| No relevant target |
LogP |
= |
-2.33 |
|
Partition coefficient (logP) (dodecane) |
CHEMBL1135392 |
| No relevant target |
LogP |
= |
-0.09 |
|
Partition coefficient (logP) |
CHEMBL1135392 |
| No relevant target |
LogP |
= |
-2.3 |
|
Partition coefficient across water-dodecane interface by statistical simulation |
CHEMBL1135392 |
| Serum albumin |
Log K' |
= |
0.92 |
|
Binding constant against human serum albumin (HSA) |
CHEMBL1134302 |
| ADMET |
Vdss |
= |
0.61 |
L.kg-1 |
Volume of distribution in man (IV dose) |
CHEMBL1135488 |
| ADMET |
Fu |
= |
0.64 |
|
Unbound fraction (plasma) |
CHEMBL1135488 |
| ADMET |
Fu |
= |
0.5429999999999999 |
|
Unbound fraction (tissues) |
CHEMBL1135488 |
| ADMET |
eLog D |
= |
-0.01 |
|
HPLC capacity factor (k') |
CHEMBL1135488 |
| ADMET |
Fraction ionised |
= |
0.0 |
|
Fraction ionized (pH 7.4) |
CHEMBL1135488 |
| No relevant target |
Log Pmic |
= |
0.52 |
|
Micelle/water partition coefficient (Pmic) of the compound was determined |
CHEMBL1129683 |
| Adenosine A1 receptor |
Ki |
= |
100000.0 |
nM |
Binding affinity against adenosine A1 receptor in guinea pig forebrain membranes using N6-[3H]cyclohexyladenosine as radioligand |
CHEMBL1125524 |
| Adenosine A2 receptor |
Ki |
= |
27000.0 |
nM |
Binding affinity against adenosine A2 receptor in rat striatal membranes using N-[3H]-ethyladenosin-5''-uronamide as radioligand in the presence of 50 nM cyclopentyladenosine |
CHEMBL1125524 |
| Rattus norvegicus |
Urine volume |
= |
1.84 |
ml 6hr-1 100g-1 |
Oral diuretic activity was measured after oral administration of 25 mg/kg to rats(control volume is 1.21+/-0.08) |
CHEMBL1125524 |
| Rattus norvegicus |
Urine volume |
= |
0.8 |
ml 6hr-1 100g-1 |
Oral diuretic activity was measured after oral administration of 6.25 mg/kg to rats(control volume is 0.87+/-0.04) |
CHEMBL1125524 |
| Rattus norvegicus |
Na |
= |
0.28 |
m equiv 6hr-1 100g-1 |
Effect on urinary excretion potassium and sodium after oral administration of 25 mg/kg to rats(potassium and sodium excretion in control rat is 0.180+/-0.014) |
CHEMBL1125524 |
| Rattus norvegicus |
Na |
= |
0.162 |
m equiv 6hr-1 100g-1 |
Effect on urinary excretion potassium and sodium after oral administration of 6.25 mg/kg to rats(potassium and sodium excretion in control rat is 0.148+/-0.011) |
CHEMBL1125524 |
| Rattus norvegicus |
Cr |
= |
2.85 |
mg dl-1 |
Serum creatinine concentration measured after intraperitoneal administration of 10 mg/kg of compound to rats(vehicle 4.41+/-0.16) |
CHEMBL1125524 |
| Rattus norvegicus |
Cr |
= |
3.68 |
mg dl-1 |
Serum creatinine concentration measured after intraperitoneal administration of 1 mg/kg of compound to rats(vehicle 4.70+/-0.17) |
CHEMBL1125524 |
| Rattus norvegicus |
UN |
= |
109.0 |
mg dl-1 |
Urea nitrogen concentration measured after intraperitoneal administration of 10 mg/kg of compound to rats(vehicle 145.1+/-7.4) |
CHEMBL1125524 |
| Rattus norvegicus |
UN |
= |
125.7 |
mg dl-1 |
Urea nitrogen concentration measured after intraperitoneal administration of 1 mg/kg of compound to rats(vehicle 154.2+/-5) |
CHEMBL1125524 |
| Rattus norvegicus |
Inhibition |
= |
35.0 |
% |
Percent inhibition of serum creatinine by the compound given as ratio of Cr value in treated to vehicle treated ones after intraperitoneal administration of 10 mg/kg of compound to rats(vehicle 4.41+/-0.16) |
CHEMBL1125524 |
| Rattus norvegicus |
Inhibition |
= |
22.0 |
% |
Percent inhibition of serum creatinine by the compound given as ratio of Cr value in treated to vehicle treated ones after intraperitoneal administration of 1 mg/kg of compound to rats(vehicle 4.70+/-0.17) |
CHEMBL1125524 |
| Rattus norvegicus |
Inhibition |
= |
25.0 |
% |
Percent inhibition of Urea nitrogen by the compound given as ratio of UN value in treated to vehicle treated ones after intraperitoneal administration of 10 mg/kg of compound to rats(vehicle 145.1+/-7.4) |
CHEMBL1125524 |
| Rattus norvegicus |
Inhibition |
= |
18.0 |
% |
Percent inhibition of Urea nitrogen by the compound given as ratio of UN value in treated to vehicle treated ones after intraperitoneal administration of 1 mg/kg of compound to rats(vehicle 154.2+/-5) |
CHEMBL1125524 |
| Adenosine receptors; A1 & A2 |
Ki ratio |
= |
0.27 |
|
Ratio of Ki at A2 receptor to that of A1 receptor |
CHEMBL1125524 |
| Rattus norvegicus |
T/C |
= |
1.68 |
|
Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 25 mg/Kg |
CHEMBL1125524 |
| Rattus norvegicus |
T/C |
= |
0.92 |
|
Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 6.25 mg/Kg |
CHEMBL1125524 |
| Rattus norvegicus |
T/C |
= |
1.55 |
|
Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 25 mg/Kg |
CHEMBL1125524 |
| Rattus norvegicus |
T/C |
= |
1.1 |
|
Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 6.25 mg/Kg |
CHEMBL1125524 |
| Rattus norvegicus |
Na+/K+ |
= |
1.28 |
|
Ratio of sodium ion/potassium ion concentration in treated rats to that in control rats, at a peroral dose of 25 mg/Kg |
CHEMBL1125524 |
| Rattus norvegicus |
Na+/K+ |
= |
1.1 |
|
Ratio of sodium ion/potassium ion concentration in urine of rats following 6.25 mg/kg p.o. |
CHEMBL1125524 |
| Adenosine A1 receptor |
Ki |
= |
41000.0 |
nM |
Ability to inhibit binding of [3H]R-PIA to Adenosine A1 receptor in rat brain cortical membranes |
CHEMBL1130278 |
| Adenosine A1 receptor |
Ki |
= |
26000.0 |
nM |
Ability to inhibit binding of [3H]CHA to adenosine A1 receptor in rat brain cortical membranes. |
CHEMBL1130278 |
| Adenosine A2a receptor |
Ki |
= |
16000.0 |
nM |
Ability to inhibit binding of [3H]NECA to Adenosine A2A receptor in rat brain striatal membranes |
CHEMBL1130278 |
| Adenosine A2a receptor |
Ki |
= |
22000.0 |
nM |
Ability to inhibit binding of [3H]-CGS- 21680 to adenosine A2A receptor in rat brain striatal membranes. |
CHEMBL1130278 |
| Adenosine receptors; A1 & A2a |
Selectivity ratio |
= |
1.0 |
|
Selectivity ratio as adenosine A1 receptor/adenosine A2A receptor. |
CHEMBL1130278 |
| Adenosine A1 receptor |
Ki |
= |
29000.0 |
nM |
Binding affinity against Adenosine A1 receptor in rat brain membrane, using [3H]N6-cyclohexyladenosine as the radioligand |
CHEMBL1124345 |
| Adenosine A2 receptor |
Ki |
= |
48000.0 |
nM |
Binding affinity against Adenosine A2 receptor in rat brain membrane, using [3H]-NECA as the radioligand. |
CHEMBL1124345 |
| Unchecked |
Ratio |
= |
1.65 |
|
Selectivity for A2 and A1 receptors was evaluated |
CHEMBL1124345 |
| No relevant target |
Log S |
= |
-0.88 |
|
Aqueous solubility |
CHEMBL1132890 |
| Adenosine A1 receptor |
Ki |
> |
100000.0 |
nM |
Inhibition of [3H]cyclohexyladenosine binding to guinea pig forebrain membranes Adenosine A1 receptor |
CHEMBL1125889 |
| Adenosine A2 receptor |
Ki |
= |
27000.0 |
nM |
Inhibition of [3H]5'-(N-ethylcarbamoyl)-adenosine binding to Adenosine A2 receptor in rat striatal membranes in the presence of 50 nM cyclopentyladenosine |
CHEMBL1125889 |
| Rattus norvegicus |
Urine volume |
= |
0.92 |
ml 6hr-1 100g-1 |
Compound administered at a dose of 6.25 mg/25 mL/kg orally to rats, urine collected for 6 hr and measured for urine volume. |
CHEMBL1125889 |
| Rattus norvegicus |
K+ excretion |
= |
1.1 |
ml 6hr-1 100g-1 |
Compound administered at a dose of 6.25 mg/25 mL/kg orally to rats, urine collected for 6 hr and measured for Na+ excretion. |
CHEMBL1125889 |
| Rattus norvegicus |
K+ excretion |
= |
0.99 |
ml 6hr-1 100g-1 |
Compound administered at a dose of 6.25 mg/25 mL/kg orally to rats, urine collected for 6 hr and measured for K+ excretion. |
CHEMBL1125889 |
| ADMET |
Ratio |
= |
1.1 |
|
Ratio of Na+ to K+ excretion |
CHEMBL1125889 |
| Adenosine A1 receptor |
Affinity constant |
= |
30.0 |
uM |
Affinity constant for inhibition of A1 receptor control of adenylate cyclase in adipocytes, heart and brain cells |
CHEMBL1122012 |
| Adenosine A2 receptor |
Affinity constant |
= |
30.0 |
uM |
Affinity constant for A2 receptor control of adenylate cyclase in adipocytes, heart and brain cells |
CHEMBL1122012 |
| Adenosine receptor |
Affinity constant |
|
|
|
Inhibition of adenyl cyclase via P site in adipocytes; Inactive |
CHEMBL1122012 |
| Adenosine A2a receptor |
Ki |
= |
80000.0 |
nM |
Antagonist binding of N6-cyclohexyl-[3H]-adenosine to guinea pig brain |
CHEMBL1122012 |
| Adenosine receptor |
Ki |
= |
40000.0 |
nM |
Antagonist binding of N6-cyclohexyl-[3H]-adenosine to rat brain |
CHEMBL1122012 |
| Adenosine A1 receptor |
Ki |
= |
130000.0 |
nM |
Antagonist binding of N6-cyclohexyl-[3H]-adenosine to bovine brain |
CHEMBL1122012 |
| Adenosine receptor |
Ki |
= |
60000.0 |
nM |
Antagonist binding of N6-cyclohexyl-[3H]-adenosine to rat testes |
CHEMBL1122012 |
| Adenosine receptor |
Ki |
= |
25000.0 |
nM |
Antagonist binding of L-N6-phenyl-isopropyl)-[3H]adenosine to rat brain |
CHEMBL1122012 |
| Adenosine receptor |
Ki |
= |
60000.0 |
nM |
Antagonist binding of L-N6-phenyl-isopropyl)-[3H]adenosine to rat fat |
CHEMBL1122012 |
| Adenosine receptor |
Ki |
= |
15000.0 |
nM |
Antagonist binding of 2-chloro-[3H]-adenosine to rat brain |
CHEMBL1122012 |
| Mus musculus |
Retention |
= |
70.0 |
% |
Compound was tested for cognitive activity by measuring retention for passive avoidance learning in mice at dose 0.63 mg/kg |
CHEMBL1121804 |
| Mus musculus |
Retention |
= |
87.0 |
% |
Retention for passive avoidance learning in mice at dose 1.25 mg/kg |
CHEMBL1121804 |
| Mus musculus |
Retention |
= |
37.0 |
% |
Retention for passive avoidance learning in mice at dose 2.5 mg/kg |
CHEMBL1121804 |
| Mus musculus |
Retention |
= |
37.0 |
% |
Retention for passive avoidance learning in mice at dose 5 mg/kg |
CHEMBL1121804 |
| Mus musculus |
Retention |
= |
3.0 |
% |
Compound was tested for cognitive activity by measuring retention for passive avoidance learning in mice at dose 10 mg/kg |
CHEMBL1121804 |
| Mus musculus |
Retention |
= |
3.0 |
% |
Compound was tested for cognitive activity by measuring retention for passive avoidance learning in mice at dose 40 mg/kg |
CHEMBL1121804 |
| Mus musculus |
Retention |
= |
0.0 |
% |
Retention for passive avoidance learning in mice at dose 80 mg/kg |
CHEMBL1121804 |
| Adenosine A1 receptor |
Ki |
= |
29000.0 |
nM |
Affinity to A1 adenosine receptor was measured by the displacement of [3H]PIA in bovine brain cortical membrane |
CHEMBL1127455 |
| Adenosine A2a receptor |
Ki |
= |
48000.0 |
nM |
Affinity to A2 adenosine receptor was measured by the displacement of [3H]-CGS- 21680 in bovine brain striatal membrane |
CHEMBL1127455 |
| Unchecked |
Ratio |
= |
1.7 |
|
Ratio between the Ki values of A2 and A1 receptors |
CHEMBL1127455 |
| Adenosine A1 receptor |
Ki |
= |
55000.0 |
nM |
Ability to inhibit binding of 1 nM [3H]cyclohexyladenosine to adenosine A1 receptor in rat cerebral cortical membranes |
CHEMBL1123548 |
| Adenosine A2a receptor |
Ki |
= |
50000.0 |
nM |
Compound was evaluated for its ability to antagonise cyclic [3H]AMP accumulation in [3H]adenine-labeled guinea pig cerebral cortical slices. |
CHEMBL1123548 |
| Unchecked |
Selectivity ratio |
= |
1.1 |
|
Selectivity was expressed as the ratio is Ki of adenosine A1 receptor to that of adenosine A2 receptor |
CHEMBL1123548 |
| Sodium channel alpha subunits; brain (Types I, II, III) |
IC50 |
= |
660000.0 |
nM |
Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex |
CHEMBL1122963 |
| Sodium channel alpha subunits; brain (Types I, II, III) |
Inhibition |
= |
9.7 |
% |
Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex at 10 uM |
CHEMBL1122963 |
| Adenosine A1 receptor |
Ki |
= |
44000.0 |
nM |
Inhibition of 1 nM [3H]- N6-(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat cerebral cortical membranes |
CHEMBL1124484 |
| Adenosine A2 receptor |
Ki |
= |
30000.0 |
nM |
Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via adenosine A2 receptor in human platelet membranes. |
CHEMBL1124484 |
| Adenosine A1 receptor |
Ki |
= |
59000.0 |
nM |
Inhibition of 1 nM [3H]- N6 -(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat fat cell membrane |
CHEMBL1124484 |
| Adenosine A2 receptor |
Ki |
= |
37000.0 |
nM |
Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via Adenosine A2 receptor in rat PC12 membranes |
CHEMBL1124484 |
| ADMET |
Permeability coefficient |
= |
40.3 |
|
Permeability coefficient reported (Expressed as Permeability coefficient x 10 e 4 cm/s) |
CHEMBL1129412 |
| Adenosine A1 receptor |
IC50 |
= |
110000.0 |
nM |
Antagonism of adenosine A1 receptor assessed from the ability to inhibit binding of [3H]cyclohexyladenosine to rat cerebral cortical membranes |
CHEMBL1122769 |
| Cavia porcellus |
IC50 |
= |
150000.0 |
nM |
Ability to inhibit 2-chloroadenosine (15 uM)-elicited accumulations of cyclic AMP in guinea pig cerebral cortical membranes |
CHEMBL1122769 |
| ADMET |
Vdss |
= |
0.61 |
L.kg-1 |
Observed volume of distribution |
CHEMBL1148291 |
| ADMET |
Fu |
= |
0.64 |
|
Unbound fraction (plasma) |
CHEMBL1148291 |
| No relevant target |
pKa |
|
|
|
Dissociation constant (pKa) |
CHEMBL1148291 |
| ADMET |
Log k'w |
= |
-0.31 |
|
HPLC capacity factor (k) |
CHEMBL1133461 |
| No relevant target |
LogP |
= |
-0.21 |
|
Partition coefficient (logP) (HPLC) |
CHEMBL1133461 |
| No relevant target |
LogP |
= |
-0.07 |
|
Partition coefficient (logP) |
CHEMBL1133461 |
| Adenosine A1 receptor |
Ki |
= |
41000.0 |
nM |
Binding affinity to A1 adenosine receptor from rat cortical membrane in presence of [3H]R-(phenylisopropyl)-adenosine |
CHEMBL1127516 |
| Adenosine A2 receptor |
Ki |
= |
43000.0 |
nM |
Binding affinity to A2 adenosine receptor from rat striatal membrane in presence of [3H]5'-(N-ethylcarboximido)-adenosine |
CHEMBL1127516 |
| Adenosine receptors; A1 & A2 |
A1 selectivity |
= |
1.0 |
|
A1 selectivity is the ratio between A2 and A1 receptor |
CHEMBL1127516 |
| Adenosine A1 receptor |
Ki |
= |
41000.0 |
nM |
Binding affinity against Adenosine A1 receptor by displacing [3H]CHA radioligand in rat brain cortical membrane |
CHEMBL1135439 |
| Adenosine A2a receptor |
Ki |
= |
43000.0 |
nM |
Binding affinity to the adenosine A2A receptor by displacement of [3H]CGS-21680 in rat brain striatal membrane |
CHEMBL1135439 |
| Adenosine A3 receptor |
Ki |
= |
13300.0 |
nM |
Binding affinity against human recombinant Adenosine A3 receptor stably expressed in HEK293 cells by displacing [125I]AB-MECA radioligand |
CHEMBL1135439 |
| Adenosine A1 receptor |
Kb |
= |
60000.0 |
nM |
Inhibition against Adenosine A1 receptor of rat fat cell membranes (functional antagonist activity) |
CHEMBL1135439 |
| Adenosine A2a receptor |
Kb |
= |
36000.0 |
nM |
Inhibition against A2A-Adenosine Receptor of rat PC12 cell membranes (functional antagonist activity) |
CHEMBL1135439 |
| Adenosine A2b receptor |
Kb |
= |
25000.0 |
nM |
Inhibition against A2B-Adenosine Receptor in mouse NIH 3T3 fibroblast cell membranes (functional antagonist activity) |
CHEMBL1135439 |
| ADMET |
Solubility |
= |
108000000.0 |
nM |
Water solubility of the compound |
CHEMBL1135439 |
| Adenosine A1 receptor |
Ki |
= |
29000.0 |
nM |
Displacement of [3H]PIA from adenosine A1 receptors of rat brain membrane |
CHEMBL1127794 |
| Adenosine A2a receptor |
Ki |
= |
48000.0 |
nM |
Displacement of [3H]-CGS- 21680 from adenosine A2a receptors of rat striatal membrane |
CHEMBL1127794 |
| Adenosine A3 receptor |
Inhibition |
= |
30.1 |
% |
Tested for the binding affinity, for displacement of [125I]AB-MECA in membranes of CHO cells stably transfected with the rat A3-cDNA at the 10e-4 concentration (M) |
CHEMBL1127794 |
| Adenosine receptors; A1 & A3 |
Ratio |
> |
3.0 |
|
Ratio of selectivity for A3 and A1 receptors at rat brain |
CHEMBL1127794 |
| Adenosine receptor A2a and A3 |
Ratio |
> |
2.0 |
|
Ratio of selectivity for A3 and A2a receptors at rat brain |
CHEMBL1127794 |
| Mus musculus |
Permeability |
|
|
|
BBB penetration classification |
CHEMBL1133022 |
| Mus musculus |
Amnesia reversal |
= |
10.0 |
% |
Ability to reverse electroconvulsive shock (ECS) induced amnesia in mice, after administering intraperitoneally, at a dose of 0.31 mg/kg |
CHEMBL1122658 |
| Mus musculus |
Amnesia reversal |
= |
5.0 |
% |
Ability to reverse electroconvulsive shock (ECS) induced amnesia in mice, after administering intraperitoneally, at a dose of 0.63 mg/kg |
CHEMBL1122658 |
| Mus musculus |
Amnesia reversal |
= |
0.0 |
% |
Ability to reverse electroconvulsive shock induced amnesia in mice, after administering intraperitoneally at a dose of 1.25 mg/kg |
CHEMBL1122658 |
| Mus musculus |
Amnesia reversal |
= |
10.0 |
% |
Ability to reverse electroconvulsive shock induced amnesia in mice, after administering intraperitoneally at a dose of 2.5 mg/kg |
CHEMBL1122658 |
| Mus musculus |
Amnesia reversal |
= |
0.0 |
% |
Ability to reverse electroconvulsive shock (ECS) induced amnesia in mice, after administering intraperitoneally, at a dose of 5 mg/kg |
CHEMBL1122658 |
| Adenosine A1 receptor |
Ki |
= |
29000.0 |
nM |
Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligand |
CHEMBL1125572 |
| Adenosine A2 receptor |
Ratio |
= |
48000.0 |
nM |
Binding affinity against adenosine A2 receptor using [3H]- NECA as radioligand |
CHEMBL1125572 |
| Adenosine receptors; A1 & A2 |
Ratio |
= |
1.7 |
|
Ratio of A2 to A1. |
CHEMBL1125572 |
| Adenosine A1 receptor |
Ki |
= |
100000.0 |
nM |
Binding affinity against Adenosine A1 receptor from guinea pig forebrain membranes by N6-[3H]- cyclohexyladenosine displacement. |
CHEMBL1126778 |
| Adenosine A1 receptor |
Ki |
= |
29100.0 |
nM |
Tested for binding affinity against Adenosine A1 receptor from rat forebrain membranes, using N6-[3H]- cyclohexyladenosine as radioligand |
CHEMBL1126778 |
| Adenosine A2 receptor |
Ki |
= |
27000.0 |
nM |
Binding affinity at Adenosine A2 receptor from rat striatal membranes by N-[3H] ethyladenosin-5'- uronamide displacement. |
CHEMBL1126778 |
| Adenosine receptors; A1 & A2 |
Ratio |
= |
0.27 |
|
Ratio of Ki for A2 and A1 adenosine receptors |
CHEMBL1126778 |
| Rattus norvegicus |
Acquisition time |
= |
29.6 |
s |
Acquisition time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after peroral administration of 80 mg/kg |
CHEMBL1126778 |
| Rattus norvegicus |
Retention time |
= |
7.6 |
s |
Retention time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after peroral administration of 80 mg/kg |
CHEMBL1126778 |
| Mus musculus |
Acquisition time |
|
|
|
Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 80 mg/kg; NT is Not Tested |
CHEMBL1126778 |
| Mus musculus |
Retention time |
|
|
|
Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 80 mg/kg; NT is Not Tested |
CHEMBL1126778 |
| Rattus norvegicus |
Acquisition time |
= |
33.8 |
s |
Acquisition time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after peroral administration of 20 mg/kg |
CHEMBL1126778 |
| Rattus norvegicus |
Retention time |
= |
9.8 |
s |
Retention time in Scopolamine induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 20 mg/kg |
CHEMBL1126778 |
| Mus musculus |
Acquisition time |
|
|
|
Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 20 mg/kg; NT is Not Tested |
CHEMBL1126778 |
| Mus musculus |
Retention time |
|
|
|
Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 20 mg/kg; NT is Not Tested |
CHEMBL1126778 |
| Rattus norvegicus |
Acquisition time |
= |
11.5 |
s |
Acquisition time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after p.o. administration of 5 mg/kg |
CHEMBL1126778 |
| Rattus norvegicus |
Retention time |
= |
12.5 |
s |
Retention time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after peroral administration of 5 mg/kg |
CHEMBL1126778 |
| Mus musculus |
Acquisition time |
|
|
|
Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 5 mg/kg; NT is Not Tested |
CHEMBL1126778 |
| Mus musculus |
Retention time |
|
|
|
Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 5 mg/kg; NT is Not Tested |
CHEMBL1126778 |
| Rattus norvegicus |
Acquisition time |
= |
14.6 |
s |
Acquisition time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after peroral administration of 1.25 mg/kg |
CHEMBL1126778 |
| Rattus norvegicus |
Retention time |
= |
11.9 |
s |
Retention time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after peroral administration of 1.25 mg/kg |
CHEMBL1126778 |
| Mus musculus |
Acquisition time |
|
|
|
Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 1.25 mg/kg; NT is Not Tested |
CHEMBL1126778 |
| Mus musculus |
Retention time |
|
|
|
Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 1.25 mg/kg; NT is Not Tested |
CHEMBL1126778 |
| Rattus norvegicus |
Acquisition time |
= |
18.3 |
s |
Acquisition time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after p.o. administration of 0.31 mg/kg |
CHEMBL1126778 |
| Rattus norvegicus |
Retention time |
= |
14.9 |
s |
Retention time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after p.o. administration of 0.31 mg/kg |
CHEMBL1126778 |
| Mus musculus |
Acquisition time |
|
|
|
Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 0.31 mg/kg; NT is Not Tested |
CHEMBL1126778 |
| Mus musculus |
Retention time |
|
|
|
Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 0.31 mg/kg; NT is Not Tested |
CHEMBL1126778 |
| Mus musculus |
Locomotor activity |
= |
6413.0 |
Counts |
Tested for locomotor activity after oral administration of 2.5 mg/kg for 120 min |
CHEMBL1126778 |
| Mus musculus |
Locomotor activity |
= |
9386.0 |
Counts |
Tested for locomotor activity after oral administration of 10 mg/kg for 120 min |
CHEMBL1126778 |
| Mus musculus |
Locomotor activity |
= |
9693.0 |
Counts |
Tested for locomotor activity after oral administration of 40 mg/kg for 120 min |
CHEMBL1126778 |
| Adenosine A1 receptor |
Ki |
= |
55000.0 |
nM |
Antagonism of binding of 1 nM [3H]cyclohexyladenosine to adenosine A1 receptors on rat cortical membranes |
CHEMBL1123072 |
| Adenosine A2a receptor |
Ki |
= |
50000.0 |
nM |
Antagonism of cyclic [3H]AMP accumulation in guinea pig cerebral cortical slices (elicited by 15 uM 2-chloroadenosine at adenosine A2 receptor) |
CHEMBL1123072 |
| Unchecked |
Ratio |
= |
0.9 |
|
Ratio of antagonism at A2 versus A1 receptors (Ki values) |
CHEMBL1123072 |
| Adenosine A1 receptor |
Ki |
= |
100000.0 |
nM |
Binding affinity against adenosine A1 receptor using N6-[3H]cyclohexyladenosine as radioligand in guinea pig forebrain membranes |
CHEMBL1126169 |
| Adenosine A2 receptor |
Ki |
= |
27000.0 |
nM |
Binding affinity against adenosine A2 receptor using N-[3H]-ethyladenosin-5''-uronamide as radioligand in rat striatal membranes. |
CHEMBL1126169 |
| Adenosine A1 receptor |
Ki |
= |
29100.0 |
nM |
Binding affinity against adenosine A1 receptor using N6-[3H]-cyclohexyladenosinene in rat whole brain membranes |
CHEMBL1126169 |
| Adenosine A2 receptor |
Ki |
= |
48100.0 |
nM |
Binding affinity against adenosine A2 receptor using N-[3H]-ethyl adenosine-5-uronamide in rat striatal membranes |
CHEMBL1126169 |
| Adenosine receptors; A1 & A2 |
Ratio |
= |
0.27 |
|
Selectivity is defined as the ratio of Ki(A2 adenosine receptor) / Ki(A1 adenosine receptor) |
CHEMBL1126169 |
| Adenosine A2b receptor |
Ki |
= |
10400.0 |
nM |
Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand |
CHEMBL1135414 |
| No relevant target |
LogD |
= |
-0.07 |
|
Partition coefficient (logD7.4) |
CHEMBL1134540 |
| Adenosine A1 receptor |
Ki |
= |
55000.0 |
nM |
Binding affinity for Adenosine A1 receptor from rat brain using [3H]-PIA as radioligand |
CHEMBL1124986 |
| Adenosine A2 receptor |
Ki |
= |
48000.0 |
nM |
Binding affinity for Adenosine A2 receptor from rat striatum using [3H]NECA as radioligand |
CHEMBL1124986 |
| Adenosine A2 receptor |
Ki |
= |
37000.0 |
nM |
Antagonism of N-ethylcarboxamido adenosine-stimulated adenylate cyclase associated with stimulation of Adenosine A2 receptor of rat PC12 membranes |
CHEMBL1124986 |
| Adenosine A1 receptor |
Ki |
= |
29000.0 |
nM |
Binding affinity for adenosine A1 receptor from rat brain membranes using [3H]PIA as radioligand |
CHEMBL1126793 |
| Adenosine A2a receptor |
Ki |
= |
23000.0 |
nM |
Binding affinity for adenosine A2A receptor from rat brain membranes using [3H]CGS-21680 |
CHEMBL1126793 |
| No relevant target |
LogD |
= |
-0.07 |
|
Partition coefficient (logD6.5) |
CHEMBL1133765 |
| ADMET |
delta logD |
= |
0.0 |
|
Delta logD (logD6.5 - logD7.4) |
CHEMBL1133765 |
| ADMET |
F |
> |
80.0 |
% |
Oral bioavailability in human |
CHEMBL1133765 |
| No relevant target |
pKa |
|
|
|
Ionization constant (pKa) |
CHEMBL1133765 |
| Rattus norvegicus |
Clearance |
= |
0.6 |
ul min-1 |
In vitro clearance in rat in 1000000 cells |
CHEMBL1132496 |
| Canis familiaris |
Clearance |
= |
0.2 |
ul min-1 |
In vitro clearance in dog in 1000000 cells |
CHEMBL1132496 |
| Homo sapiens |
Clearance |
= |
0.1 |
ul min-1 |
In vitro clearance in human in 1000000 cells |
CHEMBL1132496 |
| Rattus norvegicus |
CL |
= |
13.0 |
mL.min-1.kg-1 |
In vivo clearance in rat |
CHEMBL1132496 |
| Canis familiaris |
CL |
= |
2.6 |
mL.min-1.kg-1 |
In vivo clearance in dog |
CHEMBL1132496 |
| Homo sapiens |
CL |
= |
2.0 |
mL.min-1.kg-1 |
In vivo clearance in human |
CHEMBL1132496 |
| No relevant target |
LogP |
> |
19.0 |
|
Lipid solubility measured as chloroform-water partition coefficient |
CHEMBL1123133 |
| Unchecked |
Activity |
= |
100.0 |
% |
Calcium release in PC12 cells at 2 mM as percent of 1 mM caffeine effect |
CHEMBL1132292 |
| Unchecked |
Potentiation |
= |
100.0 |
% |
compound was screened for their ability to potentiate [Ca2+] release induced by cADRP(an endogenous modulator of ryanodine receptor) in sea urchin egg homogenates at a concentration 1 mM |
CHEMBL1132292 |
| Adenosine A1 receptor |
Ki |
= |
100000.0 |
nM |
Binding affinity against adenosine A1 receptor from guinea pig forebrain membranes, using N6-[3H]cyclohexyladenosine as radioligand. |
CHEMBL1126087 |
| Adenosine A2 receptor |
Ki |
= |
27000.0 |
nM |
Binding affinity against adenosine A2 receptor from rat striatal membranes, using N-[3H]-ethyladenosin-5''-uronamide as radioligand (in the presence of 50 nM cyclopentyl adenosine). |
CHEMBL1126087 |
| Adenosine A1 receptor |
Ki |
= |
44000.0 |
nM |
Inhibition of (R)-N6-([3H]-phenylisopropyl) adenosine binding to adenosine A1 receptor from rat cortical membranes |
CHEMBL1126087 |
| Brain adenylate cyclase 1 |
Kb |
= |
30000.0 |
nM |
Inhibition of adenylate cyclase stimulation by N-[3H]-ethyladenosin-5''-uronamide in human platelet membranes |
CHEMBL1126087 |
| Adenosine A1 receptor |
Ki |
= |
29100.0 |
nM |
Inhibition of N6-[3H]cyclohexyladenosine binding to adenosine A1 receptor from whole brain membranes |
CHEMBL1126087 |
| Adenosine A2 receptor |
Ki |
= |
48100.0 |
nM |
Inhibition of N-[3H]-ethyladenosin-5''-uronamide binding to adenosine A2 receptor from rat striatal membranes |
CHEMBL1126087 |
| Unchecked |
Ki ratio |
= |
3.7 |
|
Ratio against A1 adenosine receptor to the A2 adenosine receptor (guinea pig forebrain membranes, using N6-[3H]cyclohexyladenosine as radioligand. |
CHEMBL1126087 |
| Caco-2 |
Pc |
= |
4.4 |
cm s-1 |
Caco-2 permeability coefficient value was determined |
CHEMBL1136441 |
| Rattus norvegicus |
MED |
= |
3.2 |
mg kg-1 |
Minimal effective dose in an rat anti-immobility effect using behavioral despair test |
CHEMBL1124880 |
| Adenosine A1 receptor |
IC50 |
= |
117000.0 |
nM |
Binding affinity towards the adenosine A1 receptor in cerebral cortices of Sprague-Dawley male rats using [3H]CHA as radioligand. |
CHEMBL1124880 |
| Adenosine A2 receptor |
IC50 |
= |
63000.0 |
nM |
Evaluated for the binding affinity towards the Adenosine A2 receptor in corpora striata of rats using [3H]NECA as radioligand. |
CHEMBL1124880 |
| Phosphodiesterase 1 |
IC50 |
= |
70000.0 |
nM |
Evaluated for Ca++ dependent phosphodiesterase activity. |
CHEMBL1124880 |
| Rattus norvegicus |
IC50 |
= |
170000.0 |
nM |
Evaluated for Ca++ independent phosphodiesterase activity. |
CHEMBL1124880 |
| Adenosine A1 receptor |
Kd |
= |
45000.0 |
nM |
Dissociation constant against Adenosine A1 receptor |
CHEMBL1142733 |
| Adenosine A1 receptor |
KD hydro |
= |
150.0 |
mM |
Dissociation constant against Adenosine A1 receptor |
CHEMBL1142733 |
| Muscle glycogen phosphorylase |
IC50 |
= |
114000.0 |
nM |
Inhibitory concentration against rabbit muscle glycogen phosphorylase |
CHEMBL1143491 |
| Liver glycogen phosphorylase |
IC50 |
= |
648000.0 |
nM |
Inhibitory concentration against rat liver glycogen phosphorylase |
CHEMBL1143491 |
| Glycogen phosphorylase, muscle form |
IC50 |
= |
114000.0 |
nM |
Inhibitory activity against rabbit muscle GPa |
CHEMBL1138121 |
| Glycogen phosphorylase, muscle form |
IC50 |
= |
114000.0 |
nM |
Inhibition of rabbit muscle GPa |
CHEMBL1148669 |
| ADMET |
Activity |
= |
14.4 |
% |
Membrane permeability, CA(t)/CD(0) in 100% IPM membrane |
CHEMBL1138041 |
| ADMET |
Activity |
< |
1.0 |
% |
Membrane retention in 100% IPM membrane |
CHEMBL1138041 |
| ADMET |
Activity |
< |
1.0 |
% |
Membrane permeability, CA(t)/CD(0) in 100% silicon membrane |
CHEMBL1138041 |
| ADMET |
Activity |
< |
1.0 |
% |
Membrane retention in 100% silicon membrane |
CHEMBL1138041 |
| No relevant target |
pKa |
= |
0.6 |
|
Dissociation constant, pKa of the compound |
CHEMBL1138041 |
| Homo sapiens |
log Kp |
= |
-7.56 |
cm/s |
Permeability in human skin |
CHEMBL1138041 |
| ADMET |
log Pe |
= |
-5.63 |
cm/s |
Effective permeability coefficient in 70% silicon-30% IPM membrane |
CHEMBL1138041 |
| ADMET |
Activity |
= |
4.3 |
% |
Membrane permeability, CA(t)/CD(0) in 70% silicon-30% IPM membrane |
CHEMBL1138041 |
| ADMET |
Activity |
< |
1.0 |
% |
Membrane retention in 70% silicon-30% IPM membrane |
CHEMBL1138041 |
| ADMET |
log Pe |
= |
-5.05 |
cm/s |
Effective permeability coefficient in 100% IPM membrane |
CHEMBL1138041 |
| ADMET |
LogP app |
= |
-5.41 |
|
Permeability coefficient through artificial membrane in presence of unstirred water layer by PAMPA |
CHEMBL1143050 |
| ADMET |
Papp |
= |
15.95 |
10^-6 cm/s |
Permeability coefficient through artificial membrane in presence of stirred water layer |
CHEMBL1143050 |
| ADMET |
LogP app |
= |
-4.8 |
|
Permeability coefficient through artificial membrane in presence of stirred water layer |
CHEMBL1143050 |
| No relevant target |
LogP |
= |
-0.07 |
|
Partition coefficient, log P of the compound |
CHEMBL1143050 |
| Vibrio harveyi |
Activity |
= |
293.0 |
|
Effect on 1-methyl-4-phenyl-2,3-dihydropyridinium-induced mutagenicity in Vibrio harveyi BB7XM assessed as number of neomycin-resistant mutants at 10 uM |
CHEMBL1149602 |
| Vibrio harveyi |
Activity |
= |
70.0 |
|
Effect on 1-methyl-4-phenyl-2,3-dihydropyridinium-induced mutagenicity in Vibrio harveyi BB7XM assessed as number of neomycin-resistant mutants at 100 uM |
CHEMBL1149602 |
| Vibrio harveyi |
Activity |
= |
51.0 |
|
Effect on 1-methyl-4-phenyl-2,3-dihydropyridinium-induced mutagenicity in Vibrio harveyi BB7XM assessed as number of neomycin-resistant mutants at 500 uM |
CHEMBL1149602 |
| Vibrio harveyi |
Activity |
= |
47.0 |
|
Effect on 1-methyl-4-phenyl-2,3-dihydropyridinium-induced mutagenicity in Vibrio harveyi BB7XM assessed as number of neomycin-resistant mutants at 1000 uM |
CHEMBL1149602 |
| Vibrio harveyi |
Activity |
= |
103.0 |
|
Effect on 1-methyl-4-phenylpyridinium-induced mutagenicity in Vibrio harveyi BB7XM assessed as number of neomycin-resistant mutants at 10 uM |
CHEMBL1149602 |
| Vibrio harveyi |
Activity |
= |
50.0 |
|
Effect on 1-methyl-4-phenylpyridinium-induced mutagenicity in Vibrio harveyi BB7XM assessed as number of neomycin-resistant mutants at 100 uM |
CHEMBL1149602 |
| Vibrio harveyi |
Activity |
= |
31.0 |
|
Effect on 1-methyl-4-phenylpyridinium-induced mutagenicity in Vibrio harveyi BB7XM assessed as number of neomycin-resistant mutants at 500 uM |
CHEMBL1149602 |
| Vibrio harveyi |
Activity |
= |
7.0 |
|
Effect on 1-methyl-4-phenylpyridinium-induced mutagenicity in Vibrio harveyi BB7XM assessed as number of neomycin-resistant mutants at 1000 uM |
CHEMBL1149602 |
| Adenosine A2a receptor |
Ki |
= |
32500.0 |
nM |
Displacement of [3H]MSX2 from adenosine A2A receptor in rat brain striatal membrane |
CHEMBL1137492 |
| Adenosine A1 receptor |
Ki |
= |
18800.0 |
nM |
Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membrane |
CHEMBL1137492 |
| Unchecked |
IC50 |
= |
114000.0 |
nM |
Inhibition of rabbit muscle glycogen phosphorylase a |
CHEMBL1137508 |
| Adenosine A1 receptor |
Activity |
|
|
|
Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membrane at 25 uM |
CHEMBL1139979 |
| Adenosine A1 receptor |
Ki |
= |
18800.0 |
nM |
Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membrane |
CHEMBL1139979 |
| Adenosine A2a receptor |
Activity |
|
|
|
Displacement of [3H]MSX2 from adenosine A2A receptor in rat striatal membrane at 25 uM |
CHEMBL1139979 |
| Adenosine A2a receptor |
Ki |
= |
32500.0 |
nM |
Displacement of [3H]MSX2 from adenosine A2A receptor in rat striatal membrane |
CHEMBL1139979 |
| Ryanodine receptor 2 |
Activity |
|
|
|
Activation of ryanodine receptor in human IMR32 cells assessed as induction of calcium mobilization |
CHEMBL1140509 |
| No relevant target |
LogP |
= |
-0.07 |
|
Partition coefficient, log P of the compound |
CHEMBL1140614 |
| Skin |
log Kp |
= |
-7.56 |
|
Permeability across human Skin |
CHEMBL1140614 |
| ADMET |
log Pe |
= |
-5.63 |
|
Permeability across PAMPA membrane after 7 hrs |
CHEMBL1140614 |
| Skin |
log Kp |
= |
-7.3 |
|
Permeability coefficient in human skin |
CHEMBL1141284 |
| No relevant target |
LogP |
= |
0.01 |
|
Lipophilicity, log P of the compound |
CHEMBL1141284 |
| Homo sapiens |
F |
= |
100.0 |
% |
Oral bioavailability in human |
CHEMBL1141299 |
| Adenosine A1 receptor |
Ki |
= |
49000.0 |
nM |
Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in HEK293T cells |
CHEMBL1142932 |
| Adenosine A2a receptor |
Ki |
= |
18100.0 |
nM |
Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in HEK293T cells |
CHEMBL1142932 |
| Adenosine A3 receptor |
Activity |
= |
9.0 |
% |
Displacement of [3H]NECA from human recombinant adenosine A3 receptor expressed in HEK293T cells at 100 uM |
CHEMBL1142932 |
| Liver microsomes |
Activity |
= |
8.31 |
pmol/mg/min |
Antioxidant activity in rat liver microsomes assessed as inhibition of ethoxyresorufin O-deethylase activity at 1000 uM |
CHEMBL1144752 |
| Liver microsomes |
IC50 |
= |
520000.0 |
nM |
Antioxidant activity in rat liver microsomes assessed as inhibition of ethoxyresorufin O-deethylase activity |
CHEMBL1144752 |
| Liver microsomes |
Inhibition |
= |
80.0 |
% |
Antioxidant activity in rat liver microsomes assessed as inhibition of ethoxyresorufin O-deethylase activity at 1000 uM |
CHEMBL1144752 |
| Adenosine A1 receptor |
Ki |
= |
29000.0 |
nM |
Binding affinity to adenosine A1 receptor |
CHEMBL1155686 |
| Adenosine A1 receptor |
Ki |
= |
49000.0 |
nM |
Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in HEK293T cells |
CHEMBL1157148 |
| Adenosine A2a receptor |
Ki |
= |
18100.0 |
nM |
Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in HEK293T cells |
CHEMBL1157148 |
| Adenosine A3 receptor |
Ki |
> |
100000.0 |
nM |
Displacement of [3H]NECA from human recombinant adenosine A3 receptor expressed in HEK293T cells |
CHEMBL1157148 |
| ADMET |
permeability |
= |
1.8 |
10'6cm/s |
Membrane permeability by PAMPA |
CHEMBL1156575 |
| ADMET |
permeability |
= |
3.6 |
% |
Membrane permeability assessed as passive transport after 4 hrs by PAMPA |
CHEMBL1156575 |
| ADMET |
permeability |
= |
1.8 |
10'6cm/s |
Membrane permeability by PAMPA in presence of 20% 1-propanol |
CHEMBL1156575 |
| ADMET |
permeability |
= |
3.6 |
% |
Membrane permeability assessed as passive transport after 4 hrs by PAMPA in presence of 20% 1-propanol |
CHEMBL1156575 |
| No relevant target |
LogD |
= |
-0.14 |
|
Lipophilicity, log D of compound at pH 7.4 by microfluidic liquid-liquid extraction method |
CHEMBL1156576 |
| No relevant target |
LogD |
= |
-0.13 |
|
Lipophilicity, log D of compound at pH 7.4 by shake flask method |
CHEMBL1156576 |
| Caco-2 |
Papp |
= |
267.8 |
nm/s |
Apparent permeability across human Caco-2 cells |
CHEMBL1153391 |
| Serum albumin |
PPB |
= |
37.8 |
% |
Binding affinity to human plasma albumin by ultracentrifugation |
CHEMBL1137733 |
| Unchecked |
KSV |
= |
1.631 |
L/mol |
Binding affinity to bovine hemoglobin assessed as Stern-Volmer quenching constant at 290 K by fluorescence and UV/vis spectroscopy |
CHEMBL1137733 |
| Unchecked |
KSV |
= |
1.443 |
L/mol |
Binding affinity to bovine hemoglobin assessed as Stern-Volmer quenching constant at 300 K by fluorescence and UV/vis spectroscopy |
CHEMBL1137733 |
| Unchecked |
KSV |
= |
1.263 |
L/mol |
Binding affinity to bovine hemoglobin assessed as Stern-Volmer quenching constant at 310 K by fluorescence and UV/vis spectroscopy |
CHEMBL1137733 |
| Unchecked |
Ka |
= |
1.956 |
L/mol |
Binding affinity to bovine hemoglobin assessed as association constant at 290 K by fluorescence and UV/vis spectroscopy |
CHEMBL1137733 |
| Unchecked |
Ka |
= |
1.672 |
L/mol |
Binding affinity to bovine hemoglobin assessed as association constant at 300 K by fluorescence and UV/vis spectroscopy |
CHEMBL1137733 |
| Unchecked |
Ka |
= |
1.454 |
L/mol |
Binding affinity to bovine hemoglobin assessed as association constant at 310 K by fluorescence and UV/vis spectroscopy |
CHEMBL1137733 |
| Hepatocyte |
logCL |
= |
0.1461 |
|
Hepatic clearance in human hepatocytes in absence of fetal calf serum |
CHEMBL1137707 |
| Hepatocyte |
CL |
= |
1.4 |
mL.min-1.kg-1 |
Hepatic clearance in human hepatocytes in absence of fetal calf serum |
CHEMBL1137707 |
| Adenosine A1 receptor |
Inhibition |
|
|
% |
Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membrane at 100 uM by liquid scintillation counting |
CHEMBL1150660 |
| Adenosine A2a receptor |
Inhibition |
= |
58.0 |
% |
Displacement of [3H]MSX-2 from A2A receptor in rat brain striatal membrane at 100 uM by liquid scintillation counting |
CHEMBL1150660 |
| Adenosine A1 receptor |
Ki |
= |
23500.0 |
nM |
Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membrane by liquid scintillation counting |
CHEMBL1150660 |
| Adenosine A2a receptor |
Ki |
= |
32500.0 |
nM |
Displacement of [3H]MSX-2 from A2A receptor in rat brain striatal membrane by liquid scintillation counting |
CHEMBL1150660 |
| Cyclooxygenase-2 |
Inhibition |
< |
30.0 |
% |
Inhibition of COX2 at 100 uM by scintillation proximity assay |
CHEMBL1150665 |
| Adenosine A1 receptor |
Ki |
= |
17000.0 |
nM |
Displacement of [3H]CHA from adenosine A1 receptor in rat brain cortical membrane |
CHEMBL1141731 |
| Adenosine A2a receptor |
Ki |
= |
9400.0 |
nM |
Displacement of [3H]CGS21680 from adenosine A2A receptor in rat brain striatal membrane |
CHEMBL1141731 |
| Unchecked |
Ki |
= |
376000.0 |
nM |
Displacement of [3H]diazepam from benzodiazepine binding site of GABAA receptor in rat brain cortical membrane |
CHEMBL1141731 |
| Glycogen phosphorylase, muscle form |
IC50 |
= |
114000.0 |
nM |
Inhibition of rabbit muscle glycogen phosphorylase A assessed as phosphate release from glucose-1-phosphate |
CHEMBL1150776 |
| Solute carrier family 22 member 1 |
Inhibition |
= |
-1.4 |
% |
Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells at 100 uM by confocal microscopy |
CHEMBL1140113 |
| Adenosine A2a receptor |
Ki |
= |
22000.0 |
nM |
Displacement of [3H]NECA from Sprague-Dawley rat adenosine A2A receptor by scintillation counting |
CHEMBL1144166 |
| Mus musculus |
Activity |
= |
428.9 |
|
Anxiolytic-like activity in ddY mouse assessed as number of shuttle per hour at 10 mg/kg, po by discrete shuttle avoidance test |
CHEMBL1147232 |
| Mus musculus |
Activity |
= |
3.4 |
|
Anxiolytic-like activity in ddY mouse assessed as number of shocks per hour at 10 mg/kg, po by discrete shuttle avoidance test |
CHEMBL1147232 |
| Propionibacterium acnes |
MIC |
> |
400.0 |
ug.mL-1 |
Antimicrobial activity Propionibacterium acnes ATCC 11827 after 2 days by broth dilution method |
CHEMBL1149024 |
| Monoamine oxidase B |
Ki |
= |
3600000.0 |
nM |
Inhibition of recombinant wild-type MAOB from human liver expressed in Pichia pastoris |
CHEMBL1138612 |
| ADMET |
permeability |
= |
1.0 |
10'-6 cm/s |
Permeability across porcine brain lipid coated polyvinylidene fluoride membrane by PAMPA |
CHEMBL1138487 |
| Monoamine oxidase A |
Activity |
|
|
|
Inhibition of mouse liver MAOA |
CHEMBL1152129 |
| Monoamine oxidase A |
Activity |
|
|
|
Inhibition of mouse brain MAOA |
CHEMBL1152129 |
| No relevant target |
LogP |
= |
0.08 |
|
Lipophilicity, log P of the compound |
CHEMBL1152804 |
| No relevant target |
LogP |
= |
-0.42 |
|
Lipophilicity, log P by microemulsion electrokinetic chromatography |
CHEMBL1152804 |
| Adenosine A2b receptor |
Ki |
= |
33800.0 |
nM |
Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells |
CHEMBL1137016 |
| Adenosine A2b receptor |
Ki |
= |
10400.0 |
nM |
Displacement of [125I]I-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells |
CHEMBL1137016 |
| Homo sapiens |
CL |
= |
1.4 |
mL.min-1.kg-1 |
Total body clearance in human |
CHEMBL1151930 |
| Homo sapiens |
CL_renal |
= |
0.02 |
mL.min-1.kg-1 |
Renal clearance in human |
CHEMBL1151930 |
| Glycogen phosphorylase, muscle form |
IC50 |
= |
283000.0 |
nM |
Inhibition of rabbit muscle glycogen phosphorylase |
CHEMBL1152931 |
| ADMET |
permeability |
= |
1.3 |
10'-6 cm/s |
Membrane permeability by PAMPA-BBB assay |
CHEMBL1152433 |
| ADMET |
permeability |
= |
4.4 |
10'-6 cm/s |
Membrane permeability dissolved in PBS/EtOH (70:30) mixture by PAMPA-BBB assay |
CHEMBL1152433 |
| ADMET |
permeability |
= |
4.7 |
10'-6 cm/s |
Membrane permeability dissolved in PBS/EtOH (80:20) mixture by PAMPA-BBB assay |
CHEMBL1152433 |
| Adenosine A3 receptor |
Inhibition |
= |
9.0 |
% |
Inhibition of [3H]NECA binding to human recombinant adenosine A3 receptor expressed in HEK293T cells at 100 uM by scintillation counting |
CHEMBL1152960 |
| Adenosine A2a receptor |
Ki |
= |
18100.0 |
nM |
Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in HEK293T cells by scintillation counting |
CHEMBL1152960 |
| Adenosine A1 receptor |
Ki |
= |
49000.0 |
nM |
Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in HEK293T cells by scintillation counting |
CHEMBL1152960 |
| ADMET |
Papp |
= |
1.77 |
10'6cm/s |
Apparent permeability at pH 7.4 after 24 hrs by PAMPA method |
CHEMBL1153611 |
| Glycogen phosphorylase, muscle form |
IC50 |
= |
83100.0 |
nM |
Inhibition of rabbit muscle glycogen phosphorylase a assessed as glycogen synthesis |
CHEMBL1154136 |
| Homo sapiens |
Fg |
= |
1.04 |
|
Fraction escaping gut-wall elimination in human |
CHEMBL1156824 |
| Homo sapiens |
CL |
= |
1.4 |
mL.min-1.kg-1 |
Total clearance in human |
CHEMBL1156824 |
| Homo sapiens |
CL |
= |
1.4 |
mL.min-1.kg-1 |
Hepatic clearance in human |
CHEMBL1156824 |
| Glycogen phosphorylase, muscle form |
IC50 |
= |
74900.0 |
nM |
Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins |
CHEMBL1156737 |
| Homo sapiens |
CL_renal |
= |
0.017 |
mL.min-1.kg-1 |
Renal clearance in human |
CHEMBL1156824 |
| Homo sapiens |
Vdss |
= |
0.63 |
L.kg-1 |
Volume of distribution at steady state in human |
CHEMBL1156824 |
| Plasma |
Fu |
= |
0.64 |
|
Fraction unbound in human plasma |
CHEMBL1156824 |
| Homo sapiens |
Fh |
= |
0.94 |
|
Fraction escaping hepatic elimination in human |
CHEMBL1156824 |
| Homo sapiens |
F_fraction |
= |
0.98 |
|
Oral bioavailability in human |
CHEMBL1156824 |
| Homo sapiens |
Fa |
= |
1.0 |
|
Fraction absorbed in human |
CHEMBL1156824 |
| Caco-2 |
logPapp |
= |
-4.41 |
|
Permeability across human Caco-2 cells |
CHEMBL1152590 |
| Skin |
log Pe |
= |
0.14 |
|
Permeability in human skin after 48 hrs by Franz cell permeability assay |
CHEMBL1153196 |
| No relevant target |
LogD |
= |
-0.13 |
|
Lipophilicity, log D of the compound |
CHEMBL1153196 |
| Unchecked |
IC50 |
= |
510000.0 |
nM |
Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation by continuous spectrophotometric assay in presence of 150 mM NH4Cl |
CHEMBL1153213 |
| Unchecked |
IC50 |
= |
390000.0 |
nM |
Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation by continuous spectrophotometric assay in presence of 10 mM L-glutamine and 0.15 mM GTP |
CHEMBL1153213 |
| Unchecked |
IC50 |
= |
440000.0 |
nM |
Multisite inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in Hepes buffer at pH 8 in presence of 8.16 mM NH4Cl |
CHEMBL1153213 |
| Unchecked |
IC50 |
= |
450000.0 |
nM |
Multisite inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in Hepes buffer at pH 8 in presence of 5.44 mM NH4Cl |
CHEMBL1153213 |
| Unchecked |
IC50 |
= |
420000.0 |
nM |
Multisite inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in Hepes buffer at pH 8 in presence of 2.72 mM NH4Cl |
CHEMBL1153213 |
| Unchecked |
IC50 |
= |
450000.0 |
nM |
Multisite inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in Hepes buffer at pH 8 in presence of 1.36 mM NH4Cl |
CHEMBL1153213 |
| Unchecked |
IC50 |
= |
440000.0 |
nM |
Multisite inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in Hepes buffer at pH 8 in presence of 0.54 mM NH4Cl |
CHEMBL1153213 |
| Unchecked |
Inhibition |
|
|
% |
Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation at 1 mM in presence of 1mM ATP |
CHEMBL1153213 |
| Unchecked |
Inhibition |
|
|
% |
Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation at 1 mM in presence of 1mM UTP |
CHEMBL1153213 |
| MDCK |
Papp |
= |
17.0 |
10'-6 cm/s |
Apparent permeability across apical to basolateral side of MDCK cells expressing MDR |
CHEMBL1157729 |
| Adenosine A3 receptor |
Ki |
> |
100000.0 |
nM |
Displacement of [3H]PSB-11 from human adenosine A3 receptor expressed in CHO cells |
CHEMBL1157642 |
| Adenosine A2b receptor |
Ki |
= |
33800.0 |
nM |
Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cells |
CHEMBL1157642 |
| Adenosine A2a receptor |
Ki |
= |
32500.0 |
nM |
Displacement of [3H]MSX2 from adenosine A2A receptor in rat brain striatum membrane |
CHEMBL1157642 |
| Adenosine A1 receptor |
Ki |
= |
41000.0 |
nM |
Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortex membrane |
CHEMBL1157642 |
| ADMET |
Activity |
= |
67.4 |
% |
Apparent permeability in BBMEC assessed as membrane retention |
CHEMBL1157615 |
| ADMET |
Activity |
= |
20.6 |
% |
Apparent permeability in BBMEC assessed as compound transport after 2 hrs |
CHEMBL1157615 |
| ADMET |
Papp |
= |
16.1 |
10'6cm/s |
Apparent permeability in BBMEC |
CHEMBL1157615 |
| Plasma |
logFu |
= |
0.64 |
|
Fraction unbound in human plasma |
CHEMBL1153781 |
| Homo sapiens |
Vdss |
= |
0.61 |
L.kg-1 |
Volume of distribution at steady state in human |
CHEMBL1153781 |
| ADMET |
permeability |
= |
4.3 |
10'-6 cm/s |
Permeability across PAMPA membrane |
CHEMBL1154393 |
| Glycogen phosphorylase, muscle form |
IC50 |
= |
75300.0 |
nM |
Inhibition of rabbit muscle glycogen phosphorylase assessed as release of phosphate from glucose-1-phosphate after 25 mins |
CHEMBL1153814 |
| Homo sapiens |
Activity |
= |
1.0 |
% |
Human intestinal absorption in po dosed human |
CHEMBL1157012 |
| MDCK |
logPapp |
= |
-4.09 |
|
Transcellular permeability at pH 6.5 calculated from in vitro P app values in Caco-2 and/or MDCK cells |
CHEMBL1158536 |
| Homo sapiens |
F |
= |
98.0 |
% |
Absolute bioavailability in human |
CHEMBL1158536 |
| Adenosine A2b receptor |
Ki |
= |
10400.0 |
nM |
Antagonist activity against human adenosine A2B receptor |
CHEMBL1208683 |
| Guanine deaminase |
Ki |
= |
10200.0 |
nM |
Inhibition of GDA by colorimetric assay |
CHEMBL1221368 |
| PC-3 |
FC |
= |
0.952 |
|
Antiproliferative activity against human PC3 cells at 50 uM after 120 hrs by MTT assay relative to DMSO |
CHEMBL1221184 |
| Mus musculus |
Activity |
|
|
|
Neurotoxicity in ddY mouse assessed as changes in behavioral activity at 110 nmol/mouse, icv measured for 60 mins |
CHEMBL1240486 |
| Unchecked |
Inhibition |
|
|
% |
Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay |
CHEMBL1255231 |
| Candida glabrata |
Activity |
|
|
|
Antifungal activity against Candida glabrata isolate 21229 with missense mutation in ERG6 gene at 2 mM |
CHEMBL1275527 |
| Candida glabrata |
Activity |
|
|
|
Antifungal activity against Candida glabrata isolate 21230 at 2 mM |
CHEMBL1275527 |
| Nuclear receptor ROR-gamma |
Potency |
= |
15848.9 |
nM |
PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) |
CHEMBL1201862 |
| 4'-phosphopantetheinyl transferase ffp |
Potency |
= |
89125.1 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) |
CHEMBL1201862 |
| Anthrax lethal factor |
Potency |
= |
1258.9 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Anthrax lethal factor |
Potency |
= |
1000.0 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Muscarinic acetylcholine receptor M1 |
Potency |
= |
35.5 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Kinetic Measurement of Intracellular Calcium Response. (Class of assay: confirmatory) |
CHEMBL1201862 |
| DNA polymerase beta |
Potency |
= |
79432.8 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) |
CHEMBL1201862 |
| ADMET |
Vdss |
= |
0.63 |
L.kg-1 |
Volume of distribution at steady state in human after iv administration |
CHEMBL1614632 |
| NON-PROTEIN TARGET |
Fu |
= |
0.64 |
|
Fraction unbound in human after iv administration |
CHEMBL1614632 |
| ADMET |
Vdss |
= |
0.73 |
L.kg-1 |
Volume of distribution at steady state in human after iv administration |
CHEMBL1614629 |
| ADMET |
Vdss |
= |
0.76 |
L.kg-1 |
Volume of distribution at steady state in dog after iv administration |
CHEMBL1614629 |
| ADMET |
Vdss |
= |
0.83 |
L.kg-1 |
Volume of distribution at steady state in monkey after iv administration |
CHEMBL1614629 |
| ADMET |
Vdss |
= |
0.92 |
mL/min/kg |
Volume of distribution at steady state in rat after iv administration |
CHEMBL1614629 |
| ADMET |
CL |
= |
1.4 |
mL.min-1.kg-1 |
Clearance in human after iv administration |
CHEMBL1614632 |
| ADMET |
CL |
= |
2.0 |
mL.min-1.kg-1 |
Clearance in human after iv administration |
CHEMBL1614629 |
| ADMET |
CL |
= |
2.1 |
mL.min-1.kg-1 |
Clearance in dog after iv administration |
CHEMBL1614629 |
| ADMET |
CL |
= |
3.1 |
mL.min-1.kg-1 |
Clearance in monkey after iv administration |
CHEMBL1614629 |
| ADMET |
T1/2 |
= |
4.9 |
hr |
Half life in human after iv administration |
CHEMBL1614632 |
| ADMET |
MRT |
= |
7.5 |
hr |
Mean residence time in human after iv administration |
CHEMBL1614632 |
| ADMET |
CL |
= |
13.0 |
mL.min-1.kg-1 |
Clearance in rat after iv administration |
CHEMBL1614629 |
| Phospholipidosis |
Phospholipidosis |
|
|
|
Phospholipidosis-negative literature compound |
CHEMBL1615345 |
| Glycogen phosphorylase, muscle form |
IC50 |
= |
75300.0 |
nM |
Inhibition of rabbit muscle glycogen phosphorylase a |
CHEMBL1641550 |
| ADMET |
log10(%HIA +10) |
= |
2.041 |
|
Drug absorption in human assessed as human intestinal absorption rate |
CHEMBL1649380 |
| HERG |
pIC50 |
= |
5.31 |
|
Inhibition of human ERG |
CHEMBL1671772 |
| Phospholipidosis |
Phospholipidosis |
|
|
|
Literature-mined public compounds from Lowe et al phospholipidosis modelling dataset |
CHEMBL1697681 |
| Hepatotoxicity |
Hepatotoxicity |
|
|
|
Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset |
CHEMBL1697692 |
| Hepatotoxicity |
Hepatotoxicity |
|
|
|
Human drug-induced liver injury (DILI) modelling dataset from Ekins et al |
CHEMBL1697723 |
| Hepatotoxicity |
Hepatotoxicity |
|
|
|
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans |
CHEMBL1697731 |
| Hepatotoxicity |
Hepatotoxicity |
|
|
|
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents |
CHEMBL1697731 |
| Hepatotoxicity |
Hepatotoxicity |
|
|
|
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents |
CHEMBL1697731 |
| Phospholipidosis |
Phospholipidosis |
|
|
|
Literature-mined public compounds from Kruhlak et al phospholipidosis modelling dataset |
CHEMBL1697821 |
| Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 |
Potency |
|
10000.0 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] |
CHEMBL1201862 |
| Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 |
Potency |
|
5011.9 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] |
CHEMBL1201862 |
| 6-phospho-1-fructokinase |
Potency |
|
42561.5 |
nM |
PUBCHEM_BIOASSAY: qHTS Validation Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] |
CHEMBL1201862 |
| Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 |
Potency |
|
1412.5 |
nM |
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] |
CHEMBL1201862 |
| Chromobox protein homolog 1 |
Potency |
|
44668.4 |
nM |
PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] |
CHEMBL1201862 |
| Cytochrome P450 1A2 |
Activity |
|
|
|
Clinically relevant substrates of human liver microsomal P450 enzymes, isoform CYP1A2 |
CHEMBL1743201 |
| Serine-protein kinase ATR |
IC50 |
= |
1100000.0 |
nM |
Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assay |
CHEMBL1765064 |
| Serine-protein kinase ATM |
IC50 |
= |
200000.0 |
nM |
Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay |
CHEMBL1765064 |
| DNA-dependent protein kinase |
IC50 |
= |
10000000.0 |
nM |
Inhibition of DNAPK after 2 hrs by radiometric phosphate incorporation assay |
CHEMBL1765064 |
| Serine/threonine-protein kinase mTOR |
IC50 |
= |
400000.0 |
nM |
Inhibition of mTOR by radiometric phosphate incorporation assay |
CHEMBL1765064 |
| Caco-2 |
logPapp |
= |
-4.47 |
|
Apparent permeability across human Caco2 cell membrane after 2 hrs by LC-MS/MS analysis |
CHEMBL1764994 |
| Caco-2 |
permeability |
|
|
|
Apparent permeability across human Caco2 cell membrane after 2 hrs by LC-MS/MS analysis |
CHEMBL1764994 |
| Adenosine A2a receptor |
Ki |
= |
5011.87 |
nM |
Displacement of [3H]ZM241385 from stabilized human adenosine receptor A2a expressed in HEK293 cells followed by receptor capturing on Biocore chips by SPR method |
CHEMBL1800001 |
| Adenosine A2a receptor |
Kd |
= |
25118.86 |
nM |
Displacement of [3H]ZM241385 from stabilized human adenosine receptor A2a expressed in HEK293 cells followed by receptor capturing on Biocore chips by SPR method |
CHEMBL1800001 |
| Adenosine A2a receptor |
FC |
= |
-1.6 |
|
Binding affinity at stabilized human adenosine receptor A2a L85A'3.33 mutant expressed in HEK293 cells followed by receptor capturing on Biocore chips assessed as log difference in receptor affinity by SPR method relative to wild type stabilized A2A receptor |
CHEMBL1800001 |
| Adenosine A2a receptor |
FC |
= |
0.1 |
|
Binding affinity at human adenosine receptor A2a L167A'extracellular loop 2 mutant expressed in HEK293 cells followed by receptor capturing on Biocore chips assessed as log difference in receptor affinity by SPR method relative to wild type stabilized A2A receptor |
CHEMBL1800001 |
| Adenosine A2a receptor |
FC |
|
|
|
Binding affinity at human adenosine receptor A2a M177A'5.38 mutant expressed in HEK293 cells followed by receptor capturing on Biocore chips assessed as log difference in receptor affinity by SPR method relative to wild type stabilized A2A receptor |
CHEMBL1800001 |
| Adenosine A2a receptor |
FC |
= |
0.0 |
|
Binding affinity at human adenosine receptor A2a receptor Y271A'7.36 mutant expressed in HEK293 cells followed by receptor capturing on Biocore chips assessed as log difference in receptor affinity by SPR method relative to wild type stabilized A2A receptor |
CHEMBL1800001 |
| Adenosine A2a receptor |
FC |
= |
-1.6 |
|
Binding affinity at human adenosine receptor A2a I66A'2.64 mutant expressed in HEK293 cells followed by receptor capturing on Biocore chips assessed as log difference in receptor affinity by SPR method relative to wild type stabilized A2A receptor |
CHEMBL1800001 |
| Adenosine A2a receptor |
FC |
= |
0.6 |
|
Binding affinity at human adenosine receptor A2a N181A'5.42 mutant expressed in HEK293 cells followed by receptor capturing on Biocore chips assessed as log difference in receptor affinity by SPR method relative to wild type stabilized A2A receptor |
CHEMBL1800001 |
| Adenosine A2a receptor |
FC |
= |
0.7 |
|
Inverse agonist activity at human adenosine receptor A2a S277A'7.42 mutant expressed in HEK293 cells followed by receptor capturing on Biocore chips assessed as log difference in receptor affinity by SPR method relative to wild type stabilized A2A receptor |
CHEMBL1800001 |
| Unchecked |
IC50 |
= |
480000.0 |
nM |
Inhibition of N-terminal His6-tagged Trypanosoma brucei CTPS assessed as NH3-dependent CTP formation by continuous spectrophotometric assay |
CHEMBL1817579 |
| ADMET |
permeability |
= |
1.4 |
10'-6 cm/s |
Permeability of the compound by PAMPA |
CHEMBL1828584 |
| Glucocorticoid receptor |
Potency |
|
17.8 |
nM |
PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of glucocorticoid receptor signaling. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Androgen Receptor |
Potency |
|
5.0 |
nM |
PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of androgen receptor signaling. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Thyroid hormone receptor beta-1 |
Potency |
|
1.4 |
nM |
PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of thyroid hormone receptor beta signaling. (Class of assay: confirmatory) |
CHEMBL1201862 |
| HepG2 |
Potency |
|
2818.4 |
nM |
PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] |
CHEMBL1201862 |
| DNA polymerase kappa |
Potency |
|
11917.3 |
nM |
PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] |
CHEMBL1201862 |
| Plasmodium falciparum |
Potency |
|
18526.0 |
nM |
PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] |
CHEMBL1201862 |
| Unchecked |
Potency |
|
316.2 |
nM |
PUBCHEM_BIOASSAY: qHTS for inhibitors of binding or entry into cells for Marburg Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249, AID540278] |
CHEMBL1201862 |
| Acetylcholinesterase |
IC50 |
|
|
|
DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) |
CHEMBL1909046 |
| Acetylcholinesterase |
Ki |
|
|
|
DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) |
CHEMBL1909046 |
| Adenosine A1 receptor |
IC50 |
|
|
|
DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) |
CHEMBL1909046 |
| Adenosine A1 receptor |
Ki |
|
|
|
DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) |
CHEMBL1909046 |
| Adenosine A2a receptor |
IC50 |
= |
20472.0 |
nM |
DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) |
CHEMBL1909046 |
| Adenosine A2a receptor |
Ki |
= |
11493.0 |
nM |
DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) |
CHEMBL1909046 |
| Adenosine A3 receptor |
IC50 |
|
|
|
DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) |
CHEMBL1909046 |
| Adenosine A3 receptor |
Ki |
|
|
|
DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Sodium/nucleoside co-transporter radioligand binding (ligand: nitrobenzylthioinosine) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Sodium/nucleoside co-transporter radioligand binding (ligand: nitrobenzylthioinosine) |
CHEMBL1909046 |
| Alpha-1a adrenergic receptor |
IC50 |
|
|
|
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) |
CHEMBL1909046 |
| Alpha-1a adrenergic receptor |
Ki |
|
|
|
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) |
CHEMBL1909046 |
| Alpha-1b adrenergic receptor |
IC50 |
|
|
|
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) |
CHEMBL1909046 |
| Alpha-1b adrenergic receptor |
Ki |
|
|
|
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) |
CHEMBL1909046 |
| Alpha-1d adrenergic receptor |
IC50 |
|
|
|
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) |
CHEMBL1909046 |
| Alpha-1d adrenergic receptor |
Ki |
|
|
|
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) |
CHEMBL1909046 |
| Alpha-2a adrenergic receptor |
IC50 |
|
|
|
DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) |
CHEMBL1909046 |
| Alpha-2a adrenergic receptor |
Ki |
|
|
|
DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) |
CHEMBL1909046 |
| Alpha-2b adrenergic receptor |
IC50 |
|
|
|
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) |
CHEMBL1909046 |
| Alpha-2b adrenergic receptor |
Ki |
|
|
|
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) |
CHEMBL1909046 |
| Alpha-2c adrenergic receptor |
IC50 |
|
|
|
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) |
CHEMBL1909046 |
| Alpha-2c adrenergic receptor |
Ki |
|
|
|
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) |
CHEMBL1909046 |
| Beta-1 adrenergic receptor |
IC50 |
|
|
|
DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) |
CHEMBL1909046 |
| Beta-1 adrenergic receptor |
Ki |
|
|
|
DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) |
CHEMBL1909046 |
| Beta-2 adrenergic receptor |
IC50 |
|
|
|
DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) |
CHEMBL1909046 |
| Beta-2 adrenergic receptor |
Ki |
|
|
|
DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) |
CHEMBL1909046 |
| Beta-3 adrenergic receptor |
IC50 |
|
|
|
DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) |
CHEMBL1909046 |
| Beta-3 adrenergic receptor |
Ki |
|
|
|
DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) |
CHEMBL1909046 |
| Norepinephrine transporter |
IC50 |
|
|
|
DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) |
CHEMBL1909046 |
| Norepinephrine transporter |
Ki |
|
|
|
DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) |
CHEMBL1909046 |
| Aldose reductase |
IC50 |
|
|
|
DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) |
CHEMBL1909046 |
| Aldose reductase |
Ki |
|
|
|
DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) |
CHEMBL1909046 |
| Angiotensin II type 2 (AT-2) receptor |
IC50 |
|
|
|
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) |
CHEMBL1909046 |
| Angiotensin II type 2 (AT-2) receptor |
Ki |
|
|
|
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: ATPase, Na+/K+ enzyme inhibition (substrate: ATP) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: ATPase, Na+/K+ enzyme inhibition (substrate: ATP) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Atrial Natriuretic Factor (ANF) radioligand binding (ligand: [125I] ANF (rat)) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Atrial Natriuretic Factor (ANF) radioligand binding (ligand: [125I] ANF (rat)) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: beta-Lactamase enzyme inhibition (substrate: Nitrocefin) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: beta-Lactamase enzyme inhibition (substrate: Nitrocefin) |
CHEMBL1909046 |
| Bradykinin B2 receptor |
IC50 |
|
|
|
DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) |
CHEMBL1909046 |
| Bradykinin B2 receptor |
Ki |
|
|
|
DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) |
CHEMBL1909046 |
| Calcitonin receptor |
IC50 |
|
|
|
DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) |
CHEMBL1909046 |
| Calcitonin receptor |
Ki |
|
|
|
DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Calcium Channel Type L, Benzothiazepine radioligand binding (ligand: [3H] Diltiazem) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Calcium Channel Type L, Benzothiazepine radioligand binding (ligand: [3H] Diltiazem) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Calcium Channel Type L, Dihydropyridine radioligand binding (ligand: [3H] Nitrendipine) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Calcium Channel Type L, Dihydropyridine radioligand binding (ligand: [3H] Nitrendipine) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) |
CHEMBL1909046 |
| Cannabinoid CB1 receptor |
IC50 |
|
|
|
DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) |
CHEMBL1909046 |
| Cannabinoid CB1 receptor |
Ki |
|
|
|
DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) |
CHEMBL1909046 |
| Carbonic anhydrase II |
IC50 |
|
|
|
DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) |
CHEMBL1909046 |
| Carbonic anhydrase II |
Ki |
|
|
|
DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) |
CHEMBL1909046 |
| C-C chemokine receptor type 2 |
IC50 |
|
|
|
DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) |
CHEMBL1909046 |
| C-C chemokine receptor type 2 |
Ki |
|
|
|
DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) |
CHEMBL1909046 |
| C-C chemokine receptor type 4 |
IC50 |
|
|
|
DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) |
CHEMBL1909046 |
| C-C chemokine receptor type 4 |
Ki |
|
|
|
DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) |
CHEMBL1909046 |
| C-C chemokine receptor type 5 |
IC50 |
|
|
|
DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) |
CHEMBL1909046 |
| C-C chemokine receptor type 5 |
Ki |
|
|
|
DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) |
CHEMBL1909046 |
| Interleukin-8 receptor A |
IC50 |
|
|
|
DRUGMATRIX: Chemokine CXCR1 (IL-8A) |
CHEMBL1909046 |
| Interleukin-8 receptor A |
Ki |
|
|
|
DRUGMATRIX: Chemokine CXCR1 (IL-8A) |
CHEMBL1909046 |
| Interleukin-8 receptor B |
IC50 |
|
|
|
DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) |
CHEMBL1909046 |
| Interleukin-8 receptor B |
Ki |
|
|
|
DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) |
CHEMBL1909046 |
| Cholecystokinin A receptor |
IC50 |
|
|
|
DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) |
CHEMBL1909046 |
| Cholecystokinin A receptor |
Ki |
|
|
|
DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) |
CHEMBL1909046 |
| Cyclooxygenase-1 |
IC50 |
|
|
|
DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) |
CHEMBL1909046 |
| Cyclooxygenase-1 |
Ki |
|
|
|
DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) |
CHEMBL1909046 |
| Cyclooxygenase-2 |
IC50 |
|
|
|
DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) |
CHEMBL1909046 |
| Cyclooxygenase-2 |
Ki |
|
|
|
DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) |
CHEMBL1909046 |
| Cytochrome P450 1A2 |
IC50 |
|
|
|
DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) |
CHEMBL1909046 |
| Cytochrome P450 1A2 |
Ki |
|
|
|
DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) |
CHEMBL1909046 |
| Cytochrome P450 2A6 |
IC50 |
|
|
|
DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) |
CHEMBL1909046 |
| Cytochrome P450 2A6 |
Ki |
|
|
|
DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) |
CHEMBL1909046 |
| Cytochrome P450 2C19 |
IC50 |
|
|
|
DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) |
CHEMBL1909046 |
| Cytochrome P450 2C19 |
Ki |
|
|
|
DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) |
CHEMBL1909046 |
| Cytochrome P450 2C9 |
IC50 |
|
|
|
DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) |
CHEMBL1909046 |
| Cytochrome P450 2C9 |
Ki |
|
|
|
DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) |
CHEMBL1909046 |
| Cytochrome P450 2D6 |
IC50 |
|
|
|
DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) |
CHEMBL1909046 |
| Cytochrome P450 2D6 |
Ki |
|
|
|
DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) |
CHEMBL1909046 |
| Cytochrome P450 2E1 |
IC50 |
|
|
|
DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) |
CHEMBL1909046 |
| Cytochrome P450 2E1 |
Ki |
|
|
|
DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) |
CHEMBL1909046 |
| Cytochrome P450 3A4 |
IC50 |
|
|
|
DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) |
CHEMBL1909046 |
| Cytochrome P450 3A4 |
Ki |
|
|
|
DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) |
CHEMBL1909046 |
| Dopamine D1 receptor |
IC50 |
|
|
|
DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) |
CHEMBL1909046 |
| Dopamine D1 receptor |
Ki |
|
|
|
DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) |
CHEMBL1909046 |
| Dopamine D2 receptor |
IC50 |
|
|
|
DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) |
CHEMBL1909046 |
| Dopamine D2 receptor |
Ki |
|
|
|
DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) |
CHEMBL1909046 |
| Dopamine D3 receptor |
IC50 |
|
|
|
DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) |
CHEMBL1909046 |
| Dopamine D3 receptor |
Ki |
|
|
|
DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) |
CHEMBL1909046 |
| Dopamine D4 receptor |
IC50 |
|
|
|
DRUGMATRIX: Dopamine D4.2 radioligand binding (ligand: [3H] Spiperone) |
CHEMBL1909046 |
| Dopamine D4 receptor |
Ki |
|
|
|
DRUGMATRIX: Dopamine D4.2 radioligand binding (ligand: [3H] Spiperone) |
CHEMBL1909046 |
| Dopamine transporter |
IC50 |
|
|
|
DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) |
CHEMBL1909046 |
| Dopamine transporter |
Ki |
|
|
|
DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) |
CHEMBL1909046 |
| Endothelin receptor ET-A |
IC50 |
|
|
|
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1) |
CHEMBL1909046 |
| Endothelin receptor ET-A |
Ki |
|
|
|
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1) |
CHEMBL1909046 |
| Estrogen receptor alpha |
IC50 |
|
|
|
DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) |
CHEMBL1909046 |
| Estrogen receptor alpha |
Ki |
|
|
|
DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) |
CHEMBL1909046 |
| Estrogen receptor beta |
IC50 |
|
|
|
DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) |
CHEMBL1909046 |
| Estrogen receptor beta |
Ki |
|
|
|
DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: GABAA, Muscimol, Central radioligand binding (ligand: [3H] Muscimol) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: GABAA, Muscimol, Central radioligand binding (ligand: [3H] Muscimol) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: GABAA, Flunitrazepam, Central radioligand binding (ligand: [3H] Flunitrazepam) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: GABAA, Flunitrazepam, Central radioligand binding (ligand: [3H] Flunitrazepam) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: GABAA, Chloride Channel, TBOB radioligand binding (ligand: [3H] TBOB) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: GABAA, Chloride Channel, TBOB radioligand binding (ligand: [3H] TBOB) |
CHEMBL1909046 |
| Glucocorticoid receptor |
IC50 |
|
|
|
DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) |
CHEMBL1909046 |
| Glucocorticoid receptor |
Ki |
|
|
|
DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Glutamate, AMPA radioligand binding (ligand: [3H] AMPA) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Glutamate, AMPA radioligand binding (ligand: [3H] AMPA) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Glutamate, Kainate radioligand binding (ligand: [3H] Kainic acid) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Glutamate, Kainate radioligand binding (ligand: [3H] Kainic acid) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Glutamate, NMDA, Agonism radioligand binding (ligand: [3H] CGP-39653) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Glutamate, NMDA, Agonism radioligand binding (ligand: [3H] CGP-39653) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Glutamate, NMDA, Phencyclidine radioligand binding (ligand: [3H] TCP) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Glutamate, NMDA, Phencyclidine radioligand binding (ligand: [3H] TCP) |
CHEMBL1909046 |
| Glycine receptor |
IC50 |
|
|
|
DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) |
CHEMBL1909046 |
| Glycine receptor |
Ki |
|
|
|
DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) |
CHEMBL1909046 |
| Histamine H1 receptor |
IC50 |
|
|
|
DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) |
CHEMBL1909046 |
| Histamine H1 receptor |
Ki |
|
|
|
DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) |
CHEMBL1909046 |
| Histamine H2 receptor |
IC50 |
|
|
|
DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) |
CHEMBL1909046 |
| Histamine H2 receptor |
Ki |
|
|
|
DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) |
CHEMBL1909046 |
| HMG-CoA reductase |
IC50 |
|
|
|
DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) |
CHEMBL1909046 |
| HMG-CoA reductase |
Ki |
|
|
|
DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Imidazoline I2, Central radioligand binding (ligand: [3H] Idazoxan) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Imidazoline I2, Central radioligand binding (ligand: [3H] Idazoxan) |
CHEMBL1909046 |
| Insulin receptor |
IC50 |
|
|
|
DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) |
CHEMBL1909046 |
| Insulin receptor |
Ki |
|
|
|
DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Interleukin IL-1 radioligand binding (ligand: [125I] interleukin 1beta) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Interleukin IL-1 radioligand binding (ligand: [125I] interleukin 1beta) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Leukotriene, BLT (LTB4) radioligand binding (ligand: [3H]LTB4) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Leukotriene, BLT (LTB4) radioligand binding (ligand: [3H]LTB4) |
CHEMBL1909046 |
| Leukotriene C4 synthase |
IC50 |
|
|
|
DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) |
CHEMBL1909046 |
| Leukotriene C4 synthase |
Ki |
|
|
|
DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) |
CHEMBL1909046 |
| Cysteinyl leukotriene receptor 1 |
IC50 |
|
|
|
DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) |
CHEMBL1909046 |
| Cysteinyl leukotriene receptor 1 |
Ki |
|
|
|
DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) |
CHEMBL1909046 |
| Arachidonate 15-lipoxygenase |
IC50 |
|
|
|
DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) |
CHEMBL1909046 |
| Arachidonate 15-lipoxygenase |
Ki |
|
|
|
DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) |
CHEMBL1909046 |
| Melanocortin receptor 3 |
IC50 |
|
|
|
DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) |
CHEMBL1909046 |
| Melanocortin receptor 3 |
Ki |
|
|
|
DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) |
CHEMBL1909046 |
| Melanocortin receptor 4 |
IC50 |
|
|
|
DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) |
CHEMBL1909046 |
| Melanocortin receptor 4 |
Ki |
|
|
|
DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) |
CHEMBL1909046 |
| Melanocortin receptor 5 |
IC50 |
|
|
|
DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH) |
CHEMBL1909046 |
| Melanocortin receptor 5 |
Ki |
|
|
|
DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH) |
CHEMBL1909046 |
| Monoamine oxidase A |
IC50 |
|
|
|
DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) |
CHEMBL1909046 |
| Monoamine oxidase A |
Ki |
|
|
|
DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) |
CHEMBL1909046 |
| Muscarinic acetylcholine receptor M1 |
IC50 |
|
|
|
DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) |
CHEMBL1909046 |
| Muscarinic acetylcholine receptor M1 |
Ki |
|
|
|
DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) |
CHEMBL1909046 |
| Muscarinic acetylcholine receptor M2 |
IC50 |
|
|
|
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) |
CHEMBL1909046 |
| Muscarinic acetylcholine receptor M2 |
Ki |
|
|
|
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) |
CHEMBL1909046 |
| Muscarinic acetylcholine receptor M3 |
IC50 |
|
|
|
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) |
CHEMBL1909046 |
| Muscarinic acetylcholine receptor M3 |
Ki |
|
|
|
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) |
CHEMBL1909046 |
| Muscarinic acetylcholine receptor M4 |
IC50 |
|
|
|
DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) |
CHEMBL1909046 |
| Muscarinic acetylcholine receptor M4 |
Ki |
|
|
|
DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) |
CHEMBL1909046 |
| Muscarinic acetylcholine receptor M5 |
IC50 |
|
|
|
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) |
CHEMBL1909046 |
| Muscarinic acetylcholine receptor M5 |
Ki |
|
|
|
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) |
CHEMBL1909046 |
| Neuropeptide Y receptor type 1 |
IC50 |
|
|
|
DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) |
CHEMBL1909046 |
| Neuropeptide Y receptor type 1 |
Ki |
|
|
|
DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) |
CHEMBL1909046 |
| Neuropeptide Y receptor type 2 |
IC50 |
|
|
|
DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) |
CHEMBL1909046 |
| Neuropeptide Y receptor type 2 |
Ki |
|
|
|
DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Nicotinic Acetylcholine radioligand binding (ligand: [125I] Epibatidine) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Nicotinic Acetylcholine radioligand binding (ligand: [125I] Epibatidine) |
CHEMBL1909046 |
| Nitric-oxide synthase, brain |
IC50 |
|
|
|
DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) |
CHEMBL1909046 |
| Nitric-oxide synthase, brain |
Ki |
|
|
|
DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) |
CHEMBL1909046 |
| Nitric oxide synthase, inducible |
IC50 |
|
|
|
DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) |
CHEMBL1909046 |
| Nitric oxide synthase, inducible |
Ki |
|
|
|
DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) |
CHEMBL1909046 |
| Delta opioid receptor |
IC50 |
|
|
|
DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) |
CHEMBL1909046 |
| Delta opioid receptor |
Ki |
|
|
|
DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) |
CHEMBL1909046 |
| Kappa opioid receptor |
IC50 |
|
|
|
DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) |
CHEMBL1909046 |
| Kappa opioid receptor |
Ki |
|
|
|
DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) |
CHEMBL1909046 |
| Mu opioid receptor |
IC50 |
|
|
|
DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) |
CHEMBL1909046 |
| Mu opioid receptor |
Ki |
|
|
|
DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Phorbol Ester radioligand binding (ligand: [3H] PDBu) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Phorbol Ester radioligand binding (ligand: [3H] PDBu) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Phosphodiesterase PDE3 enzyme inhibition (substrate: [3H]cAMP + cAMP) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Phosphodiesterase PDE3 enzyme inhibition (substrate: [3H]cAMP + cAMP) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Phosphodiesterase PDE4 enzyme inhibition (substrate: [3H]cAMP + cAMP) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Phosphodiesterase PDE4 enzyme inhibition (substrate: [3H]cAMP + cAMP) |
CHEMBL1909046 |
| Phosphodiesterase 5A |
IC50 |
|
|
|
DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) |
CHEMBL1909046 |
| Phosphodiesterase 5A |
Ki |
|
|
|
DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) |
CHEMBL1909046 |
| Platelet activating factor receptor |
IC50 |
|
|
|
DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) |
CHEMBL1909046 |
| Platelet activating factor receptor |
Ki |
|
|
|
DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Platelet-Derived Growth Factor (PDGF) radioligand binding (ligand: [125I] PDGF) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Platelet-Derived Growth Factor (PDGF) radioligand binding (ligand: [125I] PDGF) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Potassium Channel [KATP] radioligand binding (ligand: [3H] Glyburide) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Potassium Channel [KATP] radioligand binding (ligand: [3H] Glyburide) |
CHEMBL1909046 |
| HERG |
IC50 |
|
|
|
DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) |
CHEMBL1909046 |
| HERG |
Ki |
|
|
|
DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) |
CHEMBL1909046 |
| Progesterone receptor |
IC50 |
|
|
|
DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) |
CHEMBL1909046 |
| Progesterone receptor |
Ki |
|
|
|
DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) |
CHEMBL1909046 |
| Angiotensin-converting enzyme |
IC50 |
|
|
|
DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) |
CHEMBL1909046 |
| Angiotensin-converting enzyme |
Ki |
|
|
|
DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) |
CHEMBL1909046 |
| Caspase-1 |
IC50 |
|
|
|
DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) |
CHEMBL1909046 |
| Caspase-1 |
Ki |
|
|
|
DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) |
CHEMBL1909046 |
| Cathepsin G |
IC50 |
|
|
|
DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) |
CHEMBL1909046 |
| Cathepsin G |
Ki |
|
|
|
DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) |
CHEMBL1909046 |
| Leukocyte elastase |
IC50 |
|
|
|
DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) |
CHEMBL1909046 |
| Leukocyte elastase |
Ki |
|
|
|
DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) |
CHEMBL1909046 |
| Matrix metalloproteinase-1 |
IC50 |
|
|
|
DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) |
CHEMBL1909046 |
| Matrix metalloproteinase-1 |
Ki |
|
|
|
DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) |
CHEMBL1909046 |
| Matrix metalloproteinase 9 |
IC50 |
|
|
|
DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) |
CHEMBL1909046 |
| Matrix metalloproteinase 9 |
Ki |
|
|
|
DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) |
CHEMBL1909046 |
| Protein kinase C alpha |
IC50 |
|
|
|
DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) |
CHEMBL1909046 |
| Protein kinase C alpha |
Ki |
|
|
|
DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) |
CHEMBL1909046 |
| MAP kinase ERK1 |
IC50 |
|
|
|
DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) |
CHEMBL1909046 |
| MAP kinase ERK1 |
Ki |
|
|
|
DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) |
CHEMBL1909046 |
| MAP kinase ERK2 |
IC50 |
|
|
|
DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) |
CHEMBL1909046 |
| MAP kinase ERK2 |
Ki |
|
|
|
DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) |
CHEMBL1909046 |
| MAP kinase p38 alpha |
IC50 |
|
|
|
DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) |
CHEMBL1909046 |
| MAP kinase p38 alpha |
Ki |
|
|
|
DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) |
CHEMBL1909046 |
| Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform |
IC50 |
|
|
|
DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) |
CHEMBL1909046 |
| Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform |
Ki |
|
|
|
DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) |
CHEMBL1909046 |
| Epidermal growth factor receptor erbB1 |
IC50 |
|
|
|
DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) |
CHEMBL1909046 |
| Epidermal growth factor receptor erbB1 |
Ki |
|
|
|
DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) |
CHEMBL1909046 |
| Tyrosine-protein kinase FYN |
IC50 |
|
|
|
DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) |
CHEMBL1909046 |
| Tyrosine-protein kinase FYN |
Ki |
|
|
|
DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) |
CHEMBL1909046 |
| Receptor protein-tyrosine kinase erbB-2 |
IC50 |
|
|
|
DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr)) |
CHEMBL1909046 |
| Receptor protein-tyrosine kinase erbB-2 |
Ki |
|
|
|
DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr)) |
CHEMBL1909046 |
| Tyrosine-protein kinase LCK |
IC50 |
|
|
|
DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) |
CHEMBL1909046 |
| Tyrosine-protein kinase LCK |
Ki |
|
|
|
DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) |
CHEMBL1909046 |
| Leukocyte common antigen |
IC50 |
|
|
|
DRUGMATRIX: Protein Tyrosine Phosphatase, PTPRC (CD45) enzyme inhibition (substrate: DiFMUP) |
CHEMBL1909046 |
| Leukocyte common antigen |
Ki |
|
|
|
DRUGMATRIX: Protein Tyrosine Phosphatase, PTPRC (CD45) enzyme inhibition (substrate: DiFMUP) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Purinergic P2X radioligand binding (ligand: [3H] alpha, beta-Methylene-ATP) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Purinergic P2X radioligand binding (ligand: [3H] alpha, beta-Methylene-ATP) |
CHEMBL1909046 |
| Serotonin 1a (5-HT1a) receptor |
IC50 |
|
|
|
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) |
CHEMBL1909046 |
| Serotonin 1a (5-HT1a) receptor |
Ki |
|
|
|
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) |
CHEMBL1909046 |
| Serotonin 1b (5-HT1b) receptor |
IC50 |
|
|
|
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) |
CHEMBL1909046 |
| Serotonin 1b (5-HT1b) receptor |
Ki |
|
|
|
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) |
CHEMBL1909046 |
| Serotonin 2a (5-HT2a) receptor |
IC50 |
|
|
|
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) |
CHEMBL1909046 |
| Serotonin 2a (5-HT2a) receptor |
Ki |
|
|
|
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) |
CHEMBL1909046 |
| Serotonin 2b (5-HT2b) receptor |
IC50 |
|
|
|
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) |
CHEMBL1909046 |
| Serotonin 2b (5-HT2b) receptor |
Ki |
|
|
|
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) |
CHEMBL1909046 |
| Serotonin 2c (5-HT2c) receptor |
IC50 |
|
|
|
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) |
CHEMBL1909046 |
| Serotonin 2c (5-HT2c) receptor |
Ki |
|
|
|
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT3 radioligand binding (ligand: [3H] GR-65630) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT3 radioligand binding (ligand: [3H] GR-65630) |
CHEMBL1909046 |
| Serotonin 4 (5-HT4) receptor |
IC50 |
|
|
|
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) |
CHEMBL1909046 |
| Serotonin 4 (5-HT4) receptor |
Ki |
|
|
|
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) |
CHEMBL1909046 |
| Serotonin 6 (5-HT6) receptor |
IC50 |
|
|
|
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) |
CHEMBL1909046 |
| Serotonin 6 (5-HT6) receptor |
Ki |
|
|
|
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) |
CHEMBL1909046 |
| Serotonin transporter |
IC50 |
|
|
|
DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) |
CHEMBL1909046 |
| Serotonin transporter |
Ki |
|
|
|
DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) |
CHEMBL1909046 |
| Sigma opioid receptor |
IC50 |
|
|
|
DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) |
CHEMBL1909046 |
| Sigma opioid receptor |
Ki |
|
|
|
DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Sodium Channel, Site 2 radioligand binding (ligand: [3H] Batrachotoxin) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Sodium Channel, Site 2 radioligand binding (ligand: [3H] Batrachotoxin) |
CHEMBL1909046 |
| Neurokinin 1 receptor |
IC50 |
|
|
|
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) |
CHEMBL1909046 |
| Neurokinin 1 receptor |
Ki |
|
|
|
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) |
CHEMBL1909046 |
| Neurokinin 2 receptor |
IC50 |
|
|
|
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) |
CHEMBL1909046 |
| Neurokinin 2 receptor |
Ki |
|
|
|
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) |
CHEMBL1909046 |
| Androgen Receptor |
IC50 |
|
|
|
DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) |
CHEMBL1909046 |
| Androgen Receptor |
Ki |
|
|
|
DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) |
CHEMBL1909046 |
| Thromboxane-A synthase |
IC50 |
|
|
|
DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) |
CHEMBL1909046 |
| Thromboxane-A synthase |
Ki |
|
|
|
DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) |
CHEMBL1909046 |
| Unchecked |
IC50 |
|
|
|
DRUGMATRIX: Tumor Necrosis Factor (TNF), Non-Selective radioligand binding (ligand: [125I] TNF-alpha) |
CHEMBL1909046 |
| Unchecked |
Ki |
|
|
|
DRUGMATRIX: Tumor Necrosis Factor (TNF), Non-Selective radioligand binding (ligand: [125I] TNF-alpha) |
CHEMBL1909046 |
| Vascular endothelial growth factor receptor 1 |
IC50 |
|
|
|
DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) |
CHEMBL1909046 |
| Vascular endothelial growth factor receptor 1 |
Ki |
|
|
|
DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) |
CHEMBL1909046 |
| Vasoactive intestinal polypeptide receptor 1 |
IC50 |
|
|
|
DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) |
CHEMBL1909046 |
| Vasoactive intestinal polypeptide receptor 1 |
Ki |
|
|
|
DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) |
CHEMBL1909046 |
| Vasopressin V1a receptor |
IC50 |
|
|
|
DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) |
CHEMBL1909046 |
| Vasopressin V1a receptor |
Ki |
|
|
|
DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) |
CHEMBL1909046 |
| Hepatotoxicity |
HepSE_bilirubinemia |
= |
0.0 |
|
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia |
CHEMBL1909294 |
| Hepatotoxicity |
HepSE_cholecystitis |
= |
0.0 |
|
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis |
CHEMBL1909294 |
| Hepatotoxicity |
HepSE_cholelithiasis |
= |
0.0 |
|
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis |
CHEMBL1909294 |
| Hepatotoxicity |
HepSE_cirrhosis |
= |
0.0 |
|
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis |
CHEMBL1909294 |
| Hepatotoxicity |
HepSE_elevated liver function tests |
= |
0.0 |
|
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests |
CHEMBL1909294 |
| Hepatotoxicity |
HepSE_hepatic failure |
= |
0.0 |
|
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure |
CHEMBL1909294 |
| Hepatotoxicity |
HepSE_hepatic necrosis |
= |
0.0 |
|
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis |
CHEMBL1909294 |
| Hepatotoxicity |
HepSE_hepatitis |
= |
0.0 |
|
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis |
CHEMBL1909294 |
| Hepatotoxicity |
HepSE_hepatomegaly |
= |
0.0 |
|
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly |
CHEMBL1909294 |
| Hepatotoxicity |
HepSE_jaundice |
= |
0.0 |
|
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice |
CHEMBL1909294 |
| Hepatotoxicity |
HepSE_liver disease |
= |
0.0 |
|
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease |
CHEMBL1909294 |
| Hepatotoxicity |
HepSE_liver fatty |
= |
0.0 |
|
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty |
CHEMBL1909294 |
| Hepatotoxicity |
HepSE_liver function tests abnormal |
= |
0.0 |
|
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal |
CHEMBL1909294 |
| Hepatotoxicity |
HepSE_Combined Scores |
= |
0.0 |
|
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score |
CHEMBL1909294 |
| ADMET |
permeability |
= |
1.7 |
10'-6 cm/s |
Permeability of the compound after 2.5 hrs by PAMPA-BBB assay |
CHEMBL1926561 |
| ADMET |
permeability |
= |
0.9 |
ucm/s |
Permeability of the compound by PAMPA |
CHEMBL1932933 |
| Glycogen phosphorylase, muscle form |
IC50 |
= |
75300.0 |
nM |
Inhibition of rabbit muscle glycogen phosphorylase a assessed as release of phosphate from glucose-1-phosphate after 25 mins using malachite green staining |
CHEMBL1938391 |
| ADMET |
permeability |
= |
4.3 |
ucm/s |
Permeability of the compound by PAMPA assay |
CHEMBL1938277 |
| ADMET |
permeability |
= |
1.4 |
ucm/s |
Permeability of the compound in porcine brain lipid assessed as ratio of compound in acceptor plate to amount of compound in donor plate at 5 mg/ml after 10 hrs by PAMPA assay |
CHEMBL1955719 |
| Unchecked |
IC50 |
= |
196700.0 |
nM |
Inhibition of Saccharomyces cerevisiae alcohol dehydrogenase measured every 5 mins for 2 hrs by spectrophotometry |
CHEMBL1955735 |
| Radical scavenging activity |
IC50 |
> |
100000.0 |
nM |
Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometry |
CHEMBL1955735 |
| Unchecked |
Inhibition |
|
|
% |
Inhibition of aldehyde dehydrogenase |
CHEMBL1955735 |
| Unchecked |
Activity |
|
|
|
Activation of aldehyde dehydrogenase |
CHEMBL1955735 |
| ADMET |
Peff |
= |
1.6 |
ucm/s |
Effective permeability across porcine polar brain lipid after 4 hrs by PAMPA |
CHEMBL2021862 |
| Glycogen phosphorylase, muscle form |
IC50 |
= |
100000.0 |
nM |
Binding affinity to rabbit muscular GPa,b by NMR binding assay |
CHEMBL2029245 |
| Cytochrome P450 2D6 |
Inhibition |
|
|
% |
Inhibition of human CYP2D6 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 4-methylaminoethyl-7-methoxycoumarin as substrate after 30 mins |
CHEMBL2069259 |
| Cytochrome P450 2C19 |
Inhibition |
|
|
% |
Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins |
CHEMBL2069259 |
| Cytochrome P450 2C9 |
Inhibition |
|
|
% |
Inhibition of human CYP2C9 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate after 30 mins |
CHEMBL2069259 |
| Cytochrome P450 1A2 |
Inhibition |
|
|
% |
Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins |
CHEMBL2069259 |
| Liver microsomes |
Activity |
= |
11.0 |
pmol |
Covalent binding affinity to human liver microsomes assessed per mg of protein at 10 uM after 60 mins presence of NADPH |
CHEMBL2069259 |
| Liver microsomes |
Stability |
|
|
% |
Metabolic stability in human liver microsomes assessed as GSH adduct formation at 100 uM after 90 mins by HPLC-MS analysis |
CHEMBL2069259 |
| Cytochrome P450 3A4 |
Inhibition |
|
|
% |
Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-benzyloxyquinoline as substrate after 30 mins |
CHEMBL2069259 |
| Cytochrome P450 3A4 |
Inhibition |
|
|
% |
Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using diethoxyfluorescein as substrate after 30 mins |
CHEMBL2069259 |
| P-glycoprotein 1 |
Inhibition |
= |
36.0 |
% |
TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical)(Digoxin: 5 uM, Caffeine: 100 uM) in Caco-2 cells |
CHEMBL2073809 |
| P-glycoprotein 1 |
Activity |
|
|
|
TP_TRANSPORTER: transepithelial transport in Caco-2 cells |
CHEMBL2073775 |
| Geminin |
Potency |
|
231.1 |
nM |
PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Adenosine A1 receptor |
Ki |
= |
18800.0 |
nM |
Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membrane |
CHEMBL2150901 |
| Adenosine A2a receptor |
Ki |
= |
32800.0 |
nM |
Displacement of [3H]MSX-2 from adenosine A2A receptor in rat brain striatal membrane |
CHEMBL2150901 |
| Unchecked |
Ratio Ki |
= |
0.6 |
|
Selectivity ratio of Ki for adenosine A1 receptor in rat brain cortical membrane to Ki for adenosine A2A receptor in rat brain striatal membrane |
CHEMBL2150901 |
| Adenosine A1 receptor |
Ki |
= |
44900.0 |
nM |
Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells |
CHEMBL2150901 |
| Adenosine A2a receptor |
Ki |
= |
23400.0 |
nM |
Displacement of [3H]MSX-2 from human recombinant adenosine A2A receptor expressed in CHO cells |
CHEMBL2150901 |
| Adenosine A2b receptor |
Ki |
= |
20500.0 |
nM |
Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells |
CHEMBL2150901 |
| Adenosine A3 receptor |
Ki |
> |
100000.0 |
nM |
Displacement of [3H]PSB-11 from human recombinant adenosine A3 receptor expressed in CHO cells |
CHEMBL2150901 |
| Prion protein |
RUmax |
|
|
|
Binding affinity to truncated human PrP 121-231 at 50 uM by surface plasmon resonance method |
CHEMBL2150853 |
| ADMET |
Peff |
= |
2.46 |
ucm/s |
Effective permeability of the compound at pH 7.4 at 30 to 50 uM by PAMPA assay |
CHEMBL2150853 |
| ADMET |
permeability |
= |
2.2 |
ucm/s |
Permeability of the compound after 4 hrs by PAMPA assay |
CHEMBL2157864 |
| Solute carrier organic anion transporter family member 2B1 |
Inhibition |
= |
3.2 |
% |
Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake at 20 uM incubated for 5 mins by scintillation counting |
CHEMBL2163248 |
| Solute carrier organic anion transporter family member 1B3 |
Inhibition |
= |
22.1 |
% |
Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake at 20 uM incubated for 5 mins by scintillation counting |
CHEMBL2163248 |
| Solute carrier organic anion transporter family member 1B1 |
Inhibition |
= |
-1.8 |
% |
Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake at 20 uM by scintillation counting |
CHEMBL2163248 |
| No relevant target |
LogD |
= |
-0.07 |
|
Apparent hydrophobicity, log D of the compound in Octanol-buffer |
CHEMBL3046441 |
| No relevant target |
pKa |
= |
0.0 |
|
Dissociation constant, pKa of the compound at pH 7.3 |
CHEMBL3046441 |
| No relevant target |
logPapp |
= |
-5.41 |
|
Apparent permeability of the compound by PAMPA |
CHEMBL3046441 |
| No relevant target |
LogP |
= |
-0.07 |
|
Hydrophobicity, log P of the compound in octanol-water by shaking-flask method |
CHEMBL3046441 |
| Lipid bilayer |
Activity |
= |
62.8 |
% |
Binding affinity to Rattus norvegicus Wistar (rat) pancreatic phospholipid membrane by ultrafiltration-HPLC-UV/DAD method |
CHEMBL3046608 |
| Serum albumin |
Activity |
= |
72.7 |
% |
Binding affinity to 0.6 mM Homo sapiens (human) serum albumin by ultrafiltration-HPLC-UV/DAD method |
CHEMBL3046608 |
| Serum albumin |
Activity |
= |
58.4 |
% |
Binding affinity to 0.06 mM Homo sapiens (human) serum albumin by ultrafiltration-HPLC-UV/DAD method |
CHEMBL3046608 |
| Plasma |
PPB |
= |
80.0 |
% |
Total plasma protein binding in Rattus norvegicus Wistar (rat) by ultrafiltration-HPLC-UV/DAD method |
CHEMBL3046608 |
| Plasma |
PPB |
= |
80.0 |
% |
Total plasma protein binding in Homo sapiens (human) by ultrafiltration-HPLC-UV/DAD method |
CHEMBL3046608 |
| Adenosine A1 receptor |
Ki |
= |
44000.0 |
nM |
Antagonist activity at human adenosine A1 receptor assessed as cAMP level by cell based assay |
CHEMBL2380258 |
| Adenosine A2a receptor |
Ki |
= |
23400.0 |
nM |
Antagonist activity at human adenosine A2A receptor assessed as cAMP level by cell based assay |
CHEMBL2380258 |
| Salmonella typhimurium |
Activity |
|
|
|
Protective effect in Salmonella typhimurium TA98 assessed as decrease in ICR191-induced mutagenic effect at 1000 ug/plate measured 4 hrs post ICR191 removal by Ames test |
CHEMBL2384942 |
| Salmonella typhimurium |
Activity |
|
|
|
Protective effect in Salmonella typhimurium TA98 assessed as decrease in ICR191-induced mutagenic effect at 1000 ug/plate by Ames test |
CHEMBL2384942 |
| Salmonella typhimurium |
Activity |
|
|
|
Protective effect in Salmonella typhimurium TA98 assessed as decrease in ICR191-induced mutagenic effect after 4 hrs by Ames test |
CHEMBL2384942 |
| Salmonella typhimurium |
Activity |
|
|
|
Mutagenic activity in Salmonella typhimurium TA98 at 2 mg/plate after 4 hrs by Ames test |
CHEMBL2384942 |
| Unchecked |
Activity |
|
|
|
Binding affinity to ICR191 in MDBK cells assessed as decrease in formation of mutagen-chromatin complex at 1 to 12 mM by spectrophotometric analysis |
CHEMBL2384942 |
| Unchecked |
Activity |
|
|
|
Binding affinity to ICR191 in MDBK cells assessed as decrease in molar fraction of free mutagen at 1 to 12 mM by spectrophotometric analysis |
CHEMBL2384942 |
| Butyrylcholinesterase |
IC50 |
> |
50000.0 |
nM |
Inhibition of human BuChE using S-butyrylthiocholine iodide as substrate treated 5 mins before substrate addition measured up to 4 mins by Ellman's method |
CHEMBL2401650 |
| Acetylcholinesterase |
IC50 |
= |
7250.0 |
nM |
Inhibition of human AChE using acetylthiocholine iodide as substrate treated 5 mins before substrate addition measured up to 4 mins by Ellman's method |
CHEMBL2401650 |
| Adenosine A2a receptor |
Ki |
= |
9560.0 |
nM |
Displacement of [3H]CGS21680 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting analysis |
CHEMBL2412992 |
| Adenosine A2a receptor |
Ki |
= |
2480.0 |
nM |
Competitive binding affinity to human adenosine A2A receptor expressed in HEK293 cells after 60 mins by fluorescence polarization assay in presence of MRS5346 |
CHEMBL2412992 |
| Solute carrier organic anion transporter family member 1B1 |
Inhibition |
= |
103.59 |
% |
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM |
CHEMBL3039007 |
| Solute carrier organic anion transporter family member 1B3 |
Inhibition |
= |
90.35 |
% |
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM |
CHEMBL3039007 |
| Adenosine A3 receptor |
Ki |
= |
13300.0 |
nM |
Displacement of [3H]PSB-11 from human adenosine A3 receptor expressed in CHO cells |
CHEMBL3091303 |
| Adenosine A2b receptor |
Ki |
= |
33800.0 |
nM |
Displacement of [3H]PSB-603 from human adenosine A2B receptor |
CHEMBL3091303 |
| Adenosine A2a receptor |
Ki |
= |
32500.0 |
nM |
Displacement of [3H]MSX-2 from adenosine A2A receptor in rat brain striatum |
CHEMBL3091303 |
| Adenosine A2a receptor |
Ki |
= |
23400.0 |
nM |
Displacement of [3H]MSX-2 from human adenosine A2A receptor expressed in CHO cells |
CHEMBL3091303 |
| Adenosine A1 receptor |
Ki |
= |
41000.0 |
nM |
Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortex |
CHEMBL3091303 |
| Adenosine A1 receptor |
Ki |
= |
44900.0 |
nM |
Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells |
CHEMBL3091303 |
| Adenosine A3 receptor |
Ki |
= |
13300.0 |
nM |
Binding affinity to human adenosine A3 receptor |
CHEMBL3091303 |
| Adenosine A2a receptor |
Ki |
= |
32500.0 |
nM |
Binding affinity to rat adenosine A2A receptor |
CHEMBL3091303 |
| Adenosine A2a receptor |
Ki |
= |
23400.0 |
nM |
Binding affinity to human adenosine A2A receptor |
CHEMBL3091303 |
| Adenosine A1 receptor |
Ki |
= |
41000.0 |
nM |
Binding affinity to rat adenosine A1 receptor |
CHEMBL3091303 |
| Adenosine A1 receptor |
Ki |
= |
44900.0 |
nM |
Binding affinity to human adenosine A1 receptor |
CHEMBL3091303 |
| Adenosine A2b receptor |
Ki |
= |
33800.0 |
nM |
Binding affinity to human adenosine A2B receptor |
CHEMBL3091303 |
| Unchecked |
Potency |
|
2511.9 |
nM |
PubChem BioAssay. qHTS for Inhibitors of binding or entry into cells for Marburg Virus. (Class of assay: confirmatory) |
CHEMBL1201862 |
| Unchecked |
IC50 |
= |
100000.0 |
nM |
Inhibition of glycogen phosphorylase (unknown origin) by INPHARMA method |
CHEMBL3217475 |
| PI3-kinase p110-delta subunit |
IC50 |
= |
75000.0 |
nM |
Inhibition of PI3Kdelta (unknown origin) |
CHEMBL3217752 |
| PI3-kinase p110-alpha subunit |
IC50 |
= |
400000.0 |
nM |
Inhibition of PI3Kalpha (unknown origin) |
CHEMBL3217752 |
| PI3-kinase p110-beta subunit |
IC50 |
= |
400000.0 |
nM |
Inhibition of PI3Kbeta (unknown origin) |
CHEMBL3217752 |
| PI3-kinase p110-gamma subunit |
IC50 |
= |
1000000.0 |
nM |
Inhibition of PI3Kgamma (unknown origin) |
CHEMBL3217752 |
| No relevant target |
permeability |
= |
0.9 |
ucm/s |
Permeability of the compound by PAMPA |
CHEMBL3232937 |
| No relevant target |
LogP |
= |
-1.48 |
|
Oil-water partition coefficient, log P of the compound |
CHEMBL3244276 |
| No relevant target |
LogP |
= |
-1.3 |
|
Et2O-water partition coefficient, log P of the compound |
CHEMBL3244276 |
| Adenosine A2b receptor |
Ki |
= |
20500.0 |
nM |
Inhibition of human recombinant adenosine receptor A2b |
CHEMBL3259781 |
| Adenosine A2a receptor |
Ki |
= |
23400.0 |
nM |
Inhibition of human recombinant adenosine receptor A2a |
CHEMBL3259781 |
| Adenosine A1 receptor |
Ki |
= |
44900.0 |
nM |
Inhibition of human recombinant adenosine A1 receptor |
CHEMBL3259781 |
| Adenosine A3 receptor |
Ki |
> |
100000.0 |
nM |
Inhibition of rat recombinant adenosine A3 receptor |
CHEMBL3259781 |
| Rattus norvegicus |
Inhibition |
= |
35.0 |
% |
Anticataleptic activity in rat assessed as inhibition at 3 mg/kg, po after 1 hr |
CHEMBL3259781 |
| Rattus norvegicus |
Inhibition |
= |
14.0 |
% |
Anticataleptic activity in rat assessed as inhibition at 3 mg/kg, po after 4 hrs |
CHEMBL3259781 |
| No relevant target |
LogP |
= |
-0.07 |
|
Partition coefficient, log P of the compound by shake-flask technique |
CHEMBL3272075 |
| No relevant target |
LogP |
= |
-0.07 |
|
Partition coefficient, log P of the compound by HPLC analysis |
CHEMBL3272075 |
| ADMET |
PPB |
|
13.68 |
% |
ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with whole rat plasma at 37C for >5hrs. Method described in B. Testa et al (Eds.), Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies, Wiley-VCH, Weinheim, 2006, pp.119-141. Experimental range 10% to 99.95% bound. |
CHEMBL3301361 |
| ADMET |
PPB |
|
14.52 |
% |
ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with whole dog plasma at 37C for >5hrs. Method described in B. Testa et al (Eds.), Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies, Wiley-VCH, Weinheim, 2006, pp.119-141. Experimental range 10% to 99.95% bound. |
CHEMBL3301361 |
| ADMET |
PPB |
|
24.45 |
% |
ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with whole human plasma at 37C for >5hrs. Method described in B. Testa et al (Eds.), Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies, Wiley-VCH, Weinheim, 2006, pp.119-141. Experimental range 10% to 99.95% bound. |
CHEMBL3301361 |
| No relevant target |
LogD7.4 |
|
-0.03 |
|
ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake flask method described in J. Biomol. Screen. 2011, 16, 348-355. Experimental range -1.5 to 4.5 |
CHEMBL3301361 |
| ADMET |
CL |
< |
3.0 |
uL.min-1.(10^6cells)-1 |
ASTRAZENECA: Intrinsic clearance measured in rat hepatocytes following incubation at 37C. Experimental range <3 to >150 microL/min/1E6 cells. Rapid Commun. Mass Spectrom. 2010, 24, 1730-1736 |
CHEMBL3301361 |
| MDCK |
permeability |
= |
85.9 |
% |
Apparent permeability from basolateral side to apical in MDCK cells expressing MDR1 at 10 uM after 60 mins by LC/MS analysis |
CHEMBL3351944 |
| MDCK |
permeability |
= |
73.0 |
% |
Apparent permeability from basolateral side to apical in verapamil pretreated MDCK cells expressing MDR1 at 10 uM after 60 mins by LC/MS analysis |
CHEMBL3351944 |
| Glycogen phosphorylase, muscle form |
IC50 |
= |
648000.0 |
nM |
Inhibition of rabbit muscle glycogen phosphorylase a assessed as inhibition of release of phosphate from glucose-1-phosphate after 30 mins by spectrophotometry |
CHEMBL3352132 |
| PI3-kinase p110-gamma subunit |
IC50 |
= |
3630000.0 |
nM |
Inhibition of PI3Kgamma (unknown origin) assessed as decrease in fluorescence intensity using phosphorylated substrate |
CHEMBL3351785 |
| ADMET |
Peff |
= |
1.3 |
10'-6 cm/s |
Permeability of the compound by PAMPA |
CHEMBL3399969 |
| ADMET |
Peff |
= |
1.28 |
10'-6 cm/s |
Permeability of the compound in PBS/EtOH buffer at 100 ug/ml by PAMPA |
CHEMBL3399969 |
| Retinal dehydrogenase 2 |
Inhibition |
|
|
% |
Inhibition of recombinant human ALDH1A2 using propionaldehyde as substrate at 100 uM preincubated for 2 mins with NAD+ followed by substrate addition by UV-Vis spectrophotometric analysis |
CHEMBL3414499 |
| Aldehyde dehydrogenase 1A3 |
Inhibition |
|
|
% |
Inhibition of recombinant human ALDH1A3 using propionaldehyde as substrate at 100 uM preincubated for 2 mins with NAD+ followed by substrate addition by UV-Vis spectrophotometric analysis |
CHEMBL3414499 |
| Aldehyde dehydrogenase X |
Inhibition |
|
|
% |
Inhibition of recombinant human ALDH1B1 using propionaldehyde as substrate at 100 uM preincubated for 2 mins with NAD+ followed by substrate addition by UV-Vis spectrophotometric analysis |
CHEMBL3414499 |
| Aldehyde dehydrogenase 1A1 |
Inhibition |
|
|
% |
Inhibition of recombinant human ALDH1A1 using propionaldehyde as substrate at 100 uM preincubated for 2 mins with NAD+ followed by substrate addition by UV-Vis spectrophotometric analysis relative to control |
CHEMBL3414499 |
| Aldehyde dehydrogenase |
Inhibition |
|
|
% |
Inhibition of recombinant human ALDH2 using propionaldehyde as substrate at 100 uM preincubated for 2 mins with NAD+ followed by substrate addition by UV-Vis spectrophotometric analysis |
CHEMBL3414499 |
| Aldehyde dehydrogenase dimeric NADP-preferring |
Inhibition |
|
|
% |
Inhibition of recombinant human ALDH3A1 using benzaldehyde as substrate at 100 uM preincubated for 2 mins with NAD+ followed by substrate addition by UV-Vis spectrophotometric analysis |
CHEMBL3414499 |
| Aldehyde dehydrogenase 1A1 |
Activity |
|
|
|
Effect on recombinant human ALDH1A1 using propionaldehyde as substrate up to 250 uM preincubated for 2 mins with NAD+ followed by substrate addition by UV-Vis spectrophotometric analysis |
CHEMBL3414499 |
| ADMET |
permeability |
= |
2.11 |
10'-6 cm/s |
Permeability of the compound after 16 hrs by PAMPA |
CHEMBL3414495 |
| ADMET |
permeability |
= |
1.3 |
10'-6 cm/s |
Permeability of the compound by PAMPA |
CHEMBL3414495 |
| No relevant target |
Retention_time |
= |
3.2 |
min |
Retention time of the compound by HPLC-UV method |
CHEMBL3414445 |
| NON-PROTEIN TARGET |
Peff |
= |
2.2 |
ucm/s |
In vitro blood-brain barrier permeability at pH 7.4 by UV detection and HPLC based PAMPA method |
CHEMBL3414445 |
| NON-PROTEIN TARGET |
Peff |
= |
1.3 |
ucm/s |
In vitro blood-brain barrier permeability by PAMPA method |
CHEMBL3414445 |
| Liver microsome |
Drug metabolism |
|
|
|
Metabolic activation in human liver microsomes assessed as [3H]GSH adduct formation rate measured per mg of protein at 100 uM by [3H]GSH trapping assay |
CHEMBL3526118 |
| Liver microsome |
CLH |
|
|
|
Intrinsic clearance for reactive metabolites formation per mg of protein in human liver microsomes based on [3H]GSH adduct formation rate at 100 uM by [3H]GSH trapping assay |
CHEMBL3526118 |
| ADMET |
CL |
|
|
|
Intrinsic clearance for reactive metabolites formation per mg of protein based on cytochrome P450 (unknown origin) inactivation rate by TDI assay |
CHEMBL3526118 |
| Cytochrome P450 1A2 |
Inhibition |
< |
10.0 |
% |
Time dependent inhibition of CYP1A2 (unknown origin) at 100 uM by LC/MS system |
CHEMBL3526118 |
| Cytochrome P450 2B6 |
Inhibition |
< |
10.0 |
% |
Time dependent inhibition of CYP2B6 (unknown origin) at 100 uM by LC/MS system |
CHEMBL3526118 |
| Cytochrome P450 2C8 |
Inhibition |
< |
10.0 |
% |
Time dependent inhibition of CYP2C8 (unknown origin) at 100 uM by LC/MS system |
CHEMBL3526118 |
| Brain |
Fu |
= |
0.52 |
|
Fraction unbound in Wistar rat brain homogenate at 5 uM after 5 hrs by equilibrium dialysis method |
CHEMBL3526149 |
| Molecular identity unknown |
Fu |
= |
0.26 |
|
Percentage unbound in solid supported porcine brain membrane vesicles at 5 uM by TRANSIL assay |
CHEMBL3526149 |
| ADMET |
CL |
= |
2.79 |
mL.min-1.kg-1 |
Intrinsic clearance in human using well stirred liver model by LC-MS/MS method |
CHEMBL3526137 |
| Hepatocyte |
CL |
= |
3.09 |
uL.min-1.(10^6cells)-1 |
Intrinsic clearance in cryopreserved human hepatocytes cells assessed per 10'6 cells by LC-MS/MS method |
CHEMBL3526137 |
| ADMET |
CL |
= |
6.3 |
uL.min-1.(10^6cells)-1 |
Intrinsic clearance in cryopreserved human HepaRG cells assessed per 10'6 cells by LC-MS/MS method |
CHEMBL3526137 |
| ADMET |
Ratio |
= |
2.0 |
|
Ratio of fraction unbound in Wistar rat brain homogenate at 5 uM after 5 hrs by equilibrium dialysis method to fraction unbound in solid supported porcine brain membrane vesicles at 5 uM by TRANSIL assay |
CHEMBL3526149 |
| Liver microsome |
PB |
= |
9.9 |
pmol |
Covalent binding in human liver microsomes measured per mg of protein using radiolabelled compound at 10 uM after 1 hr incubation by liquid scintillation counting |
CHEMBL3526118 |
| ADMET |
logPapp |
= |
-4.51 |
|
Apparent permeability across human differentiated Caco2 cells |
CHEMBL3526071 |
| No relevant target |
LogD |
= |
0.02 |
|
1-Octanol-water distribution coefficient, log D of the compound at pH 7.4 |
CHEMBL3526071 |
| Homo sapiens |
F |
= |
100.0 |
% |
Oral bioavailability in human |
CHEMBL3526071 |
| Homo sapiens |
CL |
= |
1.67 |
mL.min-1.kg-1 |
Hepatic clearance in human |
CHEMBL3526137 |
| ADMET |
Fu |
= |
0.65 |
|
Fraction unbound in blood (not specified) |
CHEMBL3526137 |
| NON-PROTEIN TARGET |
Fu |
= |
0.989 |
|
Fraction unbound in human hepatocytes |
CHEMBL3526137 |
| No relevant target |
pKa |
= |
3.6 |
|
Dissociation constant, pKa of the compound |
CHEMBL3526137 |
| No relevant target |
LogP |
= |
0.1 |
|
Lipophilicity, log P of the compound |
CHEMBL3526137 |
| Cytochrome P450 2C9 |
Inhibition |
< |
10.0 |
% |
Time dependent inhibition of CYP2C9 (unknown origin) at 100 uM by LC/MS system |
CHEMBL3526118 |
| Cytochrome P450 2C19 |
Inhibition |
< |
10.0 |
% |
Time dependent inhibition of CYP2C19 in human liver microsomes at 100 uM by LC/MS system |
CHEMBL3526118 |
| Cytochrome P450 2D6 |
Inhibition |
< |
10.0 |
% |
Time dependent inhibition of CYP2D6 (unknown origin) at 100 uM by LC/MS system |
CHEMBL3526118 |
| Cytochrome P450 3A4 |
Inhibition |
< |
10.0 |
% |
Time dependent inhibition of CYP3A4 (unknown origin) at 100 uM by LC/MS system |
CHEMBL3526118 |
| ADMET |
CL |
|
|
|
Intrinsic clearance for reactive metabolites formation assessed as summation of [3H]GSH adduct formation rate-based reactive metabolites formation and cytochrome P450 (unknown origin) inactivation rate-based reactive metabolites formation |
CHEMBL3526118 |
| No relevant target |
permeability |
= |
1.3 |
10'-6 cm/s |
Permeability of the compound using PDVF membrane after 2 hrs 45 mins by PAMPA-BBB assay |
CHEMBL3585247 |
| No relevant target |
permeability |
= |
0.3 |
10'-6 cm/s |
Permeability of the compound by PAMPA-BBB assay |
CHEMBL3585247 |
| Monoamine oxidase B |
Ki |
= |
3800000.0 |
nM |
Inhibition of human MAOB |
CHEMBL3603809 |
| Adenosine A1 receptor |
Ki |
= |
55000.0 |
nM |
Binding affinity to Adenosine A1 receptor in rat brain tissue by radioligand displacement assay |
CHEMBL3616475 |
| Adenosine A2a receptor |
Ki |
= |
50000.0 |
nM |
Binding affinity to Adenosine A2A receptor in rat brain tissue by radioligand displacement assay |
CHEMBL3616475 |
| ADMET |
permeability |
= |
67.0 |
% |
Permeability of compound across apical to basal compartment in PBS at pH 5.5 at 10 uM after 4 hrs by PAMPA |
CHEMBL3758084 |
| ADMET |
permeability |
= |
70.0 |
% |
Permeability of compound across apical to basal compartment in PBS at pH 7.4 at 10 uM after 4 hrs by PAMPA |
CHEMBL3758084 |
| MDCK |
permeability |
= |
80.0 |
% |
Permeability across apical to basolateral side of MDCK cell BBB penetration model expressing human mdr1 at 10 uM incubated for 1 hr by mass spectrometric analysis |
CHEMBL3758084 |
| Glycogen phosphorylase, muscle form |
IC50 |
= |
229000.0 |
nM |
Inhibition of rabbit muscle glycogen phosphorylase-a assessed as formation of inorganic phosphate from glucose-1-phosphate by colorimetry |
CHEMBL3769302 |
| Adenosine A2b receptor |
Ki |
= |
33800.0 |
nM |
Displacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrs |
CHEMBL3784997 |
| ADMET |
permeability |
= |
1.28 |
ucm/s |
Permeability of the compound at 100 ug/ml after 18 hrs by PAMPA-BBB assay |
CHEMBL3785067 |
| ADMET |
permeability |
= |
1.3 |
ucm/s |
Permeability of the compound at 25 ug/ml after 18 hrs by PAMPA-BBB assay |
CHEMBL3785067 |
| Adenosine A1 receptor |
Ki |
= |
41000.0 |
nM |
Displacement of [3H]R-PIA from adenosine receptor A1 in rat brain cerebral cortical membranes |
CHEMBL3868608 |
| Adenosine A2a receptor |
Ki |
= |
43000.0 |
nM |
Displacement of [3H]NECA from adenosine receptor A2A in rat striatal membranes |
CHEMBL3868608 |
| Unchecked |
Ratio Ki |
= |
1.1 |
|
Selectivity index, ratio of Ki for adenosine receptor A2A in Sprague-Dawley rat striatal membranes to Ki for adenosine receptor A1 in Sprague-Dawley rat whole brain cell membranes |
CHEMBL3868608 |
| Adenosine A2a receptor |
Ki |
= |
50000.0 |
nM |
Antagonist activity at adenosine receptor A2A in [3H]-adenine-labeled guinea pig cerebral cortical slices assessed as inhibition of 2-chloroadenosine-mediated [3H]cAMP accumulation |
CHEMBL3868608 |
| Adenosine A1 receptor |
Ki |
= |
55000.0 |
nM |
Displacement of [3H]cyclohexyladenosine from adenosine receptor A1 in rat cerebral cortical membranes |
CHEMBL3868608 |
| No relevant target |
LogD |
= |
-0.3 |
|
1-octanol/D2O distribution coefficient, log D of the compound at pH 7.4 by 1H NMR spectroscopic analysis |
CHEMBL3870346 |
| No relevant target |
LogP |
= |
-0.07 |
|
Lipophilicity, log P of the compound |
CHEMBL3870346 |
| ADMET |
permeability |
= |
1.28 |
10'-6 cm/s |
Permeability of the compound at 100 ug/ml after 18 hrs by PAMPA assay |
CHEMBL3872257 |
| ADMET |
permeability |
= |
1.3 |
10'-6 cm/s |
Permeability of the compound at 25 ug/ml after 18 hrs by PAMPA assay |
CHEMBL3872257 |
| ADMET |
permeability |
= |
1.22 |
ucm/s |
Permeability of compound at 100 ug/ml after 18 hrs by PAMPA |
CHEMBL3875206 |
| Schistosoma mansoni |
RBC |
= |
6054000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
133000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
39.6 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
65.4 |
fL |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
22.0 |
pg |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.7 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
7.7 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1172000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
10780.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
13.4 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
0.4 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
2.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
83.4 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.7 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
21.2 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3148.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6384000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
135000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
40.7 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
63.8 |
fL |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
21.2 |
pg |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.1 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
6.9 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1171000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
11570.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
13.8 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
0.6 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
3.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
81.8 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.5 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
24.2 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3290.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6216000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
133000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
40.1 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
64.5 |
fL |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
21.4 |
pg |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.2 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
7.6 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1171000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
9090.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
12.4 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
0.4 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
1.8 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
84.4 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.8 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
21.9 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3232.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6444000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
135000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
40.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
62.2 |
fL |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
21.0 |
pg |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.8 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
6.4 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1277000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
11070.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
14.8 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
0.8 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
1.8 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
81.2 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
16.0 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
20.8 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3226.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6092000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
133000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
39.4 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
64.6 |
fL |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
21.8 |
pg |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.8 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
7.5 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1171000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
9470.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
20.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
0.8 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
2.6 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
75.4 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.3 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
24.2 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3260.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6318000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
135000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
41.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
64.9 |
fL |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
21.4 |
pg |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
6.3 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1102000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
7430.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
14.4 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
0.6 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
2.6 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
81.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.8 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
22.8 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3172.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6248000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
133000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
40.3 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
64.6 |
fL |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
21.2 |
pg |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
32.8 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
7.1 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1193000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
7600.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
18.4 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
0.2 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
2.2 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
77.8 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.6 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
22.3 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3114.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6152000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
135000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
40.2 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
65.5 |
fL |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
21.9 |
pg |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.4 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
7.1 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1200000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
10290.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
15.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
1.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
2.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
80.6 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.6 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
21.5 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3088.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6374000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
133000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
40.2 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
63.0 |
fL |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
20.9 |
pg |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.1 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
7.5 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1199000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
7430.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
20.2 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
1.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
2.4 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
75.4 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.1 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
24.1 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3146.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6310000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
135000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
41.1 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
65.2 |
fL |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
21.4 |
pg |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
32.9 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
7.1 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1147000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
10020.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
19.8 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
1.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
2.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
76.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.6 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
24.1 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3304.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6370000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
135000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
40.9 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
64.2 |
fL |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
21.2 |
pg |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
6.9 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1189000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
7510.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
19.6 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
0.8 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
2.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
76.4 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.3 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
22.1 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3186.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6330000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
133000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
40.2 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
63.7 |
fL |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
21.1 |
pg |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.1 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
6.5 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1227000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
7520.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
12.6 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
1.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
1.8 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
83.4 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.7 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
22.1 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3092.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6680000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
142000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
42.8 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
64.2 |
fL |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
21.3 |
pg |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.3 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
7.5 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1122000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
5990.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
23.6 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
0.8 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
1.8 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
73.2 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.6 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
24.8 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3410.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6712000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
141000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
42.7 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
63.7 |
fL |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
21.0 |
pg |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
7.1 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1242000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
6850.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
26.8 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
1.6 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
70.6 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.5 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
24.9 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3444.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6524000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
136000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
40.8 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
62.6 |
fL |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
20.8 |
pg |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.2 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
6.9 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1162000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
6270.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
27.4 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
0.4 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
1.8 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
69.2 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.5 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
22.9 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3254.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6614000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
140000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
42.4 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
64.2 |
fL |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
21.2 |
pg |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.1 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
6.7 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1267000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
8140.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
20.6 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
0.8 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
3.2 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
75.0 |
% |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.9 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
20.5 |
s |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3288.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6270000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
132000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
39.9 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
63.7 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
21.1 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.1 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
6.4 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1135000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
7970.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
15.6 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
0.6 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
2.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
81.2 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.7 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
21.9 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3110.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6448000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
137000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
40.7 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
63.2 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
21.2 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.6 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
6.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1162000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
12040.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
17.4 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
0.8 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
1.8 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
79.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.4 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
22.5 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3426.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6880000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
141000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
41.1 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
59.8 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
20.5 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
34.2 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
4.3 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1174000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
11760.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
11.4 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
1.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
2.4 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
84.2 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.5 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
22.6 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3114.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
7782000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
151000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
43.6 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
56.1 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
19.4 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
34.6 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
2.6 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1021000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
10330.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
14.8 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
1.2 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
1.6 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
81.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.7 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
25.4 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3170.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6186000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
129000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
38.9 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
62.9 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
20.9 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.2 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
5.7 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1188000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
7350.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
16.4 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
1.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
1.8 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
80.2 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.5 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
21.4 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3072.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6484000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
135000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
40.6 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
62.7 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
20.9 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.3 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
6.1 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1122000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
10630.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
16.8 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
1.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
2.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
79.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.3 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
22.8 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3160.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6936000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
140000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
41.1 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
59.2 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
20.1 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
34.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
4.5 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1126000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
10540.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
15.4 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
0.8 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
1.4 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
81.2 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.1 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
23.2 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3062.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
7888000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
149000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
43.1 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
54.7 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
18.9 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
34.5 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
2.5 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
993000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
10520.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
12.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
0.6 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
1.6 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
84.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
16.1 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
25.8 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3092.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6464000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
137000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
41.1 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
63.6 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
21.2 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.4 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
5.2 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1145000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
6140.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
13.6 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
0.8 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
1.2 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
84.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.5 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
20.9 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3300.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6878000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
141000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
41.9 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
60.9 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
20.5 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.6 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
5.4 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1159000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
7900.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
16.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
0.8 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
1.4 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
80.8 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.2 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
23.2 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3102.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
7438000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
146000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
43.4 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
58.4 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
19.7 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.7 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
3.9 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1099000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
10800.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
20.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
1.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
2.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
76.2 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.2 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
23.9 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3090.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
7786000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
151000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
43.1 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
55.4 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
19.4 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
35.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
2.7 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1003000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
9940.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
14.6 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
1.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
2.4 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
79.6 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.5 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
25.6 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3152.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
6860000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
141000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
41.6 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
60.6 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
20.5 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
33.8 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
4.3 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1262000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
8150.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
22.4 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
1.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
1.6 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
74.4 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.8 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
22.4 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3196.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
7054000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
145000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
42.6 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
60.4 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
20.5 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
34.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
4.8 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1092000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
10020.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
15.2 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
1.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
2.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
80.8 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.3 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
22.8 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3218.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
7504000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
151000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
44.2 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
58.9 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
20.1 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
34.1 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
3.5 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
1104000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
10570.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
16.6 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
0.4 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
2.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
80.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.5 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
24.3 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3206.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RBC |
= |
8290000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HGB |
= |
159000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
HCT |
= |
45.4 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCV |
= |
54.8 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCH |
= |
19.1 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MCHC |
= |
34.9 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
RETIRBC |
= |
2.1 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PLAT |
= |
971000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WBC |
= |
9830.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
NEUTLE |
= |
18.8 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
EOSLE |
= |
1.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
MONOLE |
= |
2.8 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LYMLE |
= |
75.6 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PT |
= |
15.9 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
APTT |
= |
23.7 |
s |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
FIBRINO |
= |
3082.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1463.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
744.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
754.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1386.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.1 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.06 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1884.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
140.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
143.2 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.4 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
105.2 |
meq/L |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
106.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
91.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
53000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
30000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.3 |
|
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
84.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
49.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
226.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1310.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
760.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
602.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1338.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.14 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.02 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1928.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
114.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
142.2 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.3 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
104.8 |
meq/L |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
104.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
97.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
54000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
29000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.2 |
|
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
65.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
39.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
164.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1160.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
790.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
542.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1352.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.12 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1884.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
134.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
142.8 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.1 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
105.8 |
meq/L |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
106.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
93.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
55000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
31000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.3 |
|
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
69.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
38.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
171.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1677.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
808.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
1030.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1570.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.1 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1968.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
164.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
141.8 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.4 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
107.0 |
meq/L |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
108.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
78.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
54000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
30000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.3 |
|
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
75.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
49.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
185.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1576.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
726.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
598.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1342.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.2 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1878.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
136.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
141.6 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
3.9 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
106.6 |
meq/L |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
105.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
86.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
54000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
30000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.2 |
|
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
80.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
49.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
172.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
2.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1363.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
766.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
614.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1348.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.14 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.02 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1832.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
130.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
141.6 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.2 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
106.0 |
meq/L |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
105.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
90.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
53000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
29000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.2 |
|
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
76.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
47.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
185.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1414.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
734.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
538.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1320.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.12 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1734.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
130.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
1.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
141.8 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.6 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
106.4 |
meq/L |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
106.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
98.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
54000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
30000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.2 |
|
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
71.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
39.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
189.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1413.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
796.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
866.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1454.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.1 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1916.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
158.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
142.0 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.1 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
106.4 |
meq/L |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
109.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
79.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
55000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
31000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.3 |
|
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
73.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
43.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
206.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1504.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
804.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
352.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1376.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.2 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.04 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1874.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
132.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
141.8 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
3.5 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
106.8 |
meq/L |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
104.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
87.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
57000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
32000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.2 |
|
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
81.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
48.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
156.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1403.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
802.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
654.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1394.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.2 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1890.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
132.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
141.6 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.0 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
108.4 |
meq/L |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
106.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
86.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
56000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
31000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.3 |
|
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
99.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
50.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
180.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1360.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
784.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
530.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1394.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.28 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.02 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1646.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
122.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
141.6 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.2 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
106.6 |
meq/L |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
109.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
94.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
56000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
31000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.3 |
|
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
79.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
46.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
158.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1549.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
744.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
796.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1384.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.06 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1870.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
158.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
141.0 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.1 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
106.4 |
meq/L |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
106.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
82.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
55000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
30000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.2 |
|
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
71.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
45.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
187.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1389.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
818.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
374.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1348.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.06 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.02 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
2004.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
134.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
141.2 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
3.6 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
105.8 |
meq/L |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
105.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
83.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
59000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
33000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.2 |
|
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
89.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
51.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
178.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1423.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
854.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
436.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1436.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.1 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
2142.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
146.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
140.0 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
3.8 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
104.8 |
meq/L |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
107.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
77.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
59000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
33000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.3 |
|
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
78.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
41.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
186.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1167.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
792.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
596.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1446.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.1 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1950.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
126.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
140.0 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.0 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
104.8 |
meq/L |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
104.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
72.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
58000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
31000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.2 |
|
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
78.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
40.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
177.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1412.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
832.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
598.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1494.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.2 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1838.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
138.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
1.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
141.0 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.3 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
106.0 |
meq/L |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
109.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
92.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
56000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
30000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.2 |
|
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
71.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
42.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
200.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1435.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
692.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
834.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1318.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.04 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1872.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
166.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
146.2 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.1 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
108.2 |
meq/L |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
109.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
79.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
56000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
30000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.2 |
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
77.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
51.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
159.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1993.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
766.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
1186.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1492.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1978.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
182.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
1.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
141.0 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.7 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
106.0 |
meq/L |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
105.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
77.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
55000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
30000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.2 |
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
70.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
46.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
185.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1572.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
698.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
1502.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1514.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
2160.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
202.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
141.8 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.5 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
104.6 |
meq/L |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
105.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
75.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
58000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
30000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.1 |
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
68.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
40.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
181.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
2.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1038.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
710.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
1388.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1450.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.04 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1974.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
190.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
143.0 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.1 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
105.0 |
meq/L |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
104.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
66.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
61000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
31000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.1 |
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
66.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
43.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
146.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
2.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1442.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
758.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
878.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1436.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.04 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1832.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
168.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
146.0 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.2 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
107.6 |
meq/L |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
108.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
75.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
56000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
30000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.2 |
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
70.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
43.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
154.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1552.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
734.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
1024.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1410.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.02 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1928.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
166.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
142.4 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.4 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
106.4 |
meq/L |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
105.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
78.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
55000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
30000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.2 |
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
75.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
47.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
179.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
2.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1475.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
684.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
1466.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1484.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.04 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1940.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
192.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
142.2 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.2 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
105.8 |
meq/L |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
106.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
68.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
58000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
30000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.1 |
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
71.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
44.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
160.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
2.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1054.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
736.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
1476.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1530.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.04 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
2044.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
176.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
143.6 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.0 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
105.8 |
meq/L |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
104.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
67.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
60000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
32000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.1 |
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
66.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
43.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
153.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
2.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1647.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
738.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
876.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1404.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.04 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1796.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
142.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
146.2 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.4 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
108.8 |
meq/L |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
107.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
81.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
56000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
31000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.2 |
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
67.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
40.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
140.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1455.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
746.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
798.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1410.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.1 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1824.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
164.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
1.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
143.2 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.1 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
106.4 |
meq/L |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
104.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
77.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
57000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
31000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.2 |
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
75.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
45.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
158.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1460.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
732.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
1396.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1554.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.02 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1960.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
184.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
143.0 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.2 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
106.6 |
meq/L |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
104.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
70.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
59000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
30000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.1 |
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
75.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
47.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
145.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
2.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1003.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
858.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
886.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1514.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.1 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1896.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
164.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
143.0 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
3.9 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
105.2 |
meq/L |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
107.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
76.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
61000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
32000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.1 |
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
71.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
44.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
126.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
2.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1109.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
792.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
430.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1318.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.18 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1696.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
124.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
145.0 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.4 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
108.6 |
meq/L |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
108.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
89.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
58000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
32000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.2 |
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
70.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
38.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
159.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1284.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
840.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
774.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1494.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.16 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1828.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
132.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
1.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
142.6 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.2 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
106.2 |
meq/L |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
104.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
85.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
57000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
30000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.1 |
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
74.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
41.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
175.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
1.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1222.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
804.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
834.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1490.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.22 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1848.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
138.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
143.4 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.2 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
105.8 |
meq/L |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
106.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
80.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
58000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
31000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.2 |
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
80.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
46.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
140.2 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
2.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALP |
= |
1068.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CHOL |
= |
802.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TRIG |
= |
770.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOSLPD |
= |
1464.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILI |
= |
0.34 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BILDIR |
= |
0.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GLUC |
= |
1808.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
BUN |
= |
142.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CREAT |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
SODIUM |
= |
142.2 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
POTASSIUM |
= |
4.2 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Cl |
= |
106.2 |
meq/L |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
CALCIUM |
= |
104.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PHOS |
= |
78.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
PROT |
= |
60000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALB |
= |
32000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALBGLOB |
= |
1.2 |
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
AST |
= |
85.4 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
53.8 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
LDH |
= |
163.0 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
GGT |
= |
2.6 |
IU.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
218.5 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
10.5 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.9 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
211.8 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
9.5 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.9 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
208.2 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
8.9 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.9 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
0.9 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
0.9 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
222.7 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
10.6 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
217.5 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
10.3 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
209.2 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
9.5 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.1 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.1 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
215.8 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
9.3 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.1 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
224.7 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
10.7 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
214.3 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
9.9 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.9 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
0.9 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
211.5 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
9.6 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
208.4 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
9.3 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
226.7 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
10.6 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
209.4 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
9.6 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.8 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
0.9 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
0.9 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
220.1 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
10.3 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
0.9 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
205.2 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
8.9 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.9 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
0.9 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
216.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
9.4 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 10 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
229.3 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
11.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
259.6 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
12.4 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.3 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.1 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.1 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
312.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
14.1 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.4 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.2 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.2 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
388.1 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
16.5 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.9 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.5 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.4 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
226.8 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
11.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
259.9 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
12.1 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.2 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.1 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.1 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
300.9 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
13.2 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.5 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.2 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.2 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
396.8 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
16.7 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
3.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.5 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.5 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
223.8 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
10.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
245.2 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
11.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.1 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
286.3 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
12.3 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.3 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.2 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.1 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
380.2 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
15.5 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
3.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.5 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.5 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
205.8 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
9.1 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.8 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
0.9 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
0.9 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
226.6 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
9.8 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
270.0 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
11.1 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.4 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.2 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.2 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
TERMBW |
= |
302.8 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
11.3 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
2.5 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.2 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
WEIGHT |
= |
1.2 |
g |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885861 |
| Schistosoma mansoni |
ALT |
= |
66.0 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
ALB |
= |
42500.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
ALP |
= |
416.0 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
AST |
= |
106.17 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BUN |
= |
126.7 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CO2 |
= |
31830000.0 |
nM |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CHLORIDE |
= |
102.5 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CHOL |
= |
690.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CK |
= |
601.83 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CREAT |
= |
1.8 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
GLUC |
= |
1545.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LDH |
= |
301.83 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LIPASE |
= |
11.17 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
PHOS |
= |
120.8 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
POTASSIUM |
= |
6.12 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
SODIUM |
= |
145.2 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BILI |
= |
1.7 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
PROT |
= |
61000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
URATE |
= |
15.7 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BASO |
= |
0.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
EOS |
= |
58.83 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LYM |
= |
11823.5 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MONO |
= |
169.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
NEUTSG |
= |
815.33 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
EOSLE |
= |
0.5 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
RBC |
= |
5520000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
HCT |
= |
35.77 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
HGB |
= |
142800.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
WBC |
= |
12870.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LYMLE |
= |
91.67 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MCH |
= |
25.92 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MCHC |
= |
399500.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MCV |
= |
64.85 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MONOLE |
= |
1.33 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
NEUTLE |
= |
6.5 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
RBCNUC |
= |
0.0 |
/100WBC |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
PLAT |
= |
1246170.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
ALT |
= |
55.33 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
ALB |
= |
40800.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
ALP |
= |
355.5 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
AST |
= |
87.67 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BUN |
= |
153.3 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CO2 |
= |
33830000.0 |
nM |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CHLORIDE |
= |
99.67 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CHOL |
= |
721.7 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CK |
= |
268.33 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CREAT |
= |
1.5 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
GLUC |
= |
1525.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LDH |
= |
212.67 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LIPASE |
= |
10.83 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
PHOS |
= |
116.5 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
POTASSIUM |
= |
6.73 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
SODIUM |
= |
142.43 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BILI |
= |
2.3 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
PROT |
= |
60700.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
URATE |
= |
17.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BASO |
= |
0.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
EOS |
= |
19.33 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LYM |
= |
12577.83 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MONO |
= |
106.33 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
NEUTSG |
= |
896.5 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
EOSLE |
= |
0.17 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
RBC |
= |
5840000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
HCT |
= |
36.88 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
HGB |
= |
144800.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
WBC |
= |
13600.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LYMLE |
= |
92.17 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MCH |
= |
24.85 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MCHC |
= |
393000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MCV |
= |
63.23 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MONOLE |
= |
0.83 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
NEUTLE |
= |
6.83 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
RBCNUC |
= |
0.0 |
/100WBC |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
PLAT |
= |
1223500.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
ALT |
= |
54.33 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
ALB |
= |
41700.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
ALP |
= |
347.33 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
AST |
= |
104.33 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BUN |
= |
143.3 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CO2 |
= |
29330000.0 |
nM |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CHLORIDE |
= |
101.0 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CHOL |
= |
730.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CK |
= |
905.33 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CREAT |
= |
1.9 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
GLUC |
= |
1620.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LDH |
= |
343.0 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LIPASE |
= |
12.0 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
PHOS |
= |
125.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
POTASSIUM |
= |
6.25 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
SODIUM |
= |
143.8 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BILI |
= |
1.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
PROT |
= |
59700.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
URATE |
= |
17.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BASO |
= |
0.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
EOS |
= |
68.67 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LYM |
= |
12940.33 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MONO |
= |
232.33 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
NEUTSG |
= |
1292.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
EOSLE |
= |
0.67 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
RBC |
= |
5400000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
HCT |
= |
34.53 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
HGB |
= |
139300.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
WBC |
= |
14530.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LYMLE |
= |
88.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MCH |
= |
25.83 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MCHC |
= |
403300.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MCV |
= |
63.97 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MONOLE |
= |
1.67 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
NEUTLE |
= |
9.67 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
RBCNUC |
= |
0.0 |
/100WBC |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
PLAT |
= |
1181330.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
ALT |
= |
44.67 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
ALB |
= |
40700.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
ALP |
= |
331.0 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
AST |
= |
85.67 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BUN |
= |
153.3 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CO2 |
= |
33330000.0 |
nM |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CHLORIDE |
= |
100.67 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CHOL |
= |
673.3 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CK |
= |
326.0 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CREAT |
= |
1.4 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
GLUC |
= |
1486.7 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LDH |
= |
448.33 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LIPASE |
= |
10.67 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
PHOS |
= |
118.3 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
POTASSIUM |
= |
6.57 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
SODIUM |
= |
143.3 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BILI |
= |
1.3 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
PROT |
= |
59300.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
URATE |
= |
15.3 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BASO |
= |
0.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
EOS |
= |
34.33 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LYM |
= |
12430.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MONO |
= |
136.33 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
NEUTSG |
= |
1032.67 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
EOSLE |
= |
0.33 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
RBC |
= |
5850000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
HCT |
= |
36.9 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
HGB |
= |
148700.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
WBC |
= |
13630.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LYMLE |
= |
91.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MCH |
= |
25.4 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MCHC |
= |
403000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MCV |
= |
63.07 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MONOLE |
= |
1.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
NEUTLE |
= |
7.67 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
RBCNUC |
= |
0.0 |
/100WBC |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
PLAT |
= |
1270670.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
ALT |
= |
52.67 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
ALB |
= |
42000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
ALP |
= |
317.33 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
AST |
= |
86.33 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BUN |
= |
96.7 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CO2 |
= |
37330000.0 |
nM |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CHLORIDE |
= |
100.0 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CHOL |
= |
800.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CK |
= |
271.0 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CREAT |
= |
1.1 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
GLUC |
= |
1403.3 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LDH |
= |
183.0 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LIPASE |
= |
10.33 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
PHOS |
= |
117.3 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
POTASSIUM |
= |
6.23 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
SODIUM |
= |
144.7 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BILI |
= |
1.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
PROT |
= |
59700.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
URATE |
= |
14.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BASO |
= |
0.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
EOS |
= |
0.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LYM |
= |
11986.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MONO |
= |
269.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
NEUTSG |
= |
645.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
EOSLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
RBC |
= |
5700000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
HCT |
= |
36.8 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
HGB |
= |
147300.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
WBC |
= |
12900.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LYMLE |
= |
92.67 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MCH |
= |
25.87 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MCHC |
= |
400300.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MCV |
= |
64.57 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MONOLE |
= |
2.33 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
NEUTLE |
= |
5.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
RBCNUC |
= |
0.0 |
/100WBC |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
PLAT |
= |
1270000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
ALT |
= |
48.33 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
ALB |
= |
41000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
ALP |
= |
321.33 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
AST |
= |
71.67 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BUN |
= |
116.7 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CO2 |
= |
34670000.0 |
nM |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CHLORIDE |
= |
100.33 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CHOL |
= |
620.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CK |
= |
192.33 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
CREAT |
= |
1.3 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
GLUC |
= |
1460.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LDH |
= |
104.0 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LIPASE |
= |
10.67 |
U.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
PHOS |
= |
112.7 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
POTASSIUM |
= |
6.6 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
SODIUM |
= |
143.3 |
mEq.L-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BILI |
= |
2.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
PROT |
= |
61000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
URATE |
= |
13.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BASO |
= |
0.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
EOS |
= |
51.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LYM |
= |
10645.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MONO |
= |
204.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
NEUTSG |
= |
866.67 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
BASOLE |
= |
0.0 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
EOSLE |
= |
0.33 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
RBC |
= |
6020000.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
HCT |
= |
39.03 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
HGB |
= |
150700.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
WBC |
= |
11770.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
LYMLE |
= |
89.67 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MCH |
= |
25.07 |
pg |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MCHC |
= |
386000.0 |
ug.mL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MCV |
= |
64.87 |
fL |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
MONOLE |
= |
1.33 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
NEUTLE |
= |
8.67 |
% |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
RBCNUC |
= |
0.0 |
/100WBC |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
PLAT |
= |
1169330.0 |
cells.uL-1 |
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| Schistosoma mansoni |
Tissue Severity Score |
|
|
|
In vitro activity on S. mansoni schistosomula at 50 uM |
CHEMBL3885881 |
| No relevant target |
Peff |
= |
1.3 |
ucm/s |
Effective permeability of the compound at pH 7.4 after 18 hrs by PAMPA |
CHEMBL3992562 |
| No relevant target |
permeability |
= |
1.22 |
ucm/s |
Permeability of the compound at 100 ug/ml after 18 hrs by PAMPA |
CHEMBL3992562 |
| Glycogen phosphorylase, muscle form |
IC50 |
= |
182000.0 |
nM |
Inhibition of rat muscle glycogen phosphorylase A assessed as release of inorganic phosphate from glucose-1- phosphate in presence of glycogen after 30 mins by malachite green based assay |
CHEMBL3997784 |
| Unchecked |
Activity |
|
|
|
Cytoprotective activity against sodium taurocholate-induced necrosis in Balb/C mouse pancreatic acinar cells at 5 mM after 40 mins by propidium iodide/Hoechst 33342 staining-based fluorescence microscopic method |
CHEMBL3997834 |
| No relevant target |
permeability |
= |
1.28 |
10'-6 cm/s |
Permeability of compound at 100 ug/ml after 18 hrs by PAMPA |
CHEMBL4002586 |
| No relevant target |
permeability |
= |
1.3 |
10'-6 cm/s |
Permeability of compound at 25 ug/ml after 18 hrs by PAMPA |
CHEMBL4002586 |
| No relevant target |
permeability |
= |
1.28 |
ucm/s |
Permeability of the compound in PBS/EtOH at 100 ug/ml after 18 hrs by PAMPA |
CHEMBL4002639 |
| No relevant target |
permeability |
= |
1.3 |
ucm/s |
Permeability of the compound by PAMPA |
CHEMBL4002639 |
| Bile salt export pump |
IC50 |
> |
135000.0 |
nM |
Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate transport preincubated for 10 mins prior to ATP addition measured after 15 mins in presence of [3H]-taurocholate by topcount based membrane vesicle transport assay |
CHEMBL4011581 |
| No relevant target |
permeability |
= |
1.28 |
10'-6 cm/s |
Permeability of the compound in PBS/EtOH at 100 ug/ml after 18 hrs by PAMPA-BBB assay |
CHEMBL4011587 |
| No relevant target |
Peff |
= |
1.3 |
10'-6 cm/s |
Effective permeability of the compound at pH 7.4 at 25 ug/ml after 18 hrs by PAMPA-BBB assay |
CHEMBL4011587 |
| Bile salt export pump |
IC50 |
> |
1000000.0 |
nM |
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-taurocholate transport into vesicles incubated for 5 mins by Topcount based rapid filtration method |
CHEMBL4017441 |
| No relevant target |
Papp |
< |
0.1 |
10'-6 cm/s |
Apparent permeability of the compound in phosphate buffer at pH 7.4 by PAMPA |
CHEMBL4017470 |
| Unchecked |
Inhibition |
|
|
% |
Inhibition of adipogenesis in human bone marrow-derived mesenchymal stem cells assessed as decrease in number and size of lipid droplets at 1 mM after 7 days in presence of IDX by oil red O staining based inverted microscopic method |
CHEMBL4017496 |
| Unchecked |
Inhibition |
|
|
% |
Inhibition of adipogenesis in human bone marrow-derived mesenchymal stem cells at 1 mM after 7 days in presence of IDX |
CHEMBL4017496 |
| Legumain |
Activity |
= |
74.3 |
% |
Inhibition of AEP (unknown origin) assessed as residual activity at 1 uM using Cbz-Ala-Ala-Asn-AMC as substrate after 15 mins by fluorescence assay relative to control |
CHEMBL4017504 |
| Bile salt export pump |
IC50 |
> |
133000.0 |
nM |
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to 20 mins by membrane vesicle transport assay |
CHEMBL4028801 |
| Canalicular multispecific organic anion transporter 1 |
IC50 |
> |
133000.0 |
nM |
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay |
CHEMBL4028801 |
| Canalicular multispecific organic anion transporter 2 |
IC50 |
> |
133000.0 |
nM |
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 10 mins by membrane vesicle transport assay |
CHEMBL4028801 |
| Multidrug resistance-associated protein 4 |
IC50 |
> |
133000.0 |
nM |
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay |
CHEMBL4028801 |
| Homo sapiens |
DILI_severity_class |
= |
0.0 |
|
Liver toxicity in human assessed as induction of drug-induced liver injury by measuring severity class index |
CHEMBL4028802 |
| Homo sapiens |
DILI_Concern |
|
|
|
Liver toxicity in human assessed as induction of drug-induced liver injury by measuring verified drug-induced liver injury concern status |
CHEMBL4028802 |
| No relevant target |
Peff |
= |
1.28 |
10'-6 cm/s |
Effective permeability of the compound at 100 ug/ml incubated for 18 hrs by PAMPA-BBB assay |
CHEMBL4033676 |
| Adenosine A1 receptor |
Ki |
= |
55000.0 |
nM |
Displacement of N6-[3H]cyclohexyladenosine from adenosine receptor A1 in rat cerebral cortical membrane |
CHEMBL4041492 |
| Unchecked |
Ki |
= |
50000.0 |
nM |
Antagonist activity at adenosine receptor A2a in [3H]adenine-labeled guinea pig cerebral cortical slices assessed as inhibition of 2-chloroadenosine-stimulated [3H]-cAMP accumulation |
CHEMBL4041492 |
| Adenosine A1 receptor |
Ki |
= |
41000.0 |
nM |
Displacement of [3H]R-PIA from adenosine receptor A1 in rat brain cortical membrane |
CHEMBL4041492 |
| Adenosine A1 receptor |
Ki |
= |
26000.0 |
nM |
Displacement of [3H]CHA from adenosine receptor A1 in rat brain cortical membrane |
CHEMBL4041492 |
| Adenosine A2a receptor |
Ki |
= |
43000.0 |
nM |
Displacement of [3H]NECA from adenosine receptor A2a in rat brain striatal membrane |
CHEMBL4041492 |
| Adenosine A2a receptor |
Ki |
= |
22000.0 |
nM |
Displacement of [3H]CGS21680 from adenosine receptor A2a in rat brain striatal membrane |
CHEMBL4041492 |
| Unchecked |
Ratio Ki |
= |
1.1 |
|
Selectivity index, ratio of Ki for adenosine receptor A2a in rat striatal membrane to Ki for adenosine receptor A1 in rat brain membrane |
CHEMBL4041492 |
| Unchecked |
Ratio Ki |
= |
0.9 |
|
Selectivity index, ratio of Ki for adenosine receptor A1 in rat brain membrane to Ki for adenosine receptor A2a in rat striatal membrane |
CHEMBL4041492 |
| Adenosine A2a receptor |
Ki |
= |
47200.0 |
nM |
Displacement of [3H]NECA from adenosine receptor A2a in rat striatial membrane |
CHEMBL4041492 |
| Adenosine A1 receptor |
Ki |
= |
43900.0 |
nM |
Displacement of [3H]DPCPX from adenosine receptor A1 in rat brain membrane |
CHEMBL4041492 |
| No relevant target |
Peff |
= |
1.28 |
10'-6 cm/s |
Effective permeability of the compound at 100 ug/ml by PAMPA-BBB assay |
CHEMBL4043275 |
| No relevant target |
Peff |
= |
1.28 |
10'-6 cm/s |
Effective permeability of the compound by PAMPA |
CHEMBL4043276 |
| No relevant target |
permeability |
= |
4.3 |
10'-6 cm/s |
Permeability of the compound at pH 7.4 at 1 mg/ml after 4 hrs by PAMPA-BBB assay |
CHEMBL4049396 |
| No relevant target |
permeability |
= |
1.3 |
10'-6 cm/s |
Permeability of the compound at pH 7.4 at 5 mg/ml after 18 hrs by PAMPA-BBB assay |
CHEMBL4049396 |
| No relevant target |
Peff |
= |
1.09 |
10'-6 cm/s |
Effective permeability of the compound in PBS/ethanol buffer after 12 hrs by PAMPA |
CHEMBL4118156 |
| No relevant target |
Peff |
= |
1.3 |
10'-6 cm/s |
Effective permeability of the compound in PBS/ethanol buffer |
CHEMBL4118156 |
| No relevant target |
Peff |
= |
1.28 |
10'-6 cm/s |
Effective permeability of the compound in PBS/EtOH at 50 ug/mL after 18 hrs by PAMPA-BBB assay |
CHEMBL4118162 |
| No relevant target |
Peff |
= |
1.3 |
10'-6 cm/s |
Effective permeability of the compound by PAMPA-BBB assay |
CHEMBL4118162 |
| No relevant target |
permeability |
= |
1.09 |
10'-6 cm/s |
Permeability of the compound in PBS/EtOH at 100 ug/ml after 12 hrs by PAMPA-BBB assay |
CHEMBL4138195 |
| No relevant target |
permeability |
= |
1.3 |
10'-6 cm/s |
Permeability of the compound at pH 7.4 at 25 ug/ml after 18 hrs by PAMPA-BBB assay |
CHEMBL4138195 |
| No relevant target |
Peff |
= |
3.3 |
10'-6 cm/s |
Effective permeability at 25 ug/ml after 16 hrs by PAMPA |
CHEMBL4145512 |
| No relevant target |
Peff |
= |
1.3 |
10'-6 cm/s |
Effective permeability at 25 ug/ml after 18 hrs by PAMPA |
CHEMBL4145512 |
| No relevant target |
Peff |
= |
1.3 |
10'-6 cm/s |
Effective permeability of the compound in pH 7.4 buffer after 18 hrs by PAMPA-BBB assay |
CHEMBL4184259 |
| No relevant target |
Peff |
= |
1.22 |
10'-6 cm/s |
Effective permeability of the compound in PBS/EtOH at 100 ug/ml after 18 hrs by PAMPA-BBB assay |
CHEMBL4184259 |
| No relevant target |
Peff |
= |
3.61 |
ucm/s |
Effective permeability of the compound at 200 uM after 5 hrs by PAMPA |
CHEMBL4184284 |
| Adenosine A2a receptor |
Ki |
= |
23400.0 |
nM |
Displacement of [3H]DPCPX from recombinant human adenosine A2A receptor |
CHEMBL4184319 |
| Adenosine A2b receptor |
Ki |
= |
23000.0 |
nM |
Displacement of [3H]PSB-603 from recombinant mouse adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method |
CHEMBL4184319 |
| Adenosine A2b receptor |
Ki |
= |
30000.0 |
nM |
Displacement of [3H]PSB-603 from recombinant rat adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method |
CHEMBL4184319 |
| Adenosine A2a receptor |
Ki |
= |
28700.0 |
nM |
Displacement of [3H]MSX-2 from adenosine A2A receptor in rat brain striatal membranes after 30 mins by liquid scintillation counting method |
CHEMBL4184319 |
| Adenosine A1 receptor |
Ki |
> |
10000.0 |
nM |
Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membranes after 90 mins by liquid scintillation counting method |
CHEMBL4184319 |
| Adenosine A1 receptor |
Ki |
> |
10000.0 |
nM |
Displacement of [3H]CCPA from recombinant human adenosine A1 receptor expressed in CHO cell membranes after 90 mins by liquid scintillation counting method |
CHEMBL4184319 |
| Adenosine A3 receptor |
Ki |
> |
13300.0 |
nM |
Displacement of [3H]PSB-11 from recombinant human adenosine A3 receptor |
CHEMBL4184319 |
| No relevant target |
permeability |
= |
1.1 |
10'-6 cm/s |
Effective permeability of the compound after 2.5 hrs at 25 degC by PAMPA assay |
CHEMBL4190250 |
| No relevant target |
permeability |
= |
1.3 |
10'-6 cm/s |
Effective permeability of the compound at 25 ug/ml by PAMPA assay |
CHEMBL4190250 |
| No relevant target |
Peff |
= |
1.8 |
10'-6 cm/s |
Effective permeability of the compound at pH 7.4 by PAMPA-BBB assay |
CHEMBL4196107 |
| No relevant target |
Peff |
= |
1.28 |
10'-6 cm/s |
Effective permeability of the compound at 100 ug/ml after 18 hrs by PAMPA-BBB assay |
CHEMBL4219111 |
| No relevant target |
Peff |
= |
1.3 |
10'-6 cm/s |
Effective permeability of the compound at 25 ug/ml after 18 hrs by PAMPA-BBB assay |
CHEMBL4219111 |
| No relevant target |
Peff |
= |
2.09 |
ucm/s |
Effective permeability of the compound at 100 ug/ml after 16 hrs by PAMPA |
CHEMBL4229448 |
| No relevant target |
permeability |
= |
0.1 |
ucm/s |
Permeability of the compound after 2.5 hrs by PAMPA |
CHEMBL4251652 |
| Adenosine A1 receptor |
Ki |
= |
10700.0 |
nM |
Binding affinity to human adenosine A1 receptor by radioligand displacement assay |
CHEMBL4257504 |
| Adenosine A2a receptor |
Ki |
= |
23400.0 |
nM |
Binding affinity to human adenosine A2A receptor by radioligand displacement assay |
CHEMBL4257504 |
| Adenosine A2b receptor |
Ki |
= |
33800.0 |
nM |
Binding affinity to human adenosine A2B receptor by radioligand displacement assay |
CHEMBL4257504 |
| Adenosine A3 receptor |
Ki |
= |
13300.0 |
nM |
Binding affinity to human adenosine A3 receptor by radioligand displacement assay |
CHEMBL4257504 |
| No relevant target |
Peff |
= |
1.3 |
10'-6 cm/s |
Effective permeability of the compound at 25 ug/ml after 18 hrs by BBB-PAMPA method |
CHEMBL4265951 |
| No relevant target |
Peff |
= |
1.9 |
10'-6 cm/s |
Effective permeability of the compound at 1 mg/ml after 4 hrs by BBB-PAMPA method |
CHEMBL4265951 |
| SARS-CoV-2 |
Inhibition index |
= |
0.5253 |
|
Inhibition of cell viability relative to arbidol control (inhibition index > 1 indicates higher activity) measured by fluorescence (OD590nm) in Vero E6 cells infected with SARS-CoV-2 (strain BavPat1) at MOI 0.002 after 72hrs |
CHEMBL4303097 |
| SARS-CoV-2 |
Inhibition |
= |
33.57 |
% |
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging |
CHEMBL4303101 |
| No relevant target |
permeability |
= |
1.28 |
10'-6 cm/s |
Permeability of the compound in pH 7.4 PBS/EtOH at 25 ug/ml after 18 hrs by PAMPA-BBB assay |
CHEMBL4311983 |
| No relevant target |
permeability |
= |
1.3 |
10'-6 cm/s |
Permeability of compound by PAMPA-BBB assay |
CHEMBL4311983 |
| No relevant target |
permeability |
= |
5.84 |
10'-6 cm/s |
Permeability of compound in PBS at pH 7.4 incubated for 5 hrs by UV spectroscopic assay based PAMPA |
CHEMBL4311995 |
| No relevant target |
Retention_time |
= |
7.56 |
min |
Retention time of compound at pH 7.4 by LC-UV analysis |
CHEMBL4312023 |
| No relevant target |
CHI |
= |
24.12 |
|
Chromatographic hydrophobicity index of compound at 250 uM at pH 7.4 by HPLC analysis |
CHEMBL4312023 |
| No relevant target |
Peff |
= |
1.28 |
10'-6 cm/s |
Permeability of the compound at 100 ug/ml measured after compound dilution in PBS/EtOH buffer (70:30) by PAMPA-BBB assay |
CHEMBL4351031 |
| No relevant target |
Peff |
= |
1.3 |
10'-6 cm/s |
Permeability of the compound at 25 ug/ml by PAMPA-BBB assay |
CHEMBL4351031 |
| No relevant target |
Peff |
= |
1.3 |
10'-6 cm/s |
Effective permeability of the compound at 25 ug/ml incubated for 18 hrs by PAMPA-BBB assay |
CHEMBL4364279 |
| No relevant target |
permeability |
= |
1.28 |
10'-6 cm/s |
Permeability of the compound in pH 7.4 PBS/EtOH at 100 ug/ml by PAMPA-BBB assay |
CHEMBL4364279 |
| No relevant target |
permeability |
= |
1.28 |
10'-6 cm/s |
Permeability of compound at 100 ug/ml measured after dilution with PBS/EtOH (70:30) at pH 7.4 after 18 hrs by PAMPA-BBB assay |
CHEMBL4364308 |
| No relevant target |
permeability |
= |
3.61 |
10'-6 cm/s |
Permeability of the compound by PAMPA |
CHEMBL4368858 |
| ADMET |
T1/2 |
= |
6.2170000000000005 |
hr |
Half life in human liver microsomes at 2 uM by LC-MS/MS analysis |
CHEMBL4368915 |
| ADMET |
CL |
= |
4.0 |
mL.min-1.g-1 |
Intrinsic clearance in human liver microsomes at 2 uM by LC-MS/MS analysis |
CHEMBL4368915 |
| No relevant target |
Peff |
= |
1.28 |
ucm/s |
Effective permeability of the compound in PBS/EtOH at 100 ug/ml after 18 hrs by PAMPA |
CHEMBL4382240 |
| No relevant target |
Peff |
= |
1.3 |
ucm/s |
Effective permeability of the compound by PAMPA |
CHEMBL4382240 |
| No relevant target |
permeability |
= |
16.1 |
10'-6 cm/s |
Permeability of compound at pH 7.4 by PAMPA |
CHEMBL4393658 |
| No relevant target |
Peff |
= |
1.4 |
10'-6 cm/s |
Effective permeability of the compound after 12 hrs by PAMPA |
CHEMBL4400538 |
| Mus musculus |
Activity |
|
|
|
Antinociceptive activity in CD-1 albino mouse model of oxaliplatin-induced neuropathic pain assessed as increase in licking latency at 10 mg/kg, po treated on day 15 post oxaliplatin treatment and measured at 15 to 60 mins post dose in presence of alpha7 nAChR antagonist methyllycaconitine by cold plate test |
CHEMBL4406810 |
| Mus musculus |
Activity |
|
|
|
Antinociceptive activity in CD-1 albino mouse model of oxaliplatin-induced neuropathic pain assessed as increase in licking latency at 10 mg/kg, po treated on day 15 post oxaliplatin treatment and measured at 15 to 60 mins post dose in presence of nonspecific nAChR antagonist mecamylamine by cold plate test |
CHEMBL4406810 |
| Mus musculus |
Activity |
|
|
|
Antinociceptive activity in CD-1 albino mouse model of oxaliplatin-induced neuropathic pain assessed as increase in licking latency at 10 mg/kg, po treated on day 15 post oxaliplatin treatment and measured at 15 to 60 mins post dose by cold plate test |
CHEMBL4406810 |
| Unchecked |
Ratio Ki |
= |
1.0 |
|
Selectivity index, ratio of Ki for human A3 adenosine receptor to Ki for human A2B adenosine receptor |
CHEMBL4422615 |
| Unchecked |
Ratio Ki |
= |
1.0 |
|
Selectivity index, ratio of Ki for human A2A adenosine receptor to Ki for human A2B adenosine receptor |
CHEMBL4422615 |
| Unchecked |
Ratio Ki |
= |
1.0 |
|
Selectivity index, ratio of Ki for human A1 adenosine receptor to Ki for human A2B adenosine receptor |
CHEMBL4422615 |
| Adenosine A2b receptor |
Ki |
= |
10000.0 |
nM |
Inhibition of human A2B adenosine receptor |
CHEMBL4422615 |
| No relevant target |
permeability |
= |
1.28 |
10'-6 cm/s |
Permeability of the compound in pH 7.4 PBS/EtOH at 100 ug/ml after 18 hrs by PAMPA-BBB assay |
CHEMBL4422689 |
| No relevant target |
permeability |
= |
1.3 |
10'-6 cm/s |
Permeability of the compound in pH 7.4 PBS at 200 uL after 18 hrs by PAMPA-BBB assay |
CHEMBL4422689 |
| No relevant target |
Activity |
|
|
|
Metal chelating activity of the compound assessed as inhibition of Fe2+-ferrozine complex formation incubated for 10 mins by spectrophotometric analysis |
CHEMBL4428045 |
| No relevant target |
Activity |
< |
10.0 |
% |
Antioxidant activity assessed as DPPH radical scavenging activity at 0.025 to 0.1 mg/ml incubated for 30 mins in dark by spectrophotometric analysis |
CHEMBL4428045 |
| Erythrocyte |
Activity |
|
|
|
Hemolytic activity in human erythrocytes assessed as change in cell shape by measuring discocytes level at 0.1 mg/ml incubated for 60 mins by spectrophotometric analysis |
CHEMBL4428045 |
| Unchecked |
Activity |
|
|
|
Induction of hemolysis in human erythrocytes assessed as effect on osmotic resistance at 0.1 mg/ml incubated for 60 mins by erythrocyte osmotic fragility assay |
CHEMBL4428045 |
| Erythrocyte |
Activity |
= |
0.0 |
% |
Hemolytic activity in human erythrocytes at 0.1 mg/ml incubated for 60 mins by spectrophotometric analysis |
CHEMBL4428045 |
| Erythrocyte |
Activity |
= |
10.0 |
% |
Cytoprotection against AAPH-induced haemolysis in human erythrocytes at 0.01 to 1 mg/l pre-incubated for 20 mins before 60 mM AAPH addition for 4 hrs by spectrophotometric analysis |
CHEMBL4428045 |
| Adenosine A2a receptor |
Ki |
= |
23400.0 |
nM |
Displacement of [3H]MSX from human A2A receptor |
CHEMBL4428125 |
| Adenosine A1 receptor |
Ki |
= |
32500.0 |
nM |
Displacement of [3H]MSX from rat A1 receptor |
CHEMBL4428125 |
| Monoamine oxidase B |
IC50 |
> |
50000.0 |
nM |
Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells preincubated for 30 mins followed by addition of p-tyramine as substrate measured over 45 mins by Amplex Red MAO assay |
CHEMBL4428125 |
| Monoamine oxidase A |
IC50 |
> |
50000.0 |
nM |
Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells preincubated for 30 mins followed by addition of p-tyramine as substrate measured over 45 mins by Amplex Red MAO assay |
CHEMBL4428125 |
| Adenosine A1 receptor |
Ki |
= |
41000.0 |
nM |
Displacement of [3H]CCPA from rat A1 receptor |
CHEMBL4428125 |
| Adenosine A1 receptor |
Ki |
= |
44900.0 |
nM |
Displacement of [3H]CCPA from human A1 receptor |
CHEMBL4428125 |
| Adenosine A2b receptor |
Ki |
= |
33800.0 |
nM |
Displacement of [3H]PSB-603 from human A2B receptor expressed in CHO cell membrane |
CHEMBL4428125 |
| Adenosine A3 receptor |
Ki |
= |
13300.0 |
nM |
Displacement of [3H]PSB-11 from human A3 receptor expressed in CHO cell membrane |
CHEMBL4428125 |
| Monoamine oxidase A |
Inhibition |
= |
33.0 |
% |
Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells at 50 uM preincubated for 30 mins followed by addition of p-tyramine as substrate measured over 45 mins by Amplex Red MAO assay relative to control |
CHEMBL4428125 |
| Monoamine oxidase B |
Inhibition |
= |
16.0 |
% |
Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells at 50 uM preincubated for 30 mins followed by addition of p-tyramine as substrate measured over 45 mins by Amplex Red MAO assay relative to control |
CHEMBL4428125 |
| Adenosine A1 receptor |
Ki |
= |
44900.0 |
nM |
Displacement of [3H]CCPA from recombinant human adenosine A1 receptor expressed in CHO cells |
CHEMBL4480426 |
| Adenosine A1 receptor |
Ki |
= |
41000.0 |
nM |
Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membranes |
CHEMBL4480426 |
| Adenosine A2a receptor |
Ki |
= |
23400.0 |
nM |
Displacement of [3H]MSX2 from recombinant human adenosine A2a receptor expressed in HEK293 cells |
CHEMBL4480426 |
| Adenosine A2a receptor |
Ki |
= |
32500.0 |
nM |
Displacement of [3H]CCPA from rat adenosine A2a receptor |
CHEMBL4480426 |
| Adenosine A2b receptor |
Ki |
= |
33800.0 |
nM |
Displacement of [3H]PSB603 from recombinant human adenosine A2b receptor expressed in HEK293 cells |
CHEMBL4480426 |
| Adenosine A3 receptor |
Ki |
= |
13300.0 |
nM |
Displacement of [3H]PSB11 from recombinant human adenosine A3 receptor expressed in CHO cells |
CHEMBL4480426 |
| Replicase polyprotein 1ab |
Inhibition |
= |
7.733 |
% |
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate |
CHEMBL4495564 |
| SARS-CoV-2 |
Inhibition |
= |
-0.1 |
% |
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging |
CHEMBL4495565 |
| No relevant target |
Drug uptake |
= |
31.9 |
uM |
Permeability of the compound assessed as drug level in acceptor plate at 200 uM measured after 5 hrs at pH 7.4 by PAMPA |
CHEMBL4619777 |
| No relevant target |
Drug uptake |
= |
159.5 |
uM |
Permeability of the compound assessed as drug level in donor plate at 200 uM measured after 5 hrs at pH 7.4 by PAMPA |
CHEMBL4619777 |
| No relevant target |
permeability |
= |
7.7 |
10'-6 cm/s |
Permeability of the compound at 200 uM measured after 5 hrs at pH 7.4 by PAMPA |
CHEMBL4619777 |
| No relevant target |
R% |
= |
9.6 |
% |
Permeability of the compound assessed as mass retention at 200 uM measured after 5 hrs at pH 7.4 by PAMPA |
CHEMBL4619777 |
| SARS-CoV-2 |
Inhibition |
= |
-0.1 |
% |
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging |
CHEMBL4495565 |
| ADMET |
permeability |
= |
15.1 |
10^-6 cm/s |
Permeability of the compound at 100 uM measured after 40 mins by PAMPA |
CHEMBL4665789 |
| Adenosine A1 receptor |
Ki |
= |
10700.0 |
nM |
Displacement of [3H]CCPA from human adenosine receptor A1 expressed in CHO cell membranes incubated for 90 mins by radioligand competition assay |
CHEMBL4680130 |
| Adenosine A1 receptor |
Ki |
= |
41000.0 |
nM |
Displacement of [3H]CCPA from adenosine receptor A1 in rat brain cortex membranes incubated for 90 mins by radioligand competition assay |
CHEMBL4680130 |
| Adenosine A2a receptor |
Ki |
= |
23400.0 |
nM |
Displacement of [3H]MSX2 from human adenosine receptor A2A expressed in HEK293 cell membranes incubated for 30 mins by radioligand competition assay |
CHEMBL4680130 |
| Adenosine A2a receptor |
Ki |
= |
45000.0 |
nM |
Displacement of [3H]MSX2 from adenosine receptor A2A in rat brain striatum membranes incubated for 30 mins by radioligand competition assay |
CHEMBL4680130 |
| Adenosine A2b receptor |
Ki |
= |
33800.0 |
nM |
Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay |
CHEMBL4680130 |
| Adenosine A3 receptor |
Ki |
= |
13300.0 |
nM |
Displacement of [3H]PSB-11 from human adenosine receptor A3 expressed in CHO cell membranes incubated for 60 mins by radioligand competition assay |
CHEMBL4680130 |
| Adenosine A3 receptor |
Ki |
> |
100000.0 |
nM |
Displacement of [3H]NECA from rat adenosine receptor A3 expressed in CHO cell membranes incubated for 60 mins by radioligand competition assay |
CHEMBL4680130 |
| Adenosine A2a receptor |
Ki |
= |
23400.0 |
nM |
Antagonist activity at human adenosine 2A receptor |
CHEMBL4699449 |
| Adenosine A2b receptor |
Ki |
= |
20500.0 |
nM |
Inhibition of human adenosine 2B receptor |
CHEMBL4699449 |
| ADMET |
permeability |
= |
1.28 |
10^-6 cm/s |
Permeability of the compound incubated for 165 mins by PAMPA-BBB assay |
CHEMBL4706524 |
| ADMET |
permeability |
= |
1.3 |
10^-6 cm/s |
Permeability of the compound by PAMPA-BBB assay |
CHEMBL4706524 |
| ADMET |
permeability |
= |
15.1 |
10^-6 cm/s |
Permeability of compound in PBS buffer assessed as permeability coefficient at pH 7.4 at 200 uM incubated for 5 hrs by PAMPA based LC-MS analysis |
CHEMBL4706551 |
| ADMET |
Peff |
= |
1.4 |
10^-6 cm/s |
Effective permeability of the compound in PBS/ethanol buffer (9:1) at 25 ug/ml after 10 hrs by UV plate reader based PAMPA-BBB assay |
CHEMBL4715782 |
| ADMET |
Peff |
= |
1.3 |
10^-6 cm/s |
Effective permeability of the compound at 25 ug/ml after 18 hrs by UV plate reader based PAMPA-BBB assay |
CHEMBL4715782 |
| ADMET |
permeability |
= |
1.3 |
10^-6 cm/s |
Permeability of compound in PBS buffer at pH 7.4 incubated for 18 hrs by PAMPA-BBB assay |
CHEMBL4732154 |
| ADMET |
permeability |
= |
1.33 |
10^-6 cm/s |
Permeability of compound in pH 7.4 PBS/EtOH buffer (7:3) incubated for 18 hrs by UV plate reader based PAMPA-BBB assay |
CHEMBL4732154 |
| ADMET |
permeability |
= |
2.18 |
10^-6 cm/s |
Permeability of the compound measured after 16 hrs by PAMPA-BBB assay |
CHEMBL4732210 |
| ADMET |
permeability |
= |
1.3 |
10^-6 cm/s |
Permeability of compound at pH 7.4 measured after 18 hrs PAMPA-BBB assay |
CHEMBL4765373 |
| ADMET |
permeability |
= |
1.54 |
10^-6 cm/s |
Permeability of compound in pH 7.4 PBS/EtOH buffer (7:3) after 16 hrs by PAMPA-BBB assay |
CHEMBL4765373 |
| ADMET |
Peff |
= |
15.1 |
10^-6 cm/s |
Effective permeability of the compound at 200 uM incubated for 5 hrs by PAMPA based UPLC/MS analysis |
CHEMBL4765382 |
| ADMET |
CL |
= |
2.0 |
mL.min-1.g-1 |
Intrinsic clearance in human liver microsomes measured upto 40 mins by LC-MS/MS analysis |
CHEMBL4811220 |
| ADMET |
T1/2 |
= |
17.17 |
hr |
Half life in human liver microsomes measured upto 40 mins by LC-MS/MS analysis |
CHEMBL4811220 |
| ADMET |
Activity |
= |
33.0 |
uM |
Passive membrane permeability of the compound in phosphate buffered saline assessed as concentration of the compound in acceptor plate at 200 uM incubated for 5 hrs by PAMPA assay based HPLC analysis |
CHEMBL4811254 |
| ADMET |
Activity |
= |
173.0 |
uM |
Passive membrane permeability of the compound in phosphate buffered saline assessed as concentration of the compound in donor plate at 200 uM incubated for 5 hrs by PAMPA assay based HPLC analysis |
CHEMBL4811254 |
| ADMET |
permeability |
= |
7.3 |
10^-6 cm/s |
Passive membrane permeability of the compound in phosphate buffered saline at 200 uM incubated for 5 hrs by PAMPA assay based HPLC analysis |
CHEMBL4811254 |
| ADMET |
Activity |
= |
2.4 |
% |
Passive membrane permeability of the compound in phosphate buffered saline assessed as mass retention of the compound at 200 uM incubated for 5 hrs by PAMPA assay based HPLC analysis |
CHEMBL4811254 |
| ADMET |
permeability |
= |
3.2 |
10^-6 cm/s |
Permeability of compound by PAMPA-BBB assay |
CHEMBL4823268 |
| No relevant target |
LogP |
= |
-0.07 |
|
Lipophilicity, logP of compound by shake flask method |
CHEMBL4825735 |
| No relevant target |
Rm |
= |
0.85 |
|
Relative lipophilicity of the compound in methanol assessed as retardation factor by reversed-phase TLC analysis |
CHEMBL4825735 |
| ADMET |
permeability |
= |
7.89 |
10^-6 cm/s |
Permeability coefficient of the compound in PBS buffer incubated for 5 hrs by PAMPA-based LC-MS analysis |
CHEMBL4842370 |
| ADMET |
Papp |
= |
2.605 |
10^-5cm/s |
Apparent permeability across apical to basolateral side in human Caco-2 cells at 5 uM measured every 15 mins for 1 hr by LC-MS/MS analysis |
CHEMBL5046217 |
| ADMET |
Papp |
= |
2.484 |
10^-5cm/s |
Apparent permeability across basolateral to apical side in human Caco-2 cells at 5 uM measured every 15 mins for 1 hr by LC-MS/MS analysis |
CHEMBL5046217 |
| ADMET |
Ratio |
= |
0.95 |
|
Efflux ratio of apparent permeability across basolateral to apical side over apical to basolateral side in human Caco-2 cells at 5 uM measured every 15 mins for 1 hr by LC-MS/MS analysis |
CHEMBL5046217 |
| Adenosine A1 receptor |
Ki |
= |
10700.0 |
nM |
Antagonist activity at adenosine A1 receptor (unknown origin) |
CHEMBL5126505 |
| Adenosine A2a receptor |
Ki |
= |
23400.0 |
nM |
Antagonist activity at adenosine A2A receptor (unknown origin) |
CHEMBL5126505 |
| Adenosine A2b receptor |
Ki |
= |
33800.0 |
nM |
Antagonist activity at adenosine A2B receptor (unknown origin) |
CHEMBL5126505 |
| Adenosine A3 receptor |
Ki |
= |
13300.0 |
nM |
Antagonist activity at adenosine A3 receptor (unknown origin) |
CHEMBL5126505 |
| ATP-binding cassette sub-family G member 2 |
IC50 |
= |
14000000.0 |
nM |
Inhibition of ABCG2 (unknown origin) expressed in human MCF7/MX100 cells assessed as BODIPY-Prazosin uptake and preincubated with substrate followed by compound addition and measured after 1 hrs by flow cytometry analysis |
CHEMBL5126555 |
| Adenosine A2a receptor |
K |
|
|
|
Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as affinity on-rate by surface plasmon resonance assay |
CHEMBL5126601 |
| Adenosine A2a receptor |
K |
|
|
|
Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as affinity off-rate by surface plasmon resonance assay |
CHEMBL5126601 |
| Adenosine A2a receptor |
Kd |
= |
5510.0 |
nM |
Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay |
CHEMBL5126601 |
| Adenosine A2a receptor |
Ki |
|
|
|
Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as inhibition constant by surface plasmon resonance assay |
CHEMBL5126601 |
| Palmitoleoyl-protein carboxylesterase NOTUM |
IC50 |
= |
18600.0 |
nM |
Inhibition of human Notum (81 to T451 residues) Cys330Ser mutant using OPTS substrate incubated for 16 hrs by fluorescence based assay |
CHEMBL5149981 |
| Palmitoleoyl-protein carboxylesterase NOTUM |
EC50 |
= |
45800.0 |
nM |
Inhibition of human Notum (S81 to T451 residues) Cys330Ser mutant in human HEK293 cells expressing Renilla and STF reporter gene and measured after 24 hrs in presence of mouse L-Wnt3a cells by Dual-Glo luciferase reporter assay |
CHEMBL5149981 |
| Palmitoleoyl-protein carboxylesterase NOTUM |
Kd |
= |
85000.0 |
nM |
Binding affinity to human Notum (S81 to T451 residues) Cys330Ser mutant expressed in human HEK293T cells by SPR analysis |
CHEMBL5149981 |
| ADMET |
permeability |
|
|
|
Permeability of the compound at pH 7.4 PBS/EtOH buffer (70:30) by PAMPA-BBB assay |
CHEMBL5154682 |
| ADMET |
Papp |
= |
1.84 |
10^-6 cm/s |
Apparent permeability of the compound across bacterial inner membrane mimic PC-phospholipids in PBS buffer at pH 7.4 incubated for 5 hrs by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
R% |
= |
12.6 |
% |
Apparent permeability of the compound across bacterial inner membrane mimic PC-phospholipids in PBS buffer assessed as membrane retention at pH 7.4 incubated for 5 hrs in presence of 1,3-bis(8-carbamimidamidooctyl)-1,3-bis({8-[N'-(cyclopropylmethyl)carbamimidamido]octyl})urea by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
R% |
= |
3.2 |
% |
Apparent permeability of the compound across bacterial inner membrane mimic PC-phospholipids in PBS buffer assessed as membrane retention at pH 7.4 incubated for 5 hrs by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
Papp |
= |
12.03 |
10^-6 cm/s |
Apparent permeability of the compound across bacterial inner membrane mimic PC-phospholipids in PBS buffer at pH 7.4 incubated for 5 hrs in presence of 1,3,3-tris(8-carbamimidamidooctyl)-1-{8-[N'-(cyclopropylmethyl)carbamimidamido]octyl}urea trifluoroacetate salt by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
Papp |
= |
1.95 |
10^-6 cm/s |
Apparent permeability of the compound across bacterial inner membrane mimic pure POPG in PBS buffer at pH 7.4 incubated for 5 hrs by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
Papp |
= |
5.0 |
10^-6 cm/s |
Apparent permeability of the compound across bacterial inner membrane mimic PC-phospholipids in PBS buffer at pH 7.4 incubated for 5 hrs in presence of 1,3-bis(8-aminooctyl)-1,3-bis(8- carbamimidamidooctyl)urea trifluoroacetate salt by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
R% |
= |
4.5 |
% |
Apparent permeability of the compound across bacterial inner membrane mimic pure POPG in PBS buffer assessed as membrane retention at pH 7.4 incubated for 5 hrs by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
Papp |
= |
13.19 |
10^-6 cm/s |
Apparent permeability of the compound across bacterial inner membrane mimic PC-phospholipids in PBS buffer at pH 7.4 incubated for 5 hrs in presence of 1,1-bis({6-[N'-(cyclopropylmethyl)carbamimidamido]hexyl})-3-{8-[N'-(cyclopropylmethyl)carbamimidamido]octyl}-3-octylurea by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
Papp |
= |
1.98 |
10^-6 cm/s |
Apparent permeability of the compound across bacterial inner membrane mimic POPE/POPG (6:4) in PBS buffer at pH 7.4 incubated for 5 hrs by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
Papp |
= |
2.04 |
10^-6 cm/s |
Apparent permeability of the compound across bacterial inner membrane mimic PC-phospholipids in PBS buffer at pH 7.4 incubated for 5 hrs in presence of {8-[N'(cyclopropylmethyl)carbamimidamido]octyl}urea trifluoroacetate salt by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
R% |
= |
3.3 |
% |
Apparent permeability of the compound across bacterial inner membrane mimic POPE/POPG (6:4) in PBS buffer assessed as membrane retention at pH 7.4 incubated for 5 hrs by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
Papp |
= |
3.54 |
10^-6 cm/s |
Apparent permeability of the compound across bacterial inner membrane mimic PC-phospholipids in PBS buffer at pH 7.4 incubated for 5 hrs in presence of 1,3-bis(8-carbamimidamidooctyl)-1,3-bis({8-[N'-(cyclopropylmethyl)carbamimidamido]octyl})urea by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
R% |
= |
12.8 |
% |
Apparent permeability of the compound across bacterial inner membrane mimic PC-phospholipids in PBS buffer assessed as membrane retention at pH 7.4 incubated for 5 hrs in presence of {8-[N'(cyclopropylmethyl)carbamimidamido]octyl}urea trifluoroacetate salt by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
R% |
= |
0.0 |
% |
Apparent permeability of the compound across bacterial inner membrane mimic PC-phospholipids in PBS buffer assessed as membrane retention at pH 7.4 incubated for 5 hrs in presence of 1,1-bis({6-[N'-(cyclopropylmethyl)carbamimidamido]hexyl})-3-{8-[N'-(cyclopropylmethyl)carbamimidamido]octyl}-3-octylurea by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
R% |
= |
15.8 |
% |
Apparent permeability of the compound across bacterial inner membrane mimic PC-phospholipids in PBS buffer assessed as membrane retention at pH 7.4 incubated for 5 hrs in presence of 1,3-bis(8-aminooctyl)-1,3-bis(8- carbamimidamidooctyl)urea trifluoroacetate salt by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
R% |
= |
8.1 |
% |
Apparent permeability of the compound across bacterial inner membrane mimic PC-phospholipids in PBS buffer assessed as membrane retention at pH 7.4 incubated for 5 hrs in presence of 1,3,3-tris(8-carbamimidamidooctyl)-1-{8-[N'-(cyclopropylmethyl)carbamimidamido]octyl}urea trifluoroacetate salt by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
Papp |
= |
2.49 |
10^-6 cm/s |
Apparent permeability of the compound across bacterial inner membrane mimic pure POPG in PBS buffer at pH 7.4 incubated for 5 hrs in presence of 1,3-bis(8-carbamimidamidooctyl)-1,3-bis({8-[N'-(cyclopropylmethyl)carbamimidamido]octyl})urea by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
Papp |
= |
2.09 |
10^-6 cm/s |
Apparent permeability of the compound across bacterial inner membrane mimic pure POPG in PBS buffer at pH 7.4 incubated for 5 hrs in presence of {8-[N'(cyclopropylmethyl)carbamimidamido]octyl}urea trifluoroacetate salt by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
Papp |
= |
5.65 |
10^-6 cm/s |
Apparent permeability of the compound across bacterial inner membrane mimic pure POPG in PBS buffer at pH 7.4 incubated for 5 hrs in presence of 1,1-bis({6-[N'-(cyclopropylmethyl)carbamimidamido]hexyl})-3-{8-[N'-(cyclopropylmethyl)carbamimidamido]octyl}-3-octylurea by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
Papp |
= |
5.04 |
10^-6 cm/s |
Apparent permeability of the compound across bacterial inner membrane mimic pure POPG in PBS buffer at pH 7.4 incubated for 5 hrs in presence of 1,3-bis(8-aminooctyl)-1,3-bis(8- carbamimidamidooctyl)urea trifluoroacetate salt by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
Papp |
= |
6.13 |
10^-6 cm/s |
Apparent permeability of the compound across bacterial inner membrane mimic pure POPG in PBS buffer at pH 7.4 incubated for 5 hrs in presence of 1,3,3-tris(8-carbamimidamidooctyl)-1-{8-[N'-(cyclopropylmethyl)carbamimidamido]octyl}urea trifluoroacetate salt by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
R% |
= |
13.5 |
% |
Apparent permeability of the compound across bacterial inner membrane mimic pure POPG in PBS buffer assessed as membrane retention at pH 7.4 incubated for 5 hrs in presence of 1,3-bis(8-carbamimidamidooctyl)-1,3-bis({8-[N'-(cyclopropylmethyl)carbamimidamido]octyl})urea by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
R% |
= |
13.4 |
% |
Apparent permeability of the compound across bacterial inner membrane mimic pure POPG in PBS buffer assessed as membrane retention at pH 7.4 incubated for 5 hrs in presence of {8-[N'(cyclopropylmethyl)carbamimidamido]octyl}urea trifluoroacetate salt by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
R% |
= |
14.7 |
% |
Apparent permeability of the compound across bacterial inner membrane mimic pure POPG in PBS buffer assessed as membrane retention at pH 7.4 incubated for 5 hrs in presence of 1,1-bis({6-[N'-(cyclopropylmethyl)carbamimidamido]hexyl})-3-{8-[N'-(cyclopropylmethyl)carbamimidamido]octyl}-3-octylurea by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
R% |
= |
17.1 |
% |
Apparent permeability of the compound across bacterial inner membrane mimic pure POPG in PBS buffer assessed as membrane retention at pH 7.4 incubated for 5 hrs in presence of 1,3-bis(8-aminooctyl)-1,3-bis(8- carbamimidamidooctyl)urea trifluoroacetate salt by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
R% |
= |
14.6 |
% |
Apparent permeability of the compound across bacterial inner membrane mimic pure POPG in PBS buffer assessed as membrane retention at pH 7.4 incubated for 5 hrs in presence of 1,3,3-tris(8-carbamimidamidooctyl)-1-{8-[N'-(cyclopropylmethyl)carbamimidamido]octyl}urea trifluoroacetate salt by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
Papp |
= |
3.03 |
10^-6 cm/s |
Apparent permeability of the compound across bacterial inner membrane mimic POPE/POPG (6:4) in PBS buffer at pH 7.4 incubated for 5 hrs in presence of 1,3-bis(8-carbamimidamidooctyl)-1,3-bis({8-[N'-(cyclopropylmethyl)carbamimidamido]octyl})urea by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
Papp |
= |
2.1 |
10^-6 cm/s |
Apparent permeability of the compound across bacterial inner membrane mimic POPE/POPG (6:4) in PBS buffer at pH 7.4 incubated for 5 hrs in presence of {8-[N'(cyclopropylmethyl)carbamimidamido]octyl}urea trifluoroacetate salt by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
Papp |
= |
4.98 |
10^-6 cm/s |
Apparent permeability of the compound across bacterial inner membrane mimic POPE/POPG (6:4) in PBS buffer at pH 7.4 incubated for 5 hrs in presence of 1,1-bis({6-[N'-(cyclopropylmethyl)carbamimidamido]hexyl})-3-{8-[N'-(cyclopropylmethyl)carbamimidamido]octyl}-3-octylurea by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
Papp |
= |
4.97 |
10^-6 cm/s |
Apparent permeability of the compound across bacterial inner membrane mimic POPE/POPG (6:4) in PBS buffer at pH 7.4 incubated for 5 hrs in presence of 1,3-bis(8-aminooctyl)-1,3-bis(8- carbamimidamidooctyl)urea trifluoroacetate salt by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
Papp |
= |
4.28 |
10^-6 cm/s |
Apparent permeability of the compound across bacterial inner membrane mimic POPE/POPG (6:4) in PBS buffer at pH 7.4 incubated for 5 hrs in presence of 1,3,3-tris(8-carbamimidamidooctyl)-1-{8-[N'-(cyclopropylmethyl)carbamimidamido]octyl}urea trifluoroacetate salt by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
R% |
= |
12.6 |
% |
Apparent permeability of the compound across bacterial inner membrane mimic POPE/POPG (6:4) in PBS buffer assessed as membrane retention at pH 7.4 incubated for 5 hrs in presence of 1,3-bis(8-carbamimidamidooctyl)-1,3-bis({8-[N'-(cyclopropylmethyl)carbamimidamido]octyl})urea by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
R% |
= |
17.5 |
% |
Apparent permeability of the compound across bacterial inner membrane mimic POPE/POPG (6:4) in PBS buffer assessed as membrane retention at pH 7.4 incubated for 5 hrs in presence of {8-[N'(cyclopropylmethyl)carbamimidamido]octyl}urea trifluoroacetate salt by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
R% |
= |
16.7 |
% |
Apparent permeability of the compound across bacterial inner membrane mimic POPE/POPG (6:4) in PBS buffer assessed as membrane retention at pH 7.4 incubated for 5 hrs in presence of 1,1-bis({6-[N'-(cyclopropylmethyl)carbamimidamido]hexyl})-3-{8-[N'-(cyclopropylmethyl)carbamimidamido]octyl}-3-octylurea by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
R% |
= |
16.5 |
% |
Apparent permeability of the compound across bacterial inner membrane mimic POPE/POPG (6:4) in PBS buffer assessed as membrane retention at pH 7.4 incubated for 5 hrs in presence of 1,3-bis(8-aminooctyl)-1,3-bis(8- carbamimidamidooctyl)urea trifluoroacetate salt by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
R% |
= |
19.0 |
% |
Apparent permeability of the compound across bacterial inner membrane mimic POPE/POPG (6:4) in PBS buffer assessed as membrane retention at pH 7.4 incubated for 5 hrs in presence of 1,3,3-tris(8-carbamimidamidooctyl)-1-{8-[N'-(cyclopropylmethyl)carbamimidamido]octyl}urea trifluoroacetate salt by PAMPA based UV-Vis spectrophotometric analysis |
CHEMBL5154741 |
| ADMET |
Kp |
= |
12.2 |
10^-6 cm/s |
Permeability coefficient of the compound in PBS buffer at pH 7.4 incubated for 5 hrs by PAMPA-based LC-MS analysis |
CHEMBL5154833 |
