| Compound ID |
Cluster
|
Compound Type
|
Target/Cell | Structure | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.000040 | 7 | ribose-match | Adenosine A1 receptor |  |
Ki | = | 840.0 | nM | Binding affinity against adenosine A1 receptor from rat brain. | CHEMBL1128362 | |
| NAs.000040 | 7 | ribose-match | Adenosine A2a receptor | |
Ki | = | 11600.0 | nM | Binding affinity against adenosine A2A receptor from rat brain. | CHEMBL1128362 | |
| NAs.000040 | 7 | ribose-match | Adenosine A3 receptor | |
Ki | = | 166000.0 | nM | Binding affinity against adenosine A3 receptor from rat brain. | CHEMBL1128362 | |
| NAs.000040 | 7 | ribose-match | Adenosine receptors; A1 & A3 | |
Other | = | 0.0051 | None | Ratio of the binding affinities against rat brain A1 and A3 receptors, KiA1/KiA3. | CHEMBL1128362 | |
| NAs.000040 | 7 | ribose-match | Adenosine receptor A2a and A3 | |
Other | = | 0.07 | None | Ratio of the binding affinities against rat brain A2a and A3 receptors, KiA2a/KiA3. | CHEMBL1128362 | |
| NAs.000336 | 7 | all-match | Adenosine A1 receptor |  |
Ki | = | 1890.0 | nM | Binding affinity against adenosine A1 receptor from rat brain. | CHEMBL1128362 | |
| NAs.000336 | 7 | all-match | Adenosine A2a receptor | |
Ki | = | 1640.0 | nM | Binding affinity against adenosine A2A receptor from rat brain. | CHEMBL1128362 | |
| NAs.000336 | 7 | all-match | Adenosine A3 receptor | |
Ki | = | 299.0 | nM | Binding affinity against adenosine A3 receptor from rat brain. | CHEMBL1128362 | |
| NAs.000336 | 7 | all-match | Adenosine A3 receptor | |
Other | = | 19.5 | % | Ability to inhibit the adenylyl cyclase in CHO cells stably transfected with rat Adenosine A3 receptor at the concentration of 100 uM | CHEMBL1128362 | |
| NAs.000336 | 7 | all-match | Adenosine A3 receptor | |
Other | = | 0.0 | None | Agonist elicited inhibition of adenylyl cyclase via rat Adenosine A3 receptor in transfected CHO cells and effect on IB-MECA was determined from dose response curves at the concentration of 100(uM) | CHEMBL1128362 | |
| NAs.000336 | 7 | all-match | Adenosine receptors; A1 & A3 | |
Other | = | 6.3 | None | Ratio of the binding affinities against rat brain A1 and A3 receptors, KiA1/KiA3. | CHEMBL1128362 | |
| NAs.000336 | 7 | all-match | Adenosine receptor A2a and A3 | |
Other | = | 5.5 | None | Ratio of the binding affinities against rat brain A2a and A3 receptors, KiA2a/KiA3. | CHEMBL1128362 | |
| NAs.000336 | 7 | all-match | Adenosine A3 receptor | |
Other | = | 330.0 | None | Ratio of the concentration (100 uM) effecting adenylyl cyclase and binding affinity against rat brain A3 receptors. | CHEMBL1128362 | |
| NAs.000517 | 7 | all-match | Adenosine receptor A2a and A3 |  |
Other | = | 0.046 | None | Ratio of the binding affinities against rat brain A2a and A3 receptors, KiA2a/KiA3. | CHEMBL1128362 | |
| NAs.000517 | 7 | all-match | Adenosine receptors; A1 & A3 | |
Other | = | 0.12 | None | Ratio of the binding affinities against rat brain A1 and A3 receptors, KiA1/KiA3. | CHEMBL1128362 | |
| NAs.000517 | 7 | all-match | Adenosine A1 receptor | |
Ki | = | 5730.0 | nM | Binding affinity against adenosine A1 receptor from rat brain. | CHEMBL1128362 | |
| NAs.000517 | 7 | all-match | Adenosine A2a receptor | |
Ki | = | 2230.0 | nM | Binding affinity against adenosine A2A receptor from rat brain. | CHEMBL1128362 | |
| NAs.000517 | 7 | all-match | Adenosine A3 receptor | |
Ki | = | 48300.0 | nM | Binding affinity against adenosine A3 receptor from rat brain. | CHEMBL1128362 | |
| NAs.000521 | 7 | all-match | Adenosine A1 receptor |  |
Ki | = | 500.0 | nM | Binding affinity against adenosine A1 receptor from rat brain. | CHEMBL1128362 | |
| NAs.000521 | 7 | all-match | Adenosine A2a receptor | |
Ki | = | 1240.0 | nM | Binding affinity against adenosine A2A receptor from rat brain. | CHEMBL1128362 | |
| NAs.000521 | 7 | all-match | Adenosine A3 receptor | |
Ki | = | 18300.0 | nM | Binding affinity against adenosine A3 receptor from rat brain. | CHEMBL1128362 | |
| NAs.000521 | 7 | all-match | Adenosine receptors; A1 & A3 | |
Other | = | 0.027 | None | Ratio of the binding affinities against rat brain A1 and A3 receptors, KiA1/KiA3. | CHEMBL1128362 | |
| NAs.000521 | 7 | all-match | Adenosine receptor A2a and A3 | |
Other | = | 0.068 | None | Ratio of the binding affinities against rat brain A2a and A3 receptors, KiA2a/KiA3. | CHEMBL1128362 | |
| NAs.001290 | 8 | all-match | Adenosine receptors; A1 & A3 |  |
Other | = | 0.0088 | None | Ratio of the binding affinities against rat brain A1 and A3 receptors, KiA1/KiA3. | CHEMBL1128362 | |
| NAs.001290 | 8 | all-match | Adenosine A1 receptor | |
Ki | = | 450.0 | nM | Binding affinity against adenosine A1 receptor from rat brain. | CHEMBL1128362 | |
| NAs.001290 | 8 | all-match | Adenosine A2a receptor | |
Ki | = | 2700.0 | nM | Binding affinity against adenosine A2A receptor from rat brain. | CHEMBL1128362 | |
| NAs.001290 | 8 | all-match | Adenosine A3 receptor | |
Ki | = | 51000.0 | nM | Binding affinity against adenosine A3 receptor from rat brain. | CHEMBL1128362 | |
| NAs.001290 | 8 | all-match | Adenosine receptor A2a and A3 | |
Other | = | 0.053 | None | Ratio of the binding affinities against rat brain A2a and A3 receptors, KiA2a/KiA3. | CHEMBL1128362 | |