Showing 1 to 50 of 126 entries Per page:
Compound ID
Cluster
Compound Type
Target/Cell Structure Activity Assay Description Source
Type
Relation
Value
Unit
NAs.000046 2 all-match Adenosine A1 receptor NAs.000046 Other = 42.8 % Ability to displace [3H]DPCPX from Adenosine A1 receptor in rat cortical membrane at 10e-5 M CHEMBL1135807
NAs.000046 2 all-match Adenosine A2a receptor NAs.000046 Ki = 3900.0 nM Binding affinity at Adenosine A2A receptor in rat striatal membrane by [3H]ZM-241385 displacement. CHEMBL1135807
NAs.000046 2 all-match Adenosine A3 receptor NAs.000046 Ki = 257.0 nM Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]-AB MECA displacement. CHEMBL1135807
NAs.000046 2 all-match Adenosine A2a receptor NAs.000046 Other = 100.0 % Maximum level of G-protein activation (Emax) compared to CGS 21680 through Adenosine A2A receptor in CHO cells using cAMP assay CHEMBL1135807
NAs.000046 2 all-match Adenosine A3 receptor NAs.000046 Other = 41.0 % % inhibition of forskolin induced (10 uM) cAMP production compared to C1-IB-MECA through Adenosine A3 receptor expressed in CHO cells at 30 uM CHEMBL1135807
NAs.000046 2 all-match Trypanosoma brucei rhodesiense NAs.000046 IC50 = 5000.0 nM Antitrypanosomal activity against bloodstream forms of Trypanosoma brucei rhodesiense STIB900 trypomastigotes after 72 hrs by alamar blue assay CHEMBL3997846
NAs.000046 2 all-match Unchecked NAs.000046 Other = 27.0 None Selectivity index, ratio of IC50 for rat L6 cells to IC50 for bloodstream forms of Trypanosoma brucei rhodesiense STIB900 trypomastigotes CHEMBL3997846
NAs.000046 2 all-match Trypanosoma cruzi NAs.000046 IC50 = 88000.0 nM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen strain C2C4 amastigote forms harboring LacZ infected in rat L6 cells after 96 hrs by CPRG/Nonidet reagent based photometric method CHEMBL3997846
NAs.000046 2 all-match Unchecked NAs.000046 Other = 2.0 None Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma cruzi Tulahuen strain C2C4 amastigote forms harboring LacZ infected in rat L6 cells CHEMBL3997846
NAs.000046 2 all-match Leishmania donovani NAs.000046 IC50 = 132000.0 nM Antileishmanial activity against Leishmania donovani MHOM/SD/62/ISCL2D axenic amastigotes after 72 hrs by alamar blue assay CHEMBL3997846
NAs.000046 2 all-match Unchecked NAs.000046 Other = 1.0 None Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Leishmania donovani MHOM/SD/62/ISCL2D axenic amastigotes CHEMBL3997846
NAs.000055 2 all-match Adenosine A2a receptor NAs.000055 EC50 = 700.0 nM G-protein activation in human Adenosine A2A receptor expressed in CHO cells using cAMP assay CHEMBL1135807
NAs.000055 2 all-match Adenosine A2a receptor NAs.000055 Other = 45.0 % Maximum level of G-protein activation (Emax) compared to CGS 21680 through Adenosine A2A receptor expressed in CHO cells using cAMP assay CHEMBL1135807
NAs.000055 2 all-match Adenosine A3 receptor NAs.000055 Other = 72.0 % Percent inhibition of forskolin induced (10 uM) cAMP production compared to C1-IB-MECA through Adenosine A3 receptor expressed in CHO cells at 3 uM CHEMBL1135807
NAs.000055 2 all-match Adenosine A2a receptor NAs.000055 Ki = 60.0 nM Binding affinity at Adenosine A2A receptor in rat striatal membrane by [3H]ZM-241385 displacement. CHEMBL1135807
NAs.000055 2 all-match Adenosine A1 receptor NAs.000055 Other = 35.9 % Ability to displace [3H]DPCPX from Adenosine A1 receptor in rat cortical membrane at 10e-5 M CHEMBL1135807
NAs.000055 2 all-match Adenosine A3 receptor NAs.000055 Ki = 14.5 nM Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]-AB MECA displacement. CHEMBL1135807
NAs.000056 2 all-match S-methyl-5-thioadenosine phosphorylase NAs.000056 Other = 106000.0 nM Km against human methylthioadenosine phosphorylase expressed in Escherichia coli BL21 DE3 cells CHEMBL1139590
NAs.000056 2 all-match S-methyl-5-thioadenosine phosphorylase NAs.000056 Other = 0.0065 1/sec Kcat against human methylthioadenosine phosphorylase expressed in Escherichia coli BL21 DE3 cells CHEMBL1139590
NAs.000056 2 all-match S-methyl-5-thioadenosine phosphorylase NAs.000056 Other = 5000.0 nM Km for human MTAP CHEMBL1140320
NAs.000056 2 all-match Adenosylhomocysteinase NAs.000056 Other = 48.0 % Percentage enzyme activity remaining was measured by the inhibition S-adenosyl-L-homocysteine hydrolase from bovine liver at 1 uM CHEMBL1125934
NAs.000056 2 all-match Adenosylhomocysteinase NAs.000056 Other = 66.0 % Percentage enzyme activity remaining was measured by the inhibition S-adenosyl-L-homocysteine hydrolase from bovine liver at 100 uM CHEMBL1125934
NAs.000056 2 all-match Adenosylhomocysteinase NAs.000056 Other = 86.0 % Percentage enzyme activity remaining was measured by the inhibition S-adenosyl-L-homocysteine hydrolase from bovine liver at 0.1 uM CHEMBL1125934
NAs.000056 2 all-match Adenosylhomocysteinase NAs.000056 Other = 101.0 % Percentage enzyme activity remaining was measured by the inhibition S-adenosyl-L-homocysteine hydrolase from bovine liver at 0.01 uM CHEMBL1125934
NAs.000056 2 all-match L5178Y NAs.000056 Other = 0.43 None Effect of compound on spermine(SPM) polyamine pool in L5178Y murine leukemia cells expressed in terms of nmol/10e6 cells CHEMBL1125934
NAs.000056 2 all-match L5178Y NAs.000056 Other = 1.85 None Effect of compound on putrescine(PUT) polyamine pool in L5178Y murine leukemia cells expressed as nmol/10e6 cells CHEMBL1125934
NAs.000056 2 all-match L1210 NAs.000056 Other = 0.19 None Effect of compound on spermine(SPM) polyamine pool in L1210 murine leukemia cells expressed in terms of nmol/10e6 cells CHEMBL1125934
NAs.000056 2 all-match L1210 NAs.000056 Other = 1.22 None Effect of compound on spermidine(SPD) polyamine pool in L1210 murine leukemia cells expressed in terms of nmol/10e6 cells CHEMBL1125934
NAs.000056 2 all-match L1210 NAs.000056 Other = 1.93 None Effect of compound on putrescine(PUT) polyamine pool in L1210 murine leukemia cells expressed in terms of nmol/10e6 cells CHEMBL1125934
NAs.000056 2 all-match MOLT-4 NAs.000056 IC50 = 11000.0 nM The concentration required to inhibit cell growth by 50% was measured on human MOLT-4 cells (96h after exposure) CHEMBL1125934
NAs.000056 2 all-match S-methyl-5-thioadenosine phosphorylase NAs.000056 Other = 0.0001 1/uM*sec Ratio of Kcat to Km against human Methylthioadenosine phosphorylase CHEMBL1139590
NAs.000056 2 all-match L5178Y NAs.000056 Other = 2.79 None Effect of compound on spermidine(SPD) polyamine pool in L5178Y murine leukemia cells expressed in terms of nmol/10e6 cells CHEMBL1125934
NAs.000056 2 all-match S-methyl-5-thioadenosine phosphorylase NAs.000056 Other = 4.6 1/sec Kcat against human methylthioadenosine phosphorylase expressed in Escherichia coli BL21 DE3 cells CHEMBL1139590
NAs.000056 2 all-match Trypanosoma brucei brucei NAs.000056 IC50 = 100000.0 nM Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei LAB 110 EATRO after 48 hrs by Z1 zoulter counter CHEMBL1151452
NAs.000056 2 all-match S-methyl-5-thioadenosine phosphorylase NAs.000056 Other = 3.2 1/uM*sec Ratio of Kcat to Km against human Methylthioadenosine phosphorylase CHEMBL1139590
NAs.000056 2 all-match PRMT5/MEP50 complex NAs.000056 Other = 661.0 nM Inhibition of streptavidin sensor chip immobilized biotinylated human PRMT5/MEP50 assessed as dissociation constant by SPR analysis CHEMBL5046262
NAs.000056 2 all-match Unchecked NAs.000056 Other None None % Inhibition of protein kinase in human HuH7 cells assessed as increase in ATP level at 5 uM after 72 hrs by Kinase-Glo assay CHEMBL2040791
NAs.000056 2 all-match Unchecked NAs.000056 Other = 100.0 % Activity at mouse liver 5'-deoxy-5'-(methylthio)-adenosine phosphorylase CHEMBL1151452
NAs.000056 2 all-match Unchecked NAs.000056 Other = 100.0 % Activity at bloodstream Trypanosoma brucei brucei 5'-deoxy-5'-(methylthio)-adenosine phosphorylase by spectrophotometry relative to control CHEMBL1151452
NAs.000056 2 all-match Unchecked NAs.000056 Other = 100.0 % Activity at bloodstream Trypanosoma brucei brucei 5'-deoxy-5'-(methylthio)-adenosine phosphorylase by spectrophotometry in presence of 50 mM PO4- relative to control CHEMBL1151452
NAs.000056 2 all-match Trypanosoma brucei brucei NAs.000056 IC50 None None None Antitrypanosomal activity against diamidine and melarsoprol-resistant bloodstream form of Trypanosoma brucei brucei isolate KETRI 243-As10-3 after 48 hrs by Z1 zoulter counter CHEMBL1151452
NAs.000056 2 all-match Trypanosoma brucei brucei NAs.000056 IC50 None None None Antitrypanosomal activity against pentamidine-resistant bloodstream form of Trypanosoma brucei brucei isolate KETRI 269 after 48 hrs by Z1 zoulter counter CHEMBL1151452
NAs.000056 2 all-match Trypanosoma brucei brucei NAs.000056 IC50 None None None Antitrypanosomal activity against pentamidine and melarsoprol-resistant bloodstream form of Trypanosoma brucei brucei isolate KETRI 243 after 48 hrs by Z1 zoulter counter CHEMBL1151452
NAs.000056 2 all-match CCRF-CEM NAs.000056 IC50 = 150000.0 nM The concentration required to inhibit cell growth by 50% was measured on human CCRF-CEM cells (96h after exposure) CHEMBL1125934
NAs.000056 2 all-match Spermidine synthase NAs.000056 IC50 = 159000.0 nM Inhibition of Plasmodium falciparum spermidine synthase CHEMBL1150259
NAs.000056 2 all-match 5-methylthioadenosine/S-adenosylhomocysteine deaminase NAs.000056 Other = 1.5 10^5/M/s Ratio of Kcat to Km for Thermotoga maritima S-adenosyl-homocysteine deaminase Tm0936 assessed as ammonia production CHEMBL1145524
NAs.000056 2 all-match 5-methylthioadenosine/S-adenosylhomocysteine deaminase NAs.000056 Other = 7.2 /s Activity of Thermotoga maritima S-adenosyl-homocysteine deaminase Tm0936 assessed as ammonia production CHEMBL1145524
NAs.000056 2 all-match 5-methylthioadenosine/S-adenosylhomocysteine deaminase NAs.000056 Other = 44000.0 nM Activity of Thermotoga maritima S-adenosyl-homocysteine deaminase Tm0936 assessed as ammonia production CHEMBL1145524
NAs.000056 2 all-match Unchecked NAs.000056 Other None None None Inhibition of M.HhaI DNA methyltransferase expressed in ER1727 cells at 15 uM after 30 mins CHEMBL1142331
NAs.000056 2 all-match Unchecked NAs.000056 Other None None None Inhibition of Escherichia coli DNA methyltransferase at 15 uM after 30 mins CHEMBL1142331