| Unchecked |
Inhibition |
= |
6.545 |
% |
Human HepG2 cell viability assay in 384 well format |
CHEMBL3507680 |
| Schistosoma mansoni |
Inhibition |
= |
2.075 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3988442 |
| Plasmodium berghei |
INHIBITION |
= |
-34.26 |
% |
Screen against P. berghei liver stage (PbLuc), transformed with Luciferase, at 2uM |
CHEMBL4513216 |
| Plasmodium berghei |
INHIBITION |
= |
-22.9 |
% |
Screen against P. berghei liver stage (PbLuc), transformed with Luciferase, at 10uM |
CHEMBL4513216 |
| HepG2 |
INHIBITION |
= |
0.795 |
% |
Toxicity liver stage against HepG2, at 10uM |
CHEMBL4513216 |
| Plasmodium falciparum |
INHIBITION |
= |
-66.6 |
% |
Screen against P. falciparum Asexual Blood Stage (ABS), at 5uM |
CHEMBL4513216 |
| Plasmodium falciparum |
INHIBITION |
= |
1.14 |
% |
Screen against P. falciparum Stg V gametocytes, at 2uM |
CHEMBL4513216 |
| Coenzyme A biosynthesis bifunctional protein CoaBC |
Percent Effect |
= |
1.211 |
% |
Biomol Green assay for MtCoaBC inhibitor, OD650 read |
CHEMBL3988442 |
| Lysine--tRNA ligase |
Percent Effect |
= |
24.36 |
% |
Pf-KRS-1 (Lysyl-RNA Synthetase-1, KRS-1, cytosolic KRS) from Plasmodium falciparum. Inhibitor assay, 384 well plate, luminescence read. |
CHEMBL3988442 |
| Unchecked |
Percent Effect |
= |
-3.323 |
% |
Phenotypic growth assay for Mycobacterium tuberculosis grown for 3 days on 7H9, glucose tyloxapol based media |
CHEMBL3988442 |
| Unchecked |
Percent Effect |
= |
0.3929 |
% |
Trypanosoma cruzi phosphomannomutase and mannose-1-phosphate guanylyltransferase assay |
CHEMBL3988442 |
| Trypanosoma brucei |
Percent Effect |
= |
-8.417 |
% |
Trypanosoma brucei 72 hour study |
CHEMBL3988442 |
| Trypanosoma cruzi |
Percent Effect |
= |
-31.77 |
% |
T. cruzi routine single point assay with increased parasite load to give indication of cidality of compounds (rank compounds by MAX Percent Inhibition) |
CHEMBL3988442 |
| Proteasome subunit beta |
Percent Effect |
= |
9.797 |
% |
Trypanosoma cruzi proteasome chymotrypsin-like activity (TcProtChymo) assay. |
CHEMBL3988442 |
| Plasmodium falciparum |
Percent Effect |
= |
-70.09 |
% |
Calibr Malaria Delayed Death Assay SOP |
CHEMBL3988442 |
| Tyrosyl-tRNA synthetase, putative |
Percent Effect |
= |
-1.058 |
% |
Trypanosoma cruzi tyrosyl tRNA synthetase (TcYRS) _High Tyrosine SOP |
CHEMBL3988442 |
| Unchecked |
Percent Effect |
= |
11.84 |
% |
To identify inhibition of the IFN signalling (Jak-Stat) pathway via expression of an eGFP reporter gene under the control of an IFN-stimulated response element (ISRE) containing MxA promoter. |
CHEMBL3988442 |
| Ubiquitin-activating enzyme e1, putative |
Percent Effect |
= |
-4.0 |
% |
Leishmania donovani Ubiquitin Activating Enzyme (LdE1) |
CHEMBL3988442 |
| Chromo domain-containing protein 1 |
Percent Effect |
= |
0.3086 |
% |
ScCHD-1 Enzyme Inhibition Assay |
CHEMBL3988442 |
| Protein translocase subunit SecA |
Percent Effect |
= |
-1.624 |
% |
Assay to Identify E. coli SecA ATPase Inhibitors |
CHEMBL3988442 |
| Unchecked |
Percent Effect |
= |
-0.9564 |
% |
In vitro enzyme assay to detect hydrolysis of chlorophenol red-beta-D-galactopyranosidase directly proportional to the number of Toxoplasma stably expressing beta-galactosidase |
CHEMBL3988442 |
| Shiga toxin 2 |
Percent Effect |
= |
1.285 |
% |
E. coli 0.157:H7 Shiga Toxin SOP - stx2 screening assay |
CHEMBL3988442 |
| Arginase-2, mitochondrial |
Percent Effect |
= |
1.585 |
% |
in vitro enzyme assay to detect the production of urea directly proportional to the activity of Arginase II |
CHEMBL3988442 |
| Wolbachia pipientis |
Percent Effect |
= |
-8.343 |
% |
Anti-Wolbachia Cell-Based Screen |
CHEMBL3988442 |
| Leishmania donovani |
Percent Effect |
= |
-1.622 |
% |
Leishmania intramacrophage assay |
CHEMBL3988442 |
| Plasmodium falciparum |
Percent Effect |
= |
-3.728 |
% |
Plasmodium falciparum sporozoite viability assay |
CHEMBL3988442 |
| Tryptophan--tRNA ligase |
Percent Effect |
= |
-1.608 |
% |
Biochemical assay for Mt-TrpRS |
CHEMBL3988442 |
| Tyrosyl-tRNA synthetase, putative |
Percent Effect |
= |
0.0 |
% |
Trypanosoma cruzi tyrosyl tRNA synthetase (TcYRS) SOP |
CHEMBL3988442 |
| Polyketide synthase Pks13 |
Percent Effect |
= |
-36.34 |
% |
Mycobacterium tuberculosis Polyketide synthase 13 Thioesterase (PKS13) |
CHEMBL3988442 |
| ClpP1P2 |
Percent Effect |
= |
-0.9476 |
% |
in vitro assay to detect presence of AMC directly proportional to the activity of ClpP1P2. GHDDI collaboration. |
CHEMBL3988442 |
| Aspartate--tRNA(Asp/Asn) ligase |
Percent Effect |
= |
3.049 |
% |
Assay for Asp RNA synthetase-1 from Mycobacterium tuberculosis |
CHEMBL3988442 |
| Unchecked |
Percent Effect |
= |
-17.43 |
% |
Phenotypic growth assay for Mycobacterium tuberculosis grown for 4 days on DPPC, cholesterol, tyloxapol based media |
CHEMBL3988442 |
| Arginase-2, mitochondrial |
Percent Effect |
= |
-11.35 |
% |
in vitro enzyme assay to detect the production of urea directly proportional to the activity of Arginase II |
CHEMBL3988442 |
| AMP-activated protein kinase, AMPK |
Percent Effect |
= |
-24.62 |
% |
AMP-dependent Kinase enzyme assay. An in vitro enzyme assay that detects ADP turnover that is directly proportional to AMPK activity. This uses naive AMPK that is activated during the assay with MK-8722 |
CHEMBL3988442 |
| Mycobacterium tuberculosis |
Percent Effect |
= |
11.99 |
% |
Cornell M. t heat shock assay |
CHEMBL3988442 |
| Sialic acid-binding Ig-like lectin 9 |
Percent Effect |
= |
-0.2969 |
% |
Hs-Siglec9 ALPHAscreen SOP 20170721 |
CHEMBL3988442 |
| Histidine--tRNA ligase |
Percent Effect |
= |
4.918 |
% |
Trypanosoma cruzi histidyl tRNA synthetase (Tc-HisRS) |
CHEMBL3988442 |
| Histidine--tRNA ligase |
Percent Effect |
= |
1.942 |
% |
Leishmania infantum Histidine tRNA synthetase (LdHisRS) |
CHEMBL3988442 |
| Lysine--tRNA ligase |
IC50 |
< |
50118.72 |
nM |
Pf-KRS-1 (Lysyl-RNA Synthetase-1, KRS-1, cytosolic KRS) from Plasmodium falciparum. Inhibitor assay, 384 well plate, luminescence read. |
CHEMBL3988442 |
