Showing 1 to 36 of 36 entries Per page:
Compound ID
Cluster
Compound Type
Target/Cell Structure Activity Assay Description Source
Type
Relation
Value
Unit
NAs.000007 2 all-match Adenosine A1 receptor NAs.000007 Other = 22.0 % Ability to displace [3H]DPCPX from Adenosine A1 receptor in rat cortical membrane at 10e-5 M CHEMBL1135807
NAs.000007 2 all-match Adenosine A2a receptor NAs.000007 Ki = 1500.0 nM Binding affinity at Adenosine A2A receptor in rat striatal membrane by [3H]ZM-241385 displacement. CHEMBL1135807
NAs.000007 2 all-match Adenosine A3 receptor NAs.000007 Ki = 697.0 nM Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]-AB MECA displacement. CHEMBL1135807
NAs.000007 2 all-match Adenosine A2a receptor NAs.000007 Other = 126.0 % Maximum level of G-protein activation (Emax) compared to CGS 21680 through Adenosine A2A receptor expressed in CHO cells using cAMP assay CHEMBL1135807
NAs.000007 2 all-match Adenosine A2a receptor NAs.000007 EC50 = 12900.0 nM G-protein activation in human Adenosine A2A receptor expressed in CHO cells using cAMP assay CHEMBL1135807
NAs.000007 2 all-match Adenosine A3 receptor NAs.000007 Other = 16.0 % Percent inhibition of forskolin induced (10 uM) cAMP production compared to C1-IB-MECA through Adenosine A3 receptor expressed in CHO cells at 100 uM CHEMBL1135807
NAs.000187 2 all-match Adenosine A2a receptor NAs.000187 Other = 30.0 % Maximum level of G-protein activation (Emax) compared to CGS 21680 through Adenosine A2A receptor expressed in CHO cells using cAMP assay CHEMBL1135807
NAs.000187 2 all-match Adenosine A3 receptor NAs.000187 Ki = 558.0 nM Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]-AB MECA displacement. CHEMBL1135807
NAs.000187 2 all-match Adenosine A3 receptor NAs.000187 Other = 10.0 % % inhibition of forskolin induced (10 uM) cAMP production compared to C1-IB-MECA through Adenosine A3 receptor expressed in CHO cells at 30 uM CHEMBL1135807
NAs.000187 2 all-match Adenosine A1 receptor NAs.000187 Ki = 1050.0 nM Ability to displace [3H]DPCPX from Adenosine A1 receptor in rat cortical membrane CHEMBL1135807
NAs.000187 2 all-match Adenosine A2a receptor NAs.000187 Ki = 440.0 nM Binding affinity at Adenosine A2A receptor in rat striatal membrane by [3H]ZM-241385 displacement. CHEMBL1135807
NAs.000656 2 all-match Adenosine A1 receptor NAs.000656 Other = 46.5 % Displacement of [3H]DPCPX from Adenosine A1 receptor in rat cortical membrane at 10e-5 M CHEMBL1135807
NAs.000656 2 all-match Adenosine A2a receptor NAs.000656 Ki = 170.0 nM Binding affinity at Adenosine A2A receptor in rat striatal membrane by [3H]ZM-241385 displacement. CHEMBL1135807
NAs.000656 2 all-match Adenosine A3 receptor NAs.000656 Ki = 88.3 nM Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]-AB MECA displacement. CHEMBL1135807
NAs.000656 2 all-match Adenosine A2a receptor NAs.000656 Other = 82.0 % Maximum level of G-protein activation (Emax) compared to CGS 21680 through Adenosine A2A receptor expressed in CHO cells using cAMP assay CHEMBL1135807
NAs.000656 2 all-match Adenosine A2a receptor NAs.000656 EC50 = 800.0 nM G-protein activation in human Adenosine A2A receptor expressed in CHO cells using cAMP assay CHEMBL1135807
NAs.000656 2 all-match Adenosine A3 receptor NAs.000656 Other = 33.0 % Percent inhibition of forskolin induced (10 uM) cAMP production compared to C1-IB-MECA through Adenosine A3 receptor expressed in CHO cells at 10 uM CHEMBL1135807
NAs.001352 2 all-match Adenosine A2a receptor NAs.001352 Ki = 18780.0 nM Displacement of [3H]-CGS- 21980 from Adenosine A2A receptor of rat striatal membranes CHEMBL1132635
NAs.001352 2 all-match Adenosine receptors; A1 & A3 NAs.001352 Other = 0.39 None Ratio of displacement of A1 receptor to A3 receptor CHEMBL1132635
NAs.001352 2 all-match Adenosine A3 receptor NAs.001352 Ki = 193.0 nM Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]AB-MECA displacement. CHEMBL1132635
NAs.001352 2 all-match Adenosine A1 receptor NAs.001352 Ki = 76.0 nM Displacement of [3H]DPCPX from rat cortical membranes Adenosine A1 receptor CHEMBL1132635
NAs.001352 2 all-match Adenosine A1 receptor NAs.001352 Ki = 76.0 nM Binding affinity against adenosine A1 receptor using [3H]DPCPX in rat cortical membranes in the absence of GTP CHEMBL1131197
NAs.001352 2 all-match Adenosine A1 receptor NAs.001352 EC50 = 384.0 nM Effective concentration for [35S]GTP-gamma-S, binding to adenosine A1 receptor in rat brain membranes CHEMBL1131197
NAs.001352 2 all-match Adenosine A2a receptor NAs.001352 Ki = 18800.0 nM Binding affinity against Adenosine A2A receptor using [3H]-CGS- 21680 as the radioligand in rat striatal membranes CHEMBL1131197
NAs.001352 2 all-match Adenosine A1 receptor NAs.001352 Ki = 222.0 nM Binding affinity against adenosine A1 receptor using [3H]DPCPX in rat cortical membranes in the presence of GTP. CHEMBL1131197
NAs.001352 2 all-match Adenosine A1 receptor NAs.001352 Other = 84.1 % Intrinsic activity for maximum stimulation of [35S]GTP-gamma-S, binding to adenosine A1 receptor in rat brain membranes CHEMBL1131197
NAs.001356 2 ribose-match Adenosine A1 receptor NAs.001356 Ki = 5875.0 nM Displacement of [3H]DPCPX from rat cortical membranes Adenosine A1 receptor CHEMBL1132635
NAs.001356 2 ribose-match Adenosine A2a receptor NAs.001356 Ki = 7990.0 nM Displacement of [3H]-CGS- 21680 from Adenosine A2A receptor of rat striatal membranes CHEMBL1132635
NAs.001356 2 ribose-match Adenosine A3 receptor NAs.001356 Ki = 647.0 nM Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]AB-MECA displacement. CHEMBL1132635
NAs.001356 2 ribose-match Adenosine receptors; A1 & A3 NAs.001356 Other = 8.7 None Ratio of displacement of A1 receptor to A3 receptor CHEMBL1132635
NAs.001356 2 ribose-match Adenosine A3 receptor NAs.001356 Other = 7.0 % Percentage of [35S]GTP-gamma-S, binding to the human adenosine A3 receptor stimulated at 10E-4 M CHEMBL1132635
NAs.001523 2 ribose-match Adenosine receptors; A1 & A3 NAs.001523 Other > 225.7 None Ratio of displacement of A1 receptor to A3 receptor CHEMBL1132635
NAs.001523 2 ribose-match Adenosine A1 receptor NAs.001523 Other = 42.0 % Percentage displacement of [3H]DPCPX from rat cortical membranes Adenosine A1 receptor at 10 uM CHEMBL1132635
NAs.001523 2 ribose-match Adenosine A2a receptor NAs.001523 Other = 42.0 % Percentage displacement of [3H]-CGS- 21680 from Adenosine A2A receptor of rat striatal membranes at 10 uM CHEMBL1132635
NAs.001523 2 ribose-match Adenosine A3 receptor NAs.001523 Ki = 44.3 nM Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]AB-MECA displacement. CHEMBL1132635
NAs.001523 2 ribose-match Adenosine A3 receptor NAs.001523 Other = 10.0 % Percentage of [35S]GTP-gamma-S, binding to the human adenosine A3 receptor stimulated at 10E-4 M CHEMBL1132635