| Human herpesvirus 1 DNA polymerase |
MP |
= |
55.0 |
% |
Percentage of monophosphates (MP) formed in the first step of staggered assay compound was incubated with HSV-1 thymidine kinase for 4 hr |
CHEMBL1124020 |
| Human herpesvirus 1 DNA polymerase |
MP |
= |
0.0 |
% |
Percentage of monophosphates (MP) in the second step of staggered assay mixture from step 1 was incubated with GMP kinase and crude extract of HSV-1 infected HeLa cells over night |
CHEMBL1124020 |
| Human herpesvirus 1 DNA polymerase |
DP |
= |
10.0 |
% |
Percentage of diphosphates (DP) in the second step of staggered assay mixture from step 1 was incubated with GMP kinase and crude extract of HSV-1 infected HeLa cells over night |
CHEMBL1124020 |
| Human herpesvirus 1 DNA polymerase |
TP |
= |
17.0 |
% |
Percentage of triphosphates (TP) in the second step of staggered assay mixture from step 1 was incubated with GMP kinase and crude extract of HSV-1 infected HeLa cells over night |
CHEMBL1124020 |
| Human herpesvirus 1 DNA polymerase |
Inhibition |
= |
20.0 |
% |
Inhibition of DNA polymerase |
CHEMBL1124020 |
| Unchecked |
Inhibition |
= |
20.0 |
% |
Inhibition of DNA polymerase |
CHEMBL1124020 |
| Oryctolagus cuniculus |
ED50 |
= |
3.0 |
ug ml-1 |
Antiviral activity against HSV-1 cell line (concentration required to prevent viral cytopathic effect in half of primary rabbit kidney cell cultures) |
CHEMBL1124020 |
| Oryctolagus cuniculus |
ED50 |
= |
12.0 |
ug ml-1 |
Antiviral activity against HSV-2 cell line (concentration required to prevent viral cytopathic effect in half of primary rabbit kidney cell cultures) |
CHEMBL1124020 |
| Human immunodeficiency virus 1 |
Inhibition |
|
|
% |
Antiviral activity against HIV-1 was determined; No inhibition |
CHEMBL1124905 |
| Human herpesvirus 5 |
Inhibition |
|
|
% |
Antiviral activity against HCMV was determined; No inhibition |
CHEMBL1124905 |
| Thymidine kinase, cytosolic |
Ki |
= |
2060.0 |
nM |
Binding affinity towards HSV-1 thymidine kinase was determined |
CHEMBL1128343 |
| Purine-nucleoside phosphorylase |
Ki |
= |
77000.0 |
nM |
Tested for its ability to inhibit calf spleen purine nucleoside phosphorylase (PNP) |
CHEMBL1127601 |
| Purine-nucleoside phosphorylase |
Ratio |
> |
3.0 |
|
Ratio of Ki values for guanine and related hypoxanthines in PNP inhibition assay |
CHEMBL1127601 |
| Thymidine kinase |
IC50 |
= |
60000.0 |
nM |
Inhibitory concentration against herpes simplex virus type 1 thymidine kinase |
CHEMBL1139534 |
| Thymidine kinase |
IC50 |
= |
160000.0 |
nM |
Inhibitory concentration against herpes simplex virus type 2 thymidine kinase |
CHEMBL1139534 |
| Thymidine kinase |
IC50 |
= |
177000.0 |
nM |
Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylation |
CHEMBL1145504 |
| Thymidine kinase |
Activity |
= |
94.0 |
% |
Activity of Herpes B virus recombinant thymidine kinase at 100 uM |
CHEMBL1145504 |
| Human herpesvirus 1 |
EC50 |
= |
1500.0 |
nM |
Antiviral activity against herpes simplex virus 1 KOS infected in HEL cells assessed as reduction in virus-induced cytopathogenicity by microscopic analysis |
CHEMBL4368930 |
| Human herpesvirus 2 |
EC50 |
= |
2100.0 |
nM |
Antiviral activity against herpes simplex virus 2 G infected in HEL cells assessed as reduction in virus-induced cytopathogenicity by microscopic analysis |
CHEMBL4368930 |
| Human herpesvirus 1 |
EC50 |
= |
10000.0 |
nM |
Antiviral activity against thymidine kinase deficient and aciclovir resistant herpes simplex virus 1 KOS infected in HEL cells assessed as reduction in virus-induced cytopathogenicity by microscopic analysis |
CHEMBL4368930 |
| HEL |
MCC |
> |
100000.0 |
nM |
Cytotoxicity against HEL cells assessed as effect on cell morphology at 0.32 to 200 uM by microscopic analysis |
CHEMBL4368930 |
| Human herpesvirus 3 |
EC50 |
= |
76500.0 |
nM |
Antiviral activity against Varicella-zoster virus Oka harboring thymidine kinase infected in HEL cells assessed as reduction in virus plaque formation |
CHEMBL4368930 |
| Human herpesvirus 3 |
EC50 |
> |
100000.0 |
nM |
Antiviral activity against thymidine kinase deficient Varicella-zoster virus 07-1 infected in HEL cells assessed as reduction in virus plaque formation |
CHEMBL4368930 |
| Human herpesvirus 5 |
EC50 |
> |
100000.0 |
nM |
Antiviral activity against Human cytomegalovirus AD169 assessed as reduction in virus-induced cytopathogenicity by microscopic analysis |
CHEMBL4368930 |
| Human herpesvirus 5 |
EC50 |
> |
100000.0 |
nM |
Antiviral activity against Human cytomegalovirus Davis assessed as reduction in virus-induced cytopathogenicity by microscopic analysis |
CHEMBL4368930 |
| TERT-RPE1 |
IC50 |
> |
100000.0 |
nM |
Cytostatic activity against human hTERT-RPE1 cells |
CHEMBL4368930 |
| CAPAN-1 |
IC50 |
= |
72700.0 |
nM |
Cytostatic activity against human Capan1 cells |
CHEMBL4368930 |
| Unchecked |
IC50 |
> |
100000.0 |
nM |
Cytostatic activity against human HAP1 cells |
CHEMBL4368930 |
| NCI-H460 |
IC50 |
> |
100000.0 |
nM |
Cytostatic activity against human NCI-H460 cells |
CHEMBL4368930 |
| Unchecked |
IC50 |
> |
100000.0 |
nM |
Cytostatic activity against human DND41 cells |
CHEMBL4368930 |
| HL-60 |
IC50 |
> |
100000.0 |
nM |
Cytostatic activity against human HL60 cells |
CHEMBL4368930 |
| K562 |
IC50 |
> |
100000.0 |
nM |
Cytostatic activity against human K562 cells |
CHEMBL4368930 |
| Z-138 |
IC50 |
> |
100000.0 |
nM |
Cytostatic activity against human Z138 cells |
CHEMBL4368930 |
