Showing 1 to 50 of 128 entries Per page:
Compound ID
Cluster
Compound Type
Target/Cell Structure Activity Assay Description Source
Type
Relation
Value
Unit
NAs.000099 2 all-match H9 NAs.000099 Other = 79.0 % Percentage of gag protein expression using H9 cells at 0 uM on 7th day CHEMBL1124730
NAs.000099 2 all-match ADMET NAs.000099 Other = 0.0 % Anti-HIV activity (% toxicity) in ATH-8 cells at 5 uM in absence of 2'-deoxycoformycin at 50 uM CHEMBL1125695
NAs.000099 2 all-match ADMET NAs.000099 Other = 84.0 % Anti-HIV activity (% protection) in ATH-8 cells at 5 uM in absence of 2'-deoxycoformycin at 50 uM CHEMBL1125695
NAs.000099 2 all-match ADMET NAs.000099 Other = 0.0 % Anti-HIV activity (% toxicity) in ATH-8 cells at 5 uM in absence of 2'-deoxycoformycin at 20 uM CHEMBL1125695
NAs.000099 2 all-match ADMET NAs.000099 Other = 70.0 % Anti-HIV activity (% protection) in ATH-8 cells at 5 uM in absence of 2'-deoxycoformycin at 20 uM CHEMBL1125695
NAs.000099 2 all-match ADMET NAs.000099 Other = 0.0 % Anti-HIV activity (% toxicity) in ATH-8 cells at 5 uM in absence of 2'-deoxycoformycin at 0 uM CHEMBL1125695
NAs.000099 2 all-match ADMET NAs.000099 Other = 0.0 % Anti-HIV activity (% protection) in ATH-8 cells at 5 uM in absence of 2'-deoxycoformycin at 0 uM CHEMBL1125695
NAs.000099 2 all-match ADMET NAs.000099 Other = 6.0 None Kinetic parameter relative rate measured at 50 uM at pH 7.4 and 37 degree Centigrade CHEMBL1125695
NAs.000099 2 all-match ADMET NAs.000099 Other = 0.23 None Kinetic parameter Vmax at pH 7.4 and 37 degree Centigrade CHEMBL1125695
NAs.000099 2 all-match ADMET NAs.000099 Other = 0.00033 None Kinetic parameter KM at pH 7.4 and 37 degree Centigrade CHEMBL1125695
NAs.000099 2 all-match No relevant target NAs.000099 Other = -0.18 None Partition coefficient (logP) CHEMBL1125695
NAs.000099 2 all-match Unchecked NAs.000099 Other > 18.0 None Selectivity ratio CD50 to ED50 CHEMBL1123895
NAs.000099 2 all-match MT4 NAs.000099 Other = 35.0 uM Anti-HIV activity was determined as dose required to protect 50% of the HIV-infected MT-4 cells against destruction CHEMBL1123895
NAs.000099 2 all-match MT4 NAs.000099 Other > 625.0 uM Cytotoxicity was determined as the dose required to reduce the viability of uninfected MT-4 cells by 50% CHEMBL1123895
NAs.000099 2 all-match Homo sapiens NAs.000099 IC50 > 200000.0 nM Cytotoxicity in 2.2.15 cells CHEMBL1151095
NAs.000099 2 all-match Vero NAs.000099 IC50 > 100000.0 nM Cytotoxicity in Vero cells CHEMBL1151095
NAs.000099 2 all-match ADMET NAs.000099 Other = 0.0 % Anti-HIV activity (% protection) in ATH-8 cells at 5 uM in presence of 2'-deoxycoformycin at 0 uM CHEMBL1125695
NAs.000099 2 all-match ADMET NAs.000099 Other = 11.0 % Anti-HIV activity (% toxicity) in ATH-8 cells at 5 uM in presence of 2'-deoxycoformycin at 0 uM CHEMBL1125695
NAs.000099 2 all-match ADMET NAs.000099 Other = 68.0 % Anti-HIV activity (% protection) in ATH-8 cells at 5 uM in presence of 2'-deoxycoformycin at 20 uM CHEMBL1125695
NAs.000099 2 all-match ADMET NAs.000099 Other = 17.0 % Anti-HIV activity (% toxicity) in ATH-8 cells at 5 uM in presence of 2'-deoxycoformycin at 20 uM CHEMBL1125695
NAs.000099 2 all-match Human immunodeficiency virus 1 NAs.000099 EC50 = 4400.0 nM Antiviral activity against HIV1 infected in human PBM cells assessed as inhibition of viral replication CHEMBL3632481
NAs.000099 2 all-match ADMET NAs.000099 Other > 17.0 None Therapeutic index, ratio of cytotoxicity against human H9 cells to EC50 for HIV1 RF CHEMBL1137804
NAs.000099 2 all-match ADMET NAs.000099 Other > 17.0 None Therapeutic index, ratio of cytotoxicity against human H9 cells to EC50 for HIV1 3B CHEMBL1137804
NAs.000099 2 all-match Human immunodeficiency virus 1 NAs.000099 EC50 = 1160.0 nM Antiviral activity against HIV1 RF in human H9 cells assessed as inhibition of virus-induced cytopathic effect by formazan-based conventional colorimetric technique CHEMBL1137804
NAs.000099 2 all-match Human immunodeficiency virus 1 NAs.000099 EC50 = 1160.0 nM Antiviral activity against HIV1 3B in human H9 cells assessed as inhibition of virus-induced cytopathic effect by formazan-based conventional colorimetric technique CHEMBL1137804
NAs.000099 2 all-match No relevant target NAs.000099 Other = -0.183 None Partition coefficient (logP) CHEMBL1129582
NAs.000099 2 all-match ADMET NAs.000099 IC50 = 3300.0 nM Anti-HIV activity by using phytohemagglutininin-stimulated peripheral blood mononuclear cell(PHA/PBM) test system CHEMBL1129582
NAs.000099 2 all-match CCRF-CEM NAs.000099 IC50 > 100000.0 nM Cytotoxicity in CEM cells CHEMBL1151095
NAs.000099 2 all-match Unchecked NAs.000099 Other > 6.8 None Selectivity index by CC50 of CEM cells/EC50 of CEM cells against HIV-1 CHEMBL1132719
NAs.000099 2 all-match CCRF-CEM NAs.000099 CC50 > 250000.0 nM Cytotoxic concentration in Wild Type CEM cells CHEMBL1132719
NAs.000099 2 all-match C3H/3T3 NAs.000099 EC50 > 50000.0 nM Effect of compound against Moloney murine sarcoma virus (MSV)-induced transformation of C3H/3T3 embryo murine fibroblasts CHEMBL1132719
NAs.000099 2 all-match CCRF-CEM NAs.000099 EC50 = 40000.0 nM Antiviral activity evaluated as the ability to inhibit the replication of HIV-2 in human T-lymphocytic cells (CEM) CHEMBL1132719
NAs.000099 2 all-match No relevant target NAs.000099 Other = -0.61 None Partition coefficient (logP) CHEMBL1132719
NAs.000099 2 all-match ADMET NAs.000099 Other None None hr Hydrolysis half life in phosphate buffer; Not available CHEMBL1132719
NAs.000099 2 all-match ADMET NAs.000099 Other = 54.0 % Anti-HIV activity (% toxicity) in ATH-8 cells at 5 uM in presence of 2'-deoxycoformycin at 50 uM CHEMBL1125695
NAs.000099 2 all-match ADMET NAs.000099 Other = 48.0 % Anti-HIV activity (% protection) in ATH-8 cells at 5 uM in presence of 2'-deoxycoformycin at 50 uM CHEMBL1125695
NAs.000099 2 all-match C3H/3T3 NAs.000099 Other > 50000.0 nM Minimal cytotoxic concentration required to cause morphological alteration of C3H/3T3 fibroblast culture cells CHEMBL1132719
NAs.000099 2 all-match ADMET NAs.000099 IC50 > 100000.0 nM Cytotoxicity in human peripheral blood mononuclear (PBM) cells CHEMBL1151095
NAs.000099 2 all-match CCRF-CEM NAs.000099 EC50 = 36700.0 nM Antiviral activity evaluated as the ability to inhibit the replication of HIV-1 in human T-lymphocytic cells (CEM) CHEMBL1132719
NAs.000099 2 all-match ADMET NAs.000099 EC50 = 100000.0 nM In vitro anti-HIV activity was evaluated in human peripheral blood mononuclear (PBM) cells CHEMBL1151095
NAs.000099 2 all-match H9 NAs.000099 Other = 19.0 % Percentage of gag protein expression using H9 cells at 50 uM on 12th day CHEMBL1124730
NAs.000099 2 all-match H9 NAs.000099 Other = 53.0 % Percentage of gag protein expression using H9 cells at 20 uM on 12th day CHEMBL1124730
NAs.000099 2 all-match H9 NAs.000099 Other = 66.0 % Percentage of gag protein expression using H9 cells at 5 uM on 12th day CHEMBL1124730
NAs.000099 2 all-match H9 NAs.000099 Other = 79.0 % Percentage of gag protein expression using H9 cells at 0 uM on 12th day CHEMBL1124730
NAs.000099 2 all-match H9 NAs.000099 Other = 0.0 % Percentage of gag protein expression using H9 cells at 200 uM on 10th day CHEMBL1124730
NAs.000099 2 all-match H9 NAs.000099 Other = 34.0 % Percentage of gag protein expression using H9 cells at 100 uM on 10th day CHEMBL1124730
NAs.000099 2 all-match H9 NAs.000099 Other = 20.0 % Percentage of gag protein expression using H9 cells at 50 uM on 10th day CHEMBL1124730
NAs.000099 2 all-match H9 NAs.000099 Other = 37.0 % Percentage of gag protein expression using H9 cells at 20 uM on 10th day CHEMBL1124730
NAs.000099 2 all-match H9 NAs.000099 Other = 71.0 % Percentage of gag protein expression using H9 cells at 0 uM on 10th day CHEMBL1124730
NAs.000099 2 all-match H9 NAs.000099 Other = 0.0 % Percentage of gag protein expression using H9 cells at 200 uM on 7th day CHEMBL1124730