| Compound ID |
Cluster
|
Compound Type
|
Target/Cell | Structure | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.000016 | 7 | ribose-match | Adenosine receptors; A1 & A3 |  |
Other | = | 19.0 | None | Selectivity index, ratio of Ki for recombinant human adenosine A3 receptor to Ki for recombinant human adenosine A1 receptor | CHEMBL4152191 | |
| NAs.000016 | 7 | ribose-match | Unchecked | |
Other | > | 811.0 | None | Selectivity index, ratio of Ki for recombinant human adenosine A2B receptor to Ki for recombinant human adenosine A1 receptor | CHEMBL4152191 | |
| NAs.000016 | 7 | ribose-match | Unchecked | |
Other | = | 83.0 | None | Selectivity index, ratio of Ki for recombinant human adenosine A2A receptor to Ki for recombinant human adenosine A1 receptor | CHEMBL4152191 | |
| NAs.000016 | 7 | ribose-match | Adenosine A3 receptor | |
Ki | = | 720.0 | nM | Displacement of [3H]NECA from recombinant human adenosine A3 receptor transfected in CHO cell membranes after 3 hrs by microbeta scintillation counting analysis | CHEMBL4152191 | |
| NAs.000016 | 7 | ribose-match | Adenosine A2b receptor | |
Ki | > | 30000.0 | nM | Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay | CHEMBL4152191 | |
| NAs.000016 | 7 | ribose-match | Adenosine A2a receptor | |
Ki | = | 3080.0 | nM | Displacement of [3H]NECA from recombinant human adenosine A2A receptor transfected in CHO cell membranes after 3 hrs by microbeta scintillation counting analysis | CHEMBL4152191 | |
| NAs.000016 | 7 | ribose-match | Adenosine A1 receptor | |
Ki | = | 37.0 | nM | Displacement of [3H]CCPA from recombinant human adenosine A1 receptor transfected in CHO cell membranes after 3 hrs by microbeta scintillation counting analysis | CHEMBL4152191 | |