NA-DB

Showing 1 to 10 of 10 entries Per page:

First <<
Prev <
1
Next >
Last >>

	Compound ID	Cluster 2	Compound Type ALL-match Base-match Ribose-match	Target/Cell	Structure	Activity				Assay Description	Source
	Compound ID	Cluster 2	Compound Type ALL-match Base-match Ribose-match	Target/Cell	Structure	Type Ki EC50 Other	Relation =	Value	Unit nM % None	Assay Description	Source
	NAs.000014	2	ribose-match	Adenosine A1 receptor		Ki	=	174.0	nM	Displacement of [3H]CPPA from human adenosine A1 receptor expressed in CHO cells	CHEMBL1144471
	NAs.000014	2	ribose-match	Adenosine A2a receptor		Ki	=	10.9	nM	Displacement of [3H]CGS-21680 from human adenosine A2A receptor expressed in CHO cells	CHEMBL1144471
	NAs.000014	2	ribose-match	Adenosine A3 receptor		Ki	=	93.3	nM	Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in CHO cells	CHEMBL1144471
	NAs.000014	2	ribose-match	Adenosine A2b receptor		EC50	=	1780.0	nM	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	CHEMBL1144471
	NAs.000014	2	ribose-match	Adenosine A3 receptor		Other	=	80.0	%	Maximum efficacy at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of cAMP production at 10 uM relative to NECA	CHEMBL1144471
	NAs.000014	2	ribose-match	Adenosine A2b receptor		Other	=	-3.25	None	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase	CHEMBL1145544
	NAs.000014	2	ribose-match	Adenosine A2b receptor		Other	=	-1.104	None	Agonist activity human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase relative to NECA	CHEMBL1145544
	NAs.000468	2	ribose-match	Adenosine A1 receptor		EC50	=	11748.98	nM	Effective concentration required for prolongation of the stimulus-QRS interval by 50% of the maximum response at the Adenosine A1 receptor in langendorff guinea pig heart preparation	CHEMBL1125902
	NAs.000468	2	ribose-match	Adenosine A2 receptor		EC50	=	3.715	nM	Concentration required for coronary arteries vasodilation at the Adenosine A2 receptor in langendorff guinea pig heart preparation	CHEMBL1125902
	NAs.000468	2	ribose-match	Adenosine receptors; A1 & A2		Other	=	3500.0	None	Ratio of stim-QRS (conduction block) to EC50 for vasodilation of coronary arteries	CHEMBL1125902