| Compound ID |
Cluster
|
Compound Type
|
Target/Cell | Structure | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.000002 | 7 | all-match | microRNA 21 |  |
Other | = | 16481.6 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of miRNAs and/or Activators of miR-21. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Unchecked | |
Other | None | 12589.3 | nM | PubChem BioAssay. High Throughput Screening for Foot and Mouth Disease Virus Antivirals. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Ubiquitin carboxyl-terminal hydrolase 1 | |
Other | None | 8912.5 | nM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Luciferin 4-monooxygenase | |
Other | None | 11995.5 | nM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Plasmodium falciparum | |
Other | None | 18526.0 | nM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | HepG2 | |
Other | None | 707.9 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | |
Other | = | 4176.0 | nM | PUBCHEM_BIOASSAY: MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504442] | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Chromobox protein homolog 1 | |
Other | None | 89125.1 | nM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Glucagon-like peptide 1 receptor | |
Other | None | 10000.0 | nM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | ATPase family AAA domain-containing protein 5 | |
Other | None | 20587.8 | nM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | ATPase family AAA domain-containing protein 5 | |
Other | None | 25918.5 | nM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Unchecked | |
Other | None | 6309.6 | nM | PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485345, AID485355] | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Cyclin-dependent kinase 5/CDK5 activator 1 | |
Other | = | 22233.0 | nM | PUBCHEM_BIOASSAY: Development of CDK5 inhibitors Measured in Biochemical System Using Plate Reader - 2083-01_Inhibitor_Dose_CherryPick_Activity_Set2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488916] | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | microRNA 21 | |
Other | = | 16481.6 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of miRNAs and/or Inhibitors of miR-21. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | DNA polymerase beta | |
Other | = | 100000.0 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Niemann-Pick C1 protein | |
Other | = | 3162.3 | nM | PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000002 | 7 | all-match | Plasmodium falciparum | |
Other | None | 18526.0 | nM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | CHEMBL1201862 | |
| NAs.008523 | 7 | base-match | HepG2 |  |
IC50 | = | 3320.0 | nM | Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay | CHEMBL4765302 | |
| NAs.008523 | 7 | base-match | A-375 | |
IC50 | = | 2170.0 | nM | Antiproliferative activity against human A-375 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay | CHEMBL4765302 | |
| NAs.008523 | 7 | base-match | NCI-H460 | |
IC50 | = | 3410.0 | nM | Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay | CHEMBL4765302 | |
| NAs.008523 | 7 | base-match | CDK2/Cyclin A2 | |
Other | = | 73.17 | % | Inhibition of recombinant human N-terminal GST-tagged CDK2/CyclinA2 expressed in baculovirus infected Sf21 cells at 10 uM using histone H1 as substrate incubated for 10 mins by luminescence based assay relative to control | CHEMBL4765302 | |
| NAs.008523 | 7 | base-match | Histone deacetylase 1 | |
Other | = | 89.72 | % | Inhibition of recombinant human HDAC1 at 10 uM using SIRT1 as substrate incubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence based assay relative to control | CHEMBL4765302 | |
| NAs.008523 | 7 | base-match | HepG2 | |
Other | = | 63.77 | % | Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth at 2 uM incubated for 72 hrs by CCK-8 assay relative to control | CHEMBL4765302 | |
| NAs.008523 | 7 | base-match | NCI-H460 | |
Other | = | 54.15 | % | Antiproliferative activity against human H460 cells assessed as reduction in cell growth at 2 uM incubated for 72 hrs by CCK-8 assay relative to control | CHEMBL4765302 | |
| NAs.008523 | 7 | base-match | HepG2 | |
Other | = | 74.41 | % | Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth at 8 uM incubated for 72 hrs by CCK-8 assay relative to control | CHEMBL4765302 | |
| NAs.008523 | 7 | base-match | HCT-116 | |
Other | = | 76.04 | % | Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth at 8 uM incubated for 72 hrs by CCK-8 assay relative to control | CHEMBL4765302 | |
| NAs.008523 | 7 | base-match | HCT-116 | |
Other | = | 73.2 | % | Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth at 2 uM incubated for 72 hrs by CCK-8 assay relative to control | CHEMBL4765302 | |
| NAs.008523 | 7 | base-match | HCT-116 | |
IC50 | = | 800.0 | nM | Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay | CHEMBL4765302 | |
| NAs.008523 | 7 | base-match | NCI-H460 | |
Other | = | 80.49 | % | Antiproliferative activity against human H460 cells assessed as reduction in cell growth at 8 uM incubated for 72 hrs by CCK-8 assay relative to control | CHEMBL4765302 | |
| NAs.008523 | 7 | base-match | HeLa | |
IC50 | = | 2130.0 | nM | Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay | CHEMBL4765302 | |