| Compound ID |
Cluster
|
Compound Type
|
Target/Cell | Structure | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.000023 | 7 | all-match | Cyclin-dependent kinase 1/cyclin B |  |
Other | = | 0.016 | uM | Inhibition of Cyclin-dependent kinase 1-cyclin B | CHEMBL1133166 | |
| NAs.000023 | 7 | all-match | Mitogen-activated protein kinase 6 | |
Other | = | 2.3 | degrees C | Delta TM value showing the stabilisation of ERK3 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase MST4 | |
Other | = | 2.7 | degrees C | Delta TM value showing the stabilisation of MST4(1) produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase NEK2 | |
Other | = | 1.2 | degrees C | Delta TM value showing the stabilisation of NEK2 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase NEK6 | |
Other | = | 1.1 | degrees C | Delta TM value showing the stabilisation of NEK6 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase OSR1 | |
Other | = | 2.2 | degrees C | Delta TM value showing the stabilisation of OSR1 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase PAK 4 | |
Other | = | 6.4 | degrees C | Delta TM value showing the stabilisation of PAK4 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase PAK7 | |
Other | = | 7.1 | degrees C | Delta TM value showing the stabilisation of PAK5 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase PAK6 | |
Other | = | 7.8 | degrees C | Delta TM value showing the stabilisation of PAK6 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase PCTAIRE-1 | |
Other | = | 2.3 | degrees C | Delta TM value showing the stabilisation of PCTK1 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | 3-phosphoinositide dependent protein kinase-1 | |
Other | = | -0.1 | degrees C | Delta TM value showing the stabilisation of PDK1 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase PIM1 | |
Other | = | 5.0 | degrees C | Delta TM value showing the stabilisation of PIM1 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase PIM2 | |
Other | = | 5.5 | degrees C | Delta TM value showing the stabilisation of PIM2 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase PIM3 | |
Other | = | 8.8 | degrees C | Delta TM value showing the stabilisation of PIM3 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase PLK1 | |
Other | = | 2.2 | degrees C | Delta TM value showing the stabilisation of PLK1 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | MAP kinase ERK1 | |
Other | = | 2.1 | degrees C | Delta TM value showing the stabilisation of ERK1 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase PLK4 | |
Other | = | 1.9 | degrees C | Delta TM value showing the stabilisation of PLK4 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase RIO2 | |
Other | = | 0.0 | degrees C | Delta TM value showing the stabilisation of RIOK2 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Ribosomal protein S6 kinase alpha 3 | |
Other | = | 6.6 | degrees C | Delta TM value showing the stabilisation of RSK2a produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Ribosomal protein S6 kinase alpha 3 | |
Other | = | 2.3 | degrees C | Delta TM value showing the stabilisation of RSK2b produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase 2 | |
Other | = | 6.4 | degrees C | Delta TM value showing the stabilisation of SLK produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase 10 | |
Other | = | 4.9 | degrees C | Delta TM value showing the stabilisation of LOK produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase 16 | |
Other | = | 1.7 | degrees C | Delta TM value showing the stabilisation of MPSK1 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase 17A | |
Other | = | 4.0 | degrees C | Delta TM value showing the stabilisation of DRAK1 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase 38 | |
Other | = | 3.8 | degrees C | Delta TM value showing the stabilisation of NDR1 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase MST4 | |
Other | = | 1.4 | degrees C | Delta TM value showing the stabilisation of MST4 (2) produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase MST1 | |
Other | = | 4.0 | degrees C | Delta TM value showing the stabilisation of MST1 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | TRAF2- and NCK-interacting kinase | |
Other | = | 2.3 | degrees C | Delta TM value showing the stabilisation of TNIK produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | PDZ-binding kinase | |
Other | = | 0.0 | degrees C | Delta TM value showing the stabilisation of PBK produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase VRK1 | |
Other | = | -0.2 | degrees C | Delta TM value showing the stabilisation of VRK1 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Serine/threonine-protein kinase VRK2 | |
Other | = | 0.8 | degrees C | Delta TM value showing the stabilisation of VRK2 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | cAMP-dependent protein kinase alpha-catalytic subunit | |
Other | = | 3.0 | degrees C | Delta TM value showing the stabilisation of PRKACA produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Inactive serine/threonine-protein kinase VRK3 | |
Other | = | -0.1 | degrees C | Delta TM value showing the stabilisation of VRK3 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | MAP kinase p38 beta | |
Other | = | 0.4 | degrees C | Delta TM value showing the stabilisation of p38beta produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Dual specificity mitogen-activated protein kinase kinase 6 | |
Other | = | 0.6 | degrees C | Delta TM value showing the stabilisation of MAP2K6 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Cyclin-dependent kinase 2/cyclin E | |
Other | = | 0.009 | uM | Inhibition of Cyclin-dependent kinase 2-cyclin E | CHEMBL1133166 | |
| NAs.000023 | 7 | all-match | Cyclin-dependent kinase 4/cyclin D | |
Other | = | 0.029 | uM | Inhibition of Cyclin-dependent kinase 4-cyclin D | CHEMBL1133166 | |
| NAs.000023 | 7 | all-match | Unchecked | |
IC50 | = | 25.0 | nM | Inhibition of Cdk1/cyclin B | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Epidermal growth factor receptor erbB1 | |
IC50 | > | 10000.0 | nM | Inhibition of EGFR | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Protein kinase C alpha | |
IC50 | = | 6100.0 | nM | Inhibition of PKCalpha | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Unchecked | |
IC50 | = | 125000.0 | nM | Inhibition of PKA | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | AMP-activated protein kinase, alpha-2 subunit | |
Other | = | 1.4 | degrees C | Delta TM value showing the stabilisation of AMPKA2 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | CaM kinase I delta | |
Other | = | 1.3 | degrees C | Delta TM value showing the stabilisation of CAMK1D produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | CaM kinase I gamma | |
Other | = | 1.1 | degrees C | Delta TM value showing the stabilisation of CAMK1G produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | CaM kinase II alpha | |
Other | = | 0.8 | degrees C | Delta TM value showing the stabilisation of CAMK2A produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | CaM kinase II beta | |
Other | = | -0.1 | degrees C | Delta TM value showing the stabilisation of CAMK2B produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | CaM kinase II delta | |
Other | = | -0.8 | degrees C | Delta TM value showing the stabilisation of CAMK2D produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | CaM kinase II gamma | |
Other | = | 1.2 | degrees C | Delta TM value showing the stabilisation of CAMK2G produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | CaM kinase IV | |
Other | = | 1.8 | degrees C | Delta TM value showing the stabilisation of CAMK4 produced by compound binding | CHEMBL1145498 | |
| NAs.000023 | 7 | all-match | Mitogen-activated protein kinase kinase kinase 5 | |
Other | = | 0.1 | degrees C | Delta TM value showing the stabilisation of ASK1 produced by compound binding | CHEMBL1145498 | |