Showing 1 to 17 of 17 entries Per page:
Compound ID
Cluster
Compound Type
Target/Cell Structure Activity Assay Description Source
Type
Relation
Value
Unit
NAs.000078 2 ribose-match Adenosine A1 receptor NAs.000078 Other = 35.0 % Displacement of [3H]N6-[(R)-1-methyl-2-phenylethyl]adenosine from human recombinant A1AR expressed in CHO cells at 10 uM CHEMBL3351911
NAs.000078 2 ribose-match Adenosine A2a receptor NAs.000078 Other = 22.0 % Displacement of [3H]2-[p-(2-carboxyethyl)phenylethylamino]-50-N-ethylcarboxamidoadenosine from human recombinant A2AR expressed in HEK293 cells at 10 uM CHEMBL3351911
NAs.000078 2 ribose-match Adenosine A3 receptor NAs.000078 Other = 45.0 % Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-50-N-methyluronamide from human recombinant A3AR expressed in CHO cells at 10 uM CHEMBL3351911
NAs.000579 2 ribose-match Adenosine A1 receptor NAs.000579 Other = 13.0 % Displacement of [3H]N6-[(R)-1-methyl-2-phenylethyl]adenosine from human recombinant A1AR expressed in CHO cells at 10 uM CHEMBL3351911
NAs.000579 2 ribose-match Adenosine A2a receptor NAs.000579 Other = 14.0 % Displacement of [3H]2-[p-(2-carboxyethyl)phenylethylamino]-50-N-ethylcarboxamidoadenosine from human recombinant A2AR expressed in HEK293 cells at 10 uM CHEMBL3351911
NAs.000579 2 ribose-match Adenosine A3 receptor NAs.000579 Ki = 3070.0 nM Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-50-N-methyluronamide from human recombinant A3AR expressed in CHO cells CHEMBL3351911
NAs.000579 2 ribose-match Adenosine A3 receptor NAs.000579 IC50 = 1560.0 nM Agonist activity at human recombinant A3AR expressed in CHO cells assessed as inhibition of forskolin-induced stimulation of cAMP production CHEMBL3351911
NAs.000579 2 ribose-match Adenosine A3 receptor NAs.000579 Other = 50.9 % Agonist activity at human recombinant A3AR expressed in CHO cells assessed as inhibition of forskolin-induced stimulation of cAMP production CHEMBL3351911
NAs.002203 2 ribose-match Adenosine A3 receptor NAs.002203 Other = 44.0 % Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-50-N-methyluronamide from human recombinant A3AR expressed in CHO cells at 10 uM CHEMBL3351911
NAs.002203 2 ribose-match Adenosine A1 receptor NAs.002203 Other = 19.0 % Displacement of [3H]N6-[(R)-1-methyl-2-phenylethyl]adenosine from human recombinant A1AR expressed in CHO cells at 10 uM CHEMBL3351911
NAs.002203 2 ribose-match Adenosine A2a receptor NAs.002203 Other = 15.0 % Displacement of [3H]2-[p-(2-carboxyethyl)phenylethylamino]-50-N-ethylcarboxamidoadenosine from human recombinant A2AR expressed in HEK293 cells at 10 uM CHEMBL3351911
NAs.002533 2 all-match Adenosine A2a receptor NAs.002533 Other = 64.0 % Displacement of [3H]2-[p-(2-carboxyethyl)phenylethylamino]-50-N-ethylcarboxamidoadenosine from human recombinant A2AR expressed in HEK293 cells at 50 uM CHEMBL3351911
NAs.002533 2 all-match NON-PROTEIN TARGET NAs.002533 Other = 14.0 % Immunosuppressive activity against PHA-stimulated proliferation in rat T-lymphocytes assessed as cell viability at 1 uM after 6 days by [3H]thymidine incorporation method relative to control CHEMBL3244180
NAs.002533 2 all-match NON-PROTEIN TARGET NAs.002533 Other = 85.0 % Immunosuppressive activity against PHA-stimulated proliferation in rat T-lymphocytes assessed as cell viability at 100 uM after 6 days by [3H]thymidine incorporation method relative to control CHEMBL3244180
NAs.002533 2 all-match Human herpesvirus 2 NAs.002533 Other = 42.0 % Antiviral activity against HSV2 infected in BHK cells assessed as reduction of viral plaque at 4 uM after 24 hrs CHEMBL3244180
NAs.002533 2 all-match Adenosine A1 receptor NAs.002533 Other = 0.0 % Displacement of [3H]N6-[(R)-1-methyl-2-phenylethyl]adenosine from human recombinant A1AR expressed in CHO cells at 50 uM CHEMBL3351911
NAs.002533 2 all-match Adenosine A3 receptor NAs.002533 Other = 10.0 % Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-50-N-methyluronamide from human recombinant A3AR expressed in CHO cells at 10 uM CHEMBL3351911