| Compound ID |
Cluster
|
Compound Type
|
Target/Cell | Structure | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.000095 | 2 | ribose-match | Adenosine A1 receptor |  |
Ki | = | 5620.0 | nM | Displacement of [3H]DPCPX binding to adenosine A1 receptors of bovine cortical membranes | CHEMBL1144357 | |
| NAs.000095 | 2 | ribose-match | Adenosine A2a receptor | |
Other | = | 5.0 | % | Percent displacement of [3H]CGS-21680 binding to adenosine A2A receptors of bovine striatal membranes at 0.00005 M | CHEMBL1144357 | |
| NAs.000095 | 2 | ribose-match | Adenosine A3 receptor | |
Ki | = | 3510.0 | nM | Displacement of [125I]AB-MECA from adenosine A3 receptors in bovine cortical membranes | CHEMBL1144357 | |
| NAs.000095 | 2 | ribose-match | Adenosine receptors; A1 & A2a | |
Other | > | 1.78 | None | Relative affinities against adenosine A2A and A1 receptors (ratio of KiA2A/KiA1) | CHEMBL1144357 | |
| NAs.000095 | 2 | ribose-match | Adenosine receptors; A1 & A3 | |
Other | = | 0.57 | None | Relative affinities for adenosine A3 and A1 receptors (ratio of KiA3/KiA1) | CHEMBL1144357 | |
| NAs.000245 | 8 | ribose-match | Adenylate cyclase type II |  |
Other | = | 17.8 | % | Maximum percent inhibition of adenylyl cyclase activity in rat cortical membranes | CHEMBL1144357 | |
| NAs.000245 | 8 | ribose-match | Adenylate cyclase type II | |
IC50 | = | 4908.0 | nM | Inhibition of adenylyl cyclase activity in rat cortical membranes | CHEMBL1144357 | |
| NAs.000245 | 8 | ribose-match | Adenosine receptors; A1 & A3 | |
Other | = | 1.27 | None | Relative affinities for adenosine A3 and A1 receptors (ratio of KiA3/KiA1) | CHEMBL1144357 | |
| NAs.000245 | 8 | ribose-match | Adenosine receptors; A1 & A2a | |
Other | > | 2.21 | None | Relative affinities against adenosine A2A and A1 receptors (ratio of KiA2A/KiA1) | CHEMBL1144357 | |
| NAs.000245 | 8 | ribose-match | Adenosine A3 receptor | |
Ki | = | 5780.0 | nM | Displacement of [125I]AB-MECA from adenosine A3 receptors in bovine cortical membranes | CHEMBL1144357 | |
| NAs.000245 | 8 | ribose-match | Adenosine A2a receptor | |
Other | = | 15.0 | % | Percent displacement of [3H]CGS-21680 binding to adenosine A2A receptors of bovine striatal membranes at 0.00005 M | CHEMBL1144357 | |
| NAs.000245 | 8 | ribose-match | Adenosine A1 receptor | |
Ki | = | 4530.0 | nM | Displacement of [3H]DPCPX binding to adenosine A1 receptors of bovine cortical membranes | CHEMBL1144357 | |
| NAs.001099 | 8 | ribose-match | Adenosine A1 receptor |  |
Ki | = | 1310.0 | nM | Displacement of [3H]DPCPX binding to adenosine A1 receptors of bovine cortical membranes | CHEMBL1144357 | |
| NAs.001099 | 8 | ribose-match | Adenosine A2a receptor | |
Ki | = | 4000.0 | nM | Displacement of [3H]CGS-21680 binding to adenosine A2A receptors of bovine striatal membranes | CHEMBL1144357 | |
| NAs.001099 | 8 | ribose-match | Adenosine A3 receptor | |
Ki | = | 1200.0 | nM | Displacement of [125I]AB-MECA from adenosine A3 receptors in bovine cortical membranes | CHEMBL1144357 | |
| NAs.001099 | 8 | ribose-match | Adenosine receptors; A1 & A2a | |
Other | = | 3.05 | None | Relative affinities against adenosine A2A and A1 receptors (ratio of KiA2A/KiA1) | CHEMBL1144357 | |
| NAs.001099 | 8 | ribose-match | Adenosine receptors; A1 & A3 | |
Other | = | 0.92 | None | Relative affinities for adenosine A3 and A1 receptors (ratio of KiA3/KiA1) | CHEMBL1144357 | |
| NAs.001099 | 8 | ribose-match | Adenosine receptors; A2a & A3 | |
Other | = | 3.33 | None | Relative affinities for adenosine A2A and A3 receptors (ratio of KiA2A/KiA3) | CHEMBL1144357 | |