Showing 1 to 33 of 33 entries Per page:
Compound ID
Cluster
Compound Type
Target/Cell Structure Activity Assay Description Source
Type
Relation
Value
Unit
NAs.000019 7 all-match Fructose-1,6-bisphosphatase NAs.000019 IC50 = 1800.0 nM Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry CHEMBL1138458
NAs.000185 7 all-match Fructose-1,6-bisphosphatase NAs.000185 IC50 > 10000.0 nM Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry CHEMBL1138458
NAs.000185 7 all-match Fructose-1,6-bisphosphatase NAs.000185 Other > 25.0 % Inhibition of human liver FBPase expressed in Escherichia coli at 10 uM by spectrophotometry CHEMBL1138458
NAs.001258 7 all-match Fructose-1,6-bisphosphatase NAs.001258 IC50 = 800.0 nM Inhibition of human liver FBPase 1 CHEMBL1156817
NAs.001258 7 all-match Unchecked NAs.001258 Other > 480.0 None Selectivity ratio of IC50 for porcine heart AMP deaminase to IC50 for human liver FBPase CHEMBL1138458
NAs.001258 7 all-match Rattus norvegicus NAs.001258 Other = 10.0 None Increase in fructose-1,6-bisphosphate level in overnight-fasted Sprague-Dawley rat liver at 20 mg/kg, ip relative to control CHEMBL1138458
NAs.001258 7 all-match Liver NAs.001258 Other = 51.3 nmol/g Drug concentration in overnight-fasted Sprague-Dawley rat liver at 20 mg/kg, ip after 1 hr CHEMBL1138458
NAs.001258 7 all-match Rattus norvegicus NAs.001258 Other = 38.5 uM Plasma concentration in overnight-fasted Sprague-Dawley rat at 20 mg/kg, ip after 1 hr CHEMBL1138458
NAs.001258 7 all-match Hepatocyte NAs.001258 Other None None None Increase in fructose-1,6-bisphosphate substrate level in rat primary hepatocytes at 5 to 50 uM by enzyme-coupled spectrophotometry CHEMBL1138458
NAs.001258 7 all-match Unchecked NAs.001258 Other < 2.0 None Selectivity ratio of IC50 for rat liver FBPase to IC50 for human liver FBPase CHEMBL1138458
NAs.001258 7 all-match Hepatocyte NAs.001258 EC50 = 90000.0 nM Inhibition of glucose production in rat primary hepatocytes treated for 15 to 30 mins prior to gluconeogenic substrate dihydroxyacetone addition CHEMBL1138458
NAs.001258 7 all-match Rattus norvegicus NAs.001258 Other = 65.0 % Reduction in blood glucose level in overnight-fasted Sprague-Dawley rat at 20 mg/kg, ip within 1 hr CHEMBL1138458
NAs.001258 7 all-match Rattus norvegicus NAs.001258 Other = 1.6 % Oral bioavailability in fasted Sprague-Dawley rat assessed as urinary excretion of phosphonic acid up to 300 mg/kg CHEMBL1138458
NAs.001258 7 all-match Unchecked NAs.001258 EC50 > 100000.0 nM Inhibition of New Zealand white rabbit liver phosphofructokinase CHEMBL1138458
NAs.001258 7 all-match Glycogen phosphorylase, muscle form NAs.001258 EC50 > 100000.0 nM Inhibition of rabbit muscle glycogen phosphorylase CHEMBL1138458
NAs.001258 7 all-match Unchecked NAs.001258 IC50 = 390000.0 nM Inhibition of pig heart AMP deaminase CHEMBL1138458
NAs.001258 7 all-match Adenylate kinase isoenzyme 1 NAs.001258 IC50 > 500000.0 nM Inhibition of rabbit muscle adenylate kinase CHEMBL1138458
NAs.001258 7 all-match Adenosine kinase NAs.001258 IC50 > 100000.0 nM Inhibition of human recombinant adenosine kinase expressed in Escherichia coli CHEMBL1138458
NAs.001258 7 all-match Fructose-1,6-bisphosphatase NAs.001258 IC50 = 1250.0 nM Inhibition of rat liver FBPase CHEMBL1138458
NAs.001258 7 all-match Fructose-1,6-bisphosphatase NAs.001258 IC50 = 800.0 nM Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry CHEMBL1138458
NAs.001258 7 all-match Hepatocyte NAs.001258 Other None None None Inhibition of glucose production in rat primary hepatocytes treated for 15 to 30 mins prior to gluconeogenic substrate dihydroxyacetone addition CHEMBL1138458
NAs.001399 7 all-match Fructose-1,6-bisphosphatase NAs.001399 IC50 > 2000.0 nM Inhibition of rat liver FBPase CHEMBL1138458
NAs.001399 7 all-match Hepatocyte NAs.001399 EC50 = 7500.0 nM Inhibition of glucose production in rat primary hepatocytes treated for 15 to 30 mins prior to gluconeogenic substrate dihydroxyacetone addition CHEMBL1138458
NAs.001399 7 all-match Fructose-1,6-bisphosphatase NAs.001399 IC50 = 900.0 nM Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry CHEMBL1138458
NAs.002268 7 all-match Fructose-1,6-bisphosphatase NAs.002268 IC50 = 1500.0 nM Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry CHEMBL1138458
NAs.002268 7 all-match Hepatocyte NAs.002268 EC50 = 18000.0 nM Inhibition of glucose production in rat primary hepatocytes treated for 15 to 30 mins prior to gluconeogenic substrate dihydroxyacetone addition CHEMBL1138458
NAs.002268 7 all-match Fructose-1,6-bisphosphatase NAs.002268 IC50 = 7000.0 nM Inhibition of rat liver FBPase CHEMBL1138458
NAs.002268 7 all-match Fructose-1,6-bisphosphatase NAs.002268 IC50 = 1500.0 nM Inhibition of human liver FBPase 1 CHEMBL1156817
NAs.002268 7 all-match Fructose-1,6-bisphosphatase NAs.002268 IC50 = 800.0 nM Inhibition of human liver FBP CHEMBL1649069
NAs.002418 7 ribose-match Fructose-1,6-bisphosphatase NAs.002418 IC50 > 20000.0 nM Inhibition of rat liver FBPase CHEMBL1138458
NAs.002418 7 ribose-match Fructose-1,6-bisphosphatase NAs.002418 IC50 = 4500.0 nM Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry CHEMBL1138458
NAs.002418 7 ribose-match Hepatocyte NAs.002418 EC50 = 50000.0 nM Inhibition of glucose production in rat primary hepatocytes treated for 15 to 30 mins prior to gluconeogenic substrate dihydroxyacetone addition CHEMBL1138458
NAs.002517 7 all-match Fructose-1,6-bisphosphatase NAs.002517 IC50 = 1600.0 nM Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry CHEMBL1138458