| Compound ID |
Cluster
|
Compound Type
|
Target/Cell | Structure | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.000071 | 7 | all-match | Human immunodeficiency virus type 1 reverse transcriptase |  |
Ki | = | 210.0 | nM | Inhibition of HIV1 reverse transcriptase by steady state nucleotide incorporation assay | CHEMBL1155161 | |
| NAs.000071 | 7 | all-match | Human immunodeficiency virus type 1 reverse transcriptase | |
Other | = | 0.47 | None | Ratio of Ki to Km for HIV1 reverse transcriptase by steady state nucleotide incorporation assay | CHEMBL1155161 | |
| NAs.000071 | 7 | all-match | Human immunodeficiency virus type 1 reverse transcriptase | |
Ki | = | 110.0 | nM | Inhibition of HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant by steady state nucleotide incorporation assay | CHEMBL1155161 | |
| NAs.000071 | 7 | all-match | Unchecked | |
Other | = | 0.5 | None | Ratio of Ki for HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant to Ki for wild-type reverse transcriptase | CHEMBL1155161 | |
| NAs.000071 | 7 | all-match | Human immunodeficiency virus type 1 reverse transcriptase | |
Other | = | 0.19 | None | Ratio of Ki to Km for HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant by steady state nucleotide incorporation assay | CHEMBL1155161 | |
| NAs.000071 | 7 | all-match | Unchecked | |
Other | = | 0.4 | None | Ratio of Ki/Km for HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant to Ki/Km for wild-type reverse transcriptase | CHEMBL1155161 | |
| NAs.002857 | 7 | all-match | DNA polymerase alpha subunit |  |
IC50 | > | 100000.0 | nM | Inhibition of human DNA polymerase alpha by microplate reader analysis | CHEMBL1649500 | |
| NAs.002857 | 7 | all-match | DNA polymerase beta | |
IC50 | = | 33000.0 | nM | Inhibition of human DNA polymerase beta by microplate reader analysis | CHEMBL1649500 | |
| NAs.002857 | 7 | all-match | DNA polymerase gamma subunit 1 | |
IC50 | None | None | None | Inhibition of human DNA polymerase gamma by microplate reader analysis | CHEMBL1649500 | |
| NAs.004768 | 7 | all-match | DNA polymerase alpha subunit |  |
IC50 | > | 100000.0 | nM | Inhibition of human DNA polymerase alpha by microplate reader analysis | CHEMBL1649500 | |
| NAs.004768 | 7 | all-match | DNA polymerase beta | |
IC50 | = | 13500.0 | nM | Inhibition of human DNA polymerase beta by microplate reader analysis | CHEMBL1649500 | |
| NAs.004768 | 7 | all-match | DNA polymerase gamma subunit 1 | |
IC50 | None | None | None | Inhibition of human DNA polymerase gamma by microplate reader analysis | CHEMBL1649500 | |