| Huntingtin |
Potency |
= |
31622.8 |
nM |
PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] |
CHEMBL1201862 |
| Cruzipain |
Potency |
= |
39810.7 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] |
CHEMBL1201862 |
| Nuclear receptor ROR-gamma |
Potency |
= |
35481.3 |
nM |
PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Thioredoxin glutathione reductase |
Potency |
= |
56234.1 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] |
CHEMBL1201862 |
| Menin/Histone-lysine N-methyltransferase MLL |
Potency |
= |
8912.5 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Nuclear receptor ROR-gamma |
Potency |
= |
12589.3 |
nM |
PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Unchecked |
EC50 |
= |
31160.0 |
nM |
PUBCHEM_BIOASSAY: A cytotoxicity screen of small molecule inhibitors of the PhoP region in Salmonella typhi identified in the primary screen. (Class of assay: confirmatory) [Related pubchem assays: 1850, 1864, 1985 ] |
CHEMBL1201862 |
| DNA polymerase beta |
Potency |
= |
28183.8 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Unchecked |
Potency |
|
7943.3 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485345, AID485355] |
CHEMBL1201862 |
| Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 |
Potency |
|
100000.0 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] |
CHEMBL1201862 |
| ATPase family AAA domain-containing protein 5 |
Potency |
|
18356.4 |
nM |
PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] |
CHEMBL1201862 |
| Cytochrome P450 2C9 |
AC50 |
= |
398.11 |
nM |
PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active |
CHEMBL1201862 |
| Cytochrome P450 2D6 |
AC50 |
|
|
|
PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active |
CHEMBL1201862 |
| Cytochrome P450 3A4 |
AC50 |
|
|
|
PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active |
CHEMBL1201862 |
| Cytochrome P450 2C19 |
AC50 |
= |
12589.25 |
nM |
PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active |
CHEMBL1201862 |
| Cytochrome P450 1A2 |
AC50 |
|
|
|
PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active |
CHEMBL1201862 |
| Vitamin D receptor |
Potency |
|
89125.1 |
nM |
PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] |
CHEMBL1201862 |
| Importin subunit beta-1/Snurportin-1 |
Potency |
|
56234.1 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] |
CHEMBL1201862 |
| Plasmodium falciparum |
Potency |
|
46.5 |
nM |
PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] |
CHEMBL1201862 |
| Plasmodium falciparum |
Potency |
|
8275.3 |
nM |
PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] |
CHEMBL1201862 |
| Guanine nucleotide-binding protein G(s), subunit alpha |
Potency |
|
11220.2 |
nM |
PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Unchecked |
IC50 |
= |
5690.0 |
nM |
PubChem BioAssay. Fluorescence-based biochemical high throughput dose response assay to identify molecules that bind r(CAG) RNA repeats. (Class of assay: confirmatory) |
CHEMBL1201862 |
| No relevant target |
IC50 |
> |
29906.0 |
nM |
PubChem BioAssay. Counterscreen for molecules that bind rCAG RNA repeats: fluorescent based biochemical dose response assay for inhibitors of the DNA-based (5'CAG/3'GTC) TO-PRO-1 dye complex. (Class of assay: confirmatory) |
CHEMBL1201862 |
