Showing 1 to 33 of 33 entries Per page:
Compound ID
Cluster
Compound Type
Target/Cell Structure Activity Assay Description Source
Type
Relation
Value
Unit
NAs.000007 2 all-match Adenosine A1 receptor NAs.000007 Other = 22.0 % Ability to displace [3H]DPCPX from Adenosine A1 receptor in rat cortical membrane at 10e-5 M CHEMBL1135807
NAs.000007 2 all-match Adenosine A2a receptor NAs.000007 Ki = 1500.0 nM Binding affinity at Adenosine A2A receptor in rat striatal membrane by [3H]ZM-241385 displacement. CHEMBL1135807
NAs.000007 2 all-match Adenosine A3 receptor NAs.000007 Ki = 697.0 nM Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]-AB MECA displacement. CHEMBL1135807
NAs.000007 2 all-match Adenosine A2a receptor NAs.000007 Other = 126.0 % Maximum level of G-protein activation (Emax) compared to CGS 21680 through Adenosine A2A receptor expressed in CHO cells using cAMP assay CHEMBL1135807
NAs.000007 2 all-match Adenosine A2a receptor NAs.000007 EC50 = 12900.0 nM G-protein activation in human Adenosine A2A receptor expressed in CHO cells using cAMP assay CHEMBL1135807
NAs.000007 2 all-match Adenosine A3 receptor NAs.000007 Other = 16.0 % Percent inhibition of forskolin induced (10 uM) cAMP production compared to C1-IB-MECA through Adenosine A3 receptor expressed in CHO cells at 100 uM CHEMBL1135807
NAs.000784 2 all-match Adenosine A1 receptor NAs.000784 Other = 13.0 % Displacement of [3H]DPCPX from Adenosine A1 receptor in rat cortical membrane at 10e-5 M CHEMBL1135807
NAs.000784 2 all-match Adenosine A2a receptor NAs.000784 Ki = 1800.0 nM Binding affinity at Adenosine A2A receptor in rat striatal membrane by [3H]ZM-241385 displacement. CHEMBL1135807
NAs.000784 2 all-match Adenosine A3 receptor NAs.000784 Ki = 409.0 nM Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]-AB MECA displacement. CHEMBL1135807
NAs.000784 2 all-match Adenosine A2a receptor NAs.000784 Other = 56.0 % Maximum level of G-protein activation (Emax) compared to CGS 21680 through Adenosine A2A receptor expressed in CHO cells using cAMP assay CHEMBL1135807
NAs.000784 2 all-match Adenosine A2a receptor NAs.000784 EC50 = 10400.0 nM G-protein activation in human Adenosine A2A receptor expressed in CHO cells using cAMP assay CHEMBL1135807
NAs.000784 2 all-match Adenosine A3 receptor NAs.000784 Other = 26.0 % % inhibition of forskolin induced (10 uM) cAMP production compared to C1-IB-MECA through Adenosine A3 receptor expressed in CHO cells at 30 uM CHEMBL1135807
NAs.001268 2 all-match Adenosine A3 receptor NAs.001268 Other = 7.0 % Percent inhibition of forskolin induced (10 uM) cAMP production compared to C1-IB-MECA through Adenosine A3 receptor expressed in CHO cells at 100 uM CHEMBL1135807
NAs.001268 2 all-match Adenosine A2a receptor NAs.001268 Other = 101.0 % Maximum level of G-protein activation (Emax) compared to CGS 21680 through Adenosine A2A receptor expressed in CHO cells using cAMP assay CHEMBL1135807
NAs.001268 2 all-match Adenosine A2a receptor NAs.001268 EC50 = 7500.0 nM G-protein activation in human Adenosine A2A receptor expressed in CHO cells using cAMP assay CHEMBL1135807
NAs.001268 2 all-match Adenosine A2a receptor NAs.001268 Ki = 500.0 nM Binding affinity at Adenosine A2A receptor in rat striatal membrane by [3H]ZM-241385 displacement. CHEMBL1135807
NAs.001268 2 all-match Adenosine A3 receptor NAs.001268 Ki = 814.0 nM Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]-AB MECA displacement. CHEMBL1135807
NAs.001268 2 all-match Adenosine A1 receptor NAs.001268 Other = 21.2 % Ability to displace [3H]DPCPX from Adenosine A1 receptor in rat cortical membrane at 10e-5 M CHEMBL1135807
NAs.001467 2 all-match Adenosine A2a receptor NAs.001467 EC50 = 5000.0 nM G-protein activation in human Adenosine A2A receptor expressed in CHO cells using cAMP assay CHEMBL1135807
NAs.001467 2 all-match Adenosine A2a receptor NAs.001467 Other = 44.0 % Maximum level of G-protein activation (Emax) compared to CGS 21680 through Adenosine A2A receptor expressed in CHO cells using cAMP assay CHEMBL1135807
NAs.001467 2 all-match Adenosine A3 receptor NAs.001467 Other = 41.0 % % inhibition of forskolin induced (10 uM) cAMP production compared to C1-IB-MECA through Adenosine A3 receptor expressed in CHO cells at 30 uM CHEMBL1135807
NAs.001467 2 all-match Adenosine A2a receptor NAs.001467 Ki = 220.0 nM Binding affinity at Adenosine A2A receptor in rat striatal membrane by [3H]ZM-241385 displacement. CHEMBL1135807
NAs.001467 2 all-match Adenosine A1 receptor NAs.001467 Other = 18.9 % Ability to displace [3H]DPCPX from Adenosine A1 receptor in rat cortical membrane at 10e-5 M CHEMBL1135807
NAs.001467 2 all-match Adenosine A3 receptor NAs.001467 Ki = 253.0 nM Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]-AB MECA displacement. CHEMBL1135807
NAs.002291 2 all-match Adenosine A2a receptor NAs.002291 EC50 = 1100.0 nM G-protein activation in human Adenosine A2A receptor expressed in CHO cells using cAMP assay CHEMBL1135807
NAs.002291 2 all-match Adenosine A1 receptor NAs.002291 EC50 = 20892.96 nM In vitro prolonging of the stimulus-QRS interval in guinea pig heart. CHEMBL1126185
NAs.002291 2 all-match Adenosine A2 receptor NAs.002291 EC50 = 0.4677 nM In vitro effect on coronary vasodilation in guinea pig heart. CHEMBL1126185
NAs.002291 2 all-match Adenosine receptors; A1 & A2 NAs.002291 Other = 50000.0 None Selectivity ratio for A1 and A2 receptors. CHEMBL1126185
NAs.002291 2 all-match Adenosine A1 receptor NAs.002291 Other = 18.9 % Ability to displace [3H]DPCPX from Adenosine A1 receptor in rat cortical membrane at 10e-5 M CHEMBL1135807
NAs.002291 2 all-match Adenosine A2a receptor NAs.002291 Ki = 20.0 nM Binding affinity at Adenosine A2A receptor in rat striatal membrane by [3H]ZM-241385 displacement. CHEMBL1135807
NAs.002291 2 all-match Adenosine A3 receptor NAs.002291 Ki = 38.3 nM Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]-AB MECA displacement. CHEMBL1135807
NAs.002291 2 all-match Adenosine A2a receptor NAs.002291 Other = 92.0 % Maximum level of G-protein activation (Emax) compared to CGS 21680 through Adenosine A2A receptor expressed in CHO cells using cAMP assay CHEMBL1135807
NAs.002291 2 all-match Adenosine A3 receptor NAs.002291 Other = 24.0 % Percent inhibition of forskolin induced (10 uM) cAMP production compared to C1-IB-MECA through Adenosine A3 receptor expressed in CHO cells at 3 uM CHEMBL1135807