Showing 1 to 19 of 19 entries Per page:
Compound ID
Cluster
Compound Type
Target/Cell Structure Activity Assay Description Source
Type
Relation
Value
Unit
NAs.000062 2 all-match Adenosine A1 receptor NAs.000062 Ki = 217.0 nM Binding affinity against adenosine A1 receptor from rat brain membranes using [3H]cyclohexyladenosine as radioligand. CHEMBL1125505
NAs.000062 2 all-match Adenosine A2 receptor NAs.000062 Ki = 5.2 nM Binding affinity against adenosine A2 receptor from rat striatum using [3H]NECA as radioligand. CHEMBL1125505
NAs.000062 2 all-match Rattus norvegicus NAs.000062 Other > 3.0 ug kg-1 Dose producing 30% decrease in blood pressure of anesthetized spontaneously hypertensive rats (SHR's) CHEMBL1125505
NAs.000062 2 all-match Rattus norvegicus NAs.000062 Other > 3.0 ug kg-1 Dose producing 10% decrease in heart rate of anesthetized spontaneously hypertensive rats (SHR's) CHEMBL1125505
NAs.000062 2 all-match Adenosine receptors; A1 & A2 NAs.000062 Other = 42.0 None Selectivity determined as Ratio of Ki(nM) of A1 adenosine receptor to the Ki(nM) of A2 adenosine receptor CHEMBL1125505
NAs.001979 2 all-match Adenosine A1 receptor NAs.001979 Ki = 74.0 nM Binding affinity for adenosine A1 receptor as inhibition of 3[H]-R-PIA binding in rat brain CHEMBL1130877
NAs.001979 2 all-match Adenosine A2a receptor NAs.001979 Ki = 4650.0 nM Binding affinity for adenosine A2a receptor as inhibition of 3[H]-CGS 21680 binding in rat striatum CHEMBL1130877
NAs.001979 2 all-match Adenosine A3 receptor NAs.001979 Ki = 26.0 nM Binding affinity for adenosine A3 receptor as inhibition of [125I]AB-MECA binding to human receptor expressed in HEK 293 cells CHEMBL1130877
NAs.002486 2 ribose-match Rattus norvegicus NAs.002486 Other = 0.1 mg kg-1 Cardiovascular activity (as 20% decrease in blood pressure). CHEMBL1123411
NAs.002486 2 ribose-match Rattus norvegicus NAs.002486 Other = 0.08 mg kg-1 Cardiovascular activity (as 20% decrease in rate). CHEMBL1123411
NAs.002486 2 ribose-match Mus musculus NAs.002486 Other = 100.0 mg kg-1 CNS activity measured using screen test failure CHEMBL1123411
NAs.002486 2 ribose-match Adenosine A2 receptor NAs.002486 Ki = 1900.0 nM Binding affinity for adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand CHEMBL1123411
NAs.002486 2 ribose-match Adenosine receptors; A1 & A2 NAs.002486 Other = 1200.0 None Ratio of binding affinities for A2 and A1 receptors CHEMBL1123411
NAs.002486 2 ribose-match Adenosine A1 receptor NAs.002486 Ki = 1.6 nM Binding affinity for adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand CHEMBL1123411
NAs.002486 2 ribose-match Mus musculus NAs.002486 Other = 10.0 mg kg-1 Dose required to inhibit mouse locomotor activity by 60% CHEMBL1123411
NAs.003717 2 all-match CCRF-CEM NAs.003717 Other = 4.0 uM Inhibition of human CEM lymphoblast proliferation CHEMBL1126884
NAs.003717 2 all-match Adenosine kinase NAs.003717 Ki = 300.0 nM Inhibition of human placental adenosine kinase CHEMBL1126884
NAs.003717 2 all-match Adenosine kinase NAs.003717 Other > 10.0 uM Inhibition of adenosine kinase-induced MMPR (6-methylmercaptopurine riboside) toxicity in human CEM lymphoblasts CHEMBL1126884
NAs.003717 2 all-match Adenosine kinase NAs.003717 Other < 0.4 None Selectivity for adenosine kinase, Ratio of non-specific cellular (ID50) and specific MMPR-related (ED50) toxicity CHEMBL1126884