| Compound ID |
Cluster
|
Compound Type
|
Target/Cell | Structure | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.000053 | 7 | ribose-match | PI3-kinase p110-alpha/p85-alpha |  |
IC50 | > | 1000.0 | nM | Inhibition of full length recombinant human His-tagged p110 alpha/p85 alpha expressed in baculovirus expression system incubated for 1 hr by kinase-glo assay | CHEMBL3826921 | |
| NAs.000053 | 7 | ribose-match | Histone deacetylase 1 | |
IC50 | = | 0.97 | nM | Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC as substrate assessed as release of AMC preincubated for 15 mins followed by substrate addition measured after 1 hr by fluorescence assay | CHEMBL3826921 | |
| NAs.000053 | 7 | ribose-match | MV4-11 | |
IC50 | = | 4.09 | nM | Cytotoxicity against human MV4-11 cells assessed as growth inhibition after 24 hrs by MTT assay | CHEMBL3826921 | |
| NAs.000053 | 7 | ribose-match | NON-PROTEIN TARGET | |
IC50 | = | 18.48 | nM | Cytotoxicity against human A2780S cells assessed as growth inhibition after 24 hrs by MTT assay | CHEMBL3826921 | |
| NAs.000053 | 7 | ribose-match | NON-PROTEIN TARGET | |
IC50 | = | 9.25 | nM | Cytotoxicity against human HCT116 cells assessed as growth inhibition after 24 hrs by MTT assay | CHEMBL3826921 | |