| Compound ID |
Cluster
|
Compound Type
|
Target/Cell | Structure | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.000022 | 8 | ribose-match | Adenosine A1 receptor |  |
Other | = | 8.0 | % | Displacement of [3H]R-PIA from human recombinant adenosine A1 receptor expressed in CHO cells at 10 uM after 60 mins by liquid scintillation counting | CHEMBL2062514 | |
| NAs.000022 | 8 | ribose-match | Adenosine A2a receptor | |
Ki | = | 3110.0 | nM | Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting | CHEMBL2062514 | |
| NAs.000022 | 8 | ribose-match | Adenosine A3 receptor | |
Ki | = | 68.3 | nM | Displacement of [3H]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells after 60 mins by gamma counting | CHEMBL2062514 | |
| NAs.000022 | 8 | ribose-match | Adenosine A3 receptor | |
Other | = | 77.8 | % | Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production at 10 uM incubated for 30 mins prior to forskolin-stimulation measured after 15 mins by enzyme immunoassay relative to NECA | CHEMBL2062514 | |
| NAs.000022 | 8 | ribose-match | Adenosine A2b receptor | |
Other | = | 20.0 | % | Agonist activity at human adenosine A2B receptor by cAMP accumulation assay relative to NECA | CHEMBL2062514 | |
| NAs.000022 | 8 | ribose-match | Adenosine A1 receptor | |
Other | = | 8.0 | % | Displacement of [3H]CGS21680 from mouse adenosine A1 receptor expressed in HEK293 cells at 10 uM after 60 mins by liquid scintillation counting | CHEMBL2062514 | |
| NAs.000022 | 8 | ribose-match | Adenosine A2a receptor | |
Other | = | 64.0 | % | Displacement of [3H]I-AB-MECA from mouse adenosine A2A receptor expressed in HEK293 cells at 10 uM after 60 mins by liquid scintillation counting | CHEMBL2062514 | |
| NAs.000022 | 8 | ribose-match | Adenosine A3 receptor | |
Ki | = | 47.6 | nM | Displacement of [3H]CGS21680 from mouse adenosine A3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting | CHEMBL2062514 | |
| NAs.000022 | 8 | ribose-match | Adenosine A3 receptor | |
EC50 | = | 630.96 | nM | Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as increase in ERK1/2 phosphorylation after 5 mins by alphascreen assay | CHEMBL4371007 | |
| NAs.000022 | 8 | ribose-match | Adenosine A3 receptor | |
Other | = | 107.0 | % | Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as increase in ERK1/2 phosphorylation after 5 mins by alphascreen assay relative to control | CHEMBL4371007 | |
| NAs.000022 | 8 | ribose-match | Adenosine A3 receptor | |
EC50 | = | 199.53 | nM | Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assay | CHEMBL4371007 | |
| NAs.000022 | 8 | ribose-match | Adenosine A3 receptor | |
Other | = | 70.0 | % | Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assay relative to control | CHEMBL4371007 | |
| NAs.000022 | 8 | ribose-match | Adenosine A3 receptor | |
Other | = | 2.6 | None | Ratio of pEC50 EC50 for agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation to pEC50 for agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as increase in ERK1/2 phosphorylation | CHEMBL4371007 | |
| NAs.000022 | 8 | ribose-match | Adenosine A3 receptor | |
EC50 | = | 12.59 | nM | Agonist activity at adenosine A3 receptor (unknown origin) expressed in serum starved CHO cells assessed as increase in cell survival after 24 hrs by propidium iodide staining-based assay | CHEMBL4371007 | |
| NAs.000022 | 8 | ribose-match | Adenosine A3 receptor | |
Other | = | 79.0 | % | Agonist activity at adenosine A3 receptor (unknown origin) expressed in serum starved CHO cells assessed as increase in cell survival after 24 hrs by propidium iodide staining-based assay relative to control | CHEMBL4371007 | |
| NAs.000022 | 8 | ribose-match | Adenosine A3 receptor | |
Other | = | 44.0 | None | Ratio of pEC50 for agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation to pEC50 for agonist activity at adenosine A3 receptor (unknown origin) expressed in serum starved CHO cells assessed as increase in cell survival after 24 hrs by propidium iodide staining-based assay | CHEMBL4371007 | |