| Compound ID |
Cluster
|
Compound Type
|
Target/Cell | Structure | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.000017 | 8 | ribose-match | Adenosine A1 receptor |  |
Other | = | 14.0 | % | Displacement of [3H]R-PIA from human recombinant adenosine A1 receptor expressed in CHO cells at 10 uM after 60 mins by liquid scintillation counting | CHEMBL2062514 | |
| NAs.000017 | 8 | ribose-match | Adenosine A2a receptor | |
Other | = | 30.0 | % | Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in HEK293 cells at 10 uM after 60 mins by liquid scintillation counting | CHEMBL2062514 | |
| NAs.000017 | 8 | ribose-match | Adenosine A3 receptor | |
Ki | = | 1.22 | nM | Displacement of [3H]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells after 60 mins by gamma counting | CHEMBL2062514 | |
| NAs.000017 | 8 | ribose-match | Adenosine A3 receptor | |
Other | = | 97.4 | % | Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production at 10 uM incubated for 30 mins prior to forskolin-stimulation measured after 15 mins by enzyme immunoassay relative to NECA | CHEMBL2062514 | |
| NAs.000017 | 8 | ribose-match | Adenosine A1 receptor | |
Other | = | 13.0 | % | Displacement of [3H]R-PIA from human recombinant A1 adenosine receptor expressed in CHO cells at 10 uM after 60 mins by liquid scintillation counting | CHEMBL3407461 | |
| NAs.000017 | 8 | ribose-match | Adenosine A2a receptor | |
Other | = | 30.0 | % | Displacement of [3H]CGS21680 from human recombinant A2A adenosine receptor expressed in HEK293 cells at 10 uM after 60 mins by liquid scintillation counting | CHEMBL3407461 | |
| NAs.000017 | 8 | ribose-match | Adenosine A3 receptor | |
Ki | = | 1.22 | nM | Displacement of [125I]I-AB-MECA from human recombinant A3 adenosine receptor expressed in CHO cells after 60 mins by liquid scintillation counting | CHEMBL3407461 | |
| NAs.000017 | 8 | ribose-match | Mus musculus | |
Other | = | 0.5 | hr | Antinociceptive activity in chronic constriction injury neutropathic pain CD-1 mouse model assessed as time for peak protection at 3 umol/kg, po | CHEMBL3407461 | |
| NAs.000017 | 8 | ribose-match | Mus musculus | |
Other | = | 40.4 | % | Antinociceptive activity in chronic constriction injury neutropathic pain CD-1 mouse model assessed as maximum protection on ipsilateral hind paw at 3 umol/kg, po after 30 mins to 5 hrs post dose relative to control | CHEMBL3407461 | |
| NAs.000017 | 8 | ribose-match | Mus musculus | |
Other | = | 4.6 | % | Antinociceptive activity in chronic constriction injury neutropathic pain CD-1 mouse model at 3 umol/kg, po after 3 hrs post dose relative to control | CHEMBL3407461 | |