Showing 1 to 36 of 36 entries Per page:
Compound ID
Cluster
Compound Type
Target/Cell Structure Activity Assay Description Source
Type
Relation
Value
Unit
NAs.000132 4 all-match Inosine-5'-monophosphate dehydrogenase 2 NAs.000132 Other = 0.7 uM Inhibitory binding constant was determined against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II) from intercept of Michaelis-Menten plot CHEMBL1128279
NAs.000132 4 all-match Inosine-5'-monophosphate dehydrogenase 2 NAs.000132 Other = 1.5 uM Inhibitory binding constant was determined against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II) from slope of Michaelis-Menten plot CHEMBL1128279
NAs.000132 4 all-match Inosine-5'-monophosphate dehydrogenase 2 NAs.000132 IC50 = 700.0 nM The compound was assayed to determine the inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 CHEMBL1130108
NAs.000132 4 all-match K562 NAs.000132 IC50 = 3200.0 nM Antiproliferative activity against K562 erythroid leukemic cells was determined. CHEMBL1130108
NAs.000132 4 all-match K562 NAs.000132 Other = 2.5 uM The concentration used to induce differentiation in K562 cells CHEMBL1130108
NAs.000132 4 all-match K562 NAs.000132 Other = 26.0 % The ability to induce differentiation in K562 cells was estimated by determining the fraction of benzidine positive cells converted following incubation with the compound. CHEMBL1130108
NAs.000132 4 all-match Unchecked NAs.000132 Other = 10.4 % Percentage of benzidine positive cells is divided by the concentration used. CHEMBL1130108
NAs.000368 4 all-match Inosine-5'-monophosphate dehydrogenase 1 NAs.000368 Ki = 96.0 nM Inhibition of human IMPDH type 1 CHEMBL1138261
NAs.000368 4 all-match Inosine-5'-monophosphate dehydrogenase 2 NAs.000368 Ki = 94.0 nM Inhibition of human IMPDH type 2 CHEMBL1138261
NAs.000368 4 all-match Unchecked NAs.000368 IC50 > 50000.0 nM Inhibition of horse liver malate dehydrogenase CHEMBL1138261
NAs.000368 4 all-match Unchecked NAs.000368 IC50 > 50000.0 nM Inhibition of horse liver lactate dehydrogenase CHEMBL1138261
NAs.000368 4 all-match Unchecked NAs.000368 IC50 = 39000.0 nM Inhibition of horse liver alcohol dehydrogenase CHEMBL1138261
NAs.000387 4 all-match Unchecked NAs.000387 IC50 > 50000.0 nM Inhibition of horse liver alcohol dehydrogenase CHEMBL1138261
NAs.000387 4 all-match Unchecked NAs.000387 IC50 > 50000.0 nM Inhibition of horse liver lactate dehydrogenase CHEMBL1138261
NAs.000387 4 all-match Unchecked NAs.000387 Ki = 1.0 nM Inhibition of human IMPDH CHEMBL1152430
NAs.000387 4 all-match Inosine-5'-monophosphate dehydrogenase 2 NAs.000387 Ki = 14.0 nM Inhibition of human IMPDH type 2 CHEMBL1138261
NAs.000387 4 all-match Inosine-5'-monophosphate dehydrogenase 1 NAs.000387 Ki = 1.0 nM Inhibition of human IMPDH type 1 CHEMBL1138261
NAs.000387 4 all-match Unchecked NAs.000387 IC50 > 50000.0 nM Inhibition of horse liver malate dehydrogenase CHEMBL1138261
NAs.000785 4 all-match Inosine-5'-monophosphate dehydrogenase 2 NAs.000785 Other = 0.5 uM Inhibitory binding constant was determined against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II) from intercept of Michaelis-Menten plot CHEMBL1128279
NAs.000785 4 all-match Inosine-5'-monophosphate dehydrogenase 2 NAs.000785 Other = 6.0 uM Inhibitory binding constant was determined against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II) from slope of Michaelis-Menten plot CHEMBL1128279
NAs.000785 4 all-match Inosine-5'-monophosphate dehydrogenase 2 NAs.000785 IC50 = 2600.0 nM The compound was assayed to determine the inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 CHEMBL1130108
NAs.000785 4 all-match K562 NAs.000785 IC50 = 3800.0 nM Antiproliferative activity against K562 erythroid leukemic cells was determined. CHEMBL1130108
NAs.000785 4 all-match K562 NAs.000785 Other = 13.0 uM The concentration used to induce differentiation in K562 cells CHEMBL1130108
NAs.000785 4 all-match K562 NAs.000785 Other = 56.0 % The ability to induce differentiation in K562 cells was estimated by determining the fraction of benzidine positive cells converted following incubation with the compound. CHEMBL1130108
NAs.000785 4 all-match Unchecked NAs.000785 Other = 10.4 % Percentage of benzidine positive cells is divided by the concentration used. CHEMBL1130108
NAs.002708 4 all-match Unchecked NAs.002708 Ki = 10.0 nM Inhibition of human IMPDH CHEMBL1152430
NAs.002708 4 all-match Unchecked NAs.002708 IC50 > 50000.0 nM Inhibition of horse liver alcohol dehydrogenase CHEMBL1138261
NAs.002708 4 all-match Unchecked NAs.002708 IC50 > 50000.0 nM Inhibition of horse liver lactate dehydrogenase CHEMBL1138261
NAs.002708 4 all-match Inosine-5'-monophosphate dehydrogenase 1 NAs.002708 Ki = 10.0 nM Inhibition of human IMPDH type 1 CHEMBL1138261
NAs.002708 4 all-match Inosine-5'-monophosphate dehydrogenase 2 NAs.002708 Ki = 49.0 nM Inhibition of human IMPDH type 2 CHEMBL1138261
NAs.002708 4 all-match Unchecked NAs.002708 IC50 > 50000.0 nM Inhibition of horse liver malate dehydrogenase CHEMBL1138261
NAs.002933 4 all-match Inosine-5'-monophosphate dehydrogenase 1 NAs.002933 Ki = 1.0 nM Inhibition of human IMPDH1 by Spectrophotometry CHEMBL1681750
NAs.002933 4 all-match Inosine-5'-monophosphate dehydrogenase 2 NAs.002933 Ki = 14.0 nM Inhibition of human IMPDH2 by Spectrophotometer CHEMBL1681750
NAs.002933 4 all-match K562 NAs.002933 IC50 None None None Antiproliferative activity against human K562 cells after 72 hrs by MTS assay CHEMBL1681750
NAs.003074 4 all-match Inosine-5'-monophosphate dehydrogenase 2 NAs.003074 Other = 2.9 uM Inhibitory binding constant was determined against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II) from intercept of Michaelis-Menten plot CHEMBL1128279
NAs.003074 4 all-match Inosine-5'-monophosphate dehydrogenase 2 NAs.003074 Other = 13.0 uM Inhibitory binding constant was determined against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II) from slope of Michaelis-Menten plot CHEMBL1128279