| Unchecked |
Inhibition |
= |
-7.285 |
% |
Human HepG2 cell viability assay in 384 well format |
CHEMBL3507680 |
| Schistosoma mansoni |
Inhibition |
= |
18.41 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3988442 |
| Plasmodium berghei |
INHIBITION |
= |
10.78 |
% |
Screen against P. berghei liver stage (PbLuc), transformed with Luciferase, at 2uM |
CHEMBL4513216 |
| Plasmodium berghei |
INHIBITION |
= |
30.9 |
% |
Screen against P. berghei liver stage (PbLuc), transformed with Luciferase, at 10uM |
CHEMBL4513216 |
| HepG2 |
INHIBITION |
= |
-7.22 |
% |
Toxicity liver stage against HepG2, at 10uM |
CHEMBL4513216 |
| Plasmodium falciparum |
INHIBITION |
= |
-12.7 |
% |
Screen against P. falciparum Asexual Blood Stage (ABS), at 5uM |
CHEMBL4513216 |
| Plasmodium falciparum |
INHIBITION |
= |
1.42 |
% |
Screen against P. falciparum Stg V gametocytes, at 2uM |
CHEMBL4513216 |
| Coenzyme A biosynthesis bifunctional protein CoaBC |
Percent Effect |
= |
7.443 |
% |
Biomol Green assay for MtCoaBC inhibitor, OD650 read |
CHEMBL3988442 |
| Unchecked |
Percent Effect |
= |
14.61 |
% |
Phenotypic growth assay for Mycobacterium tuberculosis grown for 4 days on DPPC, cholesterol, tyloxapol based media |
CHEMBL3988442 |
| Histidine--tRNA ligase |
Percent Effect |
= |
9.045 |
% |
Trypanosoma cruzi histidyl tRNA synthetase (Tc-HisRS) |
CHEMBL3988442 |
| Polyketide synthase Pks13 |
Percent Effect |
= |
-9.191 |
% |
Mycobacterium tuberculosis Polyketide synthase 13 Thioesterase (PKS13) |
CHEMBL3988442 |
| Tryptophan--tRNA ligase |
Percent Effect |
= |
9.69 |
% |
Biochemical assay for Mt-TrpRS |
CHEMBL3988442 |
| Mycobacterium tuberculosis |
Percent Effect |
= |
8.266 |
% |
Cornell - Phenotypic assay to identify agents that inhibit growth of Mycobacterium tuberculosis |
CHEMBL3988442 |
| Wolbachia pipientis |
Percent Effect |
= |
116.31 |
% |
Anti-Wolbachia Cell-Based Screen |
CHEMBL3988442 |
| Leishmania donovani |
Percent Effect |
= |
35.45 |
% |
Leishmania intramacrophage assay |
CHEMBL3988442 |
| Lysine--tRNA ligase |
Percent Effect |
= |
2.352 |
% |
Pf-KRS-1 (Lysyl-RNA Synthetase-1, KRS-1, cytosolic KRS) from Plasmodium falciparum. Inhibitor assay, 384 well plate, luminescence read. |
CHEMBL3988442 |
| Unchecked |
Percent Effect |
= |
2.037 |
% |
In vitro enzyme assay to detect hydrolysis of chlorophenol red-beta-D-galactopyranosidase directly proportional to the number of Toxoplasma stably expressing beta-galactosidase |
CHEMBL3988442 |
| AMP-activated protein kinase, AMPK |
Percent Effect |
= |
7.314 |
% |
AMP-dependent Kinase enzyme assay. An in vitro enzyme assay that detects ADP turnover that is directly proportional to AMPK activity. This uses naive AMPK that is activated during the assay with MK-8722 |
CHEMBL3988442 |
| Mycobacterium tuberculosis |
Percent Effect |
= |
8.753 |
% |
Cornell M. t heat shock assay |
CHEMBL3988442 |
| Histidine--tRNA ligase |
Percent Effect |
= |
22.35 |
% |
Leishmania infantum Histidine tRNA synthetase (LdHisRS) |
CHEMBL3988442 |
| ClpP1P2 |
Percent Effect |
= |
6.641 |
% |
in vitro assay to detect presence of AMC directly proportional to the activity of ClpP1P2. GHDDI collaboration. |
CHEMBL3988442 |
| Trypanosoma cruzi |
Percent Effect |
= |
-190.67 |
% |
T. cruzi routine single point assay with increased parasite load to give indication of cidality of compounds (rank compounds by MAX Percent Inhibition) |
CHEMBL3988442 |
| Trypanosoma brucei |
Percent Effect |
= |
-5.395 |
% |
Trypanosoma brucei 72 hour study |
CHEMBL3988442 |
| Unchecked |
Percent Effect |
= |
11.27 |
% |
Phenotypic growth assay for Mycobacterium tuberculosis grown for 3 days on 7H9, glucose tyloxapol based media |
CHEMBL3988442 |
