1671682 |
| ADMET |
TC50 |
= |
0.66 |
uM |
Cytotoxicity against human MDM cells infected with Human immunodeficiency virus 1 BAL by MTS assay |
CHEMBL1671682 |
| ADMET |
TI |
> |
95.0 |
|
Therapeutic index, ratio of TC50 for human PBMC cells to IC50 for Human immunodeficiency virus 1 ROJO |
CHEMBL1671682 |
| ADMET |
TI |
> |
95.0 |
|
Therapeutic index, ratio of TC50 for human PBMC cells to IC50 for Human immunodeficiency virus 1 SLKA |
CHEMBL1671682 |
| ADMET |
TI |
> |
95.0 |
|
Therapeutic index, ratio of TC50 for human PBMC cells to IC50 for Human immunodeficiency virus 1 TEKI |
CHEMBL1671682 |
| ADMET |
TI |
> |
95.0 |
|
Therapeutic index, ratio of TC50 for human PBMC cells to IC50 for Human immunodeficiency virus 1 WEJO |
CHEMBL1671682 |
| ADMET |
TI |
> |
95.0 |
|
Therapeutic index, ratio of TC50 for human PBMC cells to IC50 for Human immunodeficiency virus 1 MDR 769 |
CHEMBL1671682 |
| ADMET |
TI |
> |
95.0 |
|
Therapeutic index, ratio of TC50 for human PBMC cells to IC50 for Human immunodeficiency virus 1 RW/92/016 |
CHEMBL1671682 |
| ADMET |
TI |
> |
95.0 |
|
Therapeutic index, ratio of TC50 for human PBMC cells to IC50 for Human immunodeficiency virus 1 302056 |
CHEMBL1671682 |
| ADMET |
TI |
> |
95.0 |
|
Therapeutic index, ratio of TC50 for human PBMC cells to IC50 for Human immunodeficiency virus 1 BR/92/025 |
CHEMBL1671682 |
| ADMET |
TI |
> |
95.0 |
|
Therapeutic index, ratio of TC50 for human PBMC cells to IC50 for Human immunodeficiency virus 1 UG/92/046 |
CHEMBL1671682 |
| ADMET |
TI |
> |
95.0 |
|
Therapeutic index, ratio of TC50 for human PBMC cells to IC50 for Human immunodeficiency virus 1 CMU02 |
CHEMBL1671682 |
| ADMET |
TI |
> |
95.0 |
|
Therapeutic index, ratio of TC50 for human PBMC cells to IC50 for Human immunodeficiency virus 1 BR/93/020 |
CHEMBL1671682 |
| ADMET |
TI |
> |
95.0 |
|
Therapeutic index, ratio of TC50 for human PBMC cells to IC50 for Human immunodeficiency virus 1 JV 1083 |
CHEMBL1671682 |
| ADMET |
TI |
> |
95.0 |
|
Therapeutic index, ratio of TC50 for human PBMC cells to IC50 for Human immunodeficiency virus 1 BCF01 |
CHEMBL1671682 |
| ADMET |
TI |
> |
95.0 |
|
Therapeutic index, ratio of TC50 for human PBMC cells to IC50 for Human immunodeficiency virus 1 BCF02 |
CHEMBL1671682 |
| ADMET |
TI |
> |
95.0 |
|
Therapeutic index, ratio of TC50 for human PBMC cells to IC50 for Human immunodeficiency virus 1 BCF03 |
CHEMBL1671682 |
| ADMET |
TI |
> |
95.0 |
|
Therapeutic index, ratio of TC50 for human PBMC cells to IC50 for Human immunodeficiency virus 2 CDC 310319 |
CHEMBL1671682 |
| ADMET |
TI |
> |
95.0 |
|
Therapeutic index, ratio of TC50 for human PBMC cells to IC50 for Human immunodeficiency virus 2 CDC 310342 |
CHEMBL1671682 |
| ADMET |
TI |
> |
95.0 |
|
Therapeutic index, ratio of TC50 for human PBMC cells to IC50 for Simian immunodeficiency virus Mac251 |
CHEMBL1671682 |
| ADMET |
TI |
> |
95.0 |
|
Therapeutic index, ratio of TC50 for human PBMC cells to IC50 for Simian immunodeficiency virus 69R |
CHEMBL1671682 |
| ADMET |
TI |
> |
16.0 |
|
Therapeutic index, ratio of TC50 for human MDM cells to IC50 for Human immunodeficiency virus 1 ADA |
CHEMBL1671682 |
| ADMET |
TI |
> |
16.0 |
|
Therapeutic index, ratio of TC50 for human MDM cells to IC50 for Human immunodeficiency virus 1 BAL |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
40.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 3B expressing nef protein infecting in CEM-SS cells assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
330.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 D1 harboring Tyr127His mutation in nef protein infecting in CEM-SS cells assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
500.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 A7 harboring Tyr127His mutation in nef protein infecting in CEM-SS cells assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
> |
30000.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 A12 harboring Tyr127His, Asp174Asn and Arg178Lys mutations in nef protein infecting in CEM-SS cells assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
> |
30000.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 H10 harboring Tyr127His, Gly140Glu, Glu149Lys, Asp174Asn and Arg178Lys mutations in nef protein infecting in CEM-SS cells assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
200.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 harboring plasmid NL4-3 infected in CEM-SS cells assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
> |
10000.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 harboring plasmid TAK-1 infected in CEM-SS cells assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
> |
10000.0 |
nM |
Ratio of IC50 for Human immunodeficiency virus 1 H10 infected in CEM-SS cells to IC50 for Human immunodeficiency virus 1 3B infected in CEM-SS cells |
CHEMBL1671682 |
| ADMET |
IC50 |
> |
53100.0 |
nM |
Cytotoxicity against human AA5 cells by MTS assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
< |
170.0 |
nM |
Antiviral activity against of Human immunodeficiency virus 1 3B infected in AA5 cells infected with 3.13 uL of virus stock assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
> |
53100.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 3B infected in AA5 cells infected with 3.13 uL of virus stock assessed as expression of p24 antigen after 6 days postinfection by ELISA |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
300.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 3B infected in human CEM-SS cells infected with 3.13 uL of virus stock assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
240.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 3B infected in human CEM-SS cells infected with 3.13 uL of virus stock assessed as expression of p24 antigen after 6 days postinfection by ELISA |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
1530.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 3B infected in human H9 cells infected with 50 uL of virus stock assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
> |
31300.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 3B infected in human H9 cells infected with 50 uL of virus stock assessed as expression of p24 antigen after 6 days postinfection by ELISA |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
< |
170.0 |
nM |
Antiviral activity against of Human immunodeficiency virus 1 3B infected in AA5 cells infected with 1.56 uL of virus stock assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
< |
170.0 |
nM |
Antiviral activity against of Human immunodeficiency virus 1 3B infected in AA5 cells infected with 0.78 uL of virus stock assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
> |
53100.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 3B infected in AA5 cells infected with 1.56 uL of virus stock assessed as expression of p24 antigen after 6 days postinfection by ELISA |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
> |
53100.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 3B infected in AA5 cells infected with 0.78 uL of virus stock assessed as expression of p24 antigen after 6 days postinfection by ELISA |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
290.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 3B infected in human CEM-SS cells infected with 1.56 uL of virus stock assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
80.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 3B infected in human CEM-SS cells infected with 0.78 uL of virus stock assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
= |
190.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 3B infected in human CEM-SS cells infected with 1.56 uL of virus stock assessed as expression of p24 antigen after 6 days postinfection by ELISA |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
< |
10.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 3B infected in human CEM-SS cells infected with 0.78 uL of virus stock assessed as expression of p24 antigen after 6 days postinfection by ELISA |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
< |
100.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 3B infected in human H9 cells infected with 25 uL of virus stock assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
< |
100.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 3B infected in human H9 cells infected with 12.5 uL of virus stock assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
< |
100.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 3B infected in human H9 cells infected with 6.25 uL of virus stock assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
> |
31300.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 3B infected in human H9 cells infected with 25 uL of virus stock assessed as expression of p24 antigen after 6 days postinfection by ELISA |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
< |
100.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 3B infected in human H9 cells infected with 12.5 uL of virus stock assessed as expression of p24 antigen after 6 days postinfection by ELISA |
CHEMBL1671682 |
| Human immunodeficiency virus 1 |
IC50 |
< |
100.0 |
nM |
Antiviral activity against Human immunodeficiency virus 1 3B infected in human H9 cells infected with 6.25 uL of virus stock assessed as expression of p24 antigen after 6 days postinfection by ELISA |
CHEMBL1671682 |
| Serine/threonine-protein kinase MARK1 |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of MARK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase SRPK3 |
Residual Activity |
= |
98.0 |
% |
Millipore: Percentage of residual kinase activity of SRPK3 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase SRPK3 |
Residual Activity |
= |
83.0 |
% |
Millipore: Percentage of residual kinase activity of SRPK3 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase NEK7 |
Residual Activity |
= |
108.0 |
% |
Millipore: Percentage of residual kinase activity of NEK7 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase NEK7 |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of NEK7 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase ABL2 |
Residual Activity |
= |
98.0 |
% |
Millipore: Percentage of residual kinase activity of ABL2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Aurora-A |
Residual Activity |
= |
77.0 |
% |
Millipore: Percentage of residual kinase activity of AURKA at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl, 0.1% v/v Triton-X-100 |
CHEMBL2218924 |
| Cyclin-dependent kinase 2/cyclin A |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of CDK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Cyclin-dependent kinase 2/cyclin E |
Residual Activity |
= |
109.0 |
% |
Millipore: Percentage of residual kinase activity of CDK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase I delta |
Residual Activity |
= |
92.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK1D at 1uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Death-associated protein kinase 1 |
Residual Activity |
= |
84.0 |
% |
Millipore: Percentage of residual kinase activity of DAPK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-A receptor 5 |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 2.5 mM MnCl2 |
CHEMBL2218924 |
| Fibroblast growth factor receptor 3 |
Residual Activity |
= |
107.0 |
% |
Millipore: Percentage of residual kinase activity of FGFR3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Fibroblast growth factor receptor 4 |
Residual Activity |
= |
114.0 |
% |
Millipore: Percentage of residual kinase activity of FGFR4 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Tyrosine-protein kinase FYN |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of FYN at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4 |
CHEMBL2218924 |
| Tyrosine-protein kinase HCK |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of HCK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Inhibitor of nuclear factor kappa B kinase alpha subunit |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of CHUK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Inhibitor of nuclear factor kappa B kinase beta subunit |
Residual Activity |
= |
111.0 |
% |
Millipore: Percentage of residual kinase activity of IKBKB at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| c-Jun N-terminal kinase 3 |
Residual Activity |
= |
71.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK10 at 10uM relative to control. Control inhibitor: JAK Inhibitor I at 30.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Dual specificity mitogen-activated protein kinase kinase 1 |
Residual Activity |
= |
121.0 |
% |
Millipore: Percentage of residual kinase activity of MAP2K1 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 50 mM Tris pH 7.5, 0.2 mM EGTA, 0.1% ?-mercaptoethanol, 0.01% Brij-35 |
CHEMBL2218924 |
| Dual specificity mitogen-activated protein kinase kinase 1 |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of MAP2K1 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 50 mM Tris pH 7.5, 0.2 mM EGTA, 0.1% ?-mercaptoethanol, 0.01% Brij-35 |
CHEMBL2218924 |
| Serine/threonine-protein kinase MST1 |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of STK4 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine protein kinase NLK |
Residual Activity |
= |
109.0 |
% |
Millipore: Percentage of residual kinase activity of NLK at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Aurora-A |
Residual Activity |
= |
84.0 |
% |
Millipore: Percentage of residual kinase activity of AURKA at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl, 0.1% v/v Triton-X-100 |
CHEMBL2218924 |
| Cyclin-dependent kinase 2/cyclin E |
Residual Activity |
= |
84.0 |
% |
Millipore: Percentage of residual kinase activity of CDK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase I delta |
Residual Activity |
= |
84.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK1D at 10uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase II |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK2A1 at 1uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 20 mM HEPES pH 7.6, 0.15 M NaCl, 0.1 mM EDTA, 5 mM DTT, 0.1% Triton X-100 |
CHEMBL2218924 |
| Death-associated protein kinase 1 |
Residual Activity |
= |
81.0 |
% |
Millipore: Percentage of residual kinase activity of DAPK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Death-associated protein kinase 2 |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of DAPK2 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-A receptor 5 |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 2.5 mM MnCl2 |
CHEMBL2218924 |
| Ephrin type-A receptor 7 |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA7 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Fibroblast growth factor receptor 4 |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of FGFR4 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Mitogen-activated protein kinase kinase kinase kinase 2 |
Residual Activity |
= |
98.0 |
% |
Millipore: Percentage of residual kinase activity of GCK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 200 mM NaCl, 0.2 mM EDTA |
CHEMBL2218924 |
| Mitogen-activated protein kinase kinase kinase kinase 2 |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of GCK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 200 mM NaCl, 0.2 mM EDTA |
CHEMBL2218924 |
| Insulin-like growth factor I receptor |
Residual Activity |
= |
81.0 |
% |
Millipore: Percentage of residual kinase activity of IGF1R at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Insulin-like growth factor I receptor |
Residual Activity |
= |
94.0 |
% |
Millipore: Percentage of residual kinase activity of IGF1R at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Inhibitor of nuclear factor kappa B kinase beta subunit |
Residual Activity |
= |
93.0 |
% |
Millipore: Percentage of residual kinase activity of IKBKB at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Vascular endothelial growth factor receptor 2 |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of KDR at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Vascular endothelial growth factor receptor 2 |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of KDR at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Maternal embryonic leucine zipper kinase |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of MELK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase MST1 |
Residual Activity |
= |
109.0 |
% |
Millipore: Percentage of residual kinase activity of STK4 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase MST2 |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of STK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine protein kinase NLK |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of NLK at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PAK 2 |
Residual Activity |
= |
111.0 |
% |
Millipore: Percentage of residual kinase activity of PAK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Aurora-B |
Residual Activity |
= |
112.0 |
% |
Millipore: Percentage of residual kinase activity of AURKB at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl, 0.1% v/v Triton-X-100 |
CHEMBL2218924 |
| Serine/threonine-protein kinase Aurora-B |
Residual Activity |
= |
106.0 |
% |
Millipore: Percentage of residual kinase activity of AURKB at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl, 0.1% v/v Triton-X-100 |
CHEMBL2218924 |
| CDK3/cyclin E |
Residual Activity |
= |
106.0 |
% |
Millipore: Percentage of residual kinase activity of CDK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| CDK3/cyclin E |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of CDK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase II |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK2A1 at 10uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 20 mM HEPES pH 7.6, 0.15 M NaCl, 0.1 mM EDTA, 5 mM DTT, 0.1% Triton X-100 |
CHEMBL2218924 |
| Death-associated protein kinase 2 |
Residual Activity |
= |
106.0 |
% |
Millipore: Percentage of residual kinase activity of DAPK2 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-A receptor 7 |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA7 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase FER |
Residual Activity |
= |
118.0 |
% |
Millipore: Percentage of residual kinase activity of FER at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM MnCl2 |
CHEMBL2218924 |
| Tyrosine-protein kinase FER |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of FER at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM MnCl2 |
CHEMBL2218924 |
| G protein-coupled receptor kinase 5 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of GRK5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Insulin-like growth factor I receptor |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of IGF1R at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM Na3VO4, 5 mM Na-?-glycerophosphate |
CHEMBL2218924 |
| Insulin receptor |
Residual Activity |
= |
110.0 |
% |
Millipore: Percentage of residual kinase activity of INSR at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| LIM domain kinase 1 |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of LIMK1 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Maternal embryonic leucine zipper kinase |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of MELK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Misshapen-like kinase 1 |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of MINK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase MST2 |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of STK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PAK 2 |
Residual Activity |
= |
111.0 |
% |
Millipore: Percentage of residual kinase activity of PAK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Aurora-C |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of AURKC at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl, 0.1% v/v Triton-X-100 |
CHEMBL2218924 |
| Cyclin-dependent kinase 5/CDK5 activator 1 |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of CDK5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase II alpha (prime) |
Residual Activity |
= |
110.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK2A2 at 1uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 20 mM HEPES pH 7.6, 0.15 M NaCl, 0.1 mM EDTA, 5 mM DTT, 0.1% Triton X-100 |
CHEMBL2218924 |
| Casein kinase II alpha (prime) |
Residual Activity |
= |
94.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK2A2 at 10uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 20 mM HEPES pH 7.6, 0.15 M NaCl, 0.1 mM EDTA, 5 mM DTT, 0.1% Triton X-100 |
CHEMBL2218924 |
| Serine/threonine-protein kinase DCLK2 |
Residual Activity |
= |
75.0 |
% |
Millipore: Percentage of residual kinase activity of DCLK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase DCLK2 |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of DCLK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-A receptor 8 |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA8 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-A receptor 8 |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA8 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| G protein-coupled receptor kinase 5 |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of GRK5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| G protein-coupled receptor kinase 6 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of GRK6 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Insulin receptor |
Residual Activity |
= |
107.0 |
% |
Millipore: Percentage of residual kinase activity of INSR at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Insulin receptor |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of INSR at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM Na3VO4, 5 mM Na-?-glycerophosphate |
CHEMBL2218924 |
| LIM domain kinase 1 |
Residual Activity |
= |
94.0 |
% |
Millipore: Percentage of residual kinase activity of LIMK1 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase 11 |
Residual Activity |
= |
98.0 |
% |
Millipore: Percentage of residual kinase activity of STK11 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.1% v/v Triton X-100 |
CHEMBL2218924 |
| Misshapen-like kinase 1 |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of MINK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase 24 |
Residual Activity |
= |
83.0 |
% |
Millipore: Percentage of residual kinase activity of STK24 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase 24 |
Residual Activity |
= |
81.0 |
% |
Millipore: Percentage of residual kinase activity of STK24 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PAK 3 |
Residual Activity |
= |
79.0 |
% |
Millipore: Percentage of residual kinase activity of PAK3 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PAK 3 |
Residual Activity |
= |
110.0 |
% |
Millipore: Percentage of residual kinase activity of PAK3 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Aurora-C |
Residual Activity |
= |
74.0 |
% |
Millipore: Percentage of residual kinase activity of AURKC at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl, 0.1% v/v Triton-X-100 |
CHEMBL2218924 |
| Tyrosine-protein kinase receptor UFO |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of AXL at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Cyclin-dependent kinase 5/CDK5 activator 1 |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of CDK5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Cyclin-dependent kinase 5/CDK5 activator 1 |
Residual Activity |
= |
110.0 |
% |
Millipore: Percentage of residual kinase activity of CDK5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Dual specificity protein kinase CLK2 |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of CLK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Discoidin domain-containing receptor 2 |
Residual Activity |
= |
109.0 |
% |
Millipore: Percentage of residual kinase activity of DDR2 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Ephrin type-B receptor 1 |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of EPHB1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| G protein-coupled receptor kinase 6 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of GRK6 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Insulin receptor |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of INSR at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM Na3VO4, 5 mM Na-?-glycerophosphate |
CHEMBL2218924 |
| Serine/threonine-protein kinase 11 |
Residual Activity |
= |
98.0 |
% |
Millipore: Percentage of residual kinase activity of STK11 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.1% v/v Triton X-100 |
CHEMBL2218924 |
| Dual specificity mitogen-activated protein kinase kinase 6 |
Residual Activity |
= |
108.0 |
% |
Millipore: Percentage of residual kinase activity of MAP2K6 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol, 0.1 mM Na3VO4, 1 mg/mL BSA |
CHEMBL2218924 |
| Proto-oncogene tyrosine-protein kinase MER |
Residual Activity |
= |
119.0 |
% |
Millipore: Percentage of residual kinase activity of MERTK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: mM MOPS pH 7.0, 0.2 mM EDTA, 30 mM NaCl |
CHEMBL2218924 |
| Tyrosine kinase non-receptor protein 2 |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of TNK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine kinase non-receptor protein 2 |
Residual Activity |
= |
80.0 |
% |
Millipore: Percentage of residual kinase activity of TNK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase receptor UFO |
Residual Activity |
= |
80.0 |
% |
Millipore: Percentage of residual kinase activity of AXL at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Cyclin-dependent kinase 5/CDK5 activator 1 |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of CDK5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Dual specificity protein kinase CLK2 |
Residual Activity |
= |
69.0 |
% |
Millipore: Percentage of residual kinase activity of CLK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Dual specificity protein kinase CLK3 |
Residual Activity |
= |
98.0 |
% |
Millipore: Percentage of residual kinase activity of CLK3 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Discoidin domain-containing receptor 2 |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of DDR2 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Myotonin-protein kinase |
Residual Activity |
= |
136.0 |
% |
Millipore: Percentage of residual kinase activity of DMPK at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-B receptor 1 |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of EPHB1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-B receptor 2 |
Residual Activity |
= |
112.0 |
% |
Millipore: Percentage of residual kinase activity of EPHB2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| G protein-coupled receptor kinase 7 |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of GRK7 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| G protein-coupled receptor kinase 7 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of GRK7 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Interleukin-1 receptor-associated kinase 1 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of IRAK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Interleukin-1 receptor-associated kinase 1 |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of IRAK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase 10 |
Residual Activity |
= |
111.0 |
% |
Millipore: Percentage of residual kinase activity of STK10 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase 10 |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of STK10 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Dual specificity mitogen-activated protein kinase kinase 6 |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of MAP2K6 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol, 0.1 mM Na3VO4, 1 mg/mL BSA |
CHEMBL2218924 |
| Dual specificity mitogen-activated protein kinase kinase 7 |
Residual Activity |
= |
122.0 |
% |
Millipore: Percentage of residual kinase activity of MAP2K7 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol, 0.1 mM Na3VO4 |
CHEMBL2218924 |
| Proto-oncogene tyrosine-protein kinase MER |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of MERTK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: mM MOPS pH 7.0, 0.2 mM EDTA, 30 mM NaCl |
CHEMBL2218924 |
| Hepatocyte growth factor receptor |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of MET at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| ALK tyrosine kinase receptor |
Residual Activity |
= |
89.0 |
% |
Millipore: Percentage of residual kinase activity of ALK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase BRK |
Residual Activity |
= |
109.0 |
% |
Millipore: Percentage of residual kinase activity of PTK6 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 5 mM MnCl2 |
CHEMBL2218924 |
| Tyrosine-protein kinase BRK |
Residual Activity |
= |
107.0 |
% |
Millipore: Percentage of residual kinase activity of PTK6 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 5 mM MnCl2 |
CHEMBL2218924 |
| CDK6/cyclin D3 |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of CDK6 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| CDK6/cyclin D3 |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of CDK6 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Dual specificity protein kinase CLK3 |
Residual Activity |
= |
116.0 |
% |
Millipore: Percentage of residual kinase activity of CLK3 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Myotonin-protein kinase |
Residual Activity |
= |
135.0 |
% |
Millipore: Percentage of residual kinase activity of DMPK at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-B receptor 2 |
Residual Activity |
= |
106.0 |
% |
Millipore: Percentage of residual kinase activity of EPHB2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Glycogen synthase kinase-3 alpha |
Residual Activity |
= |
116.0 |
% |
Millipore: Percentage of residual kinase activity of GSK3A at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Interleukin-1 receptor-associated kinase 4 |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of IRAK4 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase LCK |
Residual Activity |
= |
117.0 |
% |
Millipore: Percentage of residual kinase activity of LCK at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4 |
CHEMBL2218924 |
| Dual specificity mitogen-activated protein kinase kinase 7 |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of MAP2K7 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol, 0.1 mM Na3VO4 |
CHEMBL2218924 |
| Hepatocyte growth factor receptor |
Residual Activity |
= |
108.0 |
% |
Millipore: Percentage of residual kinase activity of MET at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| ALK tyrosine kinase receptor |
Residual Activity |
= |
134.0 |
% |
Millipore: Percentage of residual kinase activity of ALK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Activin receptor type-1B |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of ACVR1B at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase BTK |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of BTK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Cyclin-dependent kinase 7/ cyclin H |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of CDK7 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase CSK |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of CSK at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol, 10 mM MnCl2 |
CHEMBL2218924 |
| Tyrosine-protein kinase CSK |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of CSK at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol, 10 mM MnCl2 |
CHEMBL2218924 |
| Serine/threonine-protein kinase 17A |
Residual Activity |
= |
147.0 |
% |
Millipore: Percentage of residual kinase activity of STK17A at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase 17A |
Residual Activity |
= |
109.0 |
% |
Millipore: Percentage of residual kinase activity of STK17A at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-B receptor 3 |
Residual Activity |
= |
112.0 |
% |
Millipore: Percentage of residual kinase activity of EPHB3 at 1uM relative to control. Control inhibitor: PP2 at 30.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Tyrosine-protein kinase FES |
Residual Activity |
= |
124.0 |
% |
Millipore: Percentage of residual kinase activity of FES at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Glycogen synthase kinase-3 alpha |
Residual Activity |
= |
136.0 |
% |
Millipore: Percentage of residual kinase activity of GSK3A at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Glycogen synthase kinase-3 beta |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of GSK3B at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Interleukin-1 receptor-associated kinase 4 |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of IRAK4 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Insulin receptor-related protein |
Residual Activity |
= |
119.0 |
% |
Millipore: Percentage of residual kinase activity of INSRR at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase LCK |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of LCK at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4 |
CHEMBL2218924 |
| Tyrosine-protein kinase LCK |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of LCK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Myosin light chain kinase, smooth muscle |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of MYLK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| Myosin light chain kinase, smooth muscle |
Residual Activity |
= |
98.0 |
% |
Millipore: Percentage of residual kinase activity of MYLK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| MAP kinase signal-integrating kinase 2 |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of MKNK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| MAP kinase signal-integrating kinase 2 |
Residual Activity |
= |
94.0 |
% |
Millipore: Percentage of residual kinase activity of MKNK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Activin receptor type-1B |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of ACVR1B at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase BTK |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of BTK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase BLK |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of BLK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Cyclin-dependent kinase 7/ cyclin H |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of CDK7 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| CDK9/cyclin T1 |
Residual Activity |
= |
111.0 |
% |
Millipore: Percentage of residual kinase activity of CDK9 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| CaM kinase I alpha |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| Dual-specificity tyrosine-phosphorylation regulated kinase 2 |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of DYRK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-B receptor 3 |
Residual Activity |
= |
121.0 |
% |
Millipore: Percentage of residual kinase activity of EPHB3 at 10uM relative to control. Control inhibitor: PP2 at 30.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Ephrin type-B receptor 4 |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of EPHB4 at 1uM relative to control. Control inhibitor: PP2 at 30.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Tyrosine-protein kinase FES |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of FES at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Glycogen synthase kinase-3 beta |
Residual Activity |
= |
80.0 |
% |
Millipore: Percentage of residual kinase activity of GSK3B at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Insulin receptor-related protein |
Residual Activity |
= |
106.0 |
% |
Millipore: Percentage of residual kinase activity of INSRR at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase LCK |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of LCK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Mitogen-activated protein kinase kinase kinase 9 |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of MAP3K9 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Muscle, skeletal receptor tyrosine protein kinase |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of MUSK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 5 mM MnCl2 |
CHEMBL2218924 |
| AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of PRKAA1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP |
CHEMBL2218924 |
| AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 |
Residual Activity |
= |
75.0 |
% |
Millipore: Percentage of residual kinase activity of PRKAA1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP |
CHEMBL2218924 |
| Tyrosine-protein kinase BLK |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of BLK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| CDK9/cyclin T1 |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of CDK9 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| CaM kinase I alpha |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| CaM kinase II beta |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK2B at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| Dual-specificity tyrosine-phosphorylation regulated kinase 2 |
Residual Activity |
= |
71.0 |
% |
Millipore: Percentage of residual kinase activity of DYRK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Epidermal growth factor receptor erbB1 |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of EGFR at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Ephrin type-B receptor 4 |
Residual Activity |
= |
120.0 |
% |
Millipore: Percentage of residual kinase activity of EPHB4 at 10uM relative to control. Control inhibitor: PP2 at 30.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Tyrosine-protein kinase FGR |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of FGR at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase FGR |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of FGR at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Homeodomain-interacting protein kinase 1 |
Residual Activity |
= |
107.0 |
% |
Millipore: Percentage of residual kinase activity of HIPK1 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Homeodomain-interacting protein kinase 1 |
Residual Activity |
= |
111.0 |
% |
Millipore: Percentage of residual kinase activity of HIPK1 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase ITK/TSK |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of ITK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase ITK/TSK |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of ITK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase Lyn |
Residual Activity |
= |
77.0 |
% |
Millipore: Percentage of residual kinase activity of LYN at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Tyrosine-protein kinase Lyn |
Residual Activity |
= |
69.0 |
% |
Millipore: Percentage of residual kinase activity of LYN at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Mitogen-activated protein kinase kinase kinase 9 |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of MAP3K9 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase MRCK-A |
Residual Activity |
= |
86.0 |
% |
Millipore: Percentage of residual kinase activity of CDC42BPA at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Muscle, skeletal receptor tyrosine protein kinase |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of MUSK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 5 mM MnCl2 |
CHEMBL2218924 |
| Serine/threonine-protein kinase Nek11 |
Residual Activity |
= |
78.0 |
% |
Millipore: Percentage of residual kinase activity of NEK11 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| AMP-activated protein kinase, AMPK |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of PRKAA2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP |
CHEMBL2218924 |
| AMP-activated protein kinase, AMPK |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of PRKAA2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP |
CHEMBL2218924 |
| Tyrosine-protein kinase BMX |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of BMX at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase BMX |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of BMX at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Chk1 |
Residual Activity |
= |
98.0 |
% |
Millipore: Percentage of residual kinase activity of CHEK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Chk1 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of CHEK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| CaM kinase II beta |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK2B at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| Epidermal growth factor receptor erbB1 |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of EGFR at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Receptor protein-tyrosine kinase erbB-4 |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of ERBB4 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 2.5 mM MnCl2 |
CHEMBL2218924 |
| Receptor protein-tyrosine kinase erbB-4 |
Residual Activity |
= |
74.0 |
% |
Millipore: Percentage of residual kinase activity of ERBB4 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 2.5 mM MnCl2 |
CHEMBL2218924 |
| Vascular endothelial growth factor receptor 1 |
Residual Activity |
= |
119.0 |
% |
Millipore: Percentage of residual kinase activity of FLT1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Homeodomain-interacting protein kinase 2 |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of HIPK2 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase JAK2 |
Residual Activity |
= |
111.0 |
% |
Millipore: Percentage of residual kinase activity of JAK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| MAP kinase ERK1 |
Residual Activity |
= |
109.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK3 at 1uM relative to control. Control inhibitor: ERK Inhibitor II at 30.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase MRCK-A |
Residual Activity |
= |
93.0 |
% |
Millipore: Percentage of residual kinase activity of CDC42BPA at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Nek11 |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of NEK11 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| NUAK family SNF1-like kinase 1 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of NUAK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| BR serine/threonine-protein kinase 1 |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of BRSK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Chk2 |
Residual Activity |
= |
92.0 |
% |
Millipore: Percentage of residual kinase activity of CHEK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Chk2 |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of CHEK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| CaM kinase II gamma |
Residual Activity |
= |
110.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK2G at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| CaM kinase II gamma |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK2G at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| Ephrin type-A receptor 1 |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-A receptor 1 |
Residual Activity |
= |
111.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Focal adhesion kinase 1 |
Residual Activity |
= |
148.0 |
% |
Millipore: Percentage of residual kinase activity of PTK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Vascular endothelial growth factor receptor 1 |
Residual Activity |
= |
94.0 |
% |
Millipore: Percentage of residual kinase activity of FLT1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase receptor FLT3 |
Residual Activity |
= |
82.0 |
% |
Millipore: Percentage of residual kinase activity of FLT3 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Homeodomain-interacting protein kinase 2 |
Residual Activity |
= |
80.0 |
% |
Millipore: Percentage of residual kinase activity of HIPK2 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Homeodomain-interacting protein kinase 3 |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of HIPK3 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase JAK2 |
Residual Activity |
= |
114.0 |
% |
Millipore: Percentage of residual kinase activity of JAK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase JAK3 |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of JAK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| MAP kinase ERK1 |
Residual Activity |
= |
81.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK3 at 10uM relative to control. Control inhibitor: ERK Inhibitor II at 30.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| MAP kinase ERK2 |
Residual Activity |
= |
112.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK1 at 1uM relative to control. Control inhibitor: ERK Inhibitor II at 30.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase MRCK beta |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of CDC42BPB at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase MRCK beta |
Residual Activity |
= |
98.0 |
% |
Millipore: Percentage of residual kinase activity of CDC42BPB at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase NEK2 |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of NEK2 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase NEK2 |
Residual Activity |
= |
112.0 |
% |
Millipore: Percentage of residual kinase activity of NEK2 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| NUAK family SNF1-like kinase 1 |
Residual Activity |
= |
80.0 |
% |
Millipore: Percentage of residual kinase activity of NUAK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Mitogen-activated protein kinase kinase kinase 5 |
Residual Activity |
= |
117.0 |
% |
Millipore: Percentage of residual kinase activity of MAP3K5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| BR serine/threonine-protein kinase 1 |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of BRSK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| BR serine/threonine-protein kinase 2 |
Residual Activity |
= |
119.0 |
% |
Millipore: Percentage of residual kinase activity of BRSK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase I gamma 1 |
Residual Activity |
= |
109.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK1G1 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| CaM kinase II delta |
Residual Activity |
= |
98.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK2D at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| Ephrin type-A receptor 2 |
Residual Activity |
= |
120.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Focal adhesion kinase 1 |
Residual Activity |
= |
112.0 |
% |
Millipore: Percentage of residual kinase activity of PTK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Fibroblast growth factor receptor 1 |
Residual Activity |
= |
111.0 |
% |
Millipore: Percentage of residual kinase activity of FGFR1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase receptor FLT3 |
Residual Activity |
= |
69.0 |
% |
Millipore: Percentage of residual kinase activity of FLT3 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Homeodomain-interacting protein kinase 3 |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of HIPK3 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase JAK3 |
Residual Activity |
= |
113.0 |
% |
Millipore: Percentage of residual kinase activity of JAK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| MAP kinase ERK2 |
Residual Activity |
= |
115.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK1 at 10uM relative to control. Control inhibitor: ERK Inhibitor II at 30.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 5 |
Residual Activity |
= |
122.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Nek3 |
Residual Activity |
= |
121.0 |
% |
Millipore: Percentage of residual kinase activity of NEK3 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Mitogen-activated protein kinase kinase kinase 5 |
Residual Activity |
= |
125.0 |
% |
Millipore: Percentage of residual kinase activity of MAP3K5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| BR serine/threonine-protein kinase 2 |
Residual Activity |
= |
135.0 |
% |
Millipore: Percentage of residual kinase activity of BRSK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase I gamma 1 |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK1G1 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase I gamma 2 |
Residual Activity |
= |
94.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK1G2 at 1uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| CaM kinase II delta |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK2D at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| CaM kinase IV |
Residual Activity |
= |
92.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK4 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 40 mM HEPES pH 7.4, 5 mM CaCl2, 30 ug/mL calmodulin |
CHEMBL2218924 |
| Ephrin type-A receptor 2 |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ephrin type-A receptor 3 |
Residual Activity |
= |
119.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Fibroblast growth factor receptor 1 |
Residual Activity |
= |
94.0 |
% |
Millipore: Percentage of residual kinase activity of FGFR1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Vascular endothelial growth factor receptor 3 |
Residual Activity |
= |
92.0 |
% |
Millipore: Percentage of residual kinase activity of FLT4 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Vascular endothelial growth factor receptor 3 |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of FLT4 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase haspin |
Residual Activity |
= |
61.0 |
% |
Millipore: Percentage of residual kinase activity of GSG2 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase haspin |
Residual Activity |
= |
12.0 |
% |
Millipore: Percentage of residual kinase activity of GSG2 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| c-Jun N-terminal kinase 1 |
Residual Activity |
= |
117.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK8 at 1uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ? -mercaptoethanol |
CHEMBL2218924 |
| c-Jun N-terminal kinase 1 |
Residual Activity |
= |
94.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK8 at 10uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ? -mercaptoethanol |
CHEMBL2218924 |
| MAP kinase-activated protein kinase 2 |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of MAPKAPK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Na-?-glycerophosphate pH 7.5, 0.1 mM EGTA |
CHEMBL2218924 |
| MAP kinase-activated protein kinase 2 |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of MAPKAPK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Na-?-glycerophosphate pH 7.5, 0.1 mM EGTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 5 |
Residual Activity |
= |
113.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 4 |
Residual Activity |
= |
108.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA4 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Nek3 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of NEK3 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase NEK6 |
Residual Activity |
= |
111.0 |
% |
Millipore: Percentage of residual kinase activity of NEK6 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase ABL |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of ABL1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase ABL |
Residual Activity |
= |
89.0 |
% |
Millipore: Percentage of residual kinase activity of ABL1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Cyclin-dependent kinase 1/cyclin B1 |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of CDK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Cyclin-dependent kinase 1/cyclin B1 |
Residual Activity |
= |
94.0 |
% |
Millipore: Percentage of residual kinase activity of CDK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase I gamma 2 |
Residual Activity |
= |
82.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK1G2 at 10uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| CaM kinase IV |
Residual Activity |
= |
110.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK4 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 40 mM HEPES pH 7.4, 5 mM CaCl2, 30 ug/mL calmodulin |
CHEMBL2218924 |
| Ephrin type-A receptor 3 |
Residual Activity |
= |
106.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Fibroblast growth factor receptor 2 |
Residual Activity |
= |
114.0 |
% |
Millipore: Percentage of residual kinase activity of FGFR2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 2.5 mM MnCl2 |
CHEMBL2218924 |
| Fibroblast growth factor receptor 2 |
Residual Activity |
= |
113.0 |
% |
Millipore: Percentage of residual kinase activity of FGFR2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 2.5 mM MnCl2 |
CHEMBL2218924 |
| Macrophage colony stimulating factor receptor |
Residual Activity |
= |
93.0 |
% |
Millipore: Percentage of residual kinase activity of CSF1R at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase HCK |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of HCK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Insulin-like growth factor I receptor |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of IGF1R at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM Na3VO4, 5 mM Na-?-glycerophosphate |
CHEMBL2218924 |
| c-Jun N-terminal kinase 2 |
Residual Activity |
= |
106.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK9 at 1uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| MAP kinase-activated protein kinase 3 |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of MAPKAPK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Na-?-glycerophosphate pH 7.5, 0.1 mM EGTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 4 |
Residual Activity |
= |
111.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA4 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase NEK6 |
Residual Activity |
= |
120.0 |
% |
Millipore: Percentage of residual kinase activity of NEK6 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase ABL2 |
Residual Activity |
= |
131.0 |
% |
Millipore: Percentage of residual kinase activity of ABL2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Cyclin-dependent kinase 2/cyclin A |
Residual Activity |
= |
141.0 |
% |
Millipore: Percentage of residual kinase activity of CDK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase I isoform gamma-3 |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK1G3 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Casein kinase I isoform gamma-3 |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of CSNK1G3 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| CaM kinase I delta |
Residual Activity |
= |
120.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK1D at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| CaM kinase I delta |
Residual Activity |
= |
115.0 |
% |
Millipore: Percentage of residual kinase activity of CAMK1D at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin |
CHEMBL2218924 |
| Ephrin type-A receptor 4 |
Residual Activity |
= |
108.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA4 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Ephrin type-A receptor 4 |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of EPHA4 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Fibroblast growth factor receptor 3 |
Residual Activity |
= |
108.0 |
% |
Millipore: Percentage of residual kinase activity of FGFR3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Macrophage colony stimulating factor receptor |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of CSF1R at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase FYN |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of FYN at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4 |
CHEMBL2218924 |
| Tyrosine-protein kinase HCK |
Residual Activity |
= |
74.0 |
% |
Millipore: Percentage of residual kinase activity of HCK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase HCK |
Residual Activity |
= |
114.0 |
% |
Millipore: Percentage of residual kinase activity of HCK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Inhibitor of nuclear factor kappa B kinase alpha subunit |
Residual Activity |
= |
116.0 |
% |
Millipore: Percentage of residual kinase activity of CHUK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| c-Jun N-terminal kinase 2 |
Residual Activity |
= |
113.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK9 at 10uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| c-Jun N-terminal kinase 3 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK10 at 1uM relative to control. Control inhibitor: JAK Inhibitor I at 30.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| MAP kinase-activated protein kinase 3 |
Residual Activity |
= |
72.0 |
% |
Millipore: Percentage of residual kinase activity of MAPKAPK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Na-?-glycerophosphate pH 7.5, 0.1 mM EGTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase MARK1 |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of MARK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| cAMP-dependent protein kinase alpha-catalytic subunit |
Residual Activity |
= |
89.0 |
% |
Millipore: Percentage of residual kinase activity of PRKACA at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C theta |
Residual Activity |
= |
112.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCQ at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PIM2 |
Residual Activity |
= |
123.0 |
% |
Millipore: Percentage of residual kinase activity of PIM2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PIM3 |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of PIM3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.1% Triton X-100 |
CHEMBL2218924 |
| Tyrosine-protein kinase receptor TYRO3 |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of TYRO3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM MnCl2 |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 1 |
Residual Activity |
= |
110.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase SIK1 |
Residual Activity |
= |
81.0 |
% |
Millipore: Percentage of residual kinase activity of SIK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase tousled-like 2 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of TLK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase WNK3 |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of WNK3 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase WNK3 |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of WNK3 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| cAMP-dependent protein kinase alpha-catalytic subunit |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of PRKACA at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase AKT |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of AKT1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C theta |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCQ at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C iota |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCI at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100 |
CHEMBL2218924 |
| Serine/threonine-protein kinase PIM3 |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of PIM3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.1% Triton X-100 |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 1 |
Residual Activity |
= |
109.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase SRPK1 |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of SRPK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase SRPK1 |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of SRPK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Testis-specific serine/threonine-protein kinase 1 |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of TSSK1B at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Testis-specific serine/threonine-protein kinase 1 |
Residual Activity |
= |
94.0 |
% |
Millipore: Percentage of residual kinase activity of TSSK1B at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase YES |
Residual Activity |
= |
107.0 |
% |
Millipore: Percentage of residual kinase activity of YES1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase AKT |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of AKT1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C iota |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCI at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100 |
CHEMBL2218924 |
| Serine/threonine-protein kinase PLK1 |
Residual Activity |
= |
112.0 |
% |
Millipore: Percentage of residual kinase activity of PLK1 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 20 mM DTT |
CHEMBL2218924 |
| Serine/threonine-protein kinase PLK1 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of PLK1 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 20 mM DTT |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 3 |
Residual Activity |
= |
108.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 3 |
Residual Activity |
= |
98.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase SRPK2 |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of SRPK2 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Testis-specific serine/threonine-protein kinase 2 |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of TSSK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase YES |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of YES1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase ZAP-70 |
Residual Activity |
= |
119.0 |
% |
Millipore: Percentage of residual kinase activity of ZAP70 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Serine/threonine-protein kinase AKT2 |
Residual Activity |
= |
130.0 |
% |
Millipore: Percentage of residual kinase activity of AKT2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase AKT2 |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of AKT2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C mu |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of PRKD1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: mM HEPES pH 7.4, 0.03% Triton X-100 |
CHEMBL2218924 |
| Serine/threonine-protein kinase PLK3 |
Residual Activity |
= |
86.0 |
% |
Millipore: Percentage of residual kinase activity of PLK3 at 1uM relative to control. Control inhibitor: Wortmannin at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 2 |
Residual Activity |
= |
109.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase SRPK2 |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of SRPK2 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase 33 |
Residual Activity |
= |
94.0 |
% |
Millipore: Percentage of residual kinase activity of STK33 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Testis-specific serine/threonine-protein kinase 2 |
Residual Activity |
= |
76.0 |
% |
Millipore: Percentage of residual kinase activity of TSSK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase TEC |
Residual Activity |
= |
89.0 |
% |
Millipore: Percentage of residual kinase activity of TEC at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM Na3VO4, 5 mM Na-?-glycerophosphate |
CHEMBL2218924 |
| Tyrosine-protein kinase ZAP-70 |
Residual Activity |
= |
129.0 |
% |
Millipore: Percentage of residual kinase activity of ZAP70 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Serine/threonine-protein kinase AKT3 |
Residual Activity |
= |
109.0 |
% |
Millipore: Percentage of residual kinase activity of AKT3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C mu |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of PRKD1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: mM HEPES pH 7.4, 0.03% Triton X-100 |
CHEMBL2218924 |
| Serine/threonine-protein kinase D2 |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of PRKD2 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100 |
CHEMBL2218924 |
| Serine/threonine-protein kinase PLK3 |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of PLK3 at 10uM relative to control. Control inhibitor: Wortmannin at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PRKX |
Residual Activity |
= |
110.0 |
% |
Millipore: Percentage of residual kinase activity of PRKX at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 2 |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 6 |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA6 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 30 mM NaCl |
CHEMBL2218924 |
| Serine/threonine-protein kinase 33 |
Residual Activity |
= |
89.0 |
% |
Millipore: Percentage of residual kinase activity of STK33 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase TEC |
Residual Activity |
= |
92.0 |
% |
Millipore: Percentage of residual kinase activity of TEC at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM Na3VO4, 5 mM Na-?-glycerophosphate |
CHEMBL2218924 |
| Death-associated protein kinase 3 |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of DAPK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Death-associated protein kinase 3 |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of DAPK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PAK 4 |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of PAK4 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase AKT3 |
Residual Activity |
= |
106.0 |
% |
Millipore: Percentage of residual kinase activity of AKT3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C alpha |
Residual Activity |
= |
109.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCA at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| Serine/threonine-protein kinase D2 |
Residual Activity |
= |
111.0 |
% |
Millipore: Percentage of residual kinase activity of PRKD2 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100 |
CHEMBL2218924 |
| Serine/threonine-protein kinase PRKX |
Residual Activity |
= |
108.0 |
% |
Millipore: Percentage of residual kinase activity of PRKX at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase alpha 6 |
Residual Activity |
= |
120.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KA6 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 30 mM NaCl |
CHEMBL2218924 |
| Serine/threonine-protein kinase PLK2 |
Residual Activity |
= |
98.0 |
% |
Millipore: Percentage of residual kinase activity of PLK2 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PLK2 |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of PLK2 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase TIE-2 |
Residual Activity |
= |
83.0 |
% |
Millipore: Percentage of residual kinase activity of TEK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM MnCl2 |
CHEMBL2218924 |
| Tyrosine-protein kinase TIE-2 |
Residual Activity |
= |
80.0 |
% |
Millipore: Percentage of residual kinase activity of TEK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM MnCl2 |
CHEMBL2218924 |
| Serine/threonine-protein kinase RAF |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of RAF1 at 1uM relative to control. Control inhibitor: SB203580 at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PAK 4 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of PAK4 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PAK7 |
Residual Activity |
= |
93.0 |
% |
Millipore: Percentage of residual kinase activity of PAK7 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C alpha |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCA at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| cGMP-dependent protein kinase 1 beta |
Residual Activity |
= |
94.0 |
% |
Millipore: Percentage of residual kinase activity of PRKG1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 uM cGMP |
CHEMBL2218924 |
| cGMP-dependent protein kinase 1 beta |
Residual Activity |
= |
88.0 |
% |
Millipore: Percentage of residual kinase activity of PRKG1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 uM cGMP |
CHEMBL2218924 |
| Protein tyrosine kinase 2 beta |
Residual Activity |
= |
130.0 |
% |
Millipore: Percentage of residual kinase activity of PTK2B at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein tyrosine kinase 2 beta |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of PTK2B at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| MAP kinase p38 alpha |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK14 at 1uM relative to control. Control inhibitor: SB203580 at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| MAP kinase p38 alpha |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK14 at 10uM relative to control. Control inhibitor: SB203580 at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| Tyrosine-protein kinase SYK |
Residual Activity |
= |
118.0 |
% |
Millipore: Percentage of residual kinase activity of SYK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Nerve growth factor receptor Trk-A |
Residual Activity |
= |
94.0 |
% |
Millipore: Percentage of residual kinase activity of NTRK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase RAF |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of RAF1 at 10uM relative to control. Control inhibitor: SB203580 at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| Stem cell growth factor receptor |
Residual Activity |
= |
110.0 |
% |
Millipore: Percentage of residual kinase activity of KIT at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Serine/threonine-protein kinase PAK7 |
Residual Activity |
= |
117.0 |
% |
Millipore: Percentage of residual kinase activity of PAK7 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C beta |
Residual Activity |
= |
107.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCB at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| Protein kinase C beta |
Residual Activity |
= |
94.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCB at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| cGMP-dependent protein kinase 1 beta |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of PRKG1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 uM cGMP |
CHEMBL2218924 |
| Serine/threonine-protein kinase RIPK2 |
Residual Activity |
= |
83.0 |
% |
Millipore: Percentage of residual kinase activity of RIPK2 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| MAP kinase p38 beta |
Residual Activity |
= |
108.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK11 at 1uM relative to control. Control inhibitor: SB203580 at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| Tyrosine-protein kinase SYK |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of SYK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Mitogen-activated protein kinase kinase kinase 7 |
Residual Activity |
= |
98.0 |
% |
Millipore: Percentage of residual kinase activity of MAP3K7 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Nerve growth factor receptor Trk-A |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of NTRK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Neurotrophic tyrosine kinase receptor type 2 |
Residual Activity |
= |
118.0 |
% |
Millipore: Percentage of residual kinase activity of NTRK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Stem cell growth factor receptor |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of KIT at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Serine/threonine-protein kinase PAK6 |
Residual Activity |
= |
108.0 |
% |
Millipore: Percentage of residual kinase activity of PAK6 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C beta |
Residual Activity |
= |
106.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCB at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| cGMP-dependent protein kinase 1 beta |
Residual Activity |
= |
93.0 |
% |
Millipore: Percentage of residual kinase activity of PRKG1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 uM cGMP |
CHEMBL2218924 |
| MAP kinase-activated protein kinase 5 |
Residual Activity |
= |
86.0 |
% |
Millipore: Percentage of residual kinase activity of MAPKAPK5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Na-?-glycerophosphate pH 7.5, 0.1 mM EGTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase RIPK2 |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of RIPK2 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Rho-associated protein kinase 1 |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of ROCK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| MAP kinase p38 beta |
Residual Activity |
= |
108.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK11 at 10uM relative to control. Control inhibitor: SB203580 at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| Mitogen-activated protein kinase kinase kinase 7 |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of MAP3K7 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Neurotrophic tyrosine kinase receptor type 2 |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of NTRK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase SRC |
Residual Activity |
= |
82.0 |
% |
Millipore: Percentage of residual kinase activity of SRC at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase SRC |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of SRC at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PAK6 |
Residual Activity |
= |
91.0 |
% |
Millipore: Percentage of residual kinase activity of PAK6 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| MAP/microtubule affinity-regulating kinase 2 |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of MARK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C beta |
Residual Activity |
= |
106.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCB at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| Protein kinase C gamma |
Residual Activity |
= |
109.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCG at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| MAP kinase-activated protein kinase 5 |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of MAPKAPK5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Na-?-glycerophosphate pH 7.5, 0.1 mM EGTA |
CHEMBL2218924 |
| Rho-associated protein kinase 1 |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of ROCK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| MAP kinase p38 gamma |
Residual Activity |
= |
113.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK12 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| MAP kinase p38 gamma |
Residual Activity |
= |
113.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK12 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase TAO1 |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of TAOK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl |
CHEMBL2218924 |
| Serine/threonine-protein kinase TAO1 |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of TAOK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl |
CHEMBL2218924 |
| Tyrosine-protein kinase TXK |
Residual Activity |
= |
83.0 |
% |
Millipore: Percentage of residual kinase activity of TXK at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase TXK |
Residual Activity |
= |
83.0 |
% |
Millipore: Percentage of residual kinase activity of TXK at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase EEF2K |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of EEF2K at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| MAP/microtubule affinity-regulating kinase 2 |
Residual Activity |
= |
110.0 |
% |
Millipore: Percentage of residual kinase activity of MARK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C gamma |
Residual Activity |
= |
101.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCG at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| Protein kinase N2 |
Residual Activity |
= |
109.0 |
% |
Millipore: Percentage of residual kinase activity of PKN2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Protein kinase N2 |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of PKN2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Rho-associated protein kinase 2 |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of ROCK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA |
CHEMBL2218924 |
| Rho-associated protein kinase 2 |
Residual Activity |
= |
90.0 |
% |
Millipore: Percentage of residual kinase activity of ROCK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA |
CHEMBL2218924 |
| MAP kinase p38 delta |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK13 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase TAO2 |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of TAOK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase ULK2 |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of ULK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase EEF2K |
Residual Activity |
= |
111.0 |
% |
Millipore: Percentage of residual kinase activity of EEF2K at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase mTOR |
Residual Activity |
= |
115.0 |
% |
Millipore: Percentage of residual kinase activity of MTOR at 1uM relative to control. Control inhibitor: PI-103 at 30.0uM. Buffer: 50 mM HEPES pH 7.5, 1 mM EGTA, 0.01% Tween 20 |
CHEMBL2218924 |
| PAS domain-containing serine/threonine-protein kinase |
Residual Activity |
= |
130.0 |
% |
Millipore: Percentage of residual kinase activity of PASK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| PAS domain-containing serine/threonine-protein kinase |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of PASK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C delta |
Residual Activity |
= |
104.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCD at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| Protein kinase C delta |
Residual Activity |
= |
92.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCD at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| Tyrosine-protein kinase FRK |
Residual Activity |
= |
93.0 |
% |
Millipore: Percentage of residual kinase activity of FRK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase receptor RET |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of RET at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| MAP kinase p38 delta |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of MAPK13 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Sgk1 |
Residual Activity |
= |
113.0 |
% |
Millipore: Percentage of residual kinase activity of SGK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase TAO2 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of TAOK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase TAO3 |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of TAOK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 200 mM NaCl, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase ULK2 |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of ULK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase ULK3 |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of ULK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase mTOR |
Residual Activity |
= |
108.0 |
% |
Millipore: Percentage of residual kinase activity of MTOR at 10uM relative to control. Control inhibitor: PI-103 at 30.0uM. Buffer: 50 mM HEPES pH 7.5, 1 mM EGTA, 0.01% Tween 20 |
CHEMBL2218924 |
| Platelet-derived growth factor receptor alpha |
Residual Activity |
= |
121.0 |
% |
Millipore: Percentage of residual kinase activity of PDGFRA at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C epsilon |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCE at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| Tyrosine-protein kinase FRK |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of FRK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Phosphorylase kinase gamma subunit 2 |
Residual Activity |
= |
110.0 |
% |
Millipore: Percentage of residual kinase activity of PHKG2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase receptor RET |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of RET at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Macrophage-stimulating protein receptor |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of MST1R at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Sgk1 |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of SGK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase TAO3 |
Residual Activity |
= |
100.0 |
% |
Millipore: Percentage of residual kinase activity of TAOK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 200 mM NaCl, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase ULK3 |
Residual Activity |
= |
95.0 |
% |
Millipore: Percentage of residual kinase activity of ULK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase mTOR |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of MTOR at 1uM relative to control. Control inhibitor: Rapamycin at 10.0uM. Buffer: 50 mM HEPES pH 7.5, 1 mM EGTA, 0.01% Tween 20, 10 uM FKBP12 |
CHEMBL2218924 |
| Serine/threonine-protein kinase mTOR |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of MTOR at 10uM relative to control. Control inhibitor: Rapamycin at 10.0uM. Buffer: 50 mM HEPES pH 7.5, 1 mM EGTA, 0.01% Tween 20, 10 uM FKBP12 |
CHEMBL2218924 |
| Platelet-derived growth factor receptor alpha |
Residual Activity |
= |
111.0 |
% |
Millipore: Percentage of residual kinase activity of PDGFRA at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Platelet-derived growth factor receptor beta |
Residual Activity |
= |
109.0 |
% |
Millipore: Percentage of residual kinase activity of PDGFRB at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C epsilon |
Residual Activity |
= |
110.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCE at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| Protein kinase C zeta |
Residual Activity |
= |
107.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCZ at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Phosphorylase kinase gamma subunit 2 |
Residual Activity |
= |
119.0 |
% |
Millipore: Percentage of residual kinase activity of PHKG2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Macrophage-stimulating protein receptor |
Residual Activity |
= |
83.0 |
% |
Millipore: Percentage of residual kinase activity of MST1R at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Sgk2 |
Residual Activity |
= |
89.0 |
% |
Millipore: Percentage of residual kinase activity of SGK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase Sgk2 |
Residual Activity |
= |
68.0 |
% |
Millipore: Percentage of residual kinase activity of SGK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase TBK1 |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of TBK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase TBK1 |
Residual Activity |
= |
92.0 |
% |
Millipore: Percentage of residual kinase activity of TBK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase VRK2 |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of VRK2 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase 1 |
Residual Activity |
= |
107.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KB1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Platelet-derived growth factor receptor beta |
Residual Activity |
= |
112.0 |
% |
Millipore: Percentage of residual kinase activity of PDGFRB at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Protein kinase C zeta |
Residual Activity |
= |
105.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCZ at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PIM1 |
Residual Activity |
= |
85.0 |
% |
Millipore: Percentage of residual kinase activity of PIM1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase PIM1 |
Residual Activity |
= |
82.0 |
% |
Millipore: Percentage of residual kinase activity of PIM1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Proto-oncogene tyrosine-protein kinase ROS |
Residual Activity |
= |
106.0 |
% |
Millipore: Percentage of residual kinase activity of ROS1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Proto-oncogene tyrosine-protein kinase ROS |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of ROS1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 |
CHEMBL2218924 |
| Serine/threonine-protein kinase Sgk3 |
Residual Activity |
= |
78.0 |
% |
Millipore: Percentage of residual kinase activity of SGK3 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| TGF-beta receptor type I |
Residual Activity |
= |
97.0 |
% |
Millipore: Percentage of residual kinase activity of TGFBR1 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM MnCl2 |
CHEMBL2218924 |
| Serine/threonine-protein kinase VRK2 |
Residual Activity |
= |
92.0 |
% |
Millipore: Percentage of residual kinase activity of VRK2 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase WNK2 |
Residual Activity |
= |
106.0 |
% |
Millipore: Percentage of residual kinase activity of WNK2 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Ribosomal protein S6 kinase 1 |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of RPS6KB1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| 3-phosphoinositide dependent protein kinase-1 |
Residual Activity |
= |
111.0 |
% |
Millipore: Percentage of residual kinase activity of PDPK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| 3-phosphoinositide dependent protein kinase-1 |
Residual Activity |
= |
103.0 |
% |
Millipore: Percentage of residual kinase activity of PDPK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1% ?-mercaptoethanol |
CHEMBL2218924 |
| Protein kinase C eta |
Residual Activity |
= |
116.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCH at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| Protein kinase C eta |
Residual Activity |
= |
102.0 |
% |
Millipore: Percentage of residual kinase activity of PRKCH at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol |
CHEMBL2218924 |
| Serine/threonine-protein kinase PIM2 |
Residual Activity |
= |
89.0 |
% |
Millipore: Percentage of residual kinase activity of PIM2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosine-protein kinase receptor TYRO3 |
Residual Activity |
= |
99.0 |
% |
Millipore: Percentage of residual kinase activity of TYRO3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM MnCl2 |
CHEMBL2218924 |
| Serine/threonine-protein kinase Sgk3 |
Residual Activity |
= |
87.0 |
% |
Millipore: Percentage of residual kinase activity of SGK3 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase SIK1 |
Residual Activity |
= |
122.0 |
% |
Millipore: Percentage of residual kinase activity of SIK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| TGF-beta receptor type I |
Residual Activity |
= |
96.0 |
% |
Millipore: Percentage of residual kinase activity of TGFBR1 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM MnCl2 |
CHEMBL2218924 |
| Serine/threonine-protein kinase tousled-like 2 |
Residual Activity |
= |
98.0 |
% |
Millipore: Percentage of residual kinase activity of TLK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Serine/threonine-protein kinase WNK2 |
Residual Activity |
= |
86.0 |
% |
Millipore: Percentage of residual kinase activity of WNK2 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA |
CHEMBL2218924 |
| Tyrosyl-DNA phosphodiesterase 1 |
Potency |
|
2660.9 |
nM |
PubChem BioAssay. qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Tyrosyl-DNA phosphodiesterase 1 |
Potency |
|
2592.9 |
nM |
PubChem BioAssay. qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Tyrosyl-DNA phosphodiesterase 1 |
Potency |
|
10593.1 |
nM |
PubChem BioAssay. qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Tyrosyl-DNA phosphodiesterase 1 |
Potency |
|
23109.3 |
nM |
PubChem BioAssay. qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Unchecked |
Potency |
|
2511.9 |
nM |
PubChem BioAssay. qHTS for Inhibitors of binding or entry into cells for Marburg Virus. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Human immunodeficiency virus 1 |
IC50 |
= |
20.0 |
nM |
Antiviral activity against HIV1 by XTT assay |
CHEMBL3608235 |
| Human immunodeficiency virus 2 |
IC50 |
= |
20.0 |
nM |
Antiviral activity against HIV2 by XTT assay |
CHEMBL3608235 |
| Human immunodeficiency virus |
Inhibition |
> |
90.0 |
% |
Antiviral activity against HIV assessed as inhibition of syncytial plaque formation at 0.1 uM |
CHEMBL3608235 |
| Human immunodeficiency virus |
IC50 |
= |
20.0 |
nM |
Antiviral activity against HIV by syncytial plaque assay |
CHEMBL3608235 |
| SARS-CoV-2 |
Inhibition |
= |
13.98 |
% |
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging |
CHEMBL4303101 |
| Histone-lysine N-methyltransferase, H3 lysine-79 specific |
Inhibition |
< |
20.0 |
% |
Inhibition of DOT1L (unknown origin) at 200 uM using chicken nucleosome as substrate in presence of [3H]SAM incubated for 1 hr by TopCount method |
CHEMBL4477246 |
| Replicase polyprotein 1ab |
Inhibition |
= |
1.41 |
% |
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate |
CHEMBL4495564 |
| Replicase polyprotein 1ab |
Inhibition |
= |
16.15 |
% |
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate |
CHEMBL4495564 |
| SARS-CoV-2 |
Inhibition |
= |
0.03 |
% |
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging |
CHEMBL4495565 |
| SARS-CoV-2 |
Inhibition |
= |
0.95 |
% |
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging |
CHEMBL4495565 |
| SARS-CoV-2 |
Inhibition |
= |
0.03 |
% |
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging |
CHEMBL4495565 |
| SARS-CoV-2 |
Inhibition |
= |
0.95 |
% |
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging |
CHEMBL4495565 |
