| Compound ID |
Cluster
|
Compound Type
|
Target/Cell | Structure | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.000002 | 7 | all-match | microRNA 21 |  |
Other | = | 16481.6 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of miRNAs and/or Activators of miR-21. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Unchecked | |
Other | None | 12589.3 | nM | PubChem BioAssay. High Throughput Screening for Foot and Mouth Disease Virus Antivirals. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Ubiquitin carboxyl-terminal hydrolase 1 | |
Other | None | 8912.5 | nM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Luciferin 4-monooxygenase | |
Other | None | 11995.5 | nM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Plasmodium falciparum | |
Other | None | 18526.0 | nM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | HepG2 | |
Other | None | 707.9 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | |
Other | = | 4176.0 | nM | PUBCHEM_BIOASSAY: MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504442] | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Chromobox protein homolog 1 | |
Other | None | 89125.1 | nM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Glucagon-like peptide 1 receptor | |
Other | None | 10000.0 | nM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | ATPase family AAA domain-containing protein 5 | |
Other | None | 20587.8 | nM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | ATPase family AAA domain-containing protein 5 | |
Other | None | 25918.5 | nM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Unchecked | |
Other | None | 6309.6 | nM | PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485345, AID485355] | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Cyclin-dependent kinase 5/CDK5 activator 1 | |
Other | = | 22233.0 | nM | PUBCHEM_BIOASSAY: Development of CDK5 inhibitors Measured in Biochemical System Using Plate Reader - 2083-01_Inhibitor_Dose_CherryPick_Activity_Set2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488916] | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | microRNA 21 | |
Other | = | 16481.6 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of miRNAs and/or Inhibitors of miR-21. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | DNA polymerase beta | |
Other | = | 100000.0 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Niemann-Pick C1 protein | |
Other | = | 3162.3 | nM | PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Plasmodium falciparum | |
Other | None | 18526.0 | nM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | Luciferin 4-monooxygenase |  |
Other | None | 21331.3 | nM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | Corticotropin-releasing factor receptor 2/Corticotropin-releasing factor-binding protein | |
EC50 | > | 53000.0 | nM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | Corticotropin-releasing factor receptor 2/Corticotropin-releasing factor-binding protein | |
IC50 | > | 47100.0 | nM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | Sphingomyelin phosphodiesterase | |
Other | None | 25118.9 | nM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | Glutaminase kidney isoform, mitochondrial | |
Other | None | 35481.3 | nM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | DNA-(apurinic or apyrimidinic site) lyase | |
Other | None | 21192.3 | nM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | DNA polymerase eta | |
Other | None | 84921.4 | nM | PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | Caspase-6 | |
Other | = | 28930.0 | nM | PubChem BioAssay. VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | NAD-dependent protein deacylase sirtuin-5, mitochondrial | |
Other | = | 4290.0 | nM | PubChem BioAssay. MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_Dose_CherryPick_Activity_Set5. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | HEK293 | |
Other | None | 22387.2 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | Werner syndrome ATP-dependent helicase | |
Other | None | 7943.3 | nM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | DNA polymerase eta | |
Other | None | 35481.3 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | Lysine-specific demethylase 4A | |
Other | None | 50118.7 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | Chromobox protein homolog 1 | |
Other | None | 79432.8 | nM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | Plasmodium falciparum | |
Other | None | 1651.1 | nM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | Importin subunit beta-1/Snurportin-1 | |
Other | None | 89125.1 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | Bromodomain adjacent to zinc finger domain protein 2B | |
Other | None | 70794.6 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 | |
Other | None | 50118.7 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | Voltage-gated N-type calcium channel alpha-1B subunit/Amyloid beta A4 precursor protein-binding family A member 1 | |
IC50 | > | 50000.0 | nM | PUBCHEM_BIOASSAY: uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay. Confirmatory Screen for inhibitors of association between Mint1-PDZ domains and N-type Ca2+ channel carboxyl-terminal peptide (NC peptide). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2093, AID2489, AID2496, AID434980] | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | DNA polymerase beta | |
Other | = | 50118.7 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | Menin/Histone-lysine N-methyltransferase MLL | |
Other | = | 14125.4 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | 4'-phosphopantetheinyl transferase ffp | |
Other | = | 79432.8 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | Voltage-gated N-type calcium channel alpha-1B subunit/Amyloid beta A4 precursor protein-binding family A member 1 | |
IC50 | = | 17600.0 | nM | PUBCHEM_BIOASSAY: Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay. Confirmatory Screen for inhibitors of association between Mint1-PDZ domains and N-type Ca2+ channel carboxyl-terminal peptide (NC peptide). (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.004097 | 7 | ribose-match | DNA polymerase iota | |
Other | None | 15848.9 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | CHEMBL1201862 | |
| NAs.006534 | 7 | ribose-match | Phosphodiesterase 4 |  |
IC50 | > | 10000.0 | nM | Inhibition of phosphodiesterase 4 from rat brain cortex | CHEMBL1125241 | |
| NAs.006534 | 7 | ribose-match | Phosphodiesterase 4 | |
IC50 | > | 1000.0 | nM | Displacement of [3H]rolipram binding to Phosphodiesterase 4 in rat brain | CHEMBL1125241 | |