Showing 1 to 13 of 13 entries Per page:
Compound ID
Cluster
Compound Type
Target/Cell Structure Activity Assay Description Source
Type
Relation
Value
Unit
NAs.000068 2 all-match Trypanosoma brucei brucei NAs.000068 IC50 > 100000.0 nM Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei LAB 110 EATRO after 48 hrs by Z1 zoulter counter CHEMBL1151452
NAs.000068 2 all-match Trypanosoma brucei brucei NAs.000068 IC50 = 72500.0 nM Antitrypanosomal activity against pentamidine and melarsoprol-resistant bloodstream form of Trypanosoma brucei brucei isolate KETRI 243 after 48 hrs by Z1 zoulter counter CHEMBL1151452
NAs.000068 2 all-match Trypanosoma brucei brucei NAs.000068 IC50 > 100000.0 nM Antitrypanosomal activity against pentamidine-resistant bloodstream form of Trypanosoma brucei brucei isolate KETRI 269 after 48 hrs by Z1 zoulter counter CHEMBL1151452
NAs.000068 2 all-match Trypanosoma brucei brucei NAs.000068 IC50 = 15750.0 nM Antitrypanosomal activity against diamidine and melarsoprol-resistant bloodstream form of Trypanosoma brucei brucei isolate KETRI 243-As10-3 after 48 hrs by Z1 zoulter counter CHEMBL1151452
NAs.000068 2 all-match Unchecked NAs.000068 Other = 46.0 % Activity at bloodstream Trypanosoma brucei brucei 5'-deoxy-5'-(methylthio)-adenosine phosphorylase by spectrophotometry in presence of 50 mM PO4- relative to control CHEMBL1151452
NAs.000068 2 all-match Unchecked NAs.000068 Other = 60.0 % Activity at bloodstream Trypanosoma brucei brucei 5'-deoxy-5'-(methylthio)-adenosine phosphorylase by spectrophotometry relative to control CHEMBL1151452
NAs.000068 2 all-match DNA (cytosine-5)-methyltransferase 1 NAs.000068 IC50 > 45000.0 nM Inhibition of human recombinant DNMT1 CHEMBL1151876
NAs.000068 2 all-match DNA (cytosine-5)-methyltransferase 3B NAs.000068 IC50 = 17000.0 nM Inhibition of human recombinant DNMT3b2 CHEMBL1151876
NAs.000068 2 all-match Histone-lysine N-methyltransferase, H3 lysine-79 specific NAs.000068 Ki = 100000.0 nM Inhibition of human recombinant DOT1L catalytic domain amino acid (1 to 472) using [3H]-SAM after 30 mins by scintillation counter CHEMBL2169812
NAs.000068 2 all-match Histone-lysine N-methyltransferase, H3 lysine-79 specific NAs.000068 Ki = 100000.0 nM Competitive inhibition of recombinant human DOT1L using adenosine/deazaadenosine as substrate and SAM cofactor CHEMBL3085656
NAs.000068 2 all-match Histone-lysine N-methyltransferase EZH2 NAs.000068 Other None None % Inhibition of N-terminally FLAG-tagged wild type EZH2 in EZH2/SUZ12/EED/RbAp48 complex (unknown origin) expressed in baculovirus infected in SF9 cells assessed as inhibition of methylation of nucleosomes at H3K27 at 20 uM by scintillation counting in presence of [3H]SAM CHEMBL3396964
NAs.000068 2 all-match tRNA (cytosine(38)-C(5))-methyltransferase NAs.000068 Other None None None Binding affinity to full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS at 100 uM incubated for 5 mins by microscale thermophoresis assay CHEMBL5131574
NAs.000068 2 all-match tRNA (cytosine(38)-C(5))-methyltransferase NAs.000068 Other None None % Inhibition of full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS at 100 uM using tRNA asp as substrate and SAM as co-substrate incubated for 5 mins by tritium incorporation assay relative to control CHEMBL5131574