| Human herpesvirus 1 |
Inhibition |
= |
7.0 |
% |
Evaluated for DNA polymerase inhibition activity against herpes simplex virus-1 (HSV-1) |
CHEMBL1123083 |
| Human herpesvirus 2 |
Inhibition |
= |
0.0 |
% |
Evaluated for DNA polymerase inhibition activity against HeLa cells. |
CHEMBL1123083 |
| Human herpesvirus 1 |
ED50 |
= |
25.0 |
ug ml-1 |
In vitro anti viral activity tested against HSV-1(Schooler) virus on Rabbit kidney cell cultures. |
CHEMBL1123083 |
| Human herpesvirus 2 |
ED50 |
= |
25.0 |
ug ml-1 |
In vitro anti viral activity tested against HSV-2(Curtis) virus on Rabbit kidney cell cultures; 25-50 |
CHEMBL1123083 |
| Human herpesvirus 5 |
ED50 |
|
|
|
In vitro anti viral activity tested against HCMV(AD169) virus on MRC-5 cell monolayers; NA=Not active at 25 ug/mL |
CHEMBL1123083 |
| Human herpesvirus 3 |
ED50 |
|
|
|
In vitro anti viral activity tested against VZV(KMcC) virus on MRC-5 cell monolayers; ND=Not done |
CHEMBL1123083 |
| Human herpesvirus 1 |
Survivors |
= |
1.0 |
|
Efficacy was evaluated against Systemic HSV-1 infection in mice at a daily dose of 12.5 mg/kg administered subcutaneously; Tested mice 10 |
CHEMBL1123083 |
| Human herpesvirus 1 |
Average survival |
= |
7.5 |
day |
Efficacy was evaluated against Systemic HSV-1 infection in mice at a daily dose of 12.5 mg/kg administered subcutaneously |
CHEMBL1123083 |
| Human herpesvirus 1 |
Survivors |
= |
1.0 |
|
Efficacy was evaluated against Systemic HSV-1 infection in mice at a daily dose of 3.1 mg/kg administered subcutaneously; Tested mice 10 |
CHEMBL1123083 |
| Human herpesvirus 1 |
Average survival |
= |
6.5 |
day |
Efficacy was evaluated against Systemic HSV-1 infection in mice at a daily dose of 3.1 mg/kg administered subcutaneously |
CHEMBL1123083 |
| Human herpesvirus 1 |
Survivors |
= |
0.0 |
|
Efficacy was evaluated against Systemic HSV-1 infection in mice at a daily dose of 0.8 mg/kg administered subcutaneously; Tested mice 10 |
CHEMBL1123083 |
| Human herpesvirus 1 |
Average survival |
= |
6.3 |
day |
Efficacy was evaluated against Systemic HSV-1 infection in mice at a daily dose of 0.8 mg/kg administered subcutaneously |
CHEMBL1123083 |
| Human herpesvirus 1 |
Inhibition |
= |
14.0 |
% |
Compound was tested for the inhibition of HSV-1 polymerase |
CHEMBL1123186 |
| DNA polymerase alpha subunit |
Inhibition |
= |
0.0 |
% |
Compound was tested for the inhibition of HeLa DNA polymerase |
CHEMBL1123186 |
