| Unchecked |
Inhibition |
= |
9.478 |
% |
Human HepG2 cell viability assay in 384 well format |
CHEMBL3507680 |
| Schistosoma mansoni |
Inhibition |
= |
9.859 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3988442 |
| Plasmodium berghei |
INHIBITION |
= |
-1.56 |
% |
Screen against P. berghei liver stage (PbLuc), transformed with Luciferase, at 2uM |
CHEMBL4513216 |
| Plasmodium berghei |
INHIBITION |
= |
12.4 |
% |
Screen against P. berghei liver stage (PbLuc), transformed with Luciferase, at 10uM |
CHEMBL4513216 |
| HepG2 |
INHIBITION |
= |
-13.2 |
% |
Toxicity liver stage against HepG2, at 10uM |
CHEMBL4513216 |
| Plasmodium falciparum |
INHIBITION |
= |
-161.0 |
% |
Screen against P. falciparum Asexual Blood Stage (ABS), at 5uM |
CHEMBL4513216 |
| Plasmodium falciparum |
INHIBITION |
= |
1.05 |
% |
Screen against P. falciparum Stg V gametocytes, at 2uM |
CHEMBL4513216 |
| Coenzyme A biosynthesis bifunctional protein CoaBC |
Percent Effect |
= |
6.17 |
% |
Biomol Green assay for MtCoaBC inhibitor, OD650 read |
CHEMBL3988442 |
| Trypanosoma brucei |
Percent Effect |
= |
4.815 |
% |
Trypanosoma brucei 72 hour study |
CHEMBL3988442 |
| Histidine--tRNA ligase |
Percent Effect |
= |
5.263 |
% |
Trypanosoma cruzi histidyl tRNA synthetase (Tc-HisRS) |
CHEMBL3988442 |
| Plasmodium falciparum |
Percent Effect |
= |
0.08224 |
% |
Plasmodium falciparum sporozoite viability assay |
CHEMBL3988442 |
| Trypanosoma cruzi |
Percent Effect |
= |
-144.47 |
% |
T. cruzi routine single point assay with increased parasite load to give indication of cidality of compounds (rank compounds by MAX Percent Inhibition) |
CHEMBL3988442 |
| Unchecked |
Percent Effect |
= |
5.194 |
% |
Trypanosoma cruzi phosphomannomutase and mannose-1-phosphate guanylyltransferase assay |
CHEMBL3988442 |
| Trypanosoma cruzi |
Percent Effect |
= |
-217.64 |
% |
T. cruzi routine single point assay with increased parasite load to give indication of cidality of compounds (rank compounds by MAX Percent Inhibition) |
CHEMBL3988442 |
| Polyketide synthase Pks13 |
Percent Effect |
= |
-43.94 |
% |
Mycobacterium tuberculosis Polyketide synthase 13 Thioesterase (PKS13) |
CHEMBL3988442 |
| Protein translocase subunit SecA |
Percent Effect |
= |
-5.676 |
% |
Assay to Identify E. coli SecA ATPase Inhibitors |
CHEMBL3988442 |
| Ubiquitin-activating enzyme e1, putative |
Percent Effect |
= |
10.13 |
% |
Leishmania donovani Ubiquitin Activating Enzyme (LdE1) |
CHEMBL3988442 |
| Histidine--tRNA ligase |
Percent Effect |
= |
12.36 |
% |
Leishmania infantum Histidine tRNA synthetase (LdHisRS) |
CHEMBL3988442 |
| Unchecked |
Percent Effect |
= |
7.3039999999999985 |
% |
Phenotypic growth assay for Mycobacterium tuberculosis grown for 4 days on DPPC, cholesterol, tyloxapol based media |
CHEMBL3988442 |
| Tryptophan--tRNA ligase |
Percent Effect |
= |
2.911 |
% |
Biochemical assay for Mt-TrpRS |
CHEMBL3988442 |
| Arginase-2, mitochondrial |
Percent Effect |
= |
4.183 |
% |
in vitro enzyme assay to detect the production of urea directly proportional to the activity of Arginase II |
CHEMBL3988442 |
| AMP-activated protein kinase, AMPK |
Percent Effect |
= |
0.9646 |
% |
AMP-dependent Kinase enzyme assay. An in vitro enzyme assay that detects ADP turnover that is directly proportional to AMPK activity. This uses naive AMPK that is activated during the assay with MK-8722 |
CHEMBL3988442 |
| Wolbachia pipientis |
Percent Effect |
= |
-0.1424 |
% |
Anti-Wolbachia Cell-Based Screen |
CHEMBL3988442 |
| Unchecked |
Percent Effect |
= |
7.067 |
% |
Phenotypic growth assay for Mycobacterium tuberculosis grown for 3 days on 7H9, glucose tyloxapol based media |
CHEMBL3988442 |
| Trypanosoma cruzi |
Percent Effect |
= |
-144.85 |
% |
T. cruzi routine single point assay with increased parasite load to give indication of cidality of compounds (rank compounds by MAX Percent Inhibition) |
CHEMBL3988442 |
| Proteasome subunit beta |
Percent Effect |
= |
0.5733 |
% |
Trypanosoma cruzi proteasome chymotrypsin-like activity (TcProtChymo) assay. |
CHEMBL3988442 |
| Leishmania donovani |
Percent Effect |
= |
7.401 |
% |
Leishmania intramacrophage assay |
CHEMBL3988442 |
| Aspartate--tRNA(Asp/Asn) ligase |
Percent Effect |
= |
-3.883 |
% |
Assay for Asp RNA synthetase-1 from Mycobacterium tuberculosis |
CHEMBL3988442 |
| Tyrosyl-tRNA synthetase, putative |
Percent Effect |
= |
7.3889999999999985 |
% |
Trypanosoma cruzi tyrosyl tRNA synthetase (TcYRS) _High Tyrosine SOP |
CHEMBL3988442 |
| ClpP1P2 |
Percent Effect |
= |
-7.622999999999997 |
% |
in vitro assay to detect presence of AMC directly proportional to the activity of ClpP1P2. GHDDI collaboration. |
CHEMBL3988442 |
| Lysine--tRNA ligase |
Percent Effect |
= |
14.45 |
% |
Pf-KRS-1 (Lysyl-RNA Synthetase-1, KRS-1, cytosolic KRS) from Plasmodium falciparum. Inhibitor assay, 384 well plate, luminescence read. |
CHEMBL3988442 |
| Trypanosoma cruzi |
Percent Effect |
= |
-105.81 |
% |
T. cruzi routine single point assay with increased parasite load to give indication of cidality of compounds (rank compounds by MAX Percent Inhibition) |
CHEMBL3988442 |
| Chromo domain-containing protein 1 |
Percent Effect |
= |
-4.279 |
% |
ScCHD-1 Enzyme Inhibition Assay |
CHEMBL3988442 |
| Mycobacterium tuberculosis |
Percent Effect |
= |
2.0340000000000003 |
% |
Cornell M. t heat shock assay |
CHEMBL3988442 |
| Sialic acid-binding Ig-like lectin 9 |
Percent Effect |
= |
11.02 |
% |
Hs-Siglec9 ALPHAscreen SOP 20170721 |
CHEMBL3988442 |
| Mycobacterium tuberculosis |
Percent Effect |
= |
42.73 |
% |
Cornell - Phenotypic assay to identify agents that inhibit growth of Mycobacterium tuberculosis |
CHEMBL3988442 |
| Unchecked |
Percent Effect |
= |
1.786 |
% |
To identify inhibition of the IFN signalling (Jak-Stat) pathway via expression of an eGFP reporter gene under the control of an IFN-stimulated response element (ISRE) containing MxA promoter. |
CHEMBL3988442 |
| Shiga toxin 2 |
Percent Effect |
= |
4.481 |
% |
E. coli 0.157:H7 Shiga Toxin SOP - stx2 screening assay |
CHEMBL3988442 |
| Tyrosyl-tRNA synthetase, putative |
Percent Effect |
= |
13.92 |
% |
Trypanosoma cruzi tyrosyl tRNA synthetase (TcYRS) SOP |
CHEMBL3988442 |
