Showing 1 to 50 of 119 entries Per page:
Compound ID
Cluster
Compound Type
Target/Cell Structure Activity Assay Description Source
Type
Relation
Value
Unit
NAs.000061 8 all-match Adenosine A3 receptor NAs.000061 IC50 = 1.0 nM Inhibitory concentration against human Adenosine A3 receptor mediated inhibition of cyclic AMP in transfected CHO cells CHEMBL1145992
NAs.000061 8 all-match Adenosine A3 receptor NAs.000061 Other = 100.0 % Maximal agonistic effect at human adenosine A3 receptor in CHO cells at 10 uM by inhibition of forskolin-stimulated cAMP production CHEMBL1148606
NAs.000061 8 all-match Adenosine A2a receptor NAs.000061 Ki = 158.0 nM Displacement of [3H]CGS-21680 from human adenosine A2A receptor transfected in HEK293 cells CHEMBL1148606
NAs.000061 8 all-match Adenosine A1 receptor NAs.000061 Ki = 89.2 nM Displacement of [3H]R-PIA from human adenosine A1 receptor transfected in CHO cells CHEMBL1148606
NAs.000061 8 all-match Adenosine A3 receptor NAs.000061 Ki = 0.4 nM Binding affinity for human Adenosine A3 receptor in CHO cells using [125I]-iodo-AB-MECA CHEMBL1145992
NAs.000061 8 all-match Adenosine A3 receptor NAs.000061 Ki = 0.4 nM Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cells CHEMBL1148606
NAs.000061 8 all-match Adenosine A2a receptor NAs.000061 Ki = 158.0 nM Binding affinity for human adenosine A2A receptor in CHO cells using [3H]CGS-21680 CHEMBL1145992
NAs.000061 8 all-match Adenosine A1 receptor NAs.000061 Ki = 294.0 nM Binding affinity for rat Adenosine A1 receptor in CHO cells using [3H]N6-(R)-phenylisopropyladenosine CHEMBL1145992
NAs.000061 8 all-match Adenosine A1 receptor NAs.000061 Ki = 89.2 nM Binding affinity for human Adenosine A1 receptor in CHO cells using [3H]N6-(R)-phenylisopropyladenosine CHEMBL1145992
NAs.000061 8 all-match Adenosine A2a receptor NAs.000061 Other < 10.0 % Percent displacement of [3H]-CGS-21,680 from rat adenosine A2A receptor expressed in CHO cells at 1 uM CHEMBL1145992
NAs.000697 8 all-match Adenosine A3 receptor NAs.000697 Other = 119.0 % Maximal agonistic effect at human adenosine A3 receptor in CHO cells at 10 uM by inhibition of forskolin-stimulated cAMP production CHEMBL1148606
NAs.000697 8 all-match Adenosine A3 receptor NAs.000697 Ki = 0.28 nM Binding affinity to human adenosine A3 receptor CHEMBL1153082
NAs.000697 8 all-match Adenosine A2a receptor NAs.000697 Other = 20.0 % Displacement of [3H]CGS21680 from human adenosine A2A receptor expressed in CHO cells at 1 uM CHEMBL1153082
NAs.000697 8 all-match Adenosine A1 receptor NAs.000697 Ki = 1330.0 nM Displacement of [3H]R-PIA from human adenosine A1 receptor expressed in CHO cells CHEMBL1153082
NAs.000697 8 all-match Adenosine A3 receptor NAs.000697 Ki = 0.28 nM Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells CHEMBL1153082
NAs.000697 8 all-match Adenosine A2a receptor NAs.000697 Other = 20.0 % Inhibition of [3H]CGS-21680 binding to human adenosine A2A receptor transfected in HEK293 cells at 10 uM CHEMBL1148606
NAs.000697 8 all-match Adenosine A3 receptor NAs.000697 Ki = 0.28 nM Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cells CHEMBL1148606
NAs.000697 8 all-match Adenosine A3 receptor NAs.000697 Other None None None Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation CHEMBL1153082
NAs.000697 8 all-match Adenosine A3 receptor NAs.000697 Ki = 0.28 nM Binding affinity for human Adenosine A3 receptor in CHO cells using [125I]-iodo-AB-MECA CHEMBL1145992
NAs.000697 8 all-match Adenosine A2a receptor NAs.000697 Ki = 6340.0 nM Binding affinity for rat adenosine A2A receptor of CHO cells using [3H]CGS-21680 CHEMBL1145992
NAs.000697 8 all-match Adenosine A2a receptor NAs.000697 Ki = 20.0 nM Percent displacement of [3H]CGS-21680 from human adenosine A2A receptor expressed in CHO cells at 10 uM CHEMBL1145992
NAs.000697 8 all-match Adenosine A1 receptor NAs.000697 Ki = 198.0 nM Binding affinity for rat Adenosine A1 receptor in CHO cells using [3H]N6-(R)-phenylisopropyladenosine CHEMBL1145992
NAs.000697 8 all-match Adenosine A1 receptor NAs.000697 Ki = 1330.0 nM Binding affinity for human Adenosine A1 receptor in CHO cells using [3H]N6-(R)-phenylisopropyladenosine CHEMBL1145992
NAs.000697 8 all-match Adenosine A3 receptor NAs.000697 IC50 = 0.4 nM Inhibitory concentration against human Adenosine A3 receptor mediated inhibition of cyclic AMP in transfected CHO cells CHEMBL1145992
NAs.000697 8 all-match Adenosine A1 receptor NAs.000697 Ki = 1330.0 nM Displacement of [3H]R-PIA from human adenosine A1 receptor transfected in CHO cells CHEMBL1148606
NAs.000723 8 ribose-match Peroxisome proliferator-activated receptor delta NAs.000723 Ki = 0.16 nM Displacement of Fluormone-Pan-PPAR Green from human GST-tagged PPARdelta LBD by TR-FRET assay CHEMBL4017496
NAs.000723 8 ribose-match Unchecked NAs.000723 Other = 738.0 pg/ml Induction of adipogenesis in human bone marrow-derived mesenchymal stem cells assessed as adiponectin level at 20 uM measured on day 7 after 48 hrs by ELISA CHEMBL4017496
NAs.000723 8 ribose-match Unchecked NAs.000723 Other None None % Antimigratory activity in Sprague-Dawley rat microglial cells assessed as inhibition of MCP-1 mediated cell migration at 100 nM after 20 mins by inverted confocal microscopy CHEMBL4007510
NAs.000723 8 ribose-match Unchecked NAs.000723 Other None None None Cytotoxicity against Sprague-Dawley rat microglial cells assessed as effect on cell viability up to 50 uM after 24 hrs by presto blue assay CHEMBL4007510
NAs.000723 8 ribose-match Adenosine A3 receptor NAs.000723 Other None None None Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation CHEMBL1153082
NAs.000723 8 ribose-match Adenosine A3 receptor NAs.000723 Ki = 0.38 nM Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed CHO cells after 60 mins by gamma counting CHEMBL1250540
NAs.000723 8 ribose-match Peroxisome proliferator-activated receptor gamma NAs.000723 Ki = 4.6 nM Displacement of Fluormone-Pan-PPAR Green from human GST-tagged PPARgamma LBD by TR-FRET assay CHEMBL4017496
NAs.000723 8 ribose-match Adenosine receptors; A1 & A3 NAs.000723 Other = 508.0 None Selectivity for human adenosine A3 receptor over human adenosine A1 receptor CHEMBL1153082
NAs.000723 8 ribose-match Adenosine A3 receptor NAs.000723 Ki = 0.38 nM Binding affinity to human adenosine A3 receptor CHEMBL1153082
NAs.000723 8 ribose-match Adenosine A3 receptor NAs.000723 Ki = 0.38 nM Binding affinity to human adenosine A3 receptor CHEMBL1944553
NAs.000723 8 ribose-match Peroxisome proliferator-activated receptor alpha NAs.000723 Other = 37.8 % Displacement of Fluormone-Pan-PPAR Green from human GST-tagged PPARalpha LBD at 20 uM by TR-FRET assay relative to control CHEMBL4017496
NAs.000723 8 ribose-match Adenosine A3 receptor NAs.000723 Ki = 0.38 nM Displacement of [125I]I-AB-MECA from human A3 adenosine receptor expressed in CHO cell membranes after 60 mins by gamma counting method CHEMBL4017496
NAs.000723 8 ribose-match Adenosine A1 receptor NAs.000723 Ki = 193.0 nM Displacement of [3H]CCPA from human A1 receptor expressed in CHO cell membranes after 60 mins by gamma counting method CHEMBL4017496
NAs.000723 8 ribose-match Peroxisome proliferator-activated receptor alpha NAs.000723 Other None None None Binding affinity to GST-tagged human PPARalpha LBD up to 30 uM incubated for 2 to 6 hrs by TR-FRET assay CHEMBL4610002
NAs.000723 8 ribose-match Unchecked NAs.000723 EC50 = 20800.0 nM Induction of adipogenesis in human MSC incubated for 5 days cotreated with IDX by ELISA CHEMBL4610002
NAs.000723 8 ribose-match Peroxisome proliferator-activated receptor gamma NAs.000723 EC50 = 4640.0 nM Competitive binding affinity to GST-tagged human PPARgamma LBD incubated for 1 to 6 hrs by TR-FRET assay CHEMBL4610002
NAs.000723 8 ribose-match Peroxisome proliferator-activated receptor delta NAs.000723 EC50 = 41.1 nM Competitive binding affinity to GST-tagged human PPARdelta LBD incubated for 1 to 6 hrs by TR-FRET assay CHEMBL4610002
NAs.000723 8 ribose-match Peroxisome proliferator-activated receptor gamma NAs.000723 Other < 50.0 % Partial agonist at PPARgamma LBD (unknown origin) assessed as increase in recruitment of coactivator peptide C33 by TR-FRET assay relative to control CHEMBL4610002
NAs.000723 8 ribose-match Peroxisome proliferator-activated receptor delta NAs.000723 EC50 = 16700.0 nM Antagonist activity at PPARdelta LBD (unknown origin) assessed as increase in recruitment of SMRT ID2 corepressor peptide by TR-FRET assay CHEMBL4610002
NAs.000723 8 ribose-match Peroxisome proliferator-activated receptor delta NAs.000723 EC50 = 10700.0 nM Antagonist at PPARdelta LBD (unknown origin) assessed as increase in recruitment of coactivator peptide C33 cotreated with PPARdelta agonist GW501516 by TR-FRET assay CHEMBL4610002
NAs.000723 8 ribose-match Peroxisome proliferator-activated receptor gamma NAs.000723 Other None None None Partial agonist activity at PPARgamma LBD (unknown origin) assessed as increase in recruitment of coactivator peptide C33 by TR-FRET assay CHEMBL4610002
NAs.000723 8 ribose-match Adenosine A1 receptor NAs.000723 Ki = 193.0 nM Displacement of [3H]R-PIA from human adenosine A1 receptor expressed in CHO cells CHEMBL1153082
NAs.000723 8 ribose-match Adenosine A2a receptor NAs.000723 Ki = 223.0 nM Displacement of [3H]CGS21680 from human A2A adenosine receptor expressed in HEK293 cell membranes after 60 mins by gamma counting method CHEMBL4017496
NAs.000723 8 ribose-match Adenosine A2a receptor NAs.000723 Ki = 223.0 nM Displacement of [3H]CGS21680 from human adenosine A2A receptor expressed in CHO cells CHEMBL1153082
NAs.000723 8 ribose-match Unchecked NAs.000723 Other = 131.0 pg/ml Induction of adipogenesis in human bone marrow-derived mesenchymal stem cells assessed as adiponectin level at 4 uM measured on day 7 after 48 hrs by ELISA CHEMBL4017496