| Compound ID |
Cluster
|
Compound Type
|
Target/Cell | Structure | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.000082 | 2 | all-match | NON-PROTEIN TARGET |  |
IC50 | = | 650000.0 | nM | Growth inhibition of human HL60 cells after 48 hrs by MTT assay | CHEMBL3351354 | |
| NAs.000082 | 2 | all-match | K562 | |
IC50 | = | 500000.0 | nM | Growth inhibition of human K562 cells after 48 hrs by MTT assay | CHEMBL3351354 | |
| NAs.000082 | 2 | all-match | HuT78 | |
IC50 | = | 912000.0 | nM | Growth inhibition of human HUT78 cells after 48 hrs by MTT assay | CHEMBL3351354 | |
| NAs.000082 | 2 | all-match | HT-29 | |
IC50 | > | 1000000.0 | nM | Growth inhibition of human HT-29 cells after 48 hrs by MTT assay | CHEMBL3351354 | |
| NAs.000082 | 2 | all-match | MCF7 | |
IC50 | > | 1000000.0 | nM | Growth inhibition of human MCF7 cells after 48 hrs by MTT assay | CHEMBL3351354 | |
| NAs.000082 | 2 | all-match | HeLa | |
IC50 | > | 1000000.0 | nM | Growth inhibition of human HeLa cells after 48 hrs by MTT assay | CHEMBL3351354 | |
| NAs.000082 | 2 | all-match | NON-PROTEIN TARGET | |
IC50 | > | 1000000.0 | nM | Growth inhibition of human Caco2 cells after 48 hrs by MTT assay | CHEMBL3351354 | |
| NAs.000082 | 2 | all-match | HL-60 | |
Other | None | None | None | Induction of apoptosis in human HL60 cells after 24 to 48 hrs by acridine orange and ethidium bromide staining based fluorescence microscopy | CHEMBL3351354 | |
| NAs.000082 | 2 | all-match | No relevant target | |
Other | > | 72.0 | hr | Half life in pH 7.4 isotonic sodium phosphate buffer at 37 degC by HPLC-DAD-ESI-MS method | CHEMBL3351354 | |
| NAs.000082 | 2 | all-match | Serum | |
Other | > | 72.0 | hr | Half life in RPMI-1640 medium containing 10% fetal calf serum assessed as compound disappearance by HPLC-DAD-ESI-MS method | CHEMBL3351354 | |
| NAs.000082 | 2 | all-match | Ribonucleotide reductase | |
Other | None | None | % | Inhibition of ribonucleotide reductase in human HL60 cells assessed as intracellular dNTP pools level at 1.2 mM after 1 hr by HPLC method | CHEMBL3351354 | |
| NAs.000082 | 2 | all-match | Ribonucleotide reductase | |
Other | None | None | % | Inhibition of human recombinant ribonucleotide reductase at 1.2 mM | CHEMBL3351354 | |
| NAs.000082 | 2 | all-match | HL-60 | |
Other | = | 51.0 | % | Induction of cell cycle arrest in human HL60 cells assessed as accumulation at G1 phase at 1 mM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 32%) | CHEMBL3351354 | |
| NAs.000082 | 2 | all-match | HL-60 | |
Other | = | 40.0 | % | Induction of cell cycle arrest in human HL60 cells assessed as accumulation at S phase at 1 mM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 54%) | CHEMBL3351354 | |
| NAs.000082 | 2 | all-match | HL-60 | |
Other | = | 9.0 | % | Induction of cell cycle arrest in human HL60 cells assessed as accumulation at G2M phase at 1 mM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 12%) | CHEMBL3351354 | |