| Compound ID |
Cluster
|
Compound Type
|
Target/Cell | Structure | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.000049 | 8 | ribose-match | Adenosine A1 receptor |  |
Other | = | 24.0 | % | Activity at human A1 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production at 10 uM after 30 min | CHEMBL2169760 | |
| NAs.000049 | 8 | ribose-match | Adenosine A3 receptor | |
Ki | = | 550.0 | nM | Displacement of [125I]I-AB-MECA from human A3 adenosine receptor expressed in CHO cells after 60 min Packard Cobra 2 gamma-counter | CHEMBL2169760 | |
| NAs.000049 | 8 | ribose-match | Adenosine A2a receptor | |
Ki | = | 2550.0 | nM | Displacement of [3H]CGS21680 from human A2a adenosine receptor expressed in HEK293 cells after 60 min by Perkin Elmer Liquid Scintillation Analyzer | CHEMBL2169760 | |
| NAs.000049 | 8 | ribose-match | Adenosine A1 receptor | |
Ki | = | 170.0 | nM | Displacement of [3H]R-PIA from human A1 adenosine receptor expressed in CHO cells after 60 min by Perkin Elmer Liquid Scintillation Analyzer | CHEMBL2169760 | |
| NAs.000049 | 8 | ribose-match | Human enterovirus 71 | |
EC50 | = | 18000.0 | nM | Antiviral activity against Enterovirus 71 Tainin/4643/98 infected in Vero 76 cells assessed as reduction in virus yield incubated for 72 hrs by visual inspection method | CHEMBL4699557 | |
| NAs.000049 | 8 | ribose-match | Vero 76 | |
CC50 | > | 50000.0 | nM | Cytotoxicity against monkey Vero 76 cells by microscopic analysis | CHEMBL4699557 | |
| NAs.000049 | 8 | ribose-match | Unchecked | |
Ratio CC50/EC50 | > | 2.8 | None | Selectivity index, ratio for CC50 of monkey Vero 76 cells to EC50 for Enterovirus 71 Tainin/4643/98 by visual inspection method | CHEMBL4699557 | |
| NAs.000049 | 8 | ribose-match | Human enterovirus 71 | |
EC50 | > | 7600.0 | nM | Antiviral activity against Enterovirus 71 Tainin/4643/98 infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect incubated for 72 hrs by neutral red uptake assay | CHEMBL4699557 | |
| NAs.000049 | 8 | ribose-match | Vero 76 | |
CC50 | = | 7600.0 | nM | Cytotoxicity against monkey Vero 76 cells by neutral red uptake assay | CHEMBL4699557 | |
| NAs.000049 | 8 | ribose-match | Unchecked | |
Ratio CC50/EC50 | None | None | None | Selectivity index, ratio for CC50 of monkey Vero 76 cells to EC50 for Enterovirus 71 Tainin/4643/98 by neutral red uptake assay | CHEMBL4699557 | |