| Human immunodeficiency virus type 1 protease |
ID50 |
= |
54.0 |
uM |
Evaluated for the inhibition of HIV-1 Protease. |
CHEMBL1129680 |
| Human immunodeficiency virus |
Ki |
= |
7.0 |
nM |
The inhibition of compound was determined by reverse transcriptase assay using RNA as template |
CHEMBL1124401 |
| Human immunodeficiency virus |
Ki |
= |
84000.0 |
nM |
The inhibition of compound was determined by reverse transcriptase assay using DNA as template |
CHEMBL1124401 |
| Human immunodeficiency virus type 1 reverse transcriptase |
IC50 |
= |
3.0 |
nM |
Tested against HIV-1 reverse transcriptase (HIV-1 RT) with poly(rA)/(dT)12-18 as template and [methyl-3H]-dTTP as competing substrate |
CHEMBL1127397 |
| Human immunodeficiency virus type 1 reverse transcriptase |
IC50 |
= |
22.0 |
nM |
Compound concentration that causes 50 % inhibition of HIV-1 peptide-derived reverse transcriptase (RT) obtained from HIV-1-infected H9 cell cultures |
CHEMBL1125995 |
| Human immunodeficiency virus type 1 reverse transcriptase |
IC50 |
= |
43.0 |
nM |
Inhibitory activity against HIV-1 reverse transcriptase |
CHEMBL1150514 |
| Avian myeloblastosis virus |
IC50 |
= |
0.06 |
ug.mL-1 |
The compound was evaluated as inhibitor of avian myeloblastosis virus (AMV) reverse transcriptase |
CHEMBL1126397 |
| Human immunodeficiency virus type 1 reverse transcriptase |
IC50 |
= |
0.12 |
ug.mL-1 |
The compound was evaluated as inhibitor of recombinant HIV-l reverse transcriptase |
CHEMBL1126397 |
| No relevant target |
T1/2 |
< |
0.016669999999999997 |
hr |
Compound was evaluated for its stability to dephosphorylation. |
CHEMBL1151022 |
| Human immunodeficiency virus type 1 reverse transcriptase |
IC50 |
= |
2100.0 |
nM |
Inhibitory concentration against human immunodeficiency virus type 1 reverse transcriptase |
CHEMBL1141972 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Ki |
= |
91.0 |
nM |
Inhibitory constant against HIV-1 reverse transcriptase |
CHEMBL1143584 |
| ADMET |
T1/2 |
= |
2.0 |
hr |
Half-life determined in fetal calf serum |
CHEMBL1143584 |
| Human herpesvirus 5 DNA polymerase |
IC50 |
= |
22100.0 |
nM |
Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C |
CHEMBL1141075 |
| Human herpesvirus 1 DNA polymerase |
IC50 |
= |
3300.0 |
nM |
Inhibition of herpes simplex virus type 1 DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C |
CHEMBL1141075 |
| DNA polymerase |
IC50 |
= |
5800.0 |
nM |
Inhibition of Varicella-Zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C |
CHEMBL1141075 |
| DNA polymerase alpha subunit |
IC50 |
= |
13400.0 |
nM |
Inhibition of human alpha DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C with the compound dissolved in DMSO |
CHEMBL1141075 |
| DNA polymerase |
IC50 |
= |
12000.0 |
nM |
Inhibition of Varicella-Zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C |
CHEMBL1141075 |
| DNA polymerase delta subunit 1 |
IC50 |
= |
2300.0 |
nM |
Inhibition of human delta DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C with the compound dissolved in DMSO |
CHEMBL1141075 |
| Unchecked |
Ki |
= |
8.4 |
nM |
Inhibition of HIV1 reverse transcriptase |
CHEMBL1149314 |
| Serum |
T1/2 |
= |
2.0 |
hr |
Stability in fetal calf serum at 500 uM at 37 degC |
CHEMBL1149314 |
| CCRF-CEM |
t1/2 |
|
|
|
Stability in CEM cell extract |
CHEMBL1149314 |
| Unchecked |
IC50 |
= |
22100.0 |
nM |
Inhibition of human cytomegalovirus DNA polymerase |
CHEMBL1149529 |
| Unchecked |
IC50 |
= |
3300.0 |
nM |
Inhibition of HSV1 DNA polymerase |
CHEMBL1149529 |
| Unchecked |
IC50 |
= |
5800.0 |
nM |
Inhibition of VZV DNA polymerase |
CHEMBL1149529 |
| Unchecked |
IC50 |
= |
2300.0 |
nM |
Inhibition of human DNA polymerase delta |
CHEMBL1149529 |
| Unchecked |
IC50 |
= |
5800.0 |
nM |
Inhibition of VZV DNA polymerase by scintillation proximity assay |
CHEMBL1139940 |
| Human herpesvirus 5 DNA polymerase |
IC50 |
= |
22100.0 |
nM |
Inhibition of HCMV DNA polymerase by scintillation proximity assay |
CHEMBL1139940 |
| Unchecked |
IC50 |
= |
3300.0 |
nM |
Inhibition of HSV1 DNA polymerase by scintillation proximity assay |
CHEMBL1139940 |
| Unchecked |
IC50 |
= |
2300.0 |
nM |
Inhibition of human DNA polymerase delta by scintillation proximity assay |
CHEMBL1139940 |
| Unchecked |
IC50 |
= |
460.0 |
nM |
Inhibition of HIV1 reverse transcriptase wild type HXB2(a) in presence of 5 mM ATP by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
520.0 |
nM |
Inhibition of HIV1 reverse transcriptase 184V mutant in presence of 5 mM ATP by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
2300.0 |
nM |
Inhibition of HIV1 reverse transcriptase 41L/67N/70R/210W/215Y mutant in presence of 5 mM ATP by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
900.0 |
nM |
Inhibition of HIV1 reverse transcriptase 41L/67N/70R/184V/210W/215Y mutant in presence of 5 mM ATP by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
4400.0 |
nM |
Inhibition of HIV1 reverse transcriptase 41L/69S-SG/210W/215Y mutant in presence of 5 mM ATP by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
1200.0 |
nM |
Inhibition of HIV1 reverse transcriptase 41L/69S-SG/184V/210W/215Y mutant in presence of 5 mM ATP by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
9000.0 |
nM |
Inhibition of HIV1 reverse transcriptase 75I/77L/116Y/151M mutant in presence of 5 mM ATP by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
22000.0 |
nM |
Inhibition of HIV1 reverse transcriptase 75I/77L/116Y/151M/184V mutant in presence of 5 mM ATP by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
480.0 |
nM |
Inhibition of HIV1 reverse transcriptase wild type HXB2(b) in presence of 5 mM ATP by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
2500.0 |
nM |
Inhibition of HIV1 LAI reverse transcriptase 41L/67N/70R/215Y/219Q mutant in presence of 5 mM ATP by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Human immunodeficiency virus type 1 reverse transcriptase |
IC50 |
= |
300.0 |
nM |
Inhibition of HIV1 LAI reverse transcriptase wild type in presence of 5 mM ATP by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
610.0 |
nM |
Inhibition of HIV1 LAI reverse transcriptase 65R mutant in presence of 5 mM ATP by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
550.0 |
nM |
Inhibition of HIV1 pNL4-3 reverse transcriptase 115F mutant in presence of 5 mM ATP by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Human immunodeficiency virus type 1 reverse transcriptase |
IC50 |
= |
420.0 |
nM |
Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 in presence of 5 mM ATP by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
180.0 |
nM |
Inhibition of HIV1 reverse transcriptase wild type HXB2(a) by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
250.0 |
nM |
Inhibition of HIV1 reverse transcriptase 184V mutant by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
140.0 |
nM |
Inhibition of HIV1 reverse transcriptase 41L/67N/70R/210W/215Y mutant by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
340.0 |
nM |
Inhibition of HIV1 reverse transcriptase 41L/67N/70R/184V/210W/215Y mutant by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
160.0 |
nM |
Inhibition of HIV1 reverse transcriptase 41L/69S-SG/210W/215Y mutant by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
210.0 |
nM |
Inhibition of HIV1 reverse transcriptase 41L/69S-SG/184V/210W/215Y mutant by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
5100.0 |
nM |
Inhibition of HIV1 reverse transcriptase 75I/77L/116Y/151M mutant by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
10600.0 |
nM |
Inhibition of HIV1 reverse transcriptase 75I/77L/116Y/151M/184V mutant by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
200.0 |
nM |
Inhibition of HIV1 reverse transcriptase wild type HXB2(b) by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
190.0 |
nM |
Inhibition of HIV1 LAI reverse transcriptase 41L/67N/70R/215Y/219Q mutant by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Human immunodeficiency virus type 1 reverse transcriptase |
IC50 |
= |
80.0 |
nM |
Inhibition of HIV1 LAI reverse transcriptase wild type LAI by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
350.0 |
nM |
Inhibition of HIV1 LAI reverse transcriptase 65R mutant by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Human immunodeficiency virus type 1 reverse transcriptase |
IC50 |
= |
130.0 |
nM |
Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
130.0 |
nM |
Inhibition of HIV1 pNL4-3 reverse transcriptase 115F mutant by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
Ki |
= |
4.0 |
nM |
Inhibition of HIV1 reverse transcriptase wild type HXB2(b) in presence of 3.2 mM ATP by prA/odT assay |
CHEMBL1143844 |
| Unchecked |
Ki |
= |
5.4 |
nM |
Inhibition of HIV1 reverse transcriptase wild type HXB2(a) in presence of 3.2 mM ATP by prA/odT assay |
CHEMBL1143844 |
| Unchecked |
Ki |
= |
130.0 |
nM |
Inhibition of HIV1 reverse transcriptase 41L/67N/70R/210W/215Y mutant in presence of 3.2 mM ATP by prA/odT assay |
CHEMBL1143844 |
| Unchecked |
Ki |
= |
330.0 |
nM |
Inhibition of HIV1 reverse transcriptase 41L/69S-SG/184V/210W/215Y mutant in presence of 3.2 mM ATP by prA/odT assay |
CHEMBL1143844 |
| Unchecked |
Ki |
= |
95.0 |
nM |
Inhibition of HIV1 reverse transcriptase 41L/67N/70R/215Y/219Q mutant in presence of 3.2 mM ATP by prA/odT assay |
CHEMBL1143844 |
| Unchecked |
Ki |
= |
310.0 |
nM |
Activity of HIV1 reverse transcriptase wild type HXB2(a) in presence of 3.2 mM ATP by prA/odT assay |
CHEMBL1143844 |
| Unchecked |
Ki |
= |
430.0 |
nM |
Activity of HIV1 reverse transcriptase 41L/67N/70R/210W/215Y mutant in presence of 3.2 mM ATP by prA/odT assay |
CHEMBL1143844 |
| Unchecked |
Ki |
= |
530.0 |
nM |
Activity of HIV1 reverse transcriptase 41L/69S-SG/184V/210W/215Y mutant in presence of 3.2 mM ATP by prA/odT assay |
CHEMBL1143844 |
| Unchecked |
Ki |
= |
290.0 |
nM |
Activity of HIV1 reverse transcriptase wild type HXB2(b) in presence of 3.2 mM ATP by prA/odT assay |
CHEMBL1143844 |
| Unchecked |
Ki |
= |
490.0 |
nM |
Activity of HIV1 reverse transcriptase 41L/67N/70R/215Y/219Q mutant in presence of 3.2 mM ATP by prA/odT assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
460.0 |
nM |
Inhibition of HIV1 reverse transcriptase wild type HXB2(a) in presence of 1 uM dNTP by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
3300.0 |
nM |
Inhibition of HIV1 reverse transcriptase wild type HXB2(a) in presence of 20 uM dNTP by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
2300.0 |
nM |
Inhibition of HIV1 reverse transcriptase 41L/67N/70R/210W/215Y mutant in presence of 1 uM dNTP by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
16000.0 |
nM |
Inhibition of HIV1 reverse transcriptase 41L/67N/70R/210W/215Y mutant in presence of 20 uM dNTP by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
460.0 |
nM |
Inhibition of HIV1 reverse transcriptase wild type HXB2(a) in presence of 5'-A12-(GTCA)5-3' by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
|
|
|
Inhibition of HIV1 reverse transcriptase wild type HXB2(a) in presence of 5'-A12-(GACT)5-3' by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
2300.0 |
nM |
Inhibition of HIV1 reverse transcriptase 41L/67N/70R/210W/215Y mutant in presence of 5'-A12-(GTCA)5-3' by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
|
|
|
Inhibition of HIV1 reverse transcriptase 41L/67N/70R/210W/215Y mutant in presence of 5'-A12-(GACT)5-3' by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
= |
4400.0 |
nM |
Inhibition of HIV1 reverse transcriptase 41L/69S-SG/184V/210W/215Y mutant in presence of 5'-A12-(GTCA)5-3' by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
IC50 |
|
|
|
Inhibition of HIV1 reverse transcriptase 41L/69S-SG/184V/210W/215Y mutant in presence of 5'-A12-(GACT)5-3' by heteropolymeric DNA polymerase assay |
CHEMBL1143844 |
| Unchecked |
Inhibition |
= |
64.0 |
% |
Inhibition of HIV reverse transcriptase assessed as incorporation of [3H]dTMP at 100 nM |
CHEMBL1151134 |
| Human immunodeficiency virus type 1 reverse transcriptase |
IC50 |
= |
360.0 |
nM |
Inhibition of HIV1 RT mediated DNA-dependent DNA synthesis initiation using RNA/DNAM duplex primed substrate by scintillation proximity assay |
CHEMBL1156428 |
| Human immunodeficiency virus type 1 reverse transcriptase |
IC50 |
= |
320.0 |
nM |
Inhibition of HIV1 RT mediated DNA-dependent DNA synthesis initiation using RNA PPT primed substrate by scintillation proximity assay |
CHEMBL1156428 |
| Human immunodeficiency virus type 1 reverse transcriptase |
IC50 |
= |
51.0 |
nM |
Inhibition of DNA dependent DNA polymerase activity of HIV1 recombinant reverse transcriptase p66/p51 |
CHEMBL1158280 |
| DNA polymerase alpha subunit |
IC50 |
= |
11000.0 |
nM |
Inhibition of DNA polymerase alpha |
CHEMBL1158280 |
| DNA polymerase beta |
IC50 |
= |
16000.0 |
nM |
Inhibition of DNA polymerase beta |
CHEMBL1158280 |
| Unchecked |
IC50 |
= |
59.0 |
nM |
Inhibition of PERV reverse transcriptase from pig PK15 cells |
CHEMBL1156415 |
| Unchecked |
IC50 |
= |
19.0 |
nM |
Inhibition of PERV reverse transcriptase from Kagoshima pig KK5 cells |
CHEMBL1156415 |
| Unchecked |
IC50 |
= |
20.0 |
nM |
Inhibition of PERV reverse transcriptase from Kagoshima pig DRK4 cells |
CHEMBL1156415 |
| Human immunodeficiency virus type 1 reverse transcriptase |
IC50 |
= |
54.0 |
nM |
Inhibition of HIV1 recombinant reverse transcriptase |
CHEMBL1156415 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Ki |
= |
41.0 |
nM |
Inhibition of HIV1 reverse transcriptase by steady state nucleotide incorporation assay |
CHEMBL1155161 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Ratio |
= |
0.09 |
|
Ratio of Ki to Km for HIV1 reverse transcriptase by steady state nucleotide incorporation assay |
CHEMBL1155161 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Ki |
= |
47.0 |
nM |
Inhibition of HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant by steady state nucleotide incorporation assay |
CHEMBL1155161 |
| Unchecked |
Ratio Ki |
= |
1.2 |
|
Ratio of Ki for HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant to Ki for wild-type reverse transcriptase |
CHEMBL1155161 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Ratio |
= |
0.09 |
|
Ratio of Ki to Km for HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant by steady state nucleotide incorporation assay |
CHEMBL1155161 |
| Unchecked |
Ratio |
= |
1.0 |
|
Ratio of Ki/Km for HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant to Ki/Km for wild-type reverse transcriptase |
CHEMBL1155161 |
| Unchecked |
IC50 |
= |
2300.0 |
nM |
Inhibition of human polymerase delta by scintillation proximity assay |
CHEMBL1155120 |
| Unchecked |
IC50 |
= |
5800.0 |
nM |
Inhibition of VZV DNA polymerase by scintillation proximity assay |
CHEMBL1155120 |
| DNA polymerase catalytic subunit |
IC50 |
= |
3300.0 |
nM |
Inhibition of HSV1 DNA polymerase by scintillation proximity assay |
CHEMBL1155120 |
| Unchecked |
IC50 |
= |
22100.0 |
nM |
Inhibition of HCMV DNA polymerase by scintillation proximity assay |
CHEMBL1155120 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Ratio |
= |
4.41 |
|
Ratio of Kpol to Kd for wild type HIV1 LAI reverse transcriptase |
CHEMBL1153554 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Kd |
= |
1990.0 |
nM |
Binding affinity to wild type HIV1 LAI reverse transcriptase |
CHEMBL1153554 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Kd |
= |
2900.0 |
nM |
Binding affinity to HIV1 LAI reverse transcriptase M184V mutant |
CHEMBL1153554 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Kd |
= |
1150.0 |
nM |
Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y mutant |
CHEMBL1153554 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Kd |
= |
3500.0 |
nM |
Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y/M184V mutant |
CHEMBL1153554 |
| Unchecked |
Kd |
= |
3810.0 |
nM |
Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y/M184V/G333D mutant |
CHEMBL1153554 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Ratio |
= |
2.41 |
|
Ratio of Kpol to Kd for HIV1 LAI reverse transcriptase M184V mutant |
CHEMBL1153554 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Ratio |
= |
4.26 |
|
Ratio of Kpol to Kd for HIV1 LAI reverse transcriptase M41L/L210W/T215Y mutant |
CHEMBL1153554 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Ratio |
= |
1.3 |
|
Ratio of Kpol to Kd for HIV1 LAI reverse transcriptase M41L/L210W/T215Y/M184V mutant |
CHEMBL1153554 |
| Unchecked |
Ratio |
= |
1.1 |
|
Ratio of Kpol to Kd for HIV1 LAI reverse transcriptase M41L/L210W/T215Y/M184V/G333D mutant |
CHEMBL1153554 |
| Human immunodeficiency virus type 1 reverse transcriptase |
FC |
= |
1.13 |
|
Binding affinity to HIV1 LAI reverse transcriptase M184V mutant relative to wild type |
CHEMBL1153554 |
| Human immunodeficiency virus type 1 reverse transcriptase |
FC |
= |
1.14 |
|
Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y mutant relative to wild type |
CHEMBL1153554 |
| Human immunodeficiency virus type 1 reverse transcriptase |
FC |
= |
1.76 |
|
Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y/M184V mutant relative to wild type |
CHEMBL1153554 |
| Unchecked |
FC |
= |
1.81 |
|
Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y/M184V/G333D mutant relative to wild type |
CHEMBL1153554 |
| Unchecked |
IC50 |
= |
22100.0 |
nM |
Inhibition of HCMV recombinant DNA polymerase expressed in baculovirus infected SF9 cells after 12 mins by scintillation proximity assay |
CHEMBL1155400 |
| Unchecked |
IC50 |
= |
5800.0 |
nM |
Inhibition of Varicella zoster virus recombinant DNA polymerase expressed in baculovirus infected SF9 cells after 12 mins by scintillation proximity assay |
CHEMBL1155400 |
| Unchecked |
IC50 |
= |
22100.0 |
nM |
Inhibition of HCMV DNA polymerase infected in HFF cells |
CHEMBL1157125 |
| Human herpesvirus 1 |
IC50 |
= |
3300.0 |
nM |
Inhibition of HSV1 KOS DNA polymerase infected in african green monkey Vero cells |
CHEMBL1157125 |
| Unchecked |
IC50 |
= |
5800.0 |
nM |
Inhibition of VZV KOS DNA polymerase infected in HFF cells |
CHEMBL1157125 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Activity |
= |
8.8 |
/s |
Activity at HIV1 reverse transcriptase measured after 30 mins |
CHEMBL1671666 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Kd |
= |
2000.0 |
nM |
Binding affinity to HIV1 reverse transcriptase |
CHEMBL1671666 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Ratio |
= |
4.4 |
/uM/s |
Ratio of Kpol to Kd for HIV1 reverse transcriptase |
CHEMBL1671666 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Selectivity ratio |
= |
1.0 |
|
Selectivity, ratio of Kpol to Kd for TTP to Kpol to Kd for compound at HIV1 reverse transcriptase |
CHEMBL1671666 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Kd |
= |
55000.0 |
nM |
Binding affinity to HIV1 reverse transcriptase assessed as L-3'-azido-NTP incorporation in nascent DNA |
CHEMBL1828605 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Kd |
> |
60000.0 |
nM |
Binding affinity to HIV1 reverse transcriptase M184V mutant assessed as L-3'-azido-NTP incorporation in nascent DNA |
CHEMBL1828605 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Ratio |
= |
0.011 |
/uM/min |
Ratio Kpol to Kd for wild type HIV 1 reverse transcriptase |
CHEMBL1828605 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Selectivity ratio |
= |
21000.0 |
|
Selectivity ratio of Kpol to Kd for TTP to Kpol to Kd for compound at HIV1 reverse transcriptase |
CHEMBL1828605 |
| Human immunodeficiency virus type 1 reverse transcriptase |
Activity |
|
|
|
Binding affinity to HIV1 reverse transcriptase assessed as compound incorporation into DNA by primer extension assay |
CHEMBL3085754 |
| Unchecked |
IC50 |
= |
3700.0 |
nM |
Inhibition of DNA polymerase gamma (unknown origin) |
CHEMBL3217509 |
| Unchecked |
IC50 |
= |
7170.0 |
nM |
Inhibition of DNA polymerase alpha (unknown origin) |
CHEMBL3217509 |
| Unchecked |
IC50 |
= |
1960.0 |
nM |
Inhibition of DNA polymerase beta (unknown origin) |
CHEMBL3217509 |
| Unchecked |
IC50 |
|
|
|
Inhibition of Escherichia coli RNA polymerase |
CHEMBL4477221 |
| Human immunodeficiency virus type 1 reverse transcriptase |
IC50 |
= |
7000.0 |
nM |
Inhibition of HIV1 reverse transcriptase using T19-Cy5 labeled 23-mer DNA/T2-TAMRA labeled 63-mer DNA as primer/template assessed as inhibition of dNTP incorporation into primer/template |
CHEMBL4477221 |
