Showing 1 to 50 of 56 entries Per page:
Compound ID
Cluster
Compound Type
Target/Cell Structure Activity Assay Description Source
Type
Relation
Value
Unit
NAs.000001 7 all-match Adenosine deaminase NAs.000001 Ki = 6.4 nM Tested for binding affinity against calf intestinal Adenosine Deaminase (ADA) CHEMBL1127396
NAs.001218 2 all-match Caco-2 NAs.001218 Other = 34.0 ucm/s Apical Caco-2 cell membrane permeability CHEMBL1147762
NAs.001218 2 all-match Caco-2 NAs.001218 Other = 18.0 ucm/s Basolateral Caco-2 cell membrane permeability CHEMBL1147762
NAs.001218 2 all-match MDCK NAs.001218 Other None None None Apical cell permeability in MDCK cells overexpressing human p-glycoprotein CHEMBL1147762
NAs.001218 2 all-match Homo sapiens NAs.001218 Other > 65.0 ug.mL-1 Turbidimetric solubility at pH 7 CHEMBL1147762
NAs.001218 2 all-match Unchecked NAs.001218 Ki = 1.14 nM Inhibition of bovine spleen adenosine deaminase type 9 by spectrophotometry CHEMBL1152769
NAs.001218 2 all-match Phosphodiesterase 4 NAs.001218 IC50 = 1700.0 nM Inhibition of PDE4 (unknown origin) CHEMBL3769307
NAs.001218 2 all-match Unchecked NAs.001218 IC50 = 700.0 nM Inhibition of cGMP activated PDE2 (unknown origin) CHEMBL3769307
NAs.001218 2 all-match Unchecked NAs.001218 IC50 = 2000.0 nM Inhibition of cGMP stimulated pig PDE2A CHEMBL3769307
NAs.001218 2 all-match Phosphodiesterase 2A NAs.001218 IC50 = 800.0 nM Inhibition of cGMP stimulated human PDE2A CHEMBL3769307
NAs.001218 2 all-match Adenosine deaminase NAs.001218 Ki = 2.2 nM Inhibition of bovine adenosine deaminase pre-incubated for 5 mins before adenosine addition CHEMBL4177582
NAs.001218 2 all-match Rattus norvegicus NAs.001218 Other = 97.08 ng.hr.mL-1 AUC (0 to t) in Wistar rat at 1 mg/kg, iv after 0.25 to 24 hrs by LC/MS/MS method CHEMBL4177582
NAs.001218 2 all-match Rattus norvegicus NAs.001218 Other None None None Plasma concentration in Wistar rat at 1 mg/kg, iv after 1 hr by LC/MS/MS method CHEMBL4177582
NAs.001218 2 all-match Rattus norvegicus NAs.001218 Other None None None Clearance in Wistar rat at 1 mg/kg, iv after 1 hr by LC/MS/MS method CHEMBL4177582
NAs.001218 2 all-match Phosphodiesterase 2A NAs.001218 Other = 37.45 % Inhibition of recombinant human PDE2A catalytic domain (580 to 919 residues) expressed in Escherichia coli BL21 (Codonplus) at 1 uM using [3H]cGMP as substrate after 15 mins by liquid scintillation counting method relative to control CHEMBL4177707
NAs.001218 2 all-match Unchecked NAs.001218 IC50 = 800.0 nM Inhibition of PDE2 (unknown origin) CHEMBL4177707
NAs.001218 2 all-match Phosphodiesterase 2A NAs.001218 IC50 = 2460.0 nM Inhibition of recombinant human PDE2A catalytic domain (580 to 919 residues) expressed in Escherichia coli BL21 (Codonplus) using [3H]cGMP as substrate after 15 mins by liquid scintillation counting method CHEMBL4177707
NAs.001218 2 all-match Phosphodiesterase 2A NAs.001218 IC50 = 800.0 nM Inhibition of human PDE2 using c[8-3H]cAMP or c[8-3H]cGMP as substrate measured after 10 mins by liquid scintillation counting method CHEMBL4371070
NAs.001218 2 all-match Phosphodiesterase 2A NAs.001218 IC50 = 2620.0 nM Inhibition of human recombinant PDE2A using cGMP as substrate incubated for 20 mins measured by Kinase Glo reagent based microplate reader assay CHEMBL4732047
NAs.001218 2 all-match Adenosine deaminase NAs.001218 Ki = 1.0 nM Binding affinity to ADA (unknown origin) assessed as inhibition constant CHEMBL5150007
NAs.001218 2 all-match Liver microsomes NAs.001218 Other = 0.5167 hr Half life in rat liver microsome CHEMBL1147762
NAs.001218 2 all-match Phosphodiesterase 2A NAs.001218 Other > 25.0 None Selectivity for PDE2 CHEMBL1147762
NAs.001218 2 all-match MDCK NAs.001218 Other None None None Basolateral cell permeability in MDCK with MDR transfectant overexpressing human p-glycoprotein CHEMBL1147762
NAs.001218 2 all-match Phosphodiesterase 10A NAs.001218 IC50 > 16000.0 nM Inhibitory activity against PDE10 by scintillation proximity assay CHEMBL1147762
NAs.001218 2 all-match Adenosine deaminase NAs.001218 Ki = 1.13 nM Inhibitory activity against adenosine deaminase in calf intestinal mucosa. CHEMBL1129194
NAs.001218 2 all-match Adenosine deaminase NAs.001218 Ki = 2.0 nM Binding affinity (Ki) at calf intestinal Adenosine deaminase CHEMBL1126223
NAs.001218 2 all-match Adenosine deaminase NAs.001218 Ki = 2.0 nM Compound was evaluated for the inhibition of adenosine deaminase CHEMBL1121750
NAs.001218 2 all-match No relevant target NAs.001218 Other = 7.0 None Dissociation constant was determined CHEMBL1130254
NAs.001218 2 all-match Phosphodiesterase 11A NAs.001218 IC50 > 16000.0 nM Inhibitory activity against PDE11 by scintillation proximity assay CHEMBL1147762
NAs.001218 2 all-match Adenosine deaminase NAs.001218 Ki = 1.13 nM Inhibition of Adenosine deaminase (ADA) of calf intestine CHEMBL1133542
NAs.001218 2 all-match Adenosine deaminase NAs.001218 Ki = 0.82 nM Tested for binding affinity against calf intestinal Adenosine Deaminase (ADA) CHEMBL1127396
NAs.001218 2 all-match Adenosine deaminase NAs.001218 Ki = 1.14 nM Inhibitory constant against bovine spleen Adenosine deaminase CHEMBL1141141
NAs.001218 2 all-match Phosphodiesterase 1 NAs.001218 IC50 > 16000.0 nM Inhibitory activity against PDE1 by scintillation proximity assay CHEMBL1147762
NAs.001218 2 all-match Phosphodiesterase 2A NAs.001218 IC50 = 635.0 nM Inhibitory activity against PDE2 by scintillation proximity assay CHEMBL1147762
NAs.001218 2 all-match Adenosine deaminase NAs.001218 Ki = 2.0 nM Compound was evaluated for inhibition of calf intestinal mucosa adenosine deaminase (ADA) CHEMBL1130858
NAs.001218 2 all-match Phosphodiesterase 4A NAs.001218 IC50 > 16000.0 nM Inhibitory activity against PDE4A by scintillation proximity assay CHEMBL1147762
NAs.001218 2 all-match Phosphodiesterase 4B NAs.001218 IC50 > 16000.0 nM Inhibitory activity against PDE4B by scintillation proximity assay CHEMBL1147762
NAs.001218 2 all-match Phosphodiesterase 4C NAs.001218 IC50 > 16000.0 nM Inhibitory activity against PDE4C by scintillation proximity assay CHEMBL1147762
NAs.001218 2 all-match Phosphodiesterase 4D NAs.001218 IC50 > 16000.0 nM Inhibitory activity against PDE4D by scintillation proximity assay CHEMBL1147762
NAs.001218 2 all-match Phosphodiesterase 5A NAs.001218 IC50 > 16000.0 nM Inhibitory activity against PDE5 by scintillation proximity assay CHEMBL1147762
NAs.001218 2 all-match Phosphodiesterase 8A NAs.001218 IC50 > 16000.0 nM Inhibitory activity against PDE8A by scintillation proximity assay CHEMBL1147762
NAs.001218 2 all-match Phosphodiesterase 8B NAs.001218 IC50 > 16000.0 nM Inhibitory activity against PDE8B by scintillation proximity assay CHEMBL1147762
NAs.001218 2 all-match Phosphodiesterase 9A NAs.001218 IC50 > 16000.0 nM Inhibitory activity against PDE9 by scintillation proximity assay CHEMBL1147762
NAs.001218 2 all-match Phosphodiesterase 3 NAs.001218 IC50 > 16000.0 nM Inhibitory activity against PDE3 by scintillation proximity assay CHEMBL1147762
NAs.003036 2 all-match Cytochrome P450 1A2 NAs.003036 Other None None None PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active CHEMBL1201862
NAs.003036 2 all-match Cytochrome P450 2C19 NAs.003036 Other None None None PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active CHEMBL1201862
NAs.003036 2 all-match Cytochrome P450 2C9 NAs.003036 Other None None None PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active CHEMBL1201862
NAs.003036 2 all-match Cytochrome P450 3A4 NAs.003036 Other = 15848.9 nM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] CHEMBL1201862
NAs.003036 2 all-match Cytochrome P450 3A4 NAs.003036 Other = 15848.9 nM PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] CHEMBL1201862
NAs.003036 2 all-match Thyroid stimulating hormone receptor NAs.003036 Other = 31622.8 nM PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) CHEMBL1201862