Showing 1 to 50 of 673 entries Per page:
Compound ID
Cluster
Compound Type
Target/Cell Structure Activity Assay Description Source
Type
Relation
Value
Unit
NAs.000071 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000071 Ki = 210.0 nM Inhibition of HIV1 reverse transcriptase by steady state nucleotide incorporation assay CHEMBL1155161
NAs.000071 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000071 Other = 0.47 None Ratio of Ki to Km for HIV1 reverse transcriptase by steady state nucleotide incorporation assay CHEMBL1155161
NAs.000071 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000071 Ki = 110.0 nM Inhibition of HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant by steady state nucleotide incorporation assay CHEMBL1155161
NAs.000071 7 all-match Unchecked NAs.000071 Other = 0.5 None Ratio of Ki for HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant to Ki for wild-type reverse transcriptase CHEMBL1155161
NAs.000071 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000071 Other = 0.19 None Ratio of Ki to Km for HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant by steady state nucleotide incorporation assay CHEMBL1155161
NAs.000071 7 all-match Unchecked NAs.000071 Other = 0.4 None Ratio of Ki/Km for HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant to Ki/Km for wild-type reverse transcriptase CHEMBL1155161
NAs.000599 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000599 Other = 18000.0 nM Binding affinity to HIV1 recombinant reverse transcriptase p66/p51 K65R mutant expressed in Escherichia coli assessed as incorporation of drug to DNA by gel electrophoresis CHEMBL1154421
NAs.000599 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000599 IC50 = 170000.0 nM Inhibition of HIV1 reverse transcriptase p66/p51 K65R mutant expressed in Escherichia coli using calf thymus DNA substrate CHEMBL1154421
NAs.000599 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000599 IC50 = 22000.0 nM Inhibition of HIV1 wild type reverse transcriptase p66/p51 expressed in Escherichia coli using calf thymus DNA substrate CHEMBL1154421
NAs.000599 7 all-match Unchecked NAs.000599 Other = 8.0 None Ratio of IC50 for HIV1 reverse transcriptase p66/p51 K65R mutant to IC50 for HIV1 wild type reverse transcriptase CHEMBL1154421
NAs.000599 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000599 Other = 23000.0 nM Binding affinity to HIV1 wild type reverse transcriptase p66/p51 expressed in Escherichia coli assessed as incorporation of drug to DNA by gel electrophoresis CHEMBL1154421
NAs.000599 7 all-match Unchecked NAs.000599 IC50 = 13000.0 nM Inhibition of HIV1 reverse transcriptase 41L/67N/70R/210W/215Y mutant in presence of 5'-A12-(GTCA)5-3' by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Unchecked NAs.000599 IC50 = 24000.0 nM Inhibition of HIV1 reverse transcriptase 41L/69S-SG/184V/210W/215Y mutant in presence of 5'-A12-(GTCA)5-3' by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000599 Other = 0.3 None Binding affinity to wild type reverse transcriptase assessed as ratio of catalytic rate constant to Kd for incorporation of drug to DNA by gel electrophoresis CHEMBL1154421
NAs.000599 7 all-match Unchecked NAs.000599 IC50 = 2800.0 nM Inhibition of HIV1 reverse transcriptase wild type HXB2(a) in presence of 5'-A12-(GACT)5-3' by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Unchecked NAs.000599 IC50 = 3300.0 nM Inhibition of HIV1 reverse transcriptase wild type HXB2(a) in presence of 5'-A12-(GTCA)5-3' by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Unchecked NAs.000599 IC50 = 49000.0 nM Inhibition of HIV1 reverse transcriptase 41L/67N/70R/210W/215Y mutant in presence of 20 uM dNTP by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Unchecked NAs.000599 IC50 = 17000.0 nM Inhibition of HIV1 reverse transcriptase 41L/69S-SG/184V/210W/215Y mutant in presence of 5'-A12-(GACT)5-3' by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000599 Other = 0.02 None Binding affinity to HIV1 recombinant reverse transcriptase p66/p51 K65R mutant expressed in Escherichia coli assessed as ratio of catalytic rate constant to Kd for incorporation of drug to DNA by gel electrophoresis CHEMBL1154421
NAs.000599 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000599 Other = 74.0 % Inhibition of HIV1 wild type reverse transcriptase p66/p51 DNA polymerase activity assessed as formation of terminated DNA products CHEMBL1154421
NAs.000599 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000599 Other = 97.8 None Binding affinity to HIV1 recombinant reverse transcriptase p66/p51 K65R mutant assessed as ratio of catalytic rate constant to Kd for dATP to drug by gel electrophoresis CHEMBL1154421
NAs.000599 7 all-match Unchecked NAs.000599 IC50 = 13000.0 nM Inhibition of HIV1 reverse transcriptase 41L/67N/70R/210W/215Y mutant in presence of 1 uM dNTP by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Unchecked NAs.000599 Other = 0.2 % Inhibition of HIV1 wild type reverse transcriptase p66/p51 R72A mutant DNA polymerase activity assessed as formation of terminated DNA products CHEMBL1154421
NAs.000599 7 all-match Human immunodeficiency virus 1 NAs.000599 Other = 2.1 None Antiviral activity against HIV1 LAI with reverse transcriptase K70E mutation relative to wild type HIV1 LAI CHEMBL1151429
NAs.000599 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000599 Other = 0.79 /s Binding affinity to wild type HIV1 reverse transcriptase assessed as compound incorporation in presence of 50 nM primer template and 10 mM MgCl2 by pre-steady state kinetics study CHEMBL2046281
NAs.000599 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000599 Other = 16500.0 nM Binding affinity to wild type HIV1 reverse transcriptase by pre-steady state kinetics study CHEMBL2046281
NAs.000599 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000599 Other = 56.0 None Discrimination index, ratio of incorporation efficiency of TFV-DP to incorporation efficiency of compound for wild type HIV1 reverse transcriptase CHEMBL2046281
NAs.000599 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000599 Other = 0.048 /s/microM Inhibition of wild type HIV1 reverse transcriptase assessed as compound incorporation efficiency in presence of 50 nM primer template and 10 mM MgCl2 by pre-steady state kinetics study CHEMBL2046281
NAs.000599 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000599 Other = 0.15 /s Binding affinity to HIV1 reverse transcriptase K65R mutant assessed as compound incorporation in presence of 50 nM primer template and 10 mM MgCl2 by pre-steady state kinetics study CHEMBL2046281
NAs.000599 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000599 Other = 29100.0 nM Binding affinity to HIV1 reverse transcriptase K65R mutant by pre-steady state kinetics study CHEMBL2046281
NAs.000599 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000599 Other = 0.005 /s/microM Inhibition of HIV1 reverse transcriptase K65R mutant assessed as compound incorporation efficiency in presence of 50 nM primer template and 10 mM MgCl2 by pre-steady state kinetics study CHEMBL2046281
NAs.000599 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000599 Other = 122.0 None Discrimination index, ratio of incorporation efficiency of TFV-DP to incorporation efficiency of compound for wild type HIV1 reverse transcriptase K65R mutant CHEMBL2046281
NAs.000599 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000599 Other = 21.9 None Binding affinity to HIV1 wild type reverse transcriptase p66/p51 assessed as ratio of catalytic rate constant to Kd for dATP to drug by gel electrophoresis CHEMBL1154421
NAs.000599 7 all-match Unchecked NAs.000599 IC50 = 19000.0 nM Inhibition of HIV1 reverse transcriptase wild type HXB2(a) in presence of 20 uM dNTP by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Unchecked NAs.000599 IC50 = 8600.0 nM Inhibition of HIV1 reverse transcriptase 41L/67N/70R/210W/215Y mutant in presence of 5'-A12-(GACT)5-3' by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Unchecked NAs.000599 IC50 = 1100.0 nM Inhibition of HIV1 pNL4-3 reverse transcriptase 115F mutant by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Unchecked NAs.000599 IC50 = 3300.0 nM Inhibition of HIV1 reverse transcriptase wild type HXB2(a) in presence of 5 mM ATP by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Unchecked NAs.000599 IC50 = 2300.0 nM Inhibition of HIV1 reverse transcriptase 184V mutant in presence of 5 mM ATP by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Unchecked NAs.000599 IC50 = 13000.0 nM Inhibition of HIV1 reverse transcriptase 41L/67N/70R/210W/215Y mutant in presence of 5 mM ATP by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Unchecked NAs.000599 IC50 = 5900.0 nM Inhibition of HIV1 reverse transcriptase 41L/67N/70R/184V/210W/215Y mutant in presence of 5 mM ATP by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Unchecked NAs.000599 IC50 = 3300.0 nM Inhibition of HIV1 reverse transcriptase wild type HXB2(a) in presence of 1 uM dNTP by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Unchecked NAs.000599 IC50 None None None Inhibition of HIV1 reverse transcriptase 41L/69S-SG/184V/210W/215Y mutant in presence of 5 mM ATP by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Unchecked NAs.000599 IC50 = 4600.0 nM Inhibition of HIV1 reverse transcriptase 75I/77L/116Y/151M/184V mutant in presence of 5 mM ATP by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Unchecked NAs.000599 IC50 = 11000.0 nM Inhibition of HIV1 reverse transcriptase 75I/77L/116Y/151M mutant in presence of 5 mM ATP by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Unchecked NAs.000599 IC50 = 3200.0 nM Inhibition of HIV1 reverse transcriptase wild type HXB2(b) in presence of 5 mM ATP by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Unchecked NAs.000599 IC50 = 10500.0 nM Inhibition of HIV1 LAI reverse transcriptase 41L/67N/70R/215Y/219Q mutant in presence of 5 mM ATP by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000599 IC50 = 1300.0 nM Inhibition of HIV1 LAI reverse transcriptase wild type in presence of 5 mM ATP by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Unchecked NAs.000599 IC50 = 21000.0 nM Inhibition of HIV1 LAI reverse transcriptase 65R mutant in presence of 5 mM ATP by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.000599 IC50 = 4000.0 nM Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 in presence of 5 mM ATP by heteropolymeric DNA polymerase assay CHEMBL1143844
NAs.000599 7 all-match Unchecked NAs.000599 IC50 = 3700.0 nM Inhibition of HIV1 pNL4-3 reverse transcriptase 115F mutant in presence of 5 mM ATP by heteropolymeric DNA polymerase assay CHEMBL1143844